Jesse Roman

TitleProfessor
InstitutionThomas Jefferson University
DepartmentPulmonary Diseases
Address800 Walnut Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Roman J, Chiba H. B-cells in Idiopathic Pulmonary Fibrosis: Targeting Immune Cells with Antifibrotic Agents. Am J Respir Cell Mol Biol. 2021 Mar 16. PMID: 33725473.
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    2. Roman J. A tribute to the gang. Lancet Respir Med. 2021 04; 9(4):345-346. PMID: 33581082.
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    3. Greenwell JC, Torres-Gonzalez E, Ritzenthaler JD, Roman J. Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression. Cancer Biol Ther. 2020 Dec 01; 21(12):1109-1118. PMID: 33222614.
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    4. Li M, Yoo EJ, Baram M, McArthur M, Skeehan C, Awsare B, George G, Summer R, Zurlo J, Jallo J, Roman J. Tocilizumab in the Management of COVID-19: A Preliminary Report. Am J Med Sci. 2020 Nov 09. PMID: 33358502.
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    5. Ritzenthaler JD, Zhang M, Torres-Gonzalez E, Roman J. The Integrin Inhibitor Cilengitide and Bleomycin-Induced Pulmonary Fibrosis : Cilengitide and Bleomycin-Induced Pulmonary Fibrosis. Lung. 2020 12; 198(6):947-955. PMID: 33146772.
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    6. Fonseca M, Summer R, Roman J. Acute Exacerbation of Interstitial Lung Disease as a Sequela of COVID-19 Pneumonia. Am J Med Sci. 2021 01; 361(1):126-129. PMID: 32912600.
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    7. Venkata-Subramani M, Roman J. The Coronavirus Response in India - World's Largest Lockdown. Am J Med Sci. 2020 12; 360(6):742-748. PMID: 32892981.
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    8. Flamenbaum M, Roman J. Endemic and emerging coronavirus pulmonary infections. Am J Med Sci. 2020 Jun 12. PMID: 32631575.
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    9. Perez T, Perez RL, Roman J. Conducting Clinical Research in the Era of Covid-19. Am J Med Sci. 2020 09; 360(3):213-215. PMID: 32690272.
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    10. Zheng Y, Merchant ML, Burke TJ, Ritzenthaler JD, Li M, Gaweda AE, Benz FW, Roman J, Watson WH. Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts. Oxid Med Cell Longev. 2020; 2020:2468986. PMID: 32587657.
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    11. Roman J. The Coronavirus Pandemic - Lessons Learned? Am J Med Sci. 2020 Jun 03. PMID: 32605713.
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    12. Perez RL, Roman J. The Coronavirus Pandemic - At the Beginning of the Learning Curve. Am J Med Sci. 2020 08; 360(2):105-106. PMID: 32709279.
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    13. Watson WH, Greenwell JC, Zheng Y, Furmanek S, Torres-Gonzalez E, Ritzenthaler JD, Roman J. Impact of sex, age and diet on the cysteine/cystine and glutathione/glutathione disulfide plasma redox couples in mice. J Nutr Biochem. 2020 10; 84:108431. PMID: 32615368.
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    14. Pandit P, Perez RL, Roman J. Sex-Based Differences in Interstitial Lung Disease. Am J Med Sci. 2020 Apr 25. PMID: 32487327.
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    15. Hilton R, Summer R, Roman J, Sundaram B, George G. E-cigarettes and Vaping Associated Lung Injury: A Case Series and Brief Review. Am J Med Sci. 2020 Mar; 359(3):137-139. PMID: 32089155.
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    16. Roman J. The American Journal of the Medical Sciences-A Repository of the History of American Medicine. Am J Med Sci. 2019 Dec 05. PMID: 31889513.
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    17. Roman J, Perez RL. Granulomatous Inflammation and the Lymphatic System-Perhaps a New Target for Intervention in Tuberculosis and Sarcoidosis (Comment on https://doi.org/10.1002/bies.201900086). Bioessays. 2019 Sep 23; e1900167. PMID: 31544953.
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    18. Watson WH, Ritzenthaler JD, Peyrani P, Wiemken TL, Furmanek S, Reyes Vega AM, Burke TJ, Zheng Y, Ramirez JA, Roman J. Plasma cysteine/cystine and glutathione/glutathione disulfide redox potentials in HIV and COPD patients. Free Radic Biol Med. 2019 11 01; 143:55-61. PMID: 31369840.
