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Ross Summer

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address800 Walnut Street
Philadelphia PA 19107
Phone215-955-1672
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    Collapse Research 
    Collapse research activities and funding
    K08HL077138     (SUMMER, ROSS S)Apr 1, 2006 - Mar 31, 2011
    NIH/NHLBI
    The Identification and Study of a Lung Mesenchymal Stem Cell
    Role: Principal Investigator

    R01HL105490     (SUMMER, ROSS S)Aug 1, 2011 - Jun 30, 2016
    NIH/NHLBI
    Adiponectin inhibits activation and injury of lung endothelium
    Role: Principal Investigator

    R21AA023571     (SUMMER, ROSS S)Sep 10, 2015 - Jun 30, 2017
    NIH/NIAAA
    Alcohol-induced lung lipid changes contribute to development of acute lung injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun; 14(6):1050-1059. PMID: 28570148.
      View in: PubMed
    2. Naik MU, Naik TU, Summer R, Naik UP. Binding of CIB1 to the aIIb tail of aIIbß3 is required for FAK recruitment and activation in platelets. PLoS One. 2017; 12(5):e0176602. PMID: 28542214.
      View in: PubMed
    3. Shah D, Romero F, Guo Z, Sun J, Li J, Kallen CB, Naik UP, Summer R. Obesity-induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 Mar 09. PMID: 28277743.
      View in: PubMed
    4. Wang H, Tao L, Ambrosio A, Yan W, Summer R, Lau WB, Wang Y, Ma X. T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. Cardiovasc Diabetol. 2017 Jan 19; 16(1):12. PMID: 28103886.
      View in: PubMed
    5. Fessler MB, Summer RS. Surfactant Lipids at the Host-Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease. Am J Respir Cell Mol Biol. 2016 May; 54(5):624-35. PMID: 26859434.
      View in: PubMed
    6. George G, Vaid U, Summer R. Therapeutic advances in idiopathic pulmonary fibrosis. Clin Pharmacol Ther. 2016 Jan; 99(1):30-2. PMID: 26502087.
      View in: PubMed
    7. Shah D, Romero F, Zhu Y, Duong M, Sun J, Walsh K, Summer R. C1q Deficiency Promotes Pulmonary Vascular Inflammation and Enhances the Susceptibility of the Lung Endothelium to Injury. J Biol Chem. 2015 Dec 4; 290(49):29642-51. PMID: 26487714.
      View in: PubMed
    8. Walkey AJ, Kirkpatrick AR, Summer RS. Systemic Inflammatory Response Syndrome Criteria for Severe Sepsis. N Engl J Med. 2015 Aug 27; 373(9):879-81. PMID: 26308695.
      View in: PubMed
    9. Loro E, Seifert EL, Moffat C, Romero F, Mishra MK, Sun Z, Krajacic P, Anokye-Danso F, Summer RS, Ahima RS, Khurana TS. IL-15Ra is a determinant of muscle fuel utilization, and its loss protects against obesity. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R835-44. PMID: 26269523.
      View in: PubMed
    10. Romero F, Shah D, Duong M, Penn RB, Fessler MB, Madenspacher J, Stafstrom W, Kavuru M, Lu B, Kallen CB, Walsh K, Summer R. A Pneumocyte-Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):74-86. PMID: 25409201.
      View in: PubMed
    11. Shah D, Romero F, Duong M, Wang N, Paudyal B, Suratt BT, Kallen CB, Sun J, Zhu Y, Walsh K, Summer R. Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury. Sci Rep. 2015; 5:11362. PMID: 26068229.
      View in: PubMed
    12. Kawwass JF, Summer R, Kallen CB. Direct effects of leptin and adiponectin on peripheral reproductive tissues: a critical review. Mol Hum Reprod. 2015 Aug; 21(8):617-32. PMID: 25964237.
      View in: PubMed
    13. Rincón J, Correia D, Arcaya JL, Finol E, Fernández A, Pérez M, Yaguas K, Talavera E, Chávez M, Summer R, Romero F. Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension. Life Sci. 2015 Mar 1; 124:81-90. PMID: 25623850.
      View in: PubMed
    14. Romero F, Shah D, Duong M, Stafstrom W, Hoek JB, Kallen CB, Lang CH, Summer R. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):840-9. PMID: 24940828.
