Caspase 1

"Caspase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.

Descriptor ID	D020170
MeSH Number(s)	D08.811.277.656.262.500.126.550.100 D08.811.277.656.300.200.126.550.100 D12.644.360.075.405.550.100 D12.776.476.075.405.550.100
Concept/Terms	Caspase 1 Caspase 1 Interleukin-1beta Converting Enzyme Converting Enzyme, Interleukin-1beta Interleukin 1beta Converting Enzyme ICE Protease IL1BC Enzyme IL-1 beta Convertase Convertase, IL-1 beta IL 1 beta Convertase beta Convertase, IL-1 CASP1 Caspase Caspase, CASP1 Interleukin-1 Converting Enzyme Converting Enzyme, Interleukin-1 Interleukin 1 Converting Enzyme IL-1 beta-Converting Enzyme IL 1 beta Converting Enzyme beta-Converting Enzyme, IL-1 Procaspase-1 Procaspase-1 Procaspase 1 Pro-Caspase-1 Pro Caspase 1

Below are MeSH descriptors whose meaning is more general than "Caspase 1".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Cysteine Proteases [D08.811.277.656.262]
Cysteine Endopeptidases [D08.811.277.656.262.500]
Caspases [D08.811.277.656.262.500.126]
Caspases, Initiator [D08.811.277.656.262.500.126.550]
Caspase 1 [D08.811.277.656.262.500.126.550.100]
Endopeptidases [D08.811.277.656.300]
Cysteine Endopeptidases [D08.811.277.656.300.200]
Caspases [D08.811.277.656.300.200.126]
Caspases, Initiator [D08.811.277.656.300.200.126.550]
Caspase 1 [D08.811.277.656.300.200.126.550.100]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Apoptosis Regulatory Proteins [D12.644.360.075]
Caspases [D12.644.360.075.405]
Caspases, Initiator [D12.644.360.075.405.550]
Caspase 1 [D12.644.360.075.405.550.100]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Apoptosis Regulatory Proteins [D12.776.476.075]
Caspases [D12.776.476.075.405]
Caspases, Initiator [D12.776.476.075.405.550]
Caspase 1 [D12.776.476.075.405.550.100]

Below are MeSH descriptors whose meaning is related to "Caspase 1".

Below are MeSH descriptors whose meaning is more specific than "Caspase 1".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Caspase 1" by people in this website by year, and whether "Caspase 1" was a major or minor topic of these publications.

Bar chart showing 32 publications over 17 distinct years, with a maximum of 6 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1995	0	1	1
1996	0	6	6
1997	0	4	4
1998	1	2	3
1999	0	1	1
2000	1	0	1
2001	1	1	2
2002	2	0	2
2005	0	1	1
2006	1	0	1
2007	2	0	2
2008	1	0	1
2009	0	1	1
2010	0	3	3
2011	1	0	1
2013	0	1	1

Below are the most recent publications written about "Caspase 1" by people in Profiles.

Park S, Juliana C, Hong S, Datta P, Hwang I, Fernandes-Alnemri T, Yu JW, Alnemri ES. The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity. J Immunol. 2013 Oct 15; 191(8):4358-66.

View in: PubMed
Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, Dewamitta SR, Xu Y, Qu H, Alnemri ES, Mitsuyama M. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. J Immunol. 2011 Nov 1; 187(9):4890-9.

View in: PubMed
Wu J, Fernandes-Alnemri T, Alnemri ES. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes. J Clin Immunol. 2010 Sep; 30(5):693-702.

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Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J, Datta P, McCormick M, Huang L, McDermott E, Eisenlohr L, Landel CP, Alnemri ES. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol. 2010 May; 11(5):385-93.

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Juliana C, Fernandes-Alnemri T, Wu J, Datta P, Solorzano L, Yu JW, Meng R, Quong AA, Latz E, Scott CP, Alnemri ES. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J Biol Chem. 2010 Mar 26; 285(13):9792-802.

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Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 2009 Mar 26; 458(7237):509-13.

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Fernandes-Alnemri T, Alnemri ES. Assembly, purification, and assay of the activity of the ASC pyroptosome. Methods Enzymol. 2008; 442:251-70.

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Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES. Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants. Mol Cell. 2007 Oct 26; 28(2):214-27.

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Fernandes-Alnemri T, Wu J, Yu JW, Datta P, Miller B, Jankowski W, Rosenberg S, Zhang J, Alnemri ES. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ. 2007 Sep; 14(9):1590-604.

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Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T, Alnemri ES. Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ. 2006 Feb; 13(2):236-49.

View in: PubMed

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