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    19. Summer R, Krishna R, Schriner D, Cuevas-Mora K, Sales D, Para R, Roman J, Nieweld C, Gochuico BR, Romero F. Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome. Orphanet J Rare Dis. 2019 Jul 04; 14(1):162. PMID: 31272455.
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    20. Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK. The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities. Am J Med Sci. 2019 May; 357(5):405-410. PMID: 31010467.
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    21. Culver DA, Behr J, Belperio JA, Corte TJ, de Andrade JA, Flaherty KR, Gulati M, Huie TJ, Lancaster LH, Roman J, Ryerson CJ, Kim HJ. Patient Registries in Idiopathic Pulmonary Fibrosis (IPF). Am J Respir Crit Care Med. 2019 Apr 29. PMID: 31034241.
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    22. Gupta E, Jacobs MD, George G, Roman J. Recommended Reading from the Thomas Jefferson University Pulmonary Fellows. Am J Respir Crit Care Med. 2019 Mar 08. PMID: 30849230.
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    23. Roman J. Update on PulmonaryFibrosis: Great Advancements, but Still Searching forAnswers. Am J Med Sci. 2019 May; 357(5):357-358. PMID: 31010460.
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    24. Barnes T, Brown KK, Corcoran B, Glassberg MK, Kervitsky DJ, Limper AH, McGuire K, Williams K, Roman J. Research in Pulmonary Fibrosis Across Species: Unleashing Discovery Through Comparative Biology. Am J Med Sci. 2019 May; 357(5):399-404. PMID: 30879739.
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    25. Zelko IN, Zhu J, Roman J. Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling. Respir Res. 2018 Nov 20; 19(1):221. PMID: 30453980.
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    26. Poole LG, Beier JI, Torres-Gonzales E, Schlueter CF, Hudson SV, Artis A, Warner NL, Nguyen-Ho CT, Dolin CE, Ritzenthaler JD, Hoyle GW, Roman J, Arteel GE. Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung. Alcohol. 2019 11; 80:53-63. PMID: 30445135.
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    27. Zelko IN, Zhu J, Roman J. Maternal undernutrition during pregnancy alters the epigenetic landscape and the expression of endothelial function genes in male progeny. Nutr Res. 2019 01; 61:53-63. PMID: 30683439.
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    28. Roman J. Complementing Lung Cancer: How Tumor Cells Co-opt the Host Complement System to Reach Bone. Am J Respir Crit Care Med. 2018 May 01; 197(9):1101-1103. PMID: 29365275.
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    29. Roman J, Mutsaers SE. Epigenetic Control of CXCL10: Regulating the Counterregulator in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 Apr; 58(4):419-420. PMID: 29717923.
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    30. Roman J. Hurricane Maria: A Preventable Humanitarian and Health Care Crisis Unveiling the Puerto Rican Dilemma. Ann Am Thorac Soc. 2018 Mar; 15(3):293-295. PMID: 29361240.
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    31. Zheng Y, Ritzenthaler JD, Burke TJ, Otero J, Roman J, Watson WH. Age-dependent oxidation of extracellular cysteine/cystine redox state (Eh(Cys/CySS)) in mouse lung fibroblasts is mediated by a decline in Slc7a11 expression. Free Radic Biol Med. 2018 04; 118:13-22. PMID: 29458149.
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    32. Poole LG, Massey VL, Siow DL, Torres-Gonzáles E, Warner NL, Luyendyk JP, Ritzenthaler JD, Roman J, Arteel GE. Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2017 09; 57(3):315-323. PMID: 28445073.
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    33. Roman J. On the "TRAIL" of a Killer: MMP12 in Lung Cancer. Am J Respir Crit Care Med. 2017 08 01; 196(3):262-264. PMID: 28762787.
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    34. Roman J, Zhu J, Ritzenthaler JD, Zelko IN. Epigenetic regulation of EC-SOD expression in aging lung fibroblasts: Role of histone acetylation. Free Radic Biol Med. 2017 11; 112:212-223. PMID: 28757400.
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    35. Suliman S, Al Harash A, Roberts WN, Perez RL, Roman J. Scleroderma-related interstitial lung disease. Respir Med Case Rep. 2017; 22:109-112. PMID: 28761806.
