Dmitry Temiakov

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address1020 Locust St.
Philadelphia PA 19107
Phone856-566-6327
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hillen HS, Markov DA, Wojtas ID, Hofmann KB, Lidschreiber M, Cowan AT, Jones JL, Temiakov D, Cramer P, Anikin M. The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs. Proc Natl Acad Sci U S A. 2021 Apr 13; 118(15). PMID: 33876744.
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    2. Sarfallah A, Temiakov D. In Vitro Reconstitution of Human Mitochondrial Transcription. Methods Mol Biol. 2021; 2192:35-41. PMID: 33230763.
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    3. Kang E, Koski A, Amato P, Temiakov D, Mitalipov S. Reply to: Reversion after replacement of mitochondrial DNA. Nature. 2019 Oct; 574(7778):E12-E13. PMID: 31619780.
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    4. Jones JL, Hofmann KB, Cowan AT, Temiakov D, Cramer P, Anikin M. Yeast mitochondrial protein Pet111p binds directly to two distinct targets in COX2 mRNA, suggesting a mechanism of translational activation. J Biol Chem. 2019 Mar 25. PMID: 30910813.
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    5. Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JCI, Amato P, Mitalipov S. Author Correction: Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2019 Mar; 567(7747):E5-E9. PMID: 30814738.
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    6. Bird JG, Basu U, Kuster D, Ramachandran A, Grudzien-Nogalska E, Towheed A, Wallace DC, Kiledjian M, Temiakov D, Patel SS, Ebright RH, Nickels BE. Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase. Elife. 2018 12 12; 7. PMID: 30526856.
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    7. Hillen HS, Temiakov D, Cramer P. Structural basis of mitochondrial transcription. Nat Struct Mol Biol. 2018 Sep; 25(9):754-765. PMID: 30190598.
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    8. King GA, Hashemi Shabestari M, Taris KH, Pandey AK, Venkatesh S, Thilagavathi J, Singh K, Krishna Koppisetti R, Temiakov D, Roos WH, Suzuki CK, Wuite GJL. Acetylation and phosphorylation of human TFAM regulate TFAM-DNA interactions via contrasting mechanisms. Nucleic Acids Res. 2018 Apr 20; 46(7):3633-3642. PMID: 29897602.
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    9. Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P. Structural Basis of Mitochondrial Transcription Initiation. Cell. 2017 Nov 16; 171(5):1072-1081.e10. PMID: 29149603.
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    10. Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D. Mechanism of Transcription Anti-termination in Human Mitochondria. Cell. 2017 Nov 16; 171(5):1082-1093.e13. PMID: 29033127.
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    11. Kang E, Wu J, Gutierrez NM, Koski A, Tippner-Hedges R, Agaronyan K, Platero-Luengo A, Martinez-Redondo P, Ma H, Lee Y, Hayama T, Van Dyken C, Wang X, Luo S, Ahmed R, Li Y, Ji D, Kayali R, Cinnioglu C, Olson S, Jensen J, Battaglia D, Lee D, Wu D, Huang T, Wolf DP, Temiakov D, Belmonte JC, Amato P, Mitalipov S. Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature. 2016 12 08; 540(7632):270-275. PMID: 27919073.
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    12. Morozov YI, Temiakov D. Human Mitochondrial Transcription Initiation Complexes Have Similar Topology on the Light and Heavy Strand Promoters. J Biol Chem. 2016 Jun 24; 291(26):13432-5. PMID: 27226527; PMCID: PMC4919431.
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    13. Morozov YI, Parshin AV, Agaronyan K, Cheung AC, Anikin M, Cramer P, Temiakov D. A model for transcription initiation in human mitochondria. Nucleic Acids Res. 2015 Apr 20; 43(7):3726-35. PMID: 25800739.
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    14. Agaronyan K, Morozov YI, Anikin M, Temiakov D. Mitochondrial biology. Replication-transcription switch in human mitochondria. Science. 2015 Jan 30; 347(6221):548-51. PMID: 25635099; PMCID: PMC4677687.
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    15. Morozov YI, Agaronyan K, Cheung AC, Anikin M, Cramer P, Temiakov D. A novel intermediate in transcription initiation by human mitochondrial RNA polymerase. Nucleic Acids Res. 2014 Apr; 42(6):3884-93. PMID: 24393772.
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    16. Schwinghammer K, Cheung AC, Morozov YI, Agaronyan K, Temiakov D, Cramer P. Structure of human mitochondrial RNA polymerase elongation complex. Nat Struct Mol Biol. 2013 Nov; 20(11):1298-303. PMID: 24096365; PMCID: PMC4321815.
