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Stephen Peiper

TitleProfessor & Chair JMC
InstitutionThomas Jefferson University
DepartmentChair SKMC
Address1020 Locust St.
Philadelphia PA 19107
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    K08CA001013     (PEIPER, STEPHEN C)May 1, 1985 - Jun 30, 1990
    NIH/NCI
    GENE ENCODING P67 MYELOID DIFFERENTIATION ANTIGEN
    Role: Principal Investigator

    R01DK045242     (PEIPER, STEPHEN C)Sep 20, 1991 - Feb 28, 1995
    NIH/NIDDK
    MOLECULAR BASIS OF HEMATOPOIETIC GROWTH FACTOR SIGNALING
    Role: Principal Investigator

    R01AI041346     (PEIPER, STEPHEN C)May 1, 1997 - Feb 28, 2009
    NIH/NIAID
    Mechanism for Chemokine Receptor Fusogenic Activity
    Role: Principal Investigator

    R21CA175975     (PEIPER, STEPHEN)Sep 1, 2014 - Aug 31, 2016
    NIH/NCI
    Reactive Oxygen Species-Induced CXCL8 in Ovarian Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jiang W, Dulaimi E, Devarajan K, Parsons T, Wang Q, O'Neill R, Solomides C, Peiper SC, Testa JR, Uzzo R, Yang H. Intratumoral heterogeneity analysis reveals hidden associations between protein expression losses and patient survival in clear cell renal cell carcinoma. Oncotarget. 2017 Jun 06; 8(23):37423-37434. PMID: 28445125.
      View in: PubMed
    2. Jiang W, Dulaimi E, Devarajan K, Parsons T, Wang Q, Liao L, Cho EA, O'Neill R, Solomides C, Peiper SC, Testa JR, Uzzo R, Yang H. Immunohistochemistry Successfully Uncovers Intratumoral Heterogeneity and Widespread Co-Losses of Chromatin Regulators in Clear Cell Renal Cell Carcinoma. PLoS One. 2016; 11(10):e0164554. PMID: 27764136.
      View in: PubMed
    3. Myers RE, Wolf T, Shwae P, Hegarty S, Peiper SC, Waldman SA. A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients. BMC Cancer. 2016 Oct 03; 16(1):766. PMID: 27716119.
      View in: PubMed
    4. Brody JR, Yabar CS, Zarei M, Bender J, Matrisian LM, Rahib L, Heartwell C, Mason K, Yeo CJ, Peiper SC, Jiang W, Varieur K, Madhavan S, Petricoin E, Fortuna D, Curtis M, Wang ZX, Pishvaian MJ, Winter JM. Identification of a novel metabolic-related mutation (IDH1) in metastatic pancreatic cancer. Cancer Biol Ther. 2016 Jul 28; 0. PMID: 27466707.
      View in: PubMed
    5. Buraschi S, Xu SQ, Stefanello M, Moskalev I, Morcavallo A, Genua M, Tanimoto R, Birbe R, Peiper SC, Gomella LG, Belfiore A, Black PC, Iozzo RV, Morrione A. Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 2016 Jun 28; 7(26):39980-39995. PMID: 27220888.
      View in: PubMed
    6. Xu SQ, Buraschi S, Morcavallo A, Genua M, Shirao T, Peiper SC, Gomella LG, Birbe R, Belfiore A, Iozzo RV, Morrione A. A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. Oncotarget. 2015 May 10; 6(13):10825-39. PMID: 25839164.
      View in: PubMed
    7. Uppal G, Ly V, Wang ZX, Bajaj R, Solomides CC, Banks PM, Medeiros LJ, Peiper SC, Gong JZ. The Utility of BRAF V600E Mutation-Specific Antibody VE1 for the Diagnosis of Hairy Cell Leukemia. Am J Clin Pathol. 2015 Jan; 143(1):120-5. PMID: 25511150.
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    8. Simen BB, Yin L, Goswami CP, Davis KO, Bajaj R, Gong JZ, Peiper SC, Johnson ES, Wang ZX. Validation of a next-generation-sequencing cancer panel for use in the clinical laboratory. Arch Pathol Lab Med. 2015 Apr; 139(4):508-17. PMID: 25356985.
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    9. Mardekian SK, Solomides CC, Gong JZ, Peiper SC, Wang ZX, Bajaj R. Comparison of Chromogenic In Situ Hybridization and Fluorescence In Situ Hybridization for the Evaluation of MDM2 Amplification in Adipocytic Tumors. J Clin Lab Anal. 2015 Nov; 29(6):462-8. PMID: 25132285.
