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Last Name
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Steven McKenzie

TitleProfessor
InstitutionThomas Jefferson University
DepartmentHematology
Address1015 Walnut St.
Philadelphia PA 19107
Phone215-955-1271
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    Collapse Overview 
    Collapse overview

    REVIEW BOARD MEMBERSHIP
    1996 - present
    Review Committee Member, National Institutes of Health, National Cancer Institute
    Chair, Innovative Technologies for the Molecular Analysis of Cancer study section
    Member of reviewer reserve, Innovative Technologies
    Ad hoc, National Heart Lung and Blood Institute



    Collapse Research 
    Collapse research activities and funding
    R01HL061865     (MCKENZIE, STEVEN E.)Sep 30, 1998 - Aug 31, 2003
    NIH/NHLBI
    MODELS OF THROMBOCYTOPENIA PATHOLOGY &TREATMENT
    Role: Principal Investigator

    C06RR028626     (MCKENZIE, STEVEN E.)Jan 26, 2010 - Feb 28, 2013
    NIH/NCRR
    Jefferson Alumni Hall 3 West Lab Modernization
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 protein phosphatase suppresses activation of Syk through the GPVI platelet receptor for collagen by dephosphorylating Tyr(P)346, a regulatory site of Syk. J Biol Chem. 2017 Mar 10; 292(10):4360. PMID: 28283589.
      View in: PubMed
    2. Hayes V, Johnston I, Arepally GM, McKenzie SE, Cines DB, Rauova L, Poncz M. Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia. J Clin Invest. 2017 Mar 01; 127(3):1090-1098. PMID: 28218620.
      View in: PubMed
    3. Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (Fc?RIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice. Arterioscler Thromb Vasc Biol. 2016 Dec; 36(12):2315-2323. PMID: 27765766.
      View in: PubMed
    4. Reppschläger K, Gosselin J, Dangelmaier CA, Thomas DH, Carpino N, McKenzie SE, Kunapuli SP, Tsygankov AY. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016 Oct 21; 291(43):22427-22441. PMID: 27609517.
      View in: PubMed
    5. Piatt R, Paul DS, Lee RH, McKenzie SE, Parise LV, Cowley DO, Cooley BC, Bergmeier W. Mice Expressing Low Levels of CalDAG-GEFI Exhibit Markedly Impaired Platelet Activation With Minor Impact on Hemostasis. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1838-46. PMID: 27417588.
      View in: PubMed
    6. Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie S, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM. The antigenic complex in HIT binds to B-cells via complement and complement receptor 2 (CD21). Blood. 2016 Jul 13. PMID: 27412887.
      View in: PubMed
    7. McKenzie SE. Syk Inhibition in Ischemic Stroke. Arterioscler Thromb Vasc Biol. 2016 Jun; 36(6):1054-5. PMID: 27225787.
      View in: PubMed
    8. Buitrago L, Manne BK, Andre P, McKenzie S, Kunapuli S. Identification of novel Syk-independent functional roles of Fc?RIIa in platelet outside-in signaling using transgenic mice expressing human Fc?RIIa. Platelets. 2016 Jul; 27(5):488-90. PMID: 26809427.
      View in: PubMed
    9. Tutwiler V, Madeeva D, Ahn HS, Andrianova I, Hayes V, Zheng XL, Cines DB, McKenzie SE, Poncz M, Rauova L. Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia. Blood. 2016 Jan 28; 127(4):464-72. PMID: 26518435.
      View in: PubMed
    10. Zhou Y, Abraham S, Andre P, Edelstein LC, Shaw CA, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. Anti-miR-148a regulates platelet Fc?RIIA signaling and decreases thrombosis in vivo in mice. Blood. 2015 Dec 24; 126(26):2871-81. PMID: 26516227.
      View in: PubMed
    11. Lin X, Zhang X, Guo J, Roberts CK, McKenzie S, Wu WC, Liu S, Song Y. Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2015 Jul; 4(7). PMID: 26116691.
      View in: PubMed
    12. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
      View in: PubMed
    13. Kostyak JC, Bhavanasi D, Liverani E, McKenzie SE, Kunapuli SP. Protein Kinase C d Deficiency Enhances Megakaryopoiesis and Recovery From Thrombocytopenia. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2579-85. PMID: 25359855.
      View in: PubMed
    14. McKenzie SE, Sachais BS. Advances in the pathophysiology and treatment of heparin-induced thrombocytopenia. Curr Opin Hematol. 2014 Sep; 21(5):380-7. PMID: 24992313.
