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Deepak Deshpande

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
Phone215-955-9982
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    K99HL087560     (DESHPANDE, DEEPAK A)Dec 1, 2006 - Nov 30, 2008
    NIH/NHLBI
    Molecular Mechanisms of Airway Smooth Muscle Relaxation
    Role: Principal Investigator

    R00HL087560     (DESHPANDE, DEEPAK A)Dec 1, 2006 - Dec 31, 2012
    NIH/NHLBI
    Molecular Mechanisms of Airway Smooth Muscle Relaxation
    Role: Principal Investigator

    R01HL104119     (DESHPANDE, DEEPAK A)Jul 19, 2010 - Apr 30, 2015
    NIH/NHLBI
    Novel Mechanisms of Smooth Muscle Beta2-receptor Regulation Relevant to Asthma
    Role: Principal Investigator

    R01AG041265     (DESHPANDE, DEEPAK A)Aug 1, 2012 - Jun 30, 2017
    NIH/NIA
    Molecular basis of age-dependent changes in airway smooth muscle functions
    Role: Principal Investigator

    R21AI126492     (SHAPIRO, PAUL S)Jun 10, 2016 - May 31, 2018
    NIH/NIAID
    Evaluation of novel substrate specific inhibitors of ERK1/2 in the treatment of asthma
    Role: Co-Principal Investigator

    R01HL137030     (DESHPANDE, DEEPAK A)Dec 15, 2017 - Nov 30, 2021
    NIH/NHLBI
    Functional Diversity of Compartmentalized Calcium Signaling in Airway Smooth Muscle
    Role: Principal Investigator

