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Sunday Shoyele

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentJSP - Pharmaceutical Science
Address901 Walnut Street
Philadelphia PA 19107
Phone215-503-3407

 Overview 
 overview
Application of nanotechnology in the targeted delivery of RNAi, small organic molecules and protein therapeutics to tumors and other diseases. Analysis of biomolecules using circular dichroism, Fluorescence spectroscopy, Gel electrophoresis, Size exclusion chromatography, Thermal analysis and Raman spectroscopy.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Perepelyuk M, Maher C, Lakshmikuttyamma A, Shoyele SA. Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins. Int J Nanomedicine. 2016; 11:3533-44.
    View in: PubMed
  2. Perepelyuk M, Thangavel C, Liu Y, Den RB, Lu B, Snook AE, Shoyele SA. Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model. Mol Ther Nucleic Acids. 2016; 5:e282.
    View in: PubMed
  3. Dim N, Perepelyuk M, Gomes O, Thangavel C, Liu Y, Den R, Lakshmikuttyamma A, Shoyele SA. Novel targeted siRNA-loaded hybrid nanoparticles: preparation, characterization and in vitro evaluation. J Nanobiotechnology. 2015; 13(1):61.
    View in: PubMed
  4. Srinivasan A, Thangavel C, Liu Y, Shoyele S, Den RB, Selvakumar P, Lakshmikuttyamma A. Quercetin regulates ß-catenin signaling and reduces the migration of triple negative breast cancer. Mol Carcinog. 2015 May 12.
    View in: PubMed
  5. Lakshmikuttyamma A, Sun Y, Lu B, Undieh AS, Shoyele SA. Stable and Efficient Transfection of siRNA for Mutated KRAS Silencing Using Novel Hybrid Nanoparticles. Mol Pharm. 2014 Dec 1; 11(12):4415-24.
    View in: PubMed
  6. Asha R. Srinivasan and Sunday A. Shoyele. Influence of Surface Modification and the pH on the Release Mechanisms and Kinetics of Erlotinib from Antibody-Functionalized Chitosan Nanoparticles. Industrial and Engineering Chemistry Research. 2014; 53(8):2987-2993.
  7. Srinivasan AR, Lakshmikuttyamma A, Shoyele SA. Investigation of the Stability and Cellular Uptake of Self-Associated Monoclonal Antibody (MAb) Nanoparticles by Non-Small Lung Cancer Cells. Mol Pharm. 2013 Sep 3; 10(9):3275-84.
    View in: PubMed
  8. Srinivasan AR, Shoyele SA. Self-Associated Submicron IgG1 Particles for Pulmonary Delivery: Effects of Non-ionic Surfactants on Size, Shape, Stability, and Aerosol Performance. AAPS PharmSciTech. 2013 Mar; 14(1):200-10.
    View in: PubMed
  9. Shoyele SA, Sivadas N, Cryan SA. The effects of excipients and particle engineering on the biophysical stability and aerosol performance of parathyroid hormone (1-34) prepared as a dry powder for inhalation. AAPS PharmSciTech. 2011 Mar; 12(1):304-11.
    View in: PubMed
  10. Shoyele SA. Controlling the release of proteins/peptides via the pulmonary route. Methods Mol Biol. 2008; 437:141-8.
    View in: PubMed
  11. Shoyele SA. Engineering protein particles for pulmonary drug delivery. Methods Mol Biol. 2008; 437:149-60.
    View in: PubMed
  12. Shoyele SA, Cawthorne S. Particle engineering techniques for inhaled biopharmaceuticals. Adv Drug Deliv Rev. 2006 Oct 31; 58(9-10):1009-29.
    View in: PubMed
  13. Shoyele SA, Slowey A. Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery. Int J Pharm. 2006 May 11; 314(1):1-8.
    View in: PubMed
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