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    36. Vicary GW, Ritzenthaler JD, Panchabhai TS, Torres-González E, Roman J. Nicotine stimulates collagen type I expression in lung via a7 nicotinic acetylcholine receptors. Respir Res. 2017 06 02; 18(1):115. PMID: 28576119.
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    37. Roman J. A New Beginning. Am J Med Sci. 2017 06; 353(6):510. PMID: 28641711.
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    38. Collard HR, Richeldi L, Kim DS, Taniguchi H, Tschoepe I, Luisetti M, Roman J, Tino G, Schlenker-Herceg R, Hallmann C, du Bois RM. Acute exacerbations in the INPULSIS trials of nintedanib in idiopathic pulmonary fibrosis. Eur Respir J. 2017 05; 49(5). PMID: 28526798.
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    39. Roman J, Cribbs SK. Presentation of 2017 SSCI Founders' Medal. Am J Med Sci. 2017 07; 354(1):75-77. PMID: 28755743.
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    40. Zelko IN, Zhu J, Ritzenthaler JD, Roman J. Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica. Respir Res. 2016 11 28; 17(1):160. PMID: 27894297.
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    41. Vicary GW, Vergne Y, Santiago-Cornier A, Young LR, Roman J. Pulmonary Fibrosis in Hermansky-Pudlak Syndrome. Ann Am Thorac Soc. 2016 10; 13(10):1839-1846. PMID: 27529121.
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    42. Beier JI, Guo L, Ritzenthaler JD, Joshi-Barve S, Roman J, Arteel GE.  Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice. Ann Hepatol. 2016 Sep-Oct; 15(5):762-72. PMID: 27493116.
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    43. Watson WH, Burke TJ, Zelko IN, Torres-González E, Ritzenthaler JD, Roman J. Differential Regulation of the Extracellular Cysteine/Cystine Redox State (EhCySS) by Lung Fibroblasts from Young and Old Mice. Oxid Med Cell Longev. 2016; 2016:1561305. PMID: 27642492.
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    44. Vicary GW, Roman J. Targeting the Mammalian Target of Rapamycin in Lung Cancer. Am J Med Sci. 2016 Nov; 352(5):507-516. PMID: 27865299.
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    45. El-Kersh K, Guardiola J, Cavallazzi R, Wiemken TL, Roman J, Saad M. Open and closed models of intensive care unit have different influences on infectious complications in a tertiary care center: A retrospective data analysis. Am J Infect Control. 2016 12 01; 44(12):1744-1746. PMID: 27397908.
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    46. White ES, Borok Z, Brown KK, Eickelberg O, Guenther A, Jenkins RG, Kolb M, Martinez FJ, Roman J, Sime P. An American Thoracic Society Official Research Statement: Future Directions in Lung Fibrosis Research. Am J Respir Crit Care Med. 2016 Apr 01; 193(7):792-800. PMID: 27035782.
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    47. Watson WH, Ritzenthaler JD, Roman J. Lung extracellular matrix and redox regulation. Redox Biol. 2016 08; 8:305-15. PMID: 26938939.
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    48. Roman J. The Puerto Rico Healthcare Crisis. Ann Am Thorac Soc. 2015 Dec; 12(12):1760-3. PMID: 26551268.
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    49. Massey VL, Beier JI, Ritzenthaler JD, Roman J, Arteel GE. Potential Role of the Gut/Liver/Lung Axis in Alcohol-Induced Tissue Pathology. Biomolecules. 2015 Sep 30; 5(4):2477-503. PMID: 26437442.
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    50. Massey VL, Poole LG, Siow DL, Torres E, Warner NL, Schmidt RH, Ritzenthaler JD, Roman J, Arteel GE. Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha. Alcohol Clin Exp Res. 2015 Oct; 39(10):1978-88. PMID: 26380957.
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    51. Song N, Liu J, Shaheen S, Du L, Proctor M, Roman J, Yu J. Vagotomy attenuates bleomycin-induced pulmonary fibrosis in mice. Sci Rep. 2015 Aug 20; 5:13419. PMID: 26289670.
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    52. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondrácek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142.
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    53. Jin S, Merchant ML, Ritzenthaler JD, McLeish KR, Lederer ED, Torres-Gonzalez E, Fraig M, Barati MT, Lentsch AB, Roman J, Klein JB, Rane MJ. Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators. PLoS One. 2015; 10(4):e0121637. PMID: 25848767.
