Freddy Romero

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1025 Walnut St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tsoyi K, Liang X, De Rossi G, Ryter SW, Xiong K, Chu SG, Liu X, Ith B, Celada LJ, Romero F, Robertson MJ, Esposito AJ, Poli S, El-Chemaly S, Perrella MA, Shi Y, Whiteford J, Rosas IO. CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 Mar 30. PMID: 33784491.
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    2. Cuevas-Mora K, Roque W, Shaghaghi H, Gochuico BR, Rosas IO, Summer R, Romero F. Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung. Respir Res. 2021 Feb 08; 22(1):49. PMID: 33557836.
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    3. Roque W, Romero F. Cellular metabolomics of pulmonary fibrosis, from amino acids to lipids. Am J Physiol Cell Physiol. 2021 05 01; 320(5):C689-C695. PMID: 33471621.
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    4. Roque W, Boni A, Martinez-Manzano J, Romero F. A Tale of Two Proteolytic Machines: Matrix Metalloproteinases and the Ubiquitin-Proteasome System in Pulmonary Fibrosis. Int J Mol Sci. 2020 May 29; 21(11). PMID: 32485920.
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    5. Roque W, Cuevas-Mora K, Romero F. Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. Int J Mol Sci. 2020 Jan 18; 21(2). PMID: 31963720.
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    6. Slovinsky WS, Shaghaghi H, Para R, Romero F, Summer R. Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages. Alcohol. 2019 Sep 06. PMID: 31499142.
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    7. Summer R, Krishna R, Schriner D, Cuevas-Mora K, Sales D, Para R, Roman J, Nieweld C, Gochuico BR, Romero F. Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome. Orphanet J Rare Dis. 2019 Jul 04; 14(1):162. PMID: 31272455.
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    8. Summer R, Shaghaghi H, Schriner D, Roque W, Sales D, Cuevas-Mora K, Desai V, Bhushan A, Ramirez MI, Romero F. Activation of mTORC1/PGC1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium. Am J Physiol Lung Cell Mol Physiol. 2019 Mar 20. PMID: 30892080.
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    9. Para R, Romero F, George G, Summer R. Metabolic Reprogramming as a Driver of Fibroblast Activation in Pulmonary Fibrosis. Am J Med Sci. 2019 Feb 12. PMID: 30879738.
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    10. Shah D, Das P, Alam MA, Mahajan N, Romero F, Shahid M, Singh H, Bhandari V. MicroRNA-34a Promotes Endothelial Dysfunction and Mitochondrial-Mediated Apoptosis in Murine Models of Acute Lung Injury. Am J Respir Cell Mol Biol. 2018 Dec 04. PMID: 30512967.
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    11. Roque W, Summer R, Romero F. Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis. Connect Tissue Res. 2018 Oct 22; 1-12. PMID: 30343604.
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    12. Slovinsky WS, Romero F, Sales D, Shaghaghi H, Summer R. The involvement of GM-CSF deficiencies in parallel pathways of pulmonary alveolar proteinosis and the alcoholic lung. Alcohol. 2018 Jul 18. PMID: 31229291.
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    13. Romero F, Hong X, Shah D, Kallen CB, Rosas I, Guo Z, Schriner D, Barta J, Shaghaghi H, Hoek JB, Mesaros C, Choi AM, Snyder NW, Summer R. Lipid Synthesis is Required to Resolve ER Stress and Limit Fibrotic Responses in the Lung. Am J Respir Cell Mol Biol. 2018 Feb 21. PMID: 29465261.
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    14. Romero F, Summer R. Protein Folding and the Challenges of Maintaining Endoplasmic Reticulum Proteostasis in Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2017 Nov; 14(Supplement_5):S410-S413. PMID: 29161089.
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    15. Fertala J, Romero F, Summer R, Fertala A. Target-Specific Delivery of an Antibody That Blocks the Formation of Collagen Deposits in Skin and Lung. Monoclon Antib Immunodiagn Immunother. 2017 Oct; 36(5):199-207. PMID: 28972447.
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    16. Shah D, Romero F, Guo Z, Sun J, Li J, Kallen CB, Naik UP, Summer R. Obesity-induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 Mar 09. PMID: 28277743.
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    17. Shah D, Romero F, Zhu Y, Duong M, Sun J, Walsh K, Summer R. C1q Deficiency Promotes Pulmonary Vascular Inflammation and Enhances the Susceptibility of the Lung Endothelium to Injury. J Biol Chem. 2015 Dec 4; 290(49):29642-51. PMID: 26487714.
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    18. Loro E, Seifert EL, Moffat C, Romero F, Mishra MK, Sun Z, Krajacic P, Anokye-Danso F, Summer RS, Ahima RS, Khurana TS. IL-15Ra is a determinant of muscle fuel utilization, and its loss protects against obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R835-44. PMID: 26269523.
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    19. Romero F, Shah D, Duong M, Penn RB, Fessler MB, Madenspacher J, Stafstrom W, Kavuru M, Lu B, Kallen CB, Walsh K, Summer R. A Pneumocyte-Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):74-86. PMID: 25409201.
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    20. Shah D, Romero F, Duong M, Wang N, Paudyal B, Suratt BT, Kallen CB, Sun J, Zhu Y, Walsh K, Summer R. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury. Sci Rep. 2015; 5:11362. PMID: 26068229.
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    21. Romero F, Shah D, Duong M, Stafstrom W, Hoek JB, Kallen CB, Lang CH, Summer R. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):840-9. PMID: 24940828.
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    22. Walkey AJ, Demissie S, Shah D, Romero F, Puklin L, Summer RS. Plasma Adiponectin, Clinical Factors, and Patient Outcomes during the Acute Respiratory Distress Syndrome. PLoS One. 2014; 9(9):e108561. PMID: 25259893.
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    23. Haley S, Shah D, Romero F, Summer R. Scleroderma-related lung disease: are adipokines involved pathogenically? Curr Rheumatol Rep. 2013 Dec; 15(12):381. PMID: 24173692.
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    24. Shah D, Romero F, Stafstrom W, Duong M, Summer RS. Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27. PMID: 24285266.
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    25. Govender P, Romero F, Shah D, Paez J, Ding SY, Liu L, Gower A, Baez E, Aly SS, Pilch P, Summer R. Cavin1; a regulator of lung function and macrophage phenotype. PLoS One. 2013; 8(4):e62045. PMID: 23634221.
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    26. Durante P, Chávez M, Pérez M, Romero F, Rivera F. Effect of uric acid on hypertension progression in spontaneously hypertensive rats. Life Sci. 2010 Jun 19; 86(25-26):957-64. PMID: 20470787.
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    27. Romero F, Pérez M, Chávez M, Parra G, Durante P. Effect of uric acid on gentamicin-induced nephrotoxicity in rats - role of matrix metalloproteinases 2 and 9. Basic Clin Pharmacol Toxicol. 2009 Dec; 105(6):416-24. PMID: 19821833.
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