    R21AI135082     (DESHPANDE, DEEPAK A)Dec 20, 2017 - Nov 30, 2019
    NIH/NIAID
    Biased agonism and conformational heterogeneity of beta adrenergic receptors in bronchodilation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA, Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb; 32(2):862-874. PMID: 29042451.
      View in: PubMed
    2. Sharma P, Yi R, Nayak AP, Wang N, Tang F, Knight MJ, Pan S, Oliver B, Deshpande DA. Bitter Taste Receptor Agonists Mitigate Features of Allergic Asthma in Mice. Sci Rep. 2017 Apr 11; 7:46166. PMID: 28397820.
      View in: PubMed
    3. Kota A, Deshpande D, Haghi M, Oliver B, Sharma P. Autophagy and airway fibrosis: Is there a link? F1000Res. 2017; 6:409. PMID: 28815017.
      View in: PubMed
    4. Deshpande DA, Guedes AG, Lund FE, Subramanian S, Walseth TF, Kannan MS. CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets. Pharmacol Ther. 2017 Apr; 172:116-126. PMID: 27939939.
      View in: PubMed
    5. Sharma P, Panebra A, Pera T, Tiegs BC, Hershfeld A, Kenyon LC, Deshpande DA. Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15; 310(4):L365-76. PMID: 26684251.
      View in: PubMed
    6. Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26; 527(7579):477-83. PMID: 26550826.
      View in: PubMed
    7. Camoretti-Mercado B, Pauer SH, Yong HM, Smith DC, Deshpande DA, An SS, Liggett SB. Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. PLoS One. 2015; 10(6):e0131582. PMID: 26121686.
      View in: PubMed
    8. Pera T, Hegde A, Deshpande DA, Morgan SJ, Tiegs BC, Theriot BS, Choi YH, Walker JK, Penn RB. Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. FASEB J. 2015 Oct; 29(10):4227-35. PMID: 26103985.
      View in: PubMed
    9. Robinson MB, Deshpande DA, Chou J, Cui W, Smith S, Langefeld C, Hastie AT, Bleecker ER, Hawkins GA. IL-6 trans-signaling increases expression of airways disease genes in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15; 309(2):L129-38. PMID: 26001777.
      View in: PubMed
    10. Lakkaraju SK, Yu W, Raman EP, Hershfeld AV, Fang L, Deshpande DA, MacKerell AD. Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors. J Chem Inf Model. 2015 Mar 23; 55(3):700-8. PMID: 25692383.
      View in: PubMed
    11. Guedes AG, Deshpande DA, Dileepan M, Walseth TF, Panettieri RA, Subramanian S, Kannan MS. CD38 and airway hyper-responsiveness: studies on human airway smooth muscle cells and mouse models. Can J Physiol Pharmacol. 2015 Feb; 93(2):145-53. PMID: 25594684.
      View in: PubMed
    12. Morgan SJ, Deshpande DA, Tiegs BC, Misior AM, Yan H, Hershfeld AV, Rich TC, Panettieri RA, An SS, Penn RB. ß-Agonist-mediated Relaxation of Airway Smooth Muscle Is Protein Kinase A-dependent. J Biol Chem. 2014 Aug 15; 289(33):23065-74. PMID: 24973219.
      View in: PubMed
    13. Deshpande DA, Yan H, Kong KC, Tiegs BC, Morgan SJ, Pera T, Panettieri RA, Eckhart AD, Penn RB. Exploiting functional domains of GRK2/3 to alter the competitive balance of pro- and anticontractile signaling in airway smooth muscle. FASEB J. 2014 Feb; 28(2):956-65. PMID: 24132623.
      View in: PubMed
    14. Horvat SJ, Deshpande DA, Yan H, Panettieri RA, Codina J, DuBose TD, Xin W, Rich TC, Penn RB. A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle. FASEB J. 2012 Sep; 26(9):3670-9. PMID: 22649031.
      View in: PubMed
    15. An SS, Robinett KS, Deshpande DA, Wang WC, Liggett SB. Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nat Med. 2012 May 04; 18(5):650-1. PMID: 22561815.
      View in: PubMed
    16. Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, Liggett SB. Bronchodilator activity of bitter tastants in human tissue. Nat Med. 2011 Jul 07; 17(7):776-8. PMID: 21738150.
      View in: PubMed
    17. Robinett KS, Deshpande DA, Malone MM, Liggett SB. Agonist-promoted homologous desensitization of human airway smooth muscle bitter taste receptors. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):1069-74. PMID: 21642585.
      View in: PubMed
    18. Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med. 2010 Nov; 16(11):1299-304. PMID: 20972434.
      View in: PubMed
    19. Yan H, Deshpande DA, Misior AM, Miles MC, Saxena H, Riemer EC, Pascual RM, Panettieri RA, Penn RB. Anti-mitogenic effects of ß-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J. 2011 Jan; 25(1):389-97. PMID: 20805374.
      View in: PubMed
    20. Misior AM, Deshpande DA, Loza MJ, Pascual RM, Hipp JD, Penn RB. Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle. Am J Respir Cell Mol Biol. 2009 Jul; 41(1):24-39. PMID: 19059887.
      View in: PubMed
    21. Kong KC, Gandhi U, Martin TJ, Anz CB, Yan H, Misior AM, Pascual RM, Deshpande DA, Penn RB. Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry. 2008 Sep 2; 47(35):9279-88. PMID: 18690720.
      View in: PubMed