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    54. Zhong X, Fan Y, Ritzenthaler JD, Zhang W, Wang K, Zhou Q, Roman J. Novel link between prostaglandin E2 (PGE2) and cholinergic signaling in lung cancer: The role of c-Jun in PGE2-induced a7 nicotinic acetylcholine receptor expression and tumor cell proliferation. Thorac Cancer. 2015 Jul; 6(4):488-500. PMID: 26273406.
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    55. White ES, Brown KK, Collard HR, Conoscenti CS, Cosgrove GP, Flaherty KR, Leff JA, Martinez FJ, Roman J, Rose D, Violette S, Kaminski N. Open-access biorepository for idiopathic pulmonary fibrosis. The way forward. Ann Am Thorac Soc. 2014 Oct; 11(8):1171-5. PMID: 25167209.
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    56. Roman J. Southern Society for Clinical Investigation 2014 Founders' Medal acceptance: an academic career--it takes a village. Am J Med Sci. 2014 Jul; 348(1):8-10. PMID: 24796292.
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    57. Celedón JC, Roman J, Schraufnagel DE, Thomas A, Samet J. Respiratory health equality in the United States. The American thoracic society perspective. Ann Am Thorac Soc. 2014 May; 11(4):473-9. PMID: 24625275.
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    58. Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ. Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute. Am J Pathol. 2014 Jun; 184(6):1643-51. PMID: 24726499.
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    59. Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP. Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med. 2014 Jan 15; 189(2):214-22. PMID: 24160862; PMCID: PMC3983890.
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    60. Sueblinvong V, Neveu WA, Neujahr DC, Mills ST, Rojas M, Roman J, Guidot DM. Aging promotes pro-fibrotic matrix production and increases fibrocyte recruitment during acute lung injury. Adv Biosci Biotechnol. 2014 Jan; 5(1):19-30. PMID: 24596659.
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    61. Roman J, Brown KK, Olson A, Corcoran BM, Williams KJ. An official American thoracic society workshop report: comparative pathobiology of fibrosing lung disorders in humans and domestic animals. Ann Am Thorac Soc. 2013 Dec; 10(6):S224-9. PMID: 24364785.
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    62. Ritzenthaler JD, Roser-Page S, Guidot DM, Roman J. Nicotinic acetylcholine receptors are sensors for ethanol in lung fibroblasts. Alcohol Clin Exp Res. 2013 Jun; 37(6):914-23. PMID: 23421903.
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    63. Reddy RC, Rehan VK, Roman J, Sime PJ. PPARs: Regulators and Translational Targets in the Lung. PPAR Res. 2012; 2012:342924. PMID: 23213318.
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    64. Ramirez A, Ballard EN, Roman J. TGFß1 Controls PPAR? Expression, Transcriptional Potential, and Activity, in Part, through Smad3 Signaling in Murine Lung Fibroblasts. PPAR Res. 2012; 2012:375876. PMID: 22997505.
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    65. Sueblinvong V, Neujahr DC, Mills ST, Roser-Page S, Ritzenthaler JD, Guidot D, Rojas M, Roman J. Predisposition for disrepair in the aged lung. Am J Med Sci. 2012 Jul; 344(1):41-51. PMID: 22173045.
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    66. Kubiak NT, Guidot DM, Trimm RF, Kamen DL, Roman J. Recruitment and retention in academic medicine--what junior faculty and trainees want department chairs to know. Am J Med Sci. 2012 Jul; 344(1):24-7. PMID: 22744375.
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    67. Wongtrakool C, Wang N, Hyde DM, Roman J, Spindel ER. Prenatal nicotine exposure alters lung function and airway geometry through a7 nicotinic receptors. Am J Respir Cell Mol Biol. 2012 May; 46(5):695-702. PMID: 22246862; PMCID: PMC3359906.
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    68. Roman J. The 2010 Southern Society for Clinical Investigation president's symposium: Idiopathic pulmonary fibrosis. Am J Med Sci. 2011 Jun; 341(6):427. PMID: 21613927.
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    69. Fioret D, Perez RL, Perez T, Roman J. A case of progressive lung fibrosis. Am J Med Sci. 2011 Jun; 341(6):428-30. PMID: 21613928.