      View in: PubMed
    15. Yeung J, Tourdot BE, Fernandez-Perez P, Vesci J, Ren J, Smyrniotis CJ, Luci DK, Jadhav A, Simeonov A, Maloney DJ, Holman TR, McKenzie SE, Holinstat M. Platelet 12-LOX is essential for Fc?RIIa-mediated platelet activation. Blood. 2014 Oct 2; 124(14):2271-9. PMID: 25100742.
      View in: PubMed
    16. Teruel-Montoya R, Kong X, Abraham S, Ma L, Kunapuli SP, Holinstat M, Shaw CA, McKenzie SE, Edelstein LC, Bray PF. MicroRNA Expression Differences in Human Hematopoietic Cell Lineages Enable Regulated Transgene Expression. PLoS One. 2014; 9(7):e102259. PMID: 25029370.
      View in: PubMed
    17. Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct. 2014; 9(1):3. PMID: 24524654.
      View in: PubMed
    18. Simon LM, Edelstein LC, Nagalla S, Woodley AB, Chen ES, Kong X, Ma L, Fortina P, Kunapuli S, Holinstat M, McKenzie SE, Dong JF, Shaw CA, Bray PF. Human platelet microRNA-mRNA networks associated with age and gender revealed by integrated plateletomics. Blood. 2014 Apr 17; 123(16):e37-45. PMID: 24523238.
      View in: PubMed
    19. Pulte ED, McKenzie SE, Caro J, Ballas SK. Erythropoietin levels in patients with sickle cell disease do not correlate with known inducers of erythropoietin. Hemoglobin. 2014; 38(6):385-9. PMID: 25405915.
      View in: PubMed
    20. Bhatlekar S, Addya S, Salunek M, Orr CR, Surrey S, McKenzie S, Fields JZ, Boman BM. Identification of a Developmental Gene Expression Signature, Including HOX Genes, for the Normal Human Colonic Crypt Stem Cell Niche: Overexpression of the Signature Parallels Stem Cell Overpopulation During Colon Tumorigenesis. Stem Cells Dev. 2014 Jan 15; 23(2):167-79. PMID: 23980595.
      View in: PubMed
    21. Buitrago L, Bhavanasi D, Dangelmaier C, Manne BK, Badolia R, Borgognone A, Tsygankov AY, McKenzie SE, Kunapuli SP. Tyrosine phosphorylation on spleen tyrosine kinase (Syk) is differentially regulated in human and murine platelets by protein kinase C isoforms. J Biol Chem. 2013 Oct 4; 288(40):29160-9. PMID: 23960082.
      View in: PubMed
    22. Bray PF, McKenzie SE, Edelstein LC, Nagalla S, Delgrosso K, Ertel A, Kupper J, Jing Y, Londin E, Loher P, Chen HW, Fortina P, Rigoutsos I. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics. 2013; 14:1. PMID: 23323973.
      View in: PubMed
    23. Zhi H, Rauova L, Hayes V, Gao C, Boylan B, Newman DK, McKenzie SE, Cooley BC, Poncz M, Newman PJ. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood. 2013 Mar 7; 121(10):1858-67. PMID: 23264598.
      View in: PubMed
    24. McKenzie SE. Monocytes in HIT: an evolving story. Blood. 2012 May 31; 119(22):5065-6. PMID: 22653954.
      View in: PubMed
    25. Stolla M, Stefanini L, André P, Ouellette TD, Reilly MP, McKenzie SE, Bergmeier W. CalDAG-GEFI deficiency protects mice in a novel model of Fc? RIIA-mediated thrombosis and thrombocytopenia. Blood. 2011 Jul 28; 118(4):1113-20. PMID: 21652673.
      View in: PubMed
    26. Reilly MP, Sinha U, André P, Taylor SM, Pak Y, Deguzman FR, Nanda N, Pandey A, Stolla M, Bergmeier W, McKenzie SE. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model. Blood. 2011 Feb 17; 117(7):2241-6. PMID: 21088136.
      View in: PubMed
    27. Crow AR, Song S, Suppa SJ, Ma S, Reilly MP, Andre P, McKenzie SE, Lazarus AH. Amelioration of murine immune thrombocytopenia by CD44 antibodies: a potential therapy for ITP? Blood. 2011 Jan 20; 117(3):971-4. PMID: 21045192.
      View in: PubMed
    28. Flores M, Desai DD, Downie M, Liang B, Reilly MP, McKenzie SE, Clynes R. Dominant expression of the inhibitory FcgammaRIIB prevents antigen presentation by murine plasmacytoid dendritic cells. J Immunol. 2009 Dec 1; 183(11):7129-39. PMID: 19917701.
