Steven McMahon

TitleProfessor & Chair JMC
InstitutionThomas Jefferson University
DepartmentChair SKMC
Address233 S. 10th Street
Philadelphia PA 19107
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    F32CA067426     (MCMAHON, STEVEN B)Sep 10, 1995
    NIH
    C-MYC-BINDING PROTEIN AND TRANSFORMATION
    Role: Principal Investigator

    R01CA090465     (MCMAHON, STEVEN B.)Apr 1, 2001 - Feb 28, 2014
    NIH
    Functional analysis of transcriptional program regulated by the c-MYC oncoprotein
    Role: Principal Investigator

    R01CA098172     (MCMAHON, STEVEN B)Jul 1, 2003 - Apr 30, 2010
    NIH
    Role of TRRAP in the p53-Mediated Transcription of mdm2
    Role: Principal Investigator

    R21CA152786     (MCMAHON, STEVEN B)Jul 1, 2010 - Jun 30, 2013
    NIH
    Function of a novel, sirtuin-regulated acetylation site on p53.
    Role: Principal Investigator

    R21CA141232     (MCMAHON, STEVEN B.)Mar 4, 2011 - Feb 28, 2014
    NIH
    Role of a novel MYC/BCL2 pathway in apoptosis and transformation
    Role: Principal Investigator

    R01CA141070     (MCMAHON, STEVEN B.)Aug 1, 2011 - Sep 30, 2016
    NIH
    Role of the mitochondrial RNA polymerase POLRMT in MYC function
    Role: Principal Investigator

    R01CA164834     (MCMAHON, STEVEN B.)Aug 1, 2013 - Nov 30, 2019
    NIH
    Role of BAG1 in suppressing the intrinsic tumor suppressor activity of MYC
    Role: Principal Investigator

