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Steven McMahon

TitleProfessor
InstitutionThomas Jefferson University
DepartmentCancer Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-9064
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    Collapse Research 
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    F32CA067426     (MCMAHON, STEVEN B)Sep 10, 1995
    NIH/NCI
    C-MYC-BINDING PROTEIN AND TRANSFORMATION
    Role: Principal Investigator

    R01CA090465     (MCMAHON, STEVEN B)Apr 1, 2001 - Feb 28, 2014
    NIH/NCI
    Functional analysis of transcriptional program regulated by the c-MYC oncoprotein
    Role: Principal Investigator

    R01CA098172     (MCMAHON, STEVEN B)Jul 1, 2003 - Apr 30, 2010
    NIH/NCI
    Role of TRRAP in the p53-Mediated Transcription of mdm2
    Role: Principal Investigator

    R21CA152786     (MCMAHON, STEVEN B)Jul 1, 2010 - Jun 30, 2013
    NIH/NCI
    Function of a novel, sirtuin-regulated acetylation site on p53.
    Role: Principal Investigator

    R21CA141232     (MCMAHON, STEVEN B)Mar 4, 2011 - Feb 28, 2014
    NIH/NCI
    Role of a novel MYC/BCL2 pathway in apoptosis and transformation
    Role: Principal Investigator

    R01CA141070     (MCMAHON, STEVEN B.)Aug 1, 2011 - May 31, 2016
    NIH/NCI
    Role of the mitochondrial RNA polymerase POLRMT in MYC function
    Role: Principal Investigator

    R01CA164834     (MCMAHON, STEVEN B.)Aug 1, 2013 - May 31, 2018
    NIH/NCI
    Role of BAG1 in suppressing the intrinsic tumor suppressor activity of MYC
    Role: Principal Investigator