      View in: PubMed
    10. Schneider EH, Fowler SC, Lionakis MS, Swamydas M, Holmes G, Diaz V, Munasinghe J, Peiper SC, Gao JL, Murphy PM. Regulation of motor function and behavior by atypical chemokine receptor 1. Behav Genet. 2014 Sep; 44(5):498-515. PMID: 24997773.
      View in: PubMed
    11. Jamal SE, Li S, Bajaj R, Wang Z, Kenyon L, Glass J, Pang CS, Bhagavathi S, Peiper SC, Gong JZ. Primary central nervous system Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a clinicopathologic study of five cases. Brain Tumor Pathol. 2014 Oct; 31(4):265-73. PMID: 24399201.
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    12. Misu R, Oishi S, Setsuda S, Noguchi T, Kaneda M, Ohno H, Evans B, Navenot JM, Peiper SC, Fujii N. Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes. Bioorg Med Chem Lett. 2013 May 1; 23(9):2628-31. PMID: 23522565.
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    13. Chen B, Yi B, Mao R, Liu H, Wang J, Sharma A, Peiper S, Leonard WJ, She JX. Enhanced T Cell Lymphoma in NOD.Stat5b Transgenic Mice Is Caused by Hyperactivation of Stat5b in CD8(+) Thymocytes. PLoS One. 2013; 8(2):e56600. PMID: 23457589.
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    14. Solomides CC, Evans BJ, Navenot JM, Vadigepalli R, Peiper SC, Wang ZX. MicroRNA Profiling in Lung Cancer Reveals New Molecular Markers for Diagnosis. Acta Cytol. 2012; 56(6):645-54. PMID: 23207443.
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    15. Buraschi S, Neill T, Owens RT, Iniguez LA, Purkins G, Vadigepalli R, Evans B, Schaefer L, Peiper SC, Wang ZX, Iozzo RV. Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model. PLoS One. 2012; 7(9):e45559. PMID: 23029096.
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    16. Fiskus W, Hembruff SL, Rao R, Sharma P, Balusu R, Venkannagari S, Smith JE, Peth K, Peiper SC, Bhalla KN. Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells. Breast Cancer Res Treat. 2012 Sep; 135(2):433-44. PMID: 22825030.
      View in: PubMed
    17. Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One. 2012; 7(6):e40148. PMID: 22859931.
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    18. Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, Yano Y, Matsuzaki K, Navenot JM, Peiper SC, Fujii N. Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists. Bioconjug Chem. 2012 Jun 20; 23(6):1259-65. PMID: 22486464.
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    19. Navenot JM, Evans B, Oishi S, Setsuda S, Fujii N, Peiper SC. The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma. Melanoma Res. 2012 Apr; 22(2):140-50. PMID: 22395416.
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    20. Valsecchi ME, McDonald M, Brody JR, Hyslop T, Freydin B, Yeo CJ, Solomides C, Peiper SC, Witkiewicz AK. Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma. Cancer. 2012 Jul 15; 118(14):3484-93. PMID: 22086503.
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    21. Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, Peiper SC, Gomella LG, Owens RC, Morrione A. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling. J Biol Chem. 2011 Oct 7; 286(40):34712-21. PMID: 21840990.
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    22. Liu LZ, Jiang Y, Carpenter RL, Jing Y, Peiper SC, Jiang BH. Role and mechanism of arsenic in regulating angiogenesis. PLoS One. 2011; 6(6):e20858. PMID: 21687637.
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    23. Reid-Nicholson MD, Motiwala N, Drury SC, Peiper SC, Terris MK, Waller JL, Ramalingam P. Chromosomal abnormalities in renal cell carcinoma variants detected by Urovysion fluorescence in situ hybridization on paraffin-embedded tissue. Ann Diagn Pathol. 2011 Feb; 15(1):37-45. PMID: 21238914.
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    24. Nishizawa K, Nishiyama H, Oishi S, Tanahara N, Kotani H, Mikami Y, Toda Y, Evans BJ, Peiper SC, Saito R, Watanabe J, Fujii N, Ogawa O. Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4. Int J Cancer. 2010 Sep 1; 127(5):1180-7. PMID: 20039317.
      View in: PubMed
    25. Mandawat A, Fiskus W, Buckley KM, Robbins K, Rao R, Balusu R, Navenot JM, Wang ZX, Ustun C, Chong DG, Atadja P, Fujii N, Peiper SC, Bhalla K. Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists. Blood. 2010 Dec 9; 116(24):5306-15. PMID: 20810927.
