Khadija Rafiq

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kolpakov MA, Guo X, Rafiq K, Vlasenko L, Hooshdaran B, Seqqat R, Wang T, Fan X, Tilley DG, Kostyak JC, Kunapuli SP, Houser SR, Sabri A. Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction. Circulation. 2020 Jun 03. PMID: 32489148.
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    2. Kolpakov MA, Sikder K, Sarkar A, Chaki S, Shukla SK, Guo X, Qi Z, Barbery C, Sabri A, Rafiq K. Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy. Cell Physiol Biochem. 2019; 53(6):982-998. PMID: 31829530.
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    3. Shukla SK, Rafiq K. Proteasome biology and therapeutics in cardiac diseases. Transl Res. 2018 Sep 28. PMID: 30342797.
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    4. Sarkar A, Shukla SK, Alqatawni A, Kumar A, Addya S, Tsygankov AY, Rafiq K. The Role of Allograft Inflammatory Factor-1 in the Effects of Experimental Diabetes on B Cell Functions in the Heart. Front Cardiovasc Med. 2018; 5:126. PMID: 30258845.
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    5. Sikder K, Shukla SK, Patel N, Singh H, Rafiq K. High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-?. Cell Physiol Biochem. 2018; 48(3):1317-1331. PMID: 30048968.
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    6. Shukla SK, Sikder K, Sarkar A, Addya S, Rafiq K. Molecular network, pathway, and functional analysis of time-dependent gene changes related to cathepsin G exposure in neonatal rat cardiomyocytes. Gene. 2018 May 30. PMID: 29859287.
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    7. Sarkar A, Rafiq K. Humoral immunity in heart failure. Cardiovasc Hematol Disord Drug Targets. 2018 05 17. PMID: 29773070.
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    8. Gupta P, Garcia E, Sarkar A, Kapoor S, Rafiq K, Chand HS, Nair M, Jayant RD. Nanoparticle based treatment for Cardiovascular Diseases. Cardiovasc Hematol Disord Drug Targets. 2018 05 07. PMID: 29737265.
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    9. Thangavel C, Perepelyuk M, Boopathi E, Liu Y, Polischak S, Deshpande DA, Rafiq K, Dicker AP, Knudsen KE, Shoyele SA, Den RB. Improvement in Therapeutic Efficacy and Reduction in Cellular Toxicity: Introduction of a Novel Anti-PSMA-Conjugated Hybrid Antiandrogen Nanoparticle. Mol Pharm. 2018 Apr 04. PMID: 29616555.
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    10. Hooshdaran B, Kolpakov MA, Guo X, Miller SA, Wang T, Tilley DG, Rafiq K, Sabri A. Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury. Basic Res Cardiol. 2017 Sep 14; 112(6):62. PMID: 28913553.
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    11. Shukla SK, Liu W, Sikder K, Addya S, Sarkar A, Wei Y, Rafiq K. HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. Sci Rep. 2017 Jul 04; 7(1):4590. PMID: 28676675.
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    12. Kolpakov MA, Rafiq K, Guo X, Hooshdaran B, Wang T, Vlasenko L, Bashkirova YV, Zhang X, Chen X, Iftikhar S, Libonati JR, Kunapuli SP, Sabri A. Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury. J Mol Cell Cardiol. 2016 Jan; 90:21-9. PMID: 26643815.
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    13. Rafiq K, Kolpakov MA, Seqqat R, Guo J, Guo X, Qi Z, Yu D, Mohapatra B, Zutshi N, An W, Band H, Sanjay A, Houser SR, Sabri A. c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia. Circulation. 2014 May 20; 129(20):2031-43. PMID: 24583314.
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    14. Seqqat R, Guo X, Rafiq K, Kolpakov MA, Guo J, Koch WJ, Houser SR, Dell'italia LJ, Sabri A. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. J Mol Cell Cardiol. 2012 Aug; 53(2):240-9. PMID: 22609523.
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    15. Rafiq K, Guo J, Vlasenko L, Guo X, Kolpakov MA, Sanjay A, Houser SR, Sabri A. c-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G. J Biol Chem. 2012 Feb 17; 287(8):5327-39. PMID: 22203672.
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    16. Kolpakov MA, Seqqat R, Rafiq K, Xi H, Margulies KB, Libonati JR, Powel P, Houser SR, Dell'italia LJ, Sabri A. Pleiotropic effects of neutrophils on myocyte apoptosis and left ventricular remodeling during early volume overload. J Mol Cell Cardiol. 2009 Nov; 47(5):634-45. PMID: 19716828.
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    17. Kolwicz SC, MacDonnell SM, Renna BF, Reger PO, Seqqat R, Rafiq K, Kendrick ZV, Houser SR, Sabri A, Libonati JR. Left ventricular remodeling with exercise in hypertension. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1361-8. PMID: 19666835.
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    18. Sabri A, Rafiq K, Seqqat R, Kolpakov MA, Dillon R, Dell'italia LJ. Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dog. Circ Res. 2008 May 9; 102(9):1127-36. PMID: 18356543.
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    19. Rafiq K, Hanscom M, Valerie K, Steinberg SF, Sabri A. Novel mode for neutrophil protease cathepsin G-mediated signaling: membrane shedding of epidermal growth factor is required for cardiomyocyte anoikis. Circ Res. 2008 Jan 4; 102(1):32-41. PMID: 17975113.
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    20. Rafiq K, Kolpakov MA, Abdelfettah M, Streblow DN, Hassid A, Dell'Italia LJ, Sabri A. Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis. J Biol Chem. 2006 Jul 14; 281(28):19781-92. PMID: 16690621.
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    21. Rafiq K, Bergtold A, Clynes R. Immune complex-mediated antigen presentation induces tumor immunity. J Clin Invest. 2002 Jul; 110(1):71-9. PMID: 12093890.
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