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    70. Fioret D, Perez RL, Roman J. Management of idiopathic pulmonary fibrosis. Am J Med Sci. 2011 Jun; 341(6):450-3. PMID: 21613933.
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    71. Mehta AJ, Joshi PC, Fan X, Brown LA, Ritzenthaler JD, Roman J, Guidot DM. Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats. Alcohol Clin Exp Res. 2011 Aug; 35(8):1519-28. PMID: 21447000.
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    72. White ES, Sagana RL, Booth AJ, Yan M, Cornett AM, Bloomheart CA, Tsui JL, Wilke CA, Moore BB, Ritzenthaler JD, Roman J, Muro AF. Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway. Exp Cell Res. 2010 Oct 01; 316(16):2644-53. PMID: 20615404.
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    73. Roman J. The Southern Society for Clinical Investigation 2010 President's Address: Is it time for evolution? Am J Med Sci. 2010 Jul; 340(1):3-4. PMID: 20610955.
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    74. Han SW, Roman J. Anticancer actions of PPAR? ligands: Current state and future perspectives in human lung cancer. World J Biol Chem. 2010 Mar 26; 1(3):31-40. PMID: 21537367.
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    75. Thannickal VJ, Roman J. Challenges in translating preclinical studies to effective drug therapies in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2010 Mar 15; 181(6):532-3. PMID: 20208038.
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    76. Roman J, Ritzenthaler JD, Roser-Page S, Sun X, Han S. alpha5beta1-integrin expression is essential for tumor progression in experimental lung cancer. Am J Respir Cell Mol Biol. 2010 Dec; 43(6):684-91. PMID: 20081050; PMCID: PMC2993088.
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    77. Roman J. Getting trainees hooked on academic medicine. Am J Med Sci. 2009 Dec; 338(6):436-7. PMID: 20010153.
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    78. Ramirez AM, Wongtrakool C, Welch T, Steinmeyer A, Zügel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol. 2010 Feb 15; 118(3):142-50. PMID: 19931390.
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    79. Pozharskaya V, Torres-González E, Rojas M, Gal A, Amin M, Dollard S, Roman J, Stecenko AA, Mora AL. Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PLoS One. 2009 Oct 23; 4(10):e7559. PMID: 19851501.
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    80. Sun X, Ritzenthaler JD, Zhong X, Zheng Y, Roman J, Han S. Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. Cancer Res. 2009 Aug 15; 69(16):6445-53. PMID: 19654299.
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    81. Ahmad F, Roman J. Treating refractory asthma with antibodies against IL-5: is it ready for prime time? Expert Rev Respir Med. 2009 Jun; 3(3):227-30. PMID: 20477317.
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    82. Roman J. Moving away from PPARs - EGFR signaling and the anti-cancer effects of thiazolinedinediones. Cell Res. 2009 Jun; 19(6):669-71. PMID: 19488032.
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    83. Koval M, Ward C, Findley MK, Roser-Page S, Helms MN, Roman J. Extracellular matrix influences alveolar epithelial claudin expression and barrier function. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):172-80. PMID: 19423774; PMCID: PMC2822979.
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    84. Iyer SS, Accardi CJ, Ziegler TR, Blanco RA, Ritzenthaler JD, Rojas M, Roman J, Jones DP. Cysteine redox potential determines pro-inflammatory IL-1beta levels. PLoS One. 2009; 4(3):e5017. PMID: 19325908.
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    85. Roman J. Creating a culture of discovery through clinical trials and translational research. Am J Med Sci. 2009 Mar; 337(3):155. PMID: 19282673.
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    86. Zheng Y, Ritzenthaler JD, Sun X, Roman J, Han S. Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1. Cancer Res. 2009 Feb 01; 69(3):896-904. PMID: 19176380.
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    87. Sun X, Ritzenthaler JD, Zheng Y, Roman J, Han S. Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009 Jan; 8(1):110-8. PMID: 19139119.
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    88. Han S, Sun X, Ritzenthaler JD, Roman J. Fish oil inhibits human lung carcinoma cell growth by suppressing integrin-linked kinase. Mol Cancer Res. 2009 Jan; 7(1):108-17. PMID: 19147542.
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    89. Ritzenthaler JD, Roman J, Han S. PPARbeta/delta agonist increases the expression of PGE2 receptor subtype EP4 in human lung carcinoma cells. Methods Mol Biol. 2009; 512:309-23. PMID: 19347285.
