Mudit Tyagi

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hokello J, Sharma AL, Tyagi M. AP-1 and NF-?B synergize to transcriptionally activate latent HIV upon T-cell receptor activation. FEBS Lett. 2021 Jan 09. PMID: 33421101.
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    2. Sharma AL, Hokello J, Sonti S, Zicari S, Sun L, Alqatawni A, Bukrinsky M, Simon G, Chauhan A, Daniel R, Tyagi M. CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR. Viruses. 2020 09 18; 12(9). PMID: 32961937.
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    3. Hokello J, Sharma AL, Tyagi M. Efficient Non-Epigenetic Activation of HIV Latency through the T-Cell Receptor Signalosome. Viruses. 2020 Aug 08; 12(8). PMID: 32784426.
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    4. Alqatawni A, Sharma AL, Attilus B, Tyagi M, Daniel R. Shedding Light on the Role of Extracellular Vesicles in HIV Infection and Wound Healing. Viruses. 2020 May 27; 12(6). PMID: 32471020.
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    5. Zicari S, Sharma AL, Sahu G, Dubrovsky L, Sun L, Yue H, Jada T, Ochem A, Simon G, Bukrinsky M, Tyagi M. DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR. Oncotarget. 2020 Feb 18; 11(7):699-726. PMID: 32133046.
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    6. Hokello J, Sharma AL, Dimri M, Tyagi M. Insights into the HIV Latency and the Role of Cytokines. Pathogens. 2019 Sep 04; 8(3). PMID: 31487807.
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    7. Tyagi M, Bukrinsky M, Simon GL. Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse. Curr HIV Res. 2016; 14(5):442-454. PMID: 27009097.
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    8. Tyagi M, Weber J, Bukrinsky M, Simon GL. The effects of cocaine on HIV transcription. J Neurovirol. 2016 06; 22(3):261-74. PMID: 26572787.
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    9. Sahu G, Farley K, El-Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, Ochem A, Simon GL, Karn J, Hauser KF, Tyagi M. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-?B and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015 Sep; 483:185-202. PMID: 25980739.
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    10. Tyagi M, Bukrinsky M. Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication. Mol Med. 2012 Sep 25; 18:1096-108. PMID: 22692576.
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    11. Tyagi M, Kashanchi F. New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others. Retrovirology. 2012 Mar 09; 9:19. PMID: 22405323.
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    12. Van Duyne R, Guendel I, Narayanan A, Gregg E, Shafagati N, Tyagi M, Easley R, Klase Z, Nekhai S, Kehn-Hall K, Kashanchi F. Varying modulation of HIV-1 LTR activity by Baf complexes. J Mol Biol. 2011 Aug 19; 411(3):581-96. PMID: 21699904.
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    13. Lalonde MS, Lobritz MA, Ratcliff A, Chamanian M, Athanassiou Z, Tyagi M, Wong J, Robinson JA, Karn J, Varani G, Arts EJ. Inhibition of both HIV-1 reverse transcription and gene expression by a cyclic peptide that binds the Tat-transactivating response element (TAR) RNA. PLoS Pathog. 2011 May; 7(5):e1002038. PMID: 21625572.
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    14. Tyagi S, Ochem A, Tyagi M. DNA-dependent protein kinase interacts functionally with the RNA polymerase II complex recruited at the human immunodeficiency virus (HIV) long terminal repeat and plays an important role in HIV gene expression. J Gen Virol. 2011 Jul; 92(Pt 7):1710-1720. PMID: 21450944.
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    15. Tyagi M, Pearson RJ, Karn J. Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction. J Virol. 2010 Jul; 84(13):6425-37. PMID: 20410271.
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    16. Pearson R, Kim YK, Hokello J, Lassen K, Friedman J, Tyagi M, Karn J. Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency. J Virol. 2008 Dec; 82(24):12291-303. PMID: 18829756.
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    17. Tyagi M, Karn J. CBF-1 promotes transcriptional silencing during the establishment of HIV-1 latency. EMBO J. 2007 Dec 12; 26(24):4985-95. PMID: 18007589.
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    18. Kim YK, Bourgeois CF, Pearson R, Tyagi M, West MJ, Wong J, Wu SY, Chiang CM, Karn J. Recruitment of TFIIH to the HIV LTR is a rate-limiting step in the emergence of HIV from latency. EMBO J. 2006 Aug 09; 25(15):3596-604. PMID: 16874302.
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