      View in: PubMed
    26. Tanaka T, Nomura W, Narumi T, Esaka A, Oishi S, Ohashi N, Itotani K, Evans BJ, Wang ZX, Peiper SC, Fujii N, Tamamura H. Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids. Org Biomol Chem. 2009 Sep 21; 7(18):3805-9. PMID: 19707686.
      View in: PubMed
    27. Navenot JM, Fujii N, Peiper SC. Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis. Mol Pharmacol. 2009 Jun; 75(6):1300-6. PMID: 19286835.
      View in: PubMed
    28. Kang KA, Ren Y, Sharma VR, Peiper SC. Near real-time immuno-optical sensor for diagnosing single point mutation: a model system: sensor for factor V Leiden diagnosis. Biosens Bioelectron. 2009 May 15; 24(9):2785-90. PMID: 19318242.
      View in: PubMed
    29. Navenot JM, Fujii N, Peiper SC. KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. Mol Pharmacol. 2009 May; 75(5):1074-83. PMID: 19201817.
      View in: PubMed
    30. Tamamura H, Tanaka T, Tsutsumi H, Ohashi N, Hiramatsu K, Araki T, Ojida A, Hamachi I, Wang Z, Peiper SC, Trent JO, Ueda S, Oishi S, Fujii N. Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy. Adv Exp Med Biol. 2009; 611:145-6. PMID: 19400132.
      View in: PubMed
    31. Evans BJ, Wang Z, Broach JR, Oishi S, Fujii N, Peiper SC. Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists. Methods Enzymol. 2009; 460:399-412. PMID: 19446737.
      View in: PubMed
    32. Tomita K, Oishi S, Ohno H, Peiper SC, Fujii N. Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase. J Med Chem. 2008 Dec 11; 51(23):7645-9. PMID: 19007202.
      View in: PubMed
    33. Evans BJ, Wang Z, Mobley L, Khosravi D, Fujii N, Navenot JM, Peiper SC. Physical association of GPR54 C-terminal with protein phosphatase 2A. Biochem Biophys Res Commun. 2008 Dec 26; 377(4):1067-71. PMID: 18977201.
      View in: PubMed
    34. Reid-Nicholson MD, Ramalingam P, Adeagbo B, Cheng N, Peiper SC, Terris MK. The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder. Mod Pathol. 2009 Jan; 22(1):119-27. PMID: 18978733.
      View in: PubMed
    35. Fiskus W, Wang Y, Joshi R, Rao R, Yang Y, Chen J, Kolhe R, Balusu R, Eaton K, Lee P, Ustun C, Jillella A, Buser CA, Peiper S, Bhalla K. Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells. Clin Cancer Res. 2008 Oct 1; 14(19):6106-15. PMID: 18829489.
      View in: PubMed
    36. Fiskus W, Rao R, Fernandez P, Herger B, Yang Y, Chen J, Kolhe R, Mandawat A, Wang Y, Joshi R, Eaton K, Lee P, Atadja P, Peiper S, Bhalla K. Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells. Blood. 2008 Oct 1; 112(7):2896-905. PMID: 18660379.
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    37. Ueda S, Kato M, Inuki S, Ohno H, Evans B, Wang ZX, Peiper SC, Izumi K, Kodama E, Matsuoka M, Nagasawa H, Oishi S, Fujii N. Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4124-9. PMID: 18539453.
      View in: PubMed
    38. Romero-Sánchez M, Peiper SC, Evans B, Wang Z, Catasús L, Ribe A, Prat J, Giri JG. Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors. Hum Pathol. 2008 Jul; 39(7):1026-33. PMID: 18479732.
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    39. Oishi S, Masuda R, Evans B, Ueda S, Goto Y, Ohno H, Hirasawa A, Tsujimoto G, Wang Z, Peiper SC, Naito T, Kodama E, Matsuoka M, Fujii N. Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4. Chembiochem. 2008 May 5; 9(7):1154-8. PMID: 18412193.
      View in: PubMed
    40. Zhang W, Navenot JM, Frilot NM, Fujii N, Peiper SC. Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis. Mol Pharmacol. 2007 Nov; 72(5):1310-21. PMID: 17715399.
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    41. Lipan O, Navenot JM, Wang Z, Huang L, Peiper SC. Heat shock response in CHO mammalian cells is controlled by a nonlinear stochastic process. PLoS Comput Biol. 2007 Oct; 3(10):1859-70. PMID: 17922567.