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    90. Mitchell PO, Jensen JS, Ritzenthaler JD, Roman J, Pelaez A, Guidot DM. Alcohol primes the airway for increased interleukin-13 signaling. Alcohol Clin Exp Res. 2009 Mar; 33(3):505-13. PMID: 19120067.
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    91. Iyer SS, Ramirez AM, Ritzenthaler JD, Torres-Gonzalez E, Roser-Page S, Mora AL, Brigham KL, Jones DP, Roman J, Rojas M. Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis. . 2009 Jan; 296(1):L37-45. PMID: 18931052.
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    92. Holguin F, Ramadan B, Gal AA, Roman J. Prognostic factors for hospital mortality and ICU admission in patients with ANCA-related pulmonary vasculitis. Am J Med Sci. 2008 Oct; 336(4):321-6. PMID: 18854674.
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    93. Wongtrakool C, Roman J. Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis. Exp Lung Res. 2008 Oct; 34(8):481-99. PMID: 18850375.
      Citations:    
    94. Ritzenthaler JD, Han S, Roman J. Stimulation of lung carcinoma cell growth by fibronectin-integrin signalling. Mol Biosyst. 2008 Dec; 4(12):1160-9. PMID: 19396378.
      Citations:    
    95. Han S, Ritzenthaler JD, Sun X, Zheng Y, Roman J. Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):325-31. PMID: 18776129; PMCID: PMC2645530.
      Citations:    
    96. Khuri FR, Roman J. From nihilism to individualism: the evolution of lung cancer therapy. Am J Respir Crit Care Med. 2008 Jun 15; 177(12):1299-300. PMID: 18522951.
      Citations:    
    97. Han S, Ritzenthaler JD, Zheng Y, Roman J. PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1238-49. PMID: 18390835.
      Citations:    
    98. Hart CM, Roman J, Reddy R, Sime PJ. PPARgamma: a novel molecular target in lung disease. J Investig Med. 2008 Feb; 56(2):515-7. PMID: 18317433.
      Citations:    
    99. Han SW, Roman J. Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells. PPAR Res. 2008; 2008:254108. PMID: 18704200.
      Citations:    
    100. Kolachala VL, Bajaj R, Wang L, Yan Y, Ritzenthaler JD, Gewirtz AT, Roman J, Merlin D, Sitaraman SV. Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation. J Biol Chem. 2007 Nov 09; 282(45):32965-73. PMID: 17855340.
      Citations:    
    101. Brown LA, Ritzenthaler JD, Guidot DM, Roman J. Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation. Alcohol. 2007 Aug; 41(5):317-24. PMID: 17889308.
      Citations:    
    102. Ramirez A, Ramadan B, Ritzenthaler JD, Rivera HN, Jones DP, Roman J. Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L972-81. PMID: 17644756.
      Citations:    
    103. Zheng Y, Ritzenthaler JD, Roman J, Han S. Nicotine stimulates human lung cancer cell growth by inducing fibronectin expression. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):681-90. PMID: 17600315.
      Citations:    
    104. Collard HR, Moore BB, Flaherty KR, Brown KK, Kaner RJ, King TE, Lasky JA, Loyd JE, Noth I, Olman MA, Raghu G, Roman J, Ryu JH, Zisman DA, Hunninghake GW, Colby TV, Egan JJ, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kondoh Y, Lynch DA, Müller-Quernheim J, Myers JL, Nicholson AG, Selman M, Toews GB, Wells AU, Martinez FJ. Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2007 Oct 01; 176(7):636-43. PMID: 17585107; PMCID: PMC2094133.
      Citations:    
    105. Wongtrakool C, Roser-Page S, Rivera HN, Roman J. Nicotine alters lung branching morphogenesis through the alpha7 nicotinic acetylcholine receptor. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L611-8. PMID: 17545491.
      Citations:    
    106. Burnham EL, Moss M, Ritzenthaler JD, Roman J. Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Alcohol Clin Exp Res. 2007 Apr; 31(4):675-83. PMID: 17374047.
      Citations:    
    107. Mora AL, Torres-González E, Rojas M, Xu J, Ritzenthaler J, Speck SH, Roman J, Brigham K, Stecenko A. Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice. Am J Respir Crit Care Med. 2007 Jun 01; 175(11):1139-50. PMID: 17363768; PMCID: PMC1899276.