      View in: PubMed
    15. Walkey AJ, Demissie S, Shah D, Romero F, Puklin L, Summer RS. Plasma Adiponectin, Clinical Factors, and Patient Outcomes during the Acute Respiratory Distress Syndrome. PLoS One. 2014; 9(9):e108561. PMID: 25259893.
      View in: PubMed
    16. Ding SY, Lee MJ, Summer R, Liu L, Fried SK, Pilch PF. Pleiotropic effects of cavin-1 deficiency on lipid metabolism. J Biol Chem. 2014 Mar 21; 289(12):8473-83. PMID: 24509860.
      View in: PubMed
    17. Haley S, Shah D, Romero F, Summer R. Scleroderma-related lung disease: are adipokines involved pathogenically? Curr Rheumatol Rep. 2013 Dec; 15(12):381. PMID: 24173692.
      View in: PubMed
    18. Shah D, Romero F, Stafstrom W, Duong M, Summer RS. Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27. PMID: 24285266.
      View in: PubMed
    19. Summer RS. Obesity paradox? Am J Respir Crit Care Med. 2013 Nov 15; 188(10):1266. PMID: 24236595.
      View in: PubMed
    20. Govender P, Romero F, Shah D, Paez J, Ding SY, Liu L, Gower A, Baez E, Aly SS, Pilch P, Summer R. Cavin1; a regulator of lung function and macrophage phenotype. PLoS One. 2013; 8(4):e62045. PMID: 23634221.
      View in: PubMed
    21. Li P, Liu Y, Yi B, Wang G, You X, Zhao X, Summer R, Qin Y, Sun J. MicroRNA-638 is highly expressed in human vascular smooth muscle cells and inhibits PDGF-BB-induced cell proliferation and migration through targeting orphan nuclear receptor NOR1. Cardiovasc Res. 2013 Jul 1; 99(1):185-93. PMID: 23554459.
      View in: PubMed
    22. Fang F, Liu L, Yang Y, Tamaki Z, Wei J, Marangoni RG, Bhattacharyya S, Summer RS, Ye B, Varga J. The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy. Arthritis Res Ther. 2012 Oct 23; 14(5):R229. PMID: 23092446.
      View in: PubMed
    23. Walkey AJ, Summer R, Ho V, Alkana P. Acute respiratory distress syndrome: epidemiology and management approaches. Clin Epidemiol. 2012; 4:159-69. PMID: 22866017.
      View in: PubMed
    24. Summer R, Wiener RS, Carroll D, Sager A. Physician perception of the impact of productivity measures on academic practice. Arch Intern Med. 2012 Jun 25; 172(12):967-9. PMID: 22732756.
      View in: PubMed
    25. Konter J, Baez E, Summer RS. Obesity: "Priming" the lung for injury. Pulm Pharmacol Ther. 2013 Aug; 26(4):427-9. PMID: 22449512.
      View in: PubMed
    26. Konter JM, Parker JL, Baez E, Li SZ, Ranscht B, Denzel M, Little FF, Nakamura K, Ouchi N, Fine A, Walsh K, Summer RS. Adiponectin attenuates lipopolysaccharide-induced acute lung injury through suppression of endothelial cell activation. J Immunol. 2012 Jan 15; 188(2):854-63. PMID: 22156343.
      View in: PubMed
    27. Summer R, Walsh K, Medoff BD. Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions? Pulm Circ. 2011 Oct; 1(4):440-7. PMID: 22530098.
      View in: PubMed
    28. Walkey AJ, Rice TW, Konter J, Ouchi N, Shibata R, Walsh K, deBoisblanc BP, Summer R. Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure. Crit Care Med. 2010 Dec; 38(12):2329-34. PMID: 20890191.
      View in: PubMed
    29. Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, Gokce N, Pedersen AA, Kalthoff C, Tullin S, Sams A, Summer R, Walsh K. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem. 2010 Feb 26; 285(9):6153-60. PMID: 20028977.
      View in: PubMed
    30. Summer R, Fiack CA, Ikeda Y, Sato K, Dwyer D, Ouchi N, Fine A, Farber HW, Walsh K. Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease. Am J Physiol Lung Cell Mol Physiol. 2009 Sep; 297(3):L432-8. PMID: 19561137.