      View in: PubMed
    42. Tomita K, Oishi S, Cluzeau J, Ohno H, Navenot JM, Wang ZX, Peiper SC, Akamatsu M, Fujii N. SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54. J Med Chem. 2007 Jul 12; 50(14):3222-8. PMID: 17579384.
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    43. Cluzeau J, Oishi S, Ohno H, Wang Z, Evans B, Peiper SC, Fujii N. Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists. Org Biomol Chem. 2007 Jun 21; 5(12):1915-23. PMID: 17551641.
      View in: PubMed
    44. Nash KT, Phadke PA, Navenot JM, Hurst DR, Accavitti-Loper MA, Sztul E, Vaidya KS, Frost AR, Kappes JC, Peiper SC, Welch DR. Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy. J Natl Cancer Inst. 2007 Feb 21; 99(4):309-21. PMID: 17312308.
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    45. Ueda S, Oishi S, Wang ZX, Araki T, Tamamura H, Cluzeau J, Ohno H, Kusano S, Nakashima H, Trent JO, Peiper SC, Fujii N. Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem. 2007 Jan 25; 50(2):192-8. PMID: 17228861.
      View in: PubMed
    46. Lee JS, Wurfel MM, Matute-Bello G, Frevert CW, Rosengart MR, Ranganathan M, Wong VW, Holden T, Sutlief S, Richmond A, Peiper S, Martin TR. The Duffy antigen modifies systemic and local tissue chemokine responses following lipopolysaccharide stimulation. J Immunol. 2006 Dec 1; 177(11):8086-94. PMID: 17114483.
      View in: PubMed
    47. Tomita K, Niida A, Oishi S, Ohno H, Cluzeau J, Navenot JM, Wang ZX, Peiper SC, Fujii N. Structure-activity relationship study on small peptidic GPR54 agonists. Bioorg Med Chem. 2006 Nov 15; 14(22):7595-603. PMID: 16879969.
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    48. Napier KB, Wang ZX, Peiper SC, Trent JO. CCR5 interactions with the variable 3 loop of gp120. J Mol Model. 2007 Jan; 13(1):29-41. PMID: 16721558.
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    49. Tamamura H, Tsutsumi H, Masuno H, Mizokami S, Hiramatsu K, Wang Z, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Fujii N. Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs. Org Biomol Chem. 2006 Jun 21; 4(12):2354-7. PMID: 16763678.
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    50. Niida A, Tanigaki H, Inokuchi E, Sasaki Y, Oishi S, Ohno H, Tamamura H, Wang Z, Peiper SC, Kitaura K, Otaka A, Fujii N. Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists. J Org Chem. 2006 May 12; 71(10):3942-51. PMID: 16674071.
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    51. Wang ZX, Broach JR, Peiper SC. Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4. Methods Mol Biol. 2006; 332:115-27. PMID: 16878688.
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    52. Navenot JM, Wang ZX, Peiper SC. Characterization of constitutively active mutants of G protein-coupled receptors. Methods Mol Biol. 2006; 332:129-39. PMID: 16878689.
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    53. Navenot JM, Wang Z, Chopin M, Fujii N, Peiper SC. Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins. Cancer Res. 2005 Nov 15; 65(22):10450-6. PMID: 16288036.
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    54. Tamamura H, Esaka A, Ogawa T, Araki T, Ueda S, Wang Z, Trent JO, Tsutsumi H, Masuno H, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N. Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds. Org Biomol Chem. 2005 Dec 21; 3(24):4392-4. PMID: 16327900.
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    55. Niida A, Wang Z, Tomita K, Oishi S, Tamamura H, Otaka A, Navenot JM, Broach JR, Peiper SC, Fujii N. Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett. 2006 Jan 1; 16(1):134-7. PMID: 16242330.
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    56. Hu Q, Napier KB, Trent JO, Wang Z, Taylor S, Griffin GE, Peiper SC, Shattock RJ. Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization. J Mol Biol. 2005 Jul 22; 350(4):699-712. PMID: 15964018.
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    57. Tamamura H, Araki T, Ueda S, Wang Z, Oishi S, Esaka A, Trent JO, Nakashima H, Yamamoto N, Peiper SC, Otaka A, Fujii N. Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. J Med Chem. 2005 May 5; 48(9):3280-9. PMID: 15857134.