      View in: PubMed
    29. McKenzie SE, Reilly MP. The clot thickens (or not). Blood. 2009 Aug 27; 114(9):1722-3. PMID: 19713476.
      View in: PubMed
    30. Kline A, Mackley A, Taylor SM, McKenzie SE, Paul DA. Thrombopoietin following transfusion of platelets in preterm neonates. Platelets. 2008 Sep; 19(6):428-31. PMID: 18925510.
      View in: PubMed
    31. Cines DB, Rauova L, Arepally G, Reilly MP, McKenzie SE, Sachais BS, Poncz M. Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. J Clin Apher. 2007 Feb; 22(1):31-6. PMID: 17285619.
      View in: PubMed
    32. Liu ML, Reilly MP, Casasanto P, McKenzie SE, Williams KJ. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles. Arterioscler Thromb Vasc Biol. 2007 Feb; 27(2):430-5. PMID: 17158353.
      View in: PubMed
    33. Worth RG, Chien CD, Chien P, Reilly MP, McKenzie SE, Schreiber AD. Platelet FcgammaRIIA binds and internalizes IgG-containing complexes. Exp Hematol. 2006 Nov; 34(11):1490-5. PMID: 17046568.
      View in: PubMed
    34. Tan Sardjono C, Mottram PL, van de Velde NC, Powell MS, Power D, Slocombe RF, Wicks IP, Campbell IK, McKenzie SE, Brooks M, Stevenson AW, Hogarth PM. Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice. Arthritis Rheum. 2005 Oct; 52(10):3220-9. PMID: 16200626.
      View in: PubMed
    35. van Royen-Kerkhof A, Sanders EA, Walraven V, Voorhorst-Ogink M, Saeland E, Teeling JL, Gerritsen A, van Dijk MA, Kuis W, Rijkers GT, Vitale L, Keler T, McKenzie SE, Leusen JH, van de Winkel JG. A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcgammaRIIA transgenic mice. Br J Haematol. 2005 Jul; 130(1):130-7. PMID: 15982355.
      View in: PubMed
    36. Suvarna S, Rauova L, McCracken EK, Goss CM, Sachais BS, McKenzie SE, Reilly MP, Gunn MD, Cines DB, Poncz M, Arepally G. PF4/heparin complexes are T cell-dependent antigens. Blood. 2005 Aug 1; 106(3):929-31. PMID: 15845897.
      View in: PubMed
    37. McKenzie SE, Reilly MP. Heparin-induced thrombocytopenia and other immune thrombocytopenias: lessons from mouse models. Semin Thromb Hemost. 2004 Oct; 30(5):559-68. PMID: 15497098.
      View in: PubMed
    38. Rauova L, Poncz M, McKenzie SE, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2005 Jan 1; 105(1):131-8. PMID: 15304392.
      View in: PubMed
    39. Coleman MM, Spear ML, Finkelstein M, Leef KH, Pearlman SA, Chien C, Taylor SM, McKenzie SE. Short-term use of umbilical artery catheters may not be associated with increased risk for thrombosis. Pediatrics. 2004 Apr; 113(4):770-4. PMID: 15060226.
      View in: PubMed
    40. Cines DB, McKenzie SE, Siegel DL. Mechanisms of action of therapeutics in idiopathic thrombocytopenic purpura. J Pediatr Hematol Oncol. 2003 Dec; 25 Suppl 1:S52-6. PMID: 14668641.
      View in: PubMed
    41. Guida JD, Kunig AM, Leef KH, McKenzie SE, Paul DA. Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response? Pediatrics. 2003 Jun; 111(6 Pt 1):1411-5. PMID: 12777561.
      View in: PubMed
    42. Reilly MP, McKenzie SE. Insights from mouse models of heparin-induced thrombocytopenia and thrombosis. Curr Opin Hematol. 2002 Sep; 9(5):395-400. PMID: 12172457.
      View in: PubMed
    43. Reilly MP, McKenzie SE. Mechanisms of action of IVIg: physiology of Fc receptors. Vox Sang. 2002 Aug; 83 Suppl 1:57-63. PMID: 12617105.
      View in: PubMed
    44. Paul DA, Leef KH, Taylor S, McKenzie S. Thrombopoietin in preterm infants: gestational age-dependent response. J Pediatr Hematol Oncol. 2002 May; 24(4):304-9. PMID: 11972101.
      View in: PubMed
    45. Su HJ, Surrey S, McKenzie SE, Fortina P, Graves DJ. Kinetics of heterogeneous hybridization on indium tin oxide surfaces with and without an applied potential. Electrophoresis. 2002 May; 23(10):1551-7. PMID: 12116168.
      View in: PubMed
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