    R01CA182569     (KNUDSEN, KAREN E)Jul 1, 2015 - Jun 30, 2020
    NIH/NCI
    USP22 Function in Advanced Prostate Cancer
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhao Y, Wang S, Zhang F, Russo M, McMahon SB, Zhu J. Repression of telomerase gene promoter requires human-specific genomic context and is mediated by multiple HDAC1-containing corepressor complexes. FASEB J. 2017 Mar; 31(3):1165-1178. PMID: 27940549.
      View in: PubMed
    2. Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR, Shen C, Rigoutsos I, King MP, Cotney JL, Arnold JJ, Sharma SD, Martinez-Outschoorn UE, Vakoc CR, Chodosh LA, Thompson JE, Bradner JE, Cameron CE, Shadel GS, Eischen CM, McMahon SB. Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget. 2016 Nov 08; 7(45):72395-72414. PMID: 27590350.
      View in: PubMed
    3. Monteith JA, Mellert H, Sammons MA, Kuswanto LA, Sykes SM, Resnick-Silverman L, Manfredi JJ, Berger SL, McMahon SB. A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction. Mol Oncol. 2016 Oct; 10(8):1207-20. PMID: 27341992.
      View in: PubMed
    4. Tutton S, Azzam GA, Stong N, Vladimirova O, Wiedmer A, Monteith JA, Beishline K, Wang Z, Deng Z, Riethman H, McMahon SB, Murphy M, Lieberman PM. Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres. EMBO J. 2016 Jan 18; 35(2):193-207. PMID: 26658110.
      View in: PubMed
    5. McMahon SB. MYC and the control of apoptosis. Cold Spring Harb Perspect Med. 2014 Jul; 4(7):a014407. PMID: 24985130.
      View in: PubMed
    6. Schrecengost RS, Dean JL, Goodwin JF, Schiewer MJ, Urban MW, Stanek TJ, Sussman RT, Hicks JL, Birbe RC, Draganova-Tacheva RA, Visakorpi T, Demarzo AM, McMahon SB, Knudsen KE. USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression. Cancer Res. 2014 Jan 1; 74(1):272-86. PMID: 24197134.
      View in: PubMed
    7. Monteith J, McMahon SB. p53: The TRiC Is Knowing When to Fold 'Em. Mol Cell. 2013 Jun 27; 50(6):781-2. PMID: 23806333.
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    8. Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB. The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2). J Biol Chem. 2013 Aug 16; 288(33):24234-46. PMID: 23760504.
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    9. Chen K, Wu K, Gormley M, Ertel A, Wang J, Zhang W, Zhou J, Disante G, Li Z, Rui H, Quong AA, McMahon SB, Deng H, Lisanti MP, Wang C, Pestell RG. Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer. Oncotarget. 2013 Jun; 4(6):923-35. PMID: 23798621.
      View in: PubMed
    10. Chen K, Wu K, Cai S, Zhang W, Zhou J, Wang J, Ertel A, Li Z, Rui H, Quong A, Lisanti MP, Tozeren A, Tanes C, Addya S, Gormley M, Wang C, McMahon SB, Pestell RG. Dachshund Binds p53 to Block the Growth of Lung Adenocarcinoma Cells. Cancer Res. 2013 Jun 1; 73(11):3262-74. PMID: 23492369.
      View in: PubMed
    11. Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A High-Confidence Interaction Map Identifies SIRT1 as a Mediator of Acetylation of USP22 and the SAGA Coactivator Complex. Mol Cell Biol. 2013 Apr; 33(8):1487-502. PMID: 23382074.
      View in: PubMed
    12. Blomain ES, McMahon SB. Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation. Biochim Biophys Acta. 2012 Sep-Oct; 1819(9-10):1075-9. PMID: 22766037.
      View in: PubMed
    13. Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, Johnson J, Hodawadekar S, Ding EC, Speicher K, Abshiru N, Perry R, Wu J, Yang C, Zheng YG, Speicher DW, Thibault P, Verreault A, Johnson FB, Berger SL, Sternglanz R, McMahon SB, Côté J, Marmorstein R. MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2012 Jan 4; 31(1):58-70. PMID: 22020126.
      View in: PubMed
    14. Zhang XY, Pfeiffer HK, Mellert HS, Stanek TJ, Sussman RT, Kumari A, Yu D, Rigoutsos I, Thomas-Tikhonenko A, Seidel HE, Chodosh LA, Packham G, Baserga R, McMahon SB. Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC. Mol Cell Biol. 2011 Dec; 31(24):5037-45. PMID: 21986497.
      View in: PubMed
    15. Charvet C, Wissler M, Brauns-Schubert P, Wang SJ, Tang Y, Sigloch FC, Mellert H, Brandenburg M, Lindner SE, Breit B, Green DR, McMahon SB, Borner C, Gu W, Maurer U. Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell. 2011 Jun 10; 42(5):584-96. PMID: 21658600.
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    16. Sussman RT, Zhang XY, McMahon SB. Enzymatic assays for assessing histone deubiquitylation activity. Methods. 2011 Jul; 54(3):339-47. PMID: 21513801.
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    17. Mellert HS, Stanek TJ, Sykes SM, Rauscher FJ, Schultz DC, McMahon SB. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis. J Biol Chem. 2011 Feb 11; 286(6):4264-70. PMID: 21148320.
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    18. La Rocca G, Shi B, Audia A, Ferrari-Amorotti G, Mellert HS, Calabretta B, McMahon SB, Sepp-Lorenzino L, Baserga R. Regulation of microRNA-145 by growth arrest and differentiation. Exp Cell Res. 2011 Feb 15; 317(4):488-95. PMID: 21111732.