      View in: PubMed
    58. Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent JO, Peiper SC, Yamamoto N, Nakashima H, Otaka A, Fujii N. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27; 48(2):380-91. PMID: 15658852.
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    59. Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. Org Biomol Chem. 2004 Apr 21; 2(8):1255-7. PMID: 15064805.
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    60. Masui T, Doi R, Mori T, Toyoda E, Koizumi M, Kami K, Ito D, Peiper SC, Broach JR, Oishi S, Niida A, Fujii N, Imamura M. Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun. 2004 Feb 27; 315(1):85-92. PMID: 15013429.
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    61. Jankowski K, Kucia M, Wysoczynski M, Reca R, Zhao D, Trzyna E, Trent J, Peiper S, Zembala M, Ratajczak J, Houghton P, Janowska-Wieczorek A, Ratajczak MZ. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res. 2003 Nov 15; 63(22):7926-35. PMID: 14633723.
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    62. Tamamura H, Hiramatsu K, Kusano aS, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem. 2003 Nov 7; 1(21):3656-62. PMID: 14649896.
      View in: PubMed
    63. Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N. Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem. 2003 Nov 7; 1(21):3663-9. PMID: 14649897.
      View in: PubMed
    64. Trent JO, Wang ZX, Murray JL, Shao W, Tamamura H, Fujii N, Peiper SC. Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem. 2003 Nov 21; 278(47):47136-44. PMID: 12958314.
      View in: PubMed
    65. Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach JA, Trent JO, Wang ZX, Peiper SC. Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. Angew Chem Int Ed Engl. 2003 Jul 21; 42(28):3251-3. PMID: 12876735.
      View in: PubMed
    66. Alvarez Arias D, Navenot JM, Zhang WB, Broach J, Peiper SC. Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2. J Biol Chem. 2003 Sep 19; 278(38):36513-21. PMID: 12837756.
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    67. Lee JS, Frevert CW, Wurfel MM, Peiper SC, Wong VA, Ballman KK, Ruzinski JT, Rhim JS, Martin TR, Goodman RB. Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J Immunol. 2003 May 15; 170(10):5244-51. PMID: 12734373.
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    68. Sun D, Zhang Y, Wei B, Peiper SC, Shao H, Kaplan HJ. Encephalitogenic activity of truncated myelin oligodendrocyte glycoprotein (MOG) peptides and their recognition by CD8+ MOG-specific T cells on oligomeric MHC class I molecules. Int Immunol. 2003 Feb; 15(2):261-8. PMID: 12578856.
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    69. Kwon HJ, Peiper SC, Kang KA. Fiber optic immunosensors for cardiovascular disease diagnosis: quantification of Protein C, Factor V Leiden, and cardiac Troponin T in plasma. Adv Exp Med Biol. 2003; 510:115-9. PMID: 12580414.
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    70. Ratajczak MZ, Majka M, Kucia M, Drukala J, Pietrzkowski Z, Peiper S, Janowska-Wieczorek A. Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles. Stem Cells. 2003; 21(3):363-71. PMID: 12743331.
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    71. Fan W, Zheng JJ, Peiper SC, McLaughlin BJ. Changes in gene expression of ARPE-19 cells in response to vitreous treatment. Ophthalmic Res. 2002 Nov-Dec; 34(6):357-65. PMID: 12483023.
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    72. Libura J, Drukala J, Majka M, Tomescu O, Navenot JM, Kucia M, Marquez L, Peiper SC, Barr FG, Janowska-Wieczorek A, Ratajczak MZ. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood. 2002 Oct 1; 100(7):2597-606. PMID: 12239174.
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    73. Swardson-Olver CJ, Dawson TC, Burnett RC, Peiper SC, Maeda N, Avery AC. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion. Blood. 2002 Apr 15; 99(8):2677-84. PMID: 11929753.
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    74. Murray JL, Hu QX, Navenot JM, Peiper SC. Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1. Biochem Biophys Res Commun. 2002 Mar 29; 292(2):449-55. PMID: 11906183.
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    75. Zhang WB, Navenot JM, Haribabu B, Tamamura H, Hiramatu K, Omagari A, Pei G, Manfredi JP, Fujii N, Broach JR, Peiper SC. A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem. 2002 Jul 5; 277(27):24515-21. PMID: 11923301.
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    76. Du J, Luan J, Liu H, Daniel TO, Peiper S, Chen TS, Yu Y, Horton LW, Nanney LB, Strieter RM, Richmond A. Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. J Leukoc Biol. 2002 Jan; 71(1):141-53. PMID: 11781390.
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