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    17. Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, Bogenhagen DF, Temiakov D, Suzuki CK. Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. Mol Cell. 2013 Jan 10; 49(1):121-32. PMID: 23201127; PMCID: PMC3586414.
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    18. Ochoa-Alvarez JA, Krishnan H, Shen Y, Acharya NK, Han M, McNulty DE, Hasegawa H, Hyodo T, Senga T, Geng JG, Kosciuk M, Shin SS, Goydos JS, Temiakov D, Nagele RG, Goldberg GS. Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration. PLoS One. 2012; 7(7):e41845. PMID: 22844530; PMCID: PMC3402461.
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    19. Ringel R, Sologub M, Morozov YI, Litonin D, Cramer P, Temiakov D. Structure of human mitochondrial RNA polymerase. Nature. 2011 Sep 25; 478(7368):269-73. PMID: 21947009.
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    20. Litonin D, Sologub M, Shi Y, Savkina M, Anikin M, Falkenberg M, Gustafsson CM, Temiakov D. Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. J Biol Chem. 2010 Jun 11; 285(24):18129-33. PMID: 20410300; PMCID: PMC2881736.
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    21. Sologub M, Litonin D, Anikin M, Mustaev A, Temiakov D. TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase. Cell. 2009 Nov 25; 139(5):934-44. PMID: 19945377; PMCID: PMC2806307.
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    22. Savkina M, Temiakov D, McAllister WT, Anikin M. Multiple functions of yeast mitochondrial transcription factor Mtf1p during initiation. J Biol Chem. 2010 Feb 05; 285(6):3957-64. PMID: 19920143; PMCID: PMC2823537.
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    23. Kent T, Kashkina E, Anikin M, Temiakov D. Maintenance of RNA-DNA hybrid length in bacterial RNA polymerases. J Biol Chem. 2009 May 15; 284(20):13497-504. PMID: 19321439; PMCID: PMC2679450.
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    24. Kashkina E, Anikin M, Brueckner F, Lehmann E, Kochetkov SN, McAllister WT, Cramer P, Temiakov D. Multisubunit RNA polymerases melt only a single DNA base pair downstream of the active site. J Biol Chem. 2007 Jul 27; 282(30):21578-82. PMID: 17526498.
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    25. Kashkina E, Anikin M, Brueckner F, Pomerantz RT, McAllister WT, Cramer P, Temiakov D. Template misalignment in multisubunit RNA polymerases and transcription fidelity. Mol Cell. 2006 Oct 20; 24(2):257-66. PMID: 17052459.
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    26. Pomerantz RT, Temiakov D, Anikin M, Vassylyev DG, McAllister WT. A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment. Mol Cell. 2006 Oct 20; 24(2):245-55. PMID: 17052458; PMCID: PMC2810628.
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    27. Kashkina E, Anikin M, Tahirov TH, Kochetkov SN, Vassylyev DG, Temiakov D. Elongation complexes of Thermus thermophilus RNA polymerase that possess distinct translocation conformations. Nucleic Acids Res. 2006; 34(14):4036-45. PMID: 16914440; PMCID: PMC1557819.
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    28. Ma K, Temiakov D, Anikin M, McAllister WT. Probing conformational changes in T7 RNA polymerase during initiation and termination by using engineered disulfide linkages. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17612-7. PMID: 16301518; PMCID: PMC1308916.
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    29. Temiakov D, Zenkin N, Vassylyeva MN, Perederina A, Tahirov TH, Kashkina E, Savkina M, Zorov S, Nikiforov V, Igarashi N, Matsugaki N, Wakatsuki S, Severinov K, Vassylyev DG. Structural basis of transcription inhibition by antibiotic streptolydigin. Mol Cell. 2005 Sep 02; 19(5):655-66. PMID: 16167380.
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    30. Temiakov D, Patlan V, Anikin M, McAllister WT, Yokoyama S, Vassylyev DG. Structural basis for substrate selection by t7 RNA polymerase. Cell. 2004 Feb 06; 116(3):381-91. PMID: 15016373.
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    31. Temiakov D, Tahirov TH, Anikin M, McAllister WT, Vassylyev DG, Yokoyama S. Crystallization and preliminary crystallographic analysis of T7 RNA polymerase elongation complex. Acta Crystallogr D Biol Crystallogr. 2003 Jan; 59(Pt 1):185-7. PMID: 12499566.
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    32. Tahirov TH, Temiakov D, Anikin M, Patlan V, McAllister WT, Vassylyev DG, Yokoyama S. Structure of a T7 RNA polymerase elongation complex at 2.9 A resolution. Nature. 2002 Nov 07; 420(6911):43-50. PMID: 12422209.
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