    R01CA182569     (KNUDSEN, KAREN E)Jul 1, 2015 - Jun 30, 2021
    NIH
    USP22 Function in Advanced Prostate Cancer
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Farkas M, Hashimoto H, Bi Y, Davuluri RV, Resnick-Silverman L, Manfredi JJ, Debler EW, McMahon SB. Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates. Nat Commun. 2021 01 20; 12(1):484. PMID: 33473123.
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    2. McCann JJ, Vasilevskaya IA, Poudel Neupane N, Shafi AA, McNair C, Dylgjeri E, Mandigo AC, Schiewer MJ, Schrecengost RS, Gallagher P, Stanek TJ, McMahon SB, Berman-Booty LD, Ostrander WF, Knudsen KE. USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair. Cancer Res. 2019 Nov 18. PMID: 31740444.
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    3. Barta JA, Pauley K, Kossenkov AV, McMahon SB. The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. Carcinogenesis. 2019 May 08. PMID: 31067569.
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    4. Gennaro VJ, Wedegaertner H, McMahon SB. Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC. BMC Cancer. 2019 Mar 22; 19(1):258. PMID: 30902071.
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    5. Farkas M, McMahon SB. Rapid Detection of p53 Acetylation Status in Response to Cellular Stress Signaling. Methods Mol Biol. 2019; 1983:255-262. PMID: 31087303.
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    6. Gennaro VJ, Stanek TJ, Peck AR, Sun Y, Wang F, Qie S, Knudsen KE, Rui H, Butt T, Diehl JA, McMahon SB. Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9298-E9307. PMID: 30224477.
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    7. Barta JA, McMahon SB. Lung-Enriched Mutations in the p53 Tumor Suppressor: A Paradigm for Tissue-Specific Gain of Oncogenic Function. Mol Cancer Res. 2018 Sep 17. PMID: 30224539.
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    8. Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA. A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival. Nat Cell Biol. 2018 Jan; 20(1):104-115. PMID: 29230015.
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    9. Petruk S, Cai J, Sussman R, Sun G, Kovermann SK, Mariani SA, Calabretta B, McMahon SB, Brock HW, Iacovitti L, Mazo A. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation. Mol Cell. 2017 Apr 20; 66(2):247-257.e5. PMID: 28410996.
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    10. Zhao Y, Wang S, Zhang F, Russo M, McMahon SB, Zhu J. Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes. FASEB J. 2017 Mar; 31(3):1165-1178. PMID: 27940549.
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    11. Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. 2016 Nov 08; 7(45):72395-72414. PMID: 27590350.
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    12. Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-Silverman L, Manfredi JJ, Berger SL, McMahon SB. A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. Mol Oncol. 2016 Oct; 10(8):1207-20. PMID: 27341992.
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    13. Tutton S, Azzam GA, Stong N, Vladimirova O, Wiedmer A, Monteith JA, Beishline K, Wang Z, Deng Z, Riethman H, McMahon SB, Murphy M, Lieberman PM. Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres. EMBO J. 2016 Jan 18; 35(2):193-207. PMID: 26658110.
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    14. Thangavel C, Boopathi E, Ciment S, Liu Y, O' Neill R, Sharma A, McMahon SB, Mellert H, Addya S, Ertel A, Birbe R, Fortina P, Dicker AP, Knudsen KE, Den RB. The retinoblastoma tumor suppressor modulates DNA repair and radioresponsiveness. Clin Cancer Res. 2014 Nov 1; 20(21):5468-82. PMID: 25165096.
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    15. McMahon SB. MYC and the control of apoptosis. Cold Spring Harb Perspect Med. 2014 Jul; 4(7):a014407. PMID: 24985130.
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    16. Schrecengost RS, Dean JL, Goodwin JF, Schiewer MJ, Urban MW, Stanek TJ, Sussman RT, Hicks JL, Birbe RC, Draganova-Tacheva RA, Visakorpi T, Demarzo AM, McMahon SB, Knudsen KE. USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression. Cancer Res. 2014 Jan 1; 74(1):272-86. PMID: 24197134.
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    17. Monteith J, McMahon SB. p53: The TRiC Is Knowing When to Fold 'Em. Mol Cell. 2013 Jun 27; 50(6):781-2. PMID: 23806333.
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    18. Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB. The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2). J Biol Chem. 2013 Aug 16; 288(33):24234-46. PMID: 23760504.
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    19. Chen K, Wu K, Gormley M, Ertel A, Wang J, Zhang W, Zhou J, Disante G, Li Z, Rui H, Quong AA, McMahon SB, Deng H, Lisanti MP, Wang C, Pestell RG. Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer. Oncotarget. 2013 Jun; 4(6):923-35. PMID: 23798621.
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    20. Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Gormley M, Wang C, McMahon SB, Pestell RG. Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells. Cancer Res. 2013 Jun 1; 73(11):3262-74. PMID: 23492369.
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    21. Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex. Mol Cell Biol. 2013 Apr; 33(8):1487-502. PMID: 23382074.
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    22. Blomain ES, McMahon SB. Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):1075-9. PMID: 22766037.
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    23. Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW, Thibault P, Verreault A, Johnson FB, Berger SL, Sternglanz R, McMahon SB, Côté J, Marmorstein R. MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2012 Jan 4; 31(1):58-70. PMID: 22020126.
