Keywords
Last Name
Institution

Randall Lyle Duncan

TitleChairperson
InstitutionUniversity of Delaware
DepartmentBiological Sciences
Address105 The Green
Newark DE 19716
Phone302-831-4296
Other Positions
TitleProfessor
InstitutionUniversity of Delaware
DepartmentBiological Sciences

TitleProfessor
InstitutionUniversity of Delaware
DepartmentMechanical Engineering


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL. Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophys J. 2016 Aug 23; 111(4):864-74.
    View in: PubMed
  2. DeLucca JF, Cortes DH, Jacobs NT, Vresilovic EJ, Duncan RL, Elliott DM. Human cartilage endplate permeability varies with degeneration and intervertebral disc site. J Biomech. 2016 Feb 29; 49(4):550-7.
    View in: PubMed
  3. Han WM, Heo SJ, Driscoll TP, Delucca JF, McLeod CM, Smith LJ, Duncan RL, Mauck RL, Elliott DM. Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage. Nat Mater. 2016 Apr; 15(4):477-84.
    View in: PubMed
  4. Heo SJ, Thorpe SD, Driscoll TP, Duncan RL, Lee DA, Mauck RL. Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep. 2015; 5:16895.
    View in: PubMed
  5. Hurd L, Kirwin SM, Boggs M, Mackenzie WG, Bober MB, Funanage VL, Duncan RL. A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. Am J Med Genet A. 2015 Oct; 167(10):2286-93.
    View in: PubMed
  6. Zhou Y, David MA, Chen X, Wan LQ, Duncan RL, Wang L, Lu XL. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Ann Biomed Eng. 2016 Apr; 44(4):1138-47.
    View in: PubMed
  7. Kim HS, Kim JE, Frailey D, Nohe A, Duncan R, Czymmek KJ, Kang S. Roles of three Fusarium oxysporum calcium ion (Ca(2+)) channels in generating Ca(2+) signatures and controlling growth. Fungal Genet Biol. 2015 Sep; 82:145-57.
    View in: PubMed
  8. Rohe BG, Carter R, Thompson WR, Duncan RL, Cooper CR. Experimental integrative muscular movement technique enhances cervical range of motion in patients with chronic neck pain: a pilot study. J Altern Complement Med. 2015 Apr; 21(4):223-8.
    View in: PubMed
  9. Balasubramaniam SL, Gopalakrishnapillai A, Gangadharan V, Duncan RL, Barwe SP. Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-dependent Extracellular Signal-regulated Kinase Signaling. J Biol Chem. 2015 May 15; 290(20):12463-73.
    View in: PubMed
  10. Akkiraju H, Bonor J, Olli K, Bowen C, Bragdon B, Coombs H, Donahue LR, Duncan R, Nohe A. Systemic Injection of CK2.3, a Novel Peptide Acting Downstream of Bone Morphogenetic Protein Receptor BMPRIa, Leads to Increased Trabecular Bone Mass. J Orthop Res. 2015 Feb; 33(2):208-15.
    View in: PubMed
  11. Gangadharan V, Nohe A, Caplan J, Czymmek K, Duncan RL. Caveolin-1 regulates P2X7 receptor signaling in osteoblasts. Am J Physiol Cell Physiol. 2015 Jan 1; 308(1):C41-50.
    View in: PubMed
  12. Gardinier JD, Gangadharan V, Wang L, Duncan RL. Hydraulic Pressure during Fluid Flow Regulates Purinergic Signaling and Cytoskeleton Organization of Osteoblasts. Cell Mol Bioeng. 2014 Jun 1; 7(2):266-277.
    View in: PubMed
  13. Gardinier J, Yang W, Madden GR, Kronbergs A, Gangadharan V, Adams E, Czymmek K, Duncan RL. P2Y2 receptors regulate osteoblast mechanosensitivity during fluid flow. Am J Physiol Cell Physiol. 2014 Jun 1; 306(11):C1058-67.
    View in: PubMed
  14. Tong Z, Zerdoum AB, Duncan RL, Jia X. Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors. Tissue Eng Part A. 2014 Jul; 20(13-14):1922-34.
    View in: PubMed
  15. Katiyar A, Duncan RL, Sarkar K. Ultrasound stimulation increases proliferation of MC3T3-E1 preosteoblast-like cells. J Ther Ultrasound. 2014; 2:1.
    View in: PubMed
  16. Gong X, Yang W, Wang L, Duncan RL, Pan J. Prostaglandin E2 modulates F-actin stress fiber in FSS-stimulated MC3T3-E1 cells in a PKA-dependent manner. Acta Biochim Biophys Sin (Shanghai). 2014 Jan; 46(1):40-7.
    View in: PubMed