      Citations:    
    108. Han S, Roman J. Peroxisome proliferator-activated receptor gamma: a novel target for cancer therapeutics? Anticancer Drugs. 2007 Mar; 18(3):237-44. PMID: 17264754.
      Citations:    
    109. Han S, Ritzenthaler JD, Wingerd B, Rivera HN, Roman J. Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2. J Biol Chem. 2007 Mar 16; 282(11):7961-72. PMID: 17237224.
      Citations:    
    110. Han S, Zheng Y, Roman J. Rosiglitazone, an Agonist of PPARgamma, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2. PPAR Res. 2007; 2007:29632. PMID: 17597835.
      Citations:    
    111. Standiford TJ, Roman J. PPARs in Lung Biology and Disease. PPAR Res. 2007; 2007:28765. PMID: 18274625.
      Citations:    
    112. Keshamouni VG, Han S, Roman J. Peroxisome proliferator-activated receptors in lung cancer. PPAR Res. 2007; 2007:90289. PMID: 18274632.
      Citations:    
    113. Han S, Ritzenthaler JD, Sitaraman SV, Roman J. Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells. J Biol Chem. 2006 Oct 06; 281(40):29614-24. PMID: 16882662.
      Citations:    
    114. Mora AL, Torres-González E, Rojas M, Corredor C, Ritzenthaler J, Xu J, Roman J, Brigham K, Stecenko A. Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis. Am J Respir Cell Mol Biol. 2006 Oct; 35(4):466-73. PMID: 16709958; PMCID: PMC2643265.
      Citations:    
    115. Perez RL, Kimani AP, King TE, Aguayo SM, Roman J. Bronchoalveolar lavage fluid D dimer levels are higher and more prevalent in black patients with pulmonary sarcoidosis. Respiration. 2007; 74(3):297-303. PMID: 16534178.
      Citations:    
    116. Han S, Roman J. Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways. Mol Cancer Ther. 2006 Feb; 5(2):430-7. PMID: 16505118.
      Citations:    
    117. Han S, Roman J. COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals. Lung Cancer. 2006 Mar; 51(3):283-96. PMID: 16376453.
      Citations:    
    118. Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res. 2006 Jan 01; 66(1):315-23. PMID: 16397245.
      Citations:    
    119. Joshi PC, Applewhite L, Ritzenthaler JD, Roman J, Fernandez AL, Eaton DC, Brown LA, Guidot DM. Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage. J Immunol. 2005 Nov 15; 175(10):6837-45. PMID: 16272341.
      Citations:    
    120. Roman J, Rivera HN, Roser-Page S, Sitaraman SV, Ritzenthaler JD. Adenosine induces fibronectin expression in lung epithelial cells: implications for airway remodeling. . 2006 Feb; 290(2):L317-25. PMID: 16183671.
      Citations:    
    121. Han S, Roman J. COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites. Int J Cancer. 2005 Sep 10; 116(4):536-46. PMID: 15825163.
      Citations:    
    122. Han S, Ritzenthaler JD, Wingerd B, Roman J. Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta. J Biol Chem. 2005 Sep 30; 280(39):33240-9. PMID: 16061473.
      Citations:    
    123. Han S, Ritzenthaler JD, Rivera HN, Roman J. Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep; 289(3):L419-28. PMID: 15908479.
      Citations:    
    124. Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, Brigham KL. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol. 2005 Aug; 33(2):145-52. PMID: 15891110; PMCID: PMC2715309.
      Citations:    
    125. Han S, Sidell N, Roman J. Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase. Cancer Lett. 2005 Feb 28; 219(1):71-81. PMID: 15694666.
      Citations:    
    126. Mora AL, Woods CR, Garcia A, Xu J, Rojas M, Speck SH, Roman J, Brigham KL, Stecenko AA. Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice. Am J Physiol Lung Cell Mol Physiol. 2005 Nov; 289(5):L711-21. PMID: 15734789.
      Citations:    
    127. Han S, Rivera HN, Roman J. Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells. Am J Respir Cell Mol Biol. 2005 Apr; 32(4):350-9. PMID: 15677767.