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    24. Zhang XY, Pfeiffer HK, Mellert HS, Stanek TJ, Sussman RT, Kumari A, Yu D, Rigoutsos I, Thomas-Tikhonenko A, Seidel HE, Chodosh LA, Packham G, Baserga R, McMahon SB. Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. Mol Cell Biol. 2011 Dec; 31(24):5037-45. PMID: 21986497.
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    25. Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U. Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell. 2011 Jun 10; 42(5):584-96. PMID: 21658600.
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    26. Sussman RT, Zhang XY, McMahon SB. Enzymatic assays for assessing histone deubiquitylation activity. Methods. 2011 Jul; 54(3):339-47. PMID: 21513801.
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    27. Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ, Schultz DC, McMahon SB. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J Biol Chem. 2011 Feb 11; 286(6):4264-70. PMID: 21148320.
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    28. La Rocca G, Shi B, Audia A, Ferrari-Amorotti G, Mellert HS, Calabretta B, McMahon SB, Sepp-Lorenzino L, Baserga R. Regulation of microRNA-145 by growth arrest and differentiation. Exp Cell Res. 2011 Feb 15; 317(4):488-95. PMID: 21111732.
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    29. Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010 Oct 19; 18(4):329-40. PMID: 20951943.
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    30. Van Dang C, McMahon SB. Emerging Concepts in the Analysis of Transcriptional Targets of the MYC Oncoprotein: Are the Targets Targetable? Genes Cancer. 2010 Jun; 1(6):560-567. PMID: 21533016.
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    31. Norvell A, McMahon SB. Cell biology. Rise of the rival. Science. 2010 Feb 19; 327(5968):964-5. PMID: 20167774.
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    32. Mellert HS, McMahon SB. hMOF, a KAT(8) with many lives. Mol Cell. 2009 Oct 23; 36(2):174-5. PMID: 19854127.
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    33. Mellert HS, McMahon SB. Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells. Trends Biochem Sci. 2009 Nov; 34(11):571-8. PMID: 19819149.
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    34. Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem. 2009 Jul 24; 284(30):20197-205. PMID: 19494119.
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    35. Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A. 2008 Dec 2; 105(48):18782-7. PMID: 19033189.
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    36. McMahon SB. Control of nucleotide biosynthesis by the MYC oncoprotein. Cell Cycle. 2008 Aug; 7(15):2275-6. PMID: 18682683.
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    37. Zhang XY, Pfeiffer HK, Thorne AW, McMahon SB. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. Cell Cycle. 2008 Jun 1; 7(11):1522-4. PMID: 18469533.
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    38. Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell. 2008 Jan 18; 29(1):102-11. PMID: 18206973.
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    39. Mellert H, Sykes SM, Murphy ME, McMahon SB. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle. 2007 Jun 1; 6(11):1304-6. PMID: 17534149.
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    40. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell. 2006 Dec 28; 24(6):841-51. PMID: 17189187.
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    41. Patel JH, McMahon SB. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. J Biol Chem. 2007 Jan 5; 282(1):5-13. PMID: 17082179.
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    42. Chau CM, Zhang XY, McMahon SB, Lieberman PM. Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF. J Virol. 2006 Jun; 80(12):5723-32. PMID: 16731911.
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    43. Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Myc influences global chromatin structure. EMBO J. 2006 Jun 21; 25(12):2723-34. PMID: 16724113.
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    44. Zhang XY, DeSalle LM, McMahon SB. Identification of novel targets of MYC whose transcription requires the essential MbII domain. Cell Cycle. 2006 Feb; 5(3):238-41. PMID: 16434883.
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    45. Patel JH, McMahon SB. Targeting of Miz-1 is essential for Myc-mediated apoptosis. J Biol Chem. 2006 Feb 10; 281(6):3283-9. PMID: 16352593.
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    46. Zhang XY, DeSalle LM, Patel JH, Capobianco AJ, Yu D, Thomas-Tikhonenko A, McMahon SB. Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13968-73. PMID: 16172399.
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    47. Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman PM, Lane WS, Blobel GA, McMahon SB. The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol. 2004 Dec; 24(24):10826-34. PMID: 15572685.
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    48. Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB. Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer. 2004 Jul; 4(7):562-8. PMID: 15229481.
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    49. Ard PG, Chatterjee C, Kunjibettu S, Adside LR, Gralinski LE, McMahon SB. Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. Mol Cell Biol. 2002 Aug; 22(16):5650-61. PMID: 12138177.
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    50. Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol. 2002 Jul; 22(14):5054-63. PMID: 12077335.
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    51. Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K. Human ING1 proteins differentially regulate histone acetylation. J Biol Chem. 2002 Aug 16; 277(33):29832-9. PMID: 12015309.
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