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Sunday Shoyele

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentJSP - Pharmaceutical Science
Address901 Walnut Street
Philadelphia PA 19107
Phone215-503-3407
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    Collapse Overview 
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    Application of nanotechnology in the targeted delivery of RNAi, small organic molecules and protein therapeutics to tumors and other diseases. Analysis of biomolecules using circular dichroism, Fluorescence spectroscopy, Gel electrophoresis, Size exclusion chromatography, Thermal analysis and Raman spectroscopy.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Thangavel C, Perepelyuk M, Boopathi E, Liu Y, Polischak S, Deshpande DA, Rafiq K, Dicker AP, Knudsen KE, Shoyele SA, Den RB. Improvement in Therapeutic Efficacy and Reduction in Cellular Toxicity: Introduction of a Novel Anti-PSMA-Conjugated Hybrid Antiandrogen Nanoparticle. Mol Pharm. 2018 Apr 04. PMID: 29616555.
      View in: PubMed
    2. Perepelyuk M, Sacko K, Thangavel K, Shoyele SA. Evaluation of MUC1-Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA-29b to Nonsmall Cell Lung Cancer. Mol Pharm. 2018 Mar 05; 15(3):985-993. PMID: 29432024.
      View in: PubMed
    3. Thangavel C, Boopathi E, Liu Y, McNair C, Haber A, Perepelyuk M, Bhardwaj A, Addya S, Ertel A, Shoyele S, Birbe R, Salvino JM, Dicker AP, Knudsen KE, Den RB. Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer. Clin Cancer Res. 2018 Mar 15; 24(6):1402-1414. PMID: 29311118.
      View in: PubMed
    4. Perepelyuk M, Shoyele O, Birbe R, Thangavel C, Liu Y, Den RB, Snook AE, Lu B, Shoyele SA. siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer. Mol Ther Nucleic Acids. 2017 Mar 17; 6:259-268. PMID: 28325292.
      View in: PubMed
    5. Perepelyuk M, Maher C, Lakshmikuttyamma A, Shoyele SA. Aptamer-hybrid nanoparticle bioconjugate efficiently delivers miRNA-29b to non-small-cell lung cancer cells and inhibits growth by downregulating essential oncoproteins. Int J Nanomedicine. 2016; 11:3533-44. PMID: 27555773.
      View in: PubMed
    6. Perepelyuk M, Thangavel C, Liu Y, Den RB, Lu B, Snook AE, Shoyele SA. Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model. Mol Ther Nucleic Acids. 2016; 5:e282. PMID: 26812654.
      View in: PubMed
    7. Dim N, Perepelyuk M, Gomes O, Thangavel C, Liu Y, Den R, Lakshmikuttyamma A, Shoyele SA. Novel targeted siRNA-loaded hybrid nanoparticles: preparation, characterization and in vitro evaluation. J Nanobiotechnology. 2015; 13(1):61. PMID: 26410728.
      View in: PubMed
    8. Srinivasan A, Thangavel C, Liu Y, Shoyele S, Den RB, Selvakumar P, Lakshmikuttyamma A. Quercetin regulates ß-catenin signaling and reduces the migration of triple negative breast cancer. Mol Carcinog. 2015 May 12. PMID: 25968914.
      View in: PubMed
    9. Asha R. Srinivasan and Sunday A. Shoyele. Influence of Surface Modification and the pH on the Release Mechanisms and Kinetics of Erlotinib from Antibody-Functionalized Chitosan Nanoparticles. Industrial and Engineering Chemistry Research. 2014; 53(8):2987-2993.
    10. Srinivasan AR, Lakshmikuttyamma A, Shoyele SA. Investigation of the Stability and Cellular Uptake of Self-Associated Monoclonal Antibody (MAb) Nanoparticles by Non-Small Lung Cancer Cells. Mol Pharm. 2013 Sep 3; 10(9):3275-84. PMID: 23915336.
      View in: PubMed
    11. Srinivasan AR, Shoyele SA. Self-Associated Submicron IgG1 Particles for Pulmonary Delivery: Effects of Non-ionic Surfactants on Size, Shape, Stability, and Aerosol Performance. AAPS PharmSciTech. 2013 Mar; 14(1):200-10. PMID: 23255200.
      View in: PubMed
    12. Shoyele SA, Sivadas N, Cryan SA. The effects of excipients and particle engineering on the biophysical stability and aerosol performance of parathyroid hormone (1-34) prepared as a dry powder for inhalation. AAPS PharmSciTech. 2011 Mar; 12(1):304-11. PMID: 21271316.
      View in: PubMed
    13. Shoyele SA. Controlling the release of proteins/peptides via the pulmonary route. Methods Mol Biol. 2008; 437:141-8. PMID: 18369966.
      View in: PubMed
    14. Shoyele SA. Engineering protein particles for pulmonary drug delivery. Methods Mol Biol. 2008; 437:149-60. PMID: 18369967.
      View in: PubMed
    15. Shoyele SA, Cawthorne S. Particle engineering techniques for inhaled biopharmaceuticals. Adv Drug Deliv Rev. 2006 Oct 31; 58(9-10):1009-29. PMID: 17005293.
      View in: PubMed
    16. Shoyele SA, Slowey A. Prospects of formulating proteins/peptides as aerosols for pulmonary drug delivery. Int J Pharm. 2006 May 11; 314(1):1-8. PMID: 16563674.
      View in: PubMed
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