Edward Macarak

TitleProfessor ETO
InstitutionThomas Jefferson University
DepartmentDermatology
Address233 S. 10th Street
Philadelphia PA 19107
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    R01HL034005     (MACARAK, EDWARD JOHN)Apr 1, 1985 - Dec 31, 1995
    NIH
    MECHANICAL FORCES EFFECT ON VASCULAR CELLS
    Role: Principal Investigator

    R01DK045419     (MACARAK, EDWARD JOHN)Sep 30, 1992 - Jun 30, 2003
    NIH
    BLADDER SMOOTH MUSCLE RESPONSE TO MECHANICAL FORCE
    Role: Principal Investigator

    R01DK054987     (MACARAK, EDWARD JOHN)Mar 1, 1999 - Jan 31, 2004
    NIH
    MOLECULAR RESPONSE OF THE BLADDER TO OBSTRUCTION
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Macarak EJ, Wermuth PJ, Rosenbloom J, Uitto J. Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases. Exp Dermatol. 2021 Jan; 30(1):132-145. PMID: 33211348.
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    2. Macarak EJ, Rosenbloom J. Therapeutic Approaches to Radiation-Induced Fibrosis. J Cancer Treatment Diagn. 2018; 2(4):7-9. PMID: 30949622.
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    3. Macarak EJ, Lotto CE, Koganti D, Jin X, Wermuth PJ, Olsson AK, Montgomery M, Rosenbloom J. Trametinib prevents mesothelial-mesenchymal transition and ameliorates abdominal adhesion formation. J Surg Res. 2018 Jul; 227:198-210. PMID: 29804854.
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    4. Rosenbloom J, Macarak E, Piera-Velazquez S, Jimenez SA. Human Fibrotic Diseases: Current Challenges in Fibrosis Research. Methods Mol Biol. 2017; 1627:1-23. PMID: 28836191.
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    5. Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment. Matrix Biol. 2016 Apr; 51:37-46. PMID: 26844756.
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    6. Jin X, Ren S, Macarak E, Rosenbloom J. Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-ß1 and IL-6 requires activation of Erk1/2 and Smad2 linker region phosphorylation. Matrix Biol. 2016 Apr; 51:55-64. PMID: 26825317.
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    7. Rosenbloom J, Ren S, Macarak E. New frontiers in fibrotic disease therapies: The focus of the Joan and Joel Rosenbloom Center for Fibrotic Diseases at Thomas Jefferson University. Matrix Biol. 2016 Apr; 51:14-25. PMID: 26807756.
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    8. Andrews JP, Marttala J, Macarak E, Rosenbloom J, Uitto J. Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain. J Invest Dermatol. 2015 Jul; 135(7):1921-4. PMID: 25685931.
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    9. Moorwood C, Philippou A, Spinazzola J, Keyser B, Macarak EJ, Barton ER. Absence of ?-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle. Skelet Muscle. 2014; 4:13. PMID: 25024843.
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    10. Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH. Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. Glia. 2014 Sep; 62(9):1486-501. PMID: 24839011.
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    11. Wei W, Howard PS, Macarak EJ. Recombinant insulin-like growth factor-1 activates satellite cells in the mouse urethral rhabdosphincter. BMC Urol. 2013 Nov 26; 13:62. PMID: 24279352.
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    12. Wei W, Howard PS, Kogan B, Macarak EJ. Urinary diversion results in marked decreases in proliferation and apoptosis in fetal bladder. J Urol. 2012 Oct; 188(4):1306-12. PMID: 22902023.
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    13. Xia J, Lim JC, Lu W, Beckel JM, Macarak EJ, Laties AM, Mitchell CH. Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol. 2012 May 15; 590(10):2285-304. PMID: 22411013.
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    14. Wei W, Howard PS, Zderic SA, Macarak EJ. Beta and gamma-sarcoglycans are decreased in the detrusor smooth muscle cells of the partially obstructed rabbit bladder. J Urol. 2008 May; 179(5):2052-6. PMID: 18355841.
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    15. Wei W, Howard PS, Kogan B, Macarak EJ. Altered extracellular matrix expression in the diverted fetal sheep bladder. J Urol. 2007 Sep; 178(3 Pt 1):1104-7. PMID: 17644133.
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    16. Macarak EJ, Schulz J, Zderic SA, Sado Y, Ninomiya Y, Polyak E, Chacko S, Howard PS. Smooth muscle trans-membrane sarcoglycan complex in partial bladder outlet obstruction. Histochem Cell Biol. 2006 Jul; 126(1):71-82. PMID: 16435124.
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    17. He Y, Macarak EJ, Korostoff JM, Howard PS. Compression and tension: differential effects on matrix accumulation by periodontal ligament fibroblasts in vitro. Connect Tissue Res. 2004; 45(1):28-39. PMID: 15203938.
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    18. Han JS, Macarak E, Rosenbloom J, Chung KC, Chaqour B. Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways. Eur J Biochem. 2003 Aug; 270(16):3408-21. PMID: 12899698.
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    19. Tamura I, Sakaki T, Chaqour B, Howard PS, Ikeo T, Macarak EJ. Correlation of P-cadherin and beta-catenin expression and phosphorylation with carcinogenesis in rat tongue cancer induced with 4-nitroquinoline 1-oxide. Oral Oncol. 2003 Jul; 39(5):506-14. PMID: 12747976.
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    20. Stanton MC, Clement M, Macarak EJ, Zderic SA, Moreland RS. Partial bladder outlet obstruction alters Ca2+ sensitivity of force, but not of MLC phosphorylation, in bladder smooth muscle. Am J Physiol Renal Physiol. 2003 Oct; 285(4):F703-10. PMID: 12799305.
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    21. Coplen DE, Macarak EJ, Howard PS. Matrix synthesis by bladder smooth muscle cells is modulated by stretch frequency. In Vitro Cell Dev Biol Anim. 2003 Mar-Apr; 39(3-4):157-62. PMID: 14505431.
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    22. Matsumoto S, Kogan BA, Levin RM, Howard PS, Macarak EJ. Response of the fetal sheep bladder to urinary diversion. J Urol. 2003 Feb; 169(2):735-9. PMID: 12544354.
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    23. Kirsch AJ, Macarak EJ, Chaqour B, Quinn T, Zderic S, Flake A, Crombleholme T, Adzick NS, Canning D, Hubbard AM, Rosenbloom J, Snyder HM, Howard PS. Molecular response of the bladder to obstruction. Adv Exp Med Biol. 2003; 539(Pt A):195-216. PMID: 15088906.
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    24. Chaqour B, Whitbeck C, Han JS, Macarak E, Horan P, Chichester P, Levin R. Cyr61 and CTGF are molecular markers of bladder wall remodeling after outlet obstruction. Am J Physiol Endocrinol Metab. 2002 Oct; 283(4):E765-74. PMID: 12217894.
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    25. Meneveau NF, Klugherz BD, Chaqour B, Anand V, Tomaszewski JE, Joullié MM, Macarak E, Golden M, Weisz PB, Wilensky RL. Beta-cyclodextrin tetradecasulfate, a novel cyclic oligosaccharide, inhibits thrombus and neointimal formation after coronary vascular injury. Coron Artery Dis. 2002 May; 13(3):189-97. PMID: 12131024.
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    26. Chaqour B, Han JS, Tamura I, Macarak E. Mechanical regulation of IGF-I and IGF-binding protein gene transcription in bladder smooth muscle cells. J Cell Biochem. 2002; 84(2):264-77. PMID: 11787055.
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