    22. Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells. J Allergy Clin Immunol. 2008 Jul; 122(1):107-13, 113.e1-7. PMID: 18472152.
      View in: PubMed
    23. Deshpande DA, Theriot BS, Penn RB, Walker JK. Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. FASEB J. 2008 Jul; 22(7):2134-41. PMID: 18337459.
      View in: PubMed
    24. Misior AM, Yan H, Pascual RM, Deshpande DA, Panettieri RA, Penn RB. Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol Pharmacol. 2008 Feb; 73(2):566-74. PMID: 17993511.
      View in: PubMed
    25. Hua X, Erikson CJ, Chason KD, Rosebrock CN, Deshpande DA, Penn RB, Tilley SL. Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L25-32. PMID: 17468137.
      View in: PubMed
    26. Deshpande DA, Pascual RM, Wang SW, Eckman DM, Riemer EC, Funk CD, Penn RB. PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation. FASEB J. 2007 Aug; 21(10):2335-42. PMID: 17392478.
      View in: PubMed
    27. Deshpande DA, Penn RB. Targeting G protein-coupled receptor signaling in asthma. Cell Signal. 2006 Dec; 18(12):2105-20. PMID: 16828259.
      View in: PubMed
    28. Kang BN, Tirumurugaan KG, Deshpande DA, Amrani Y, Panettieri RA, Walseth TF, Kannan MS. Transcriptional regulation of CD38 expression by tumor necrosis factor-alpha in human airway smooth muscle cells: role of NF-kappaB and sensitivity to glucocorticoids. FASEB J. 2006 May; 20(7):1000-2. PMID: 16571778.
      View in: PubMed
    29. Dogan S, Deshpande DA, White TA, Walseth TF, Kannan MS. Regulation of CD 38 expression and function by steroid hormones in myometrium. Mol Cell Endocrinol. 2006 Feb 26; 246(1-2):101-6. PMID: 16388888.
      View in: PubMed
    30. Kang BN, Deshpande DA, Tirumurugaan KG, Panettieri RA, Walseth TF, Kannan MS. Adenoviral mediated anti-sense CD38 attenuates TNF-alpha-induced changes in calcium homeostasis of human airway smooth muscle cells. Can J Physiol Pharmacol. 2005 Aug-Sep; 83(8-9):799-804. PMID: 16333382.
      View in: PubMed
    31. Deshpande DA, White TA, Dogan S, Walseth TF, Panettieri RA, Kannan MS. CD38/cyclic ADP-ribose signaling: role in the regulation of calcium homeostasis in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L773-88. PMID: 15821018.
      View in: PubMed
    32. Naik S, Billington CK, Pascual RM, Deshpande DA, Stefano FP, Kohout TA, Eckman DM, Benovic JL, Penn RB. Regulation of cysteinyl leukotriene type 1 receptor internalization and signaling. J Biol Chem. 2005 Mar 11; 280(10):8722-32. PMID: 15590629.
      View in: PubMed
    33. Deshpande DA, White TA, Guedes AG, Milla C, Walseth TF, Lund FE, Kannan MS. Altered airway responsiveness in CD38-deficient mice. Am J Respir Cell Mol Biol. 2005 Feb; 32(2):149-56. PMID: 15557017.
      View in: PubMed
    34. Kotlikoff MI, Kannan MS, Solway J, Deng KY, Deshpande DA, Dowell M, Feldman M, Green KS, Ji G, Johnston R, Lakser O, Lee J, Lund FE, Milla C, Mitchell RW, Nakai J, Rishniw M, Walseth TF, White TA, Wilson J, Xin HB, Woodruff PG. Methodologic advancements in the study of airway smooth muscle. J Allergy Clin Immunol. 2004 Aug; 114(2 Suppl):S18-31. PMID: 15309016.
      View in: PubMed
    35. Amrani Y, Tliba O, Deshpande DA, Walseth TF, Kannan MS, Panettieri RA. Bronchial hyperresponsiveness: insights into new signaling molecules. Curr Opin Pharmacol. 2004 Jun; 4(3):230-4. PMID: 15140413.
      View in: PubMed
    36. Dogan S, Deshpande DA, Kannan MS, Walseth TF. Changes in CD38 expression and ADP-ribosyl cyclase activity in rat myometrium during pregnancy: influence of sex steroid hormones. Biol Reprod. 2004 Jul; 71(1):97-103. PMID: 14998907.
      View in: PubMed
    37. Deshpande DA, Dogan S, Walseth TF, Miller SM, Amrani Y, Panettieri RA, Kannan MS. Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway. Am J Respir Cell Mol Biol. 2004 Jul; 31(1):36-42. PMID: 14764428.
      View in: PubMed
    38. Tliba O, Deshpande D, Chen H, Van Besien C, Kannan M, Panettieri RA, Amrani Y. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol. 2003 Dec; 140(7):1159-62. PMID: 14597600.
      View in: PubMed
    39. Kannan MS, Deshpande DA. Allergic asthma in mice: what determines the phenotype? Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L29-31. PMID: 12788787.
      View in: PubMed
    40. Deshpande DA, Walseth TF, Panettieri RA, Kannan MS. CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness. FASEB J. 2003 Mar; 17(3):452-4. PMID: 12514117.
      View in: PubMed
    41. Dogan S, White TA, Deshpande DA, Murtaugh MP, Walseth TF, Kannan MS. Estrogen increases CD38 gene expression and leads to differential regulation of adenosine diphosphate (ADP)-ribosyl cyclase and cyclic ADP-ribose hydrolase activities in rat myometrium. Biol Reprod. 2002 Mar; 66(3):596-602. PMID: 11870063.
      View in: PubMed
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