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    19. Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell. 2010 Oct 19; 18(4):329-40. PMID: 20951943.
      View in: PubMed
    20. Van Dang C, McMahon SB. Emerging Concepts in the Analysis of Transcriptional Targets of the MYC Oncoprotein: Are the Targets Targetable? Genes Cancer. 2010 Jun; 1(6):560-567. PMID: 21533016.
      View in: PubMed
    21. Norvell A, McMahon SB. Cell biology. Rise of the rival. Science. 2010 Feb 19; 327(5968):964-5. PMID: 20167774.
      View in: PubMed
    22. Mellert HS, McMahon SB. hMOF, a KAT(8) with many lives. Mol Cell. 2009 Oct 23; 36(2):174-5. PMID: 19854127.
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    23. Mellert HS, McMahon SB. Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells. Trends Biochem Sci. 2009 Nov; 34(11):571-8. PMID: 19819149.
      View in: PubMed
    24. Sykes SM, Stanek TJ, Frank A, Murphy ME, McMahon SB. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J Biol Chem. 2009 Jul 24; 284(30):20197-205. PMID: 19494119.
      View in: PubMed
    25. Wise DR, DeBerardinis RJ, Mancuso A, Sayed N, Zhang XY, Pfeiffer HK, Nissim I, Daikhin E, Yudkoff M, McMahon SB, Thompson CB. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci U S A. 2008 Dec 2; 105(48):18782-7. PMID: 19033189.
      View in: PubMed
    26. McMahon SB. Control of nucleotide biosynthesis by the MYC oncoprotein. Cell Cycle. 2008 Aug; 7(15):2275-6. PMID: 18682683.
      View in: PubMed
    27. Zhang XY, Pfeiffer HK, Thorne AW, McMahon SB. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A. Cell Cycle. 2008 Jun 1; 7(11):1522-4. PMID: 18469533.
      View in: PubMed
    28. Zhang XY, Varthi M, Sykes SM, Phillips C, Warzecha C, Zhu W, Wyce A, Thorne AW, Berger SL, McMahon SB. The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression. Mol Cell. 2008 Jan 18; 29(1):102-11. PMID: 18206973.
      View in: PubMed
    29. Mellert H, Sykes SM, Murphy ME, McMahon SB. The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain. Cell Cycle. 2007 Jun 1; 6(11):1304-6. PMID: 17534149.
      View in: PubMed
    30. Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell. 2006 Dec 28; 24(6):841-51. PMID: 17189187.
      View in: PubMed
    31. Patel JH, McMahon SB. BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis. J Biol Chem. 2007 Jan 5; 282(1):5-13. PMID: 17082179.
      View in: PubMed
    32. Chau CM, Zhang XY, McMahon SB, Lieberman PM. Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF. J Virol. 2006 Jun; 80(12):5723-32. PMID: 16731911.
      View in: PubMed
    33. Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, Eisenman RN. Myc influences global chromatin structure. EMBO J. 2006 Jun 21; 25(12):2723-34. PMID: 16724113.
      View in: PubMed
    34. Zhang XY, DeSalle LM, McMahon SB. Identification of novel targets of MYC whose transcription requires the essential MbII domain. Cell Cycle. 2006 Feb; 5(3):238-41. PMID: 16434883.
      View in: PubMed
    35. Patel JH, McMahon SB. Targeting of Miz-1 is essential for Myc-mediated apoptosis. J Biol Chem. 2006 Feb 10; 281(6):3283-9. PMID: 16352593.
      View in: PubMed
    36. Zhang XY, DeSalle LM, Patel JH, Capobianco AJ, Yu D, Thomas-Tikhonenko A, McMahon SB. Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13968-73. PMID: 16172399.
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    37. Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ, Rakowski C, Chatterjee C, Lieberman PM, Lane WS, Blobel GA, McMahon SB. The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol. 2004 Dec; 24(24):10826-34. PMID: 15572685.
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    38. Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB. Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer. 2004 Jul; 4(7):562-8. PMID: 15229481.
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    39. Ard PG, Chatterjee C, Kunjibettu S, Adside LR, Gralinski LE, McMahon SB. Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. Mol Cell Biol. 2002 Aug; 22(16):5650-61. PMID: 12138177.
      View in: PubMed
    40. Nikiforov MA, Chandriani S, Park J, Kotenko I, Matheos D, Johnsson A, McMahon SB, Cole MD. TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins. Mol Cell Biol. 2002 Jul; 22(14):5054-63. PMID: 12077335.
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    41. Vieyra D, Loewith R, Scott M, Bonnefin P, Boisvert FM, Cheema P, Pastyryeva S, Meijer M, Johnston RN, Bazett-Jones DP, McMahon S, Cole MD, Young D, Riabowol K. Human ING1 proteins differentially regulate histone acetylation. J Biol Chem. 2002 Aug 16; 277(33):29832-9. PMID: 12015309.
      View in: PubMed
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