      Citations:    
    128. Roman J, Ritzenthaler JD, Bechara R, Brown LA, Guidot D. Ethanol stimulates the expression of fibronectin in lung fibroblasts via kinase-dependent signals that activate CREB. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L975-87. PMID: 15653713.
      Citations:    
    129. Tomic R, Lassiter CC, Ritzenthaler JD, Rivera HN, Roman J. Anti-tissue remodeling effects of corticosteroids: fluticasone propionate inhibits fibronectin expression in fibroblasts. Chest. 2005 Jan; 127(1):257-65. PMID: 15653993.
      Citations:    
    130. Ramirez AM, Takagawa S, Sekosan M, Jaffe HA, Varga J, Roman J. Smad3 deficiency ameliorates experimental obliterative bronchiolitis in a heterotopic tracheal transplantation model. Am J Pathol. 2004 Oct; 165(4):1223-32. PMID: 15466388.
      Citations:    
    131. Rivera-Marrero CA, Stewart J, Shafer WM, Roman J. The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli. Infect Immun. 2004 Oct; 72(10):5712-21. PMID: 15385470.
      Citations:    
    132. Han S, Sidell N, Roser-Page S, Roman J. Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression. Int J Cancer. 2004 Sep 01; 111(3):322-31. PMID: 15221958.
      Citations:    
    133. Roman J, Ritzenthaler JD, Gil-Acosta A, Rivera HN, Roser-Page S. Nicotine and fibronectin expression in lung fibroblasts: implications for tobacco-related lung tissue remodeling. FASEB J. 2004 Sep; 18(12):1436-8. PMID: 15247149.
      Citations:    
    134. Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM. Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am J Respir Crit Care Med. 2004 Jul 15; 170(2):188-94. PMID: 15105163.
      Citations:    
    135. Roman J, Ritzenthaler JD, Boles B, Lois M, Roser-Page S. Lipopolysaccharide induces expression of fibronectin alpha 5 beta 1-integrin receptors in human monocytic cells in a protein kinase C-dependent fashion. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L239-49. PMID: 15064224.
      Citations:    
    136. Han S, Roman J. Suppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth. Biochem Biophys Res Commun. 2004 Feb 20; 314(4):1093-9. PMID: 14751245.
      Citations:    
    137. Holtzclaw JD, Jack D, Aguayo SM, Eckman JR, Roman J, Hsu LL. Enhanced pulmonary and systemic response to endotoxin in transgenic sickle mice. Am J Respir Crit Care Med. 2004 Mar 15; 169(6):687-95. PMID: 14684557.
      Citations:    
    138. Bechara RI, Brown LA, Eaton DC, Roman J, Guidot DM. Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor-alpha- and angiotensin II-induced cytotoxicity via AT2 signaling in rat alveolar epithelial cells. Alcohol Clin Exp Res. 2003 Jun; 27(6):1006-14. PMID: 12824823.
      Citations:    
    139. Perez RL, Rivera-Marrero CA, Roman J. Pulmonary granulomatous inflammation: From sarcoidosis to tuberculosis. Semin Respir Infect. 2003 Mar; 18(1):23-32. PMID: 12652451.
      Citations:    
    140. Roman J, Perez RL. COPD in VA hospitals. Clin Cornerstone. 2003; 5(1):37-44. PMID: 12739310.
      Citations:    
    141. Guidot DM, Roman J. Chronic ethanol ingestion increases susceptibility to acute lung injury: role of oxidative stress and tissue remodeling. Chest. 2002 Dec; 122(6 Suppl):309S-314S. PMID: 12475807.
      Citations:    
    142. Rivera-Marrero CA, Ritzenthaler JD, Newburn SA, Roman J, Cummings RD. Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis. Microbiology. 2002 Mar; 148(Pt 3):783-92. PMID: 11882713.
      Citations:    
    143. Rivera-Marrero CA, Schuyler W, Roser S, Ritzenthaler JD, Newburn SA, Roman J. M. tuberculosis induction of matrix metalloproteinase-9: the role of mannose and receptor-mediated mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L546-55. PMID: 11839551.
      Citations:    
    144. Michaelson JE, Ritzenthaler JD, Roman J. Regulation of serum-induced fibronectin expression by protein kinases, cytoskeletal integrity, and CREB. Am J Physiol Lung Cell Mol Physiol. 2002 Feb; 282(2):L291-301. PMID: 11792634.
      Citations:    
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