      View in: PubMed
    31. Summer R, Fine A. Mesenchymal progenitor cell research: limitations and recommendations. Proc Am Thorac Soc. 2008 Aug 15; 5(6):707-10. PMID: 18684722.
      View in: PubMed
    32. Summer R, Little FF, Ouchi N, Takemura Y, Aprahamian T, Dwyer D, Fitzsimmons K, Suki B, Parameswaran H, Fine A, Walsh K. Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1035-42. PMID: 18326826.
      View in: PubMed
    33. Murphy J, Summer R, Wilson AA, Kotton DN, Fine A. The prolonged life-span of alveolar macrophages. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):380-5. PMID: 18192503.
      View in: PubMed
    34. Murphy J, Summer R, Fine A. Stem cells in airway smooth muscle: state of the art. Proc Am Thorac Soc. 2008 Jan 1; 5(1):11-4. PMID: 18094079.
      View in: PubMed
    35. Summer R, Fitzsimmons K, Dwyer D, Murphy J, Fine A. Isolation of an adult mouse lung mesenchymal progenitor cell population. Am J Respir Cell Mol Biol. 2007 Aug; 37(2):152-9. PMID: 17395889.
      View in: PubMed
    36. Takemura Y, Ouchi N, Shibata R, Aprahamian T, Kirber MT, Summer RS, Kihara S, Walsh K. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J Clin Invest. 2007 Feb; 117(2):375-86. PMID: 17256056.
      View in: PubMed
    37. Fisher KA, Summer RS. 4. Stem and progenitor cells in the formation of the pulmonary vasculature. Curr Top Dev Biol. 2006; 74:117-31. PMID: 16860666.
      View in: PubMed
    38. Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005 Nov 25; 97(11):1090-2. PMID: 16269652.
      View in: PubMed
    39. Liang SX, Summer R, Sun X, Fine A. Gene expression profiling and localization of Hoechst-effluxing CD45- and CD45+ cells in the embryonic mouse lung. Physiol Genomics. 2005 Oct 17; 23(2):172-81. PMID: 16076931.
      View in: PubMed
    40. Chang JC, Summer R, Sun X, Fitzsimmons K, Fine A. Evidence that bone marrow cells do not contribute to the alveolar epithelium. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):335-42. PMID: 15961725.
      View in: PubMed
    41. Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res. 2005 Jul 8; 97(1):52-61. PMID: 15947249.
      View in: PubMed
    42. Summer R, Kotton DN, Liang S, Fitzsimmons K, Sun X, Fine A. Embryonic lung side population cells are hematopoietic and vascular precursors. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):32-40. PMID: 15802552.
      View in: PubMed
    43. Kotton DN, Summer R, Fine A. Lung stem cells: new paradigms. Exp Hematol. 2004 Apr; 32(4):340-3. PMID: 15050743.
      View in: PubMed
    44. Summer R, Kotton DN, Sun X, Fitzsimmons K, Fine A. Translational physiology: origin and phenotype of lung side population cells. Am J Physiol Lung Cell Mol Physiol. 2004 Sep; 287(3):L477-83. PMID: 15047566.
      View in: PubMed
    45. Mogi M, Yang J, Lambert JF, Colvin GA, Shiojima I, Skurk C, Summer R, Fine A, Quesenberry PJ, Walsh K. Akt signaling regulates side population cell phenotype via Bcrp1 translocation. J Biol Chem. 2003 Oct 3; 278(40):39068-75. PMID: 12851395.
      View in: PubMed
    46. Summer R, Kotton DN, Sun X, Ma B, Fitzsimmons K, Fine A. Side population cells and Bcrp1 expression in lung. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L97-104. PMID: 12626330.
      View in: PubMed
    47. Kotton DN, Summer RS, Sun X, Ma BY, Fine A. Stem cell antigen-1 expression in the pulmonary vascular endothelium. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L990-6. PMID: 12611818.
      View in: PubMed
    48. Summer R, Zacks J, Ieong M, O'Regan A. Cough, fever and weight loss in a young male. Eur Respir J. 2002 Jun; 19(6):1210-3. PMID: 12108878.
      View in: PubMed
    49. Kotton DN, Ma BY, Cardoso WV, Sanderson EA, Summer RS, Williams MC, Fine A. Bone marrow-derived cells as progenitors of lung alveolar epithelium. Development. 2001 Dec; 128(24):5181-8. PMID: 11748153.
      View in: PubMed
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