  17. Greaney JL, Matthews EL, Boggs ME, Edwards DG, Duncan RL, Farquhar WB. Exaggerated exercise pressor reflex in adults with moderately elevated systolic blood pressure: role of purinergic receptors. Am J Physiol Heart Circ Physiol. 2014 Jan; 306(1):H132-41.
    View in: PubMed
  18. Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland. Laryngoscope. 2014 Feb; 124(2):456-61.
    View in: PubMed
  19. Pradhan-Bhatt S, Harrington DA, Duncan RL, Jia X, Witt RL, Farach-Carson MC. Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters. Tissue Eng Part A. 2013 Jul; 19(13-14):1610-20.
    View in: PubMed
  20. Moseychuk O, Akkiraju H, Dutta J, D'Angelo A, Bragdon B, Duncan RL, Nohe A. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes. J Cell Commun Signal. 2013 Dec; 7(4):265-78.
    View in: PubMed
  21. Tong Z, Duncan RL, Jia X. Modulating the behaviors of mesenchymal stem cells via the combination of high-frequency vibratory stimulations and fibrous scaffolds. Tissue Eng Part A. 2013 Aug; 19(15-16):1862-78.
    View in: PubMed
  22. Teller SS, Farran AJ, Xiao L, Jiao T, Duncan RL, Clifton RJ, Jia X. High-frequency viscoelastic shear properties of vocal fold tissues: implications for vocal fold tissue engineering. Tissue Eng Part A. 2012 Oct; 18(19-20):2008-19.
    View in: PubMed
  23. Aravindan RG, Fomin VP, Naik UP, Modelski MJ, Naik MU, Galileo DS, Duncan RL, Martin-Deleon PA. CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility. J Cell Physiol. 2012 Aug; 227(8):3138-50.
    View in: PubMed
  24. Kim HS, Czymmek KJ, Patel A, Modla S, Nohe A, Duncan R, Gilroy S, Kang S. Expression of the Cameleon calcium biosensor in fungi reveals distinct Ca(2+) signatures associated with polarized growth, development, and pathogenesis. Fungal Genet Biol. 2012 Aug; 49(8):589-601.
    View in: PubMed
  25. Boggs ME, Thompson WR, Farach-Carson MC, Duncan RL, Beebe TP. Co-culture of osteocytes and neurons on a unique patterned surface. Biointerphases. 2011 Dec; 6(4):200-9.
    View in: PubMed
  26. Jansson KH, Lynch JE, Lepori-Bui N, Czymmek KJ, Duncan RL, Sikes RA. Overexpression of the VSSC-associated CAM, ß-2, enhances LNCaP cell metastasis associated behavior. Prostate. 2012 Jul 1; 72(10):1080-92.
    View in: PubMed
  27. Farran AJ, Teller SS, Jia F, Clifton RJ, Duncan RL, Jia X. Design and characterization of a dynamic vibrational culture system. J Tissue Eng Regen Med. 2013 Mar; 7(3):213-25.
    View in: PubMed
  28. Thompson WR, Carter R, Rohe B, Duncan RL, Cooper CR. A novel massage therapy technique for management of chronic cervical pain: a case series. Int J Ther Massage Bodywork. 2011; 4(3):1-7.
    View in: PubMed
  29. Thompson WR, Majid AS, Czymmek KJ, Ruff AL, García J, Duncan RL, Farach-Carson MC. Association of the a(2)d(1) subunit with Ca(v)3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes. J Bone Miner Res. 2011 Sep; 26(9):2125-39.
    View in: PubMed
  30. Xu X, Jha AK, Duncan RL, Jia X. Heparin-decorated, hyaluronic acid-based hydrogel particles for the controlled release of bone morphogenetic protein 2. Acta Biomater. 2011 Aug; 7(8):3050-9.
    View in: PubMed
  31. Thompson WR, Modla S, Grindel BJ, Czymmek KJ, Kirn-Safran CB, Wang L, Duncan RL, Farach-Carson MC. Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res. 2011 Mar; 26(3):618-29.
    View in: PubMed
  32. Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL. Purinergic signaling is required for fluid shear stress-induced NF-?B translocation in osteoblasts. Exp Cell Res. 2011 Apr 1; 317(6):737-44.
    View in: PubMed
  33. Jha AK, Xu X, Duncan RL, Jia X. Controlling the adhesion and differentiation of mesenchymal stem cells using hyaluronic acid-based, doubly crosslinked networks. Biomaterials. 2011 Apr; 32(10):2466-78.
    View in: PubMed
  34. Jha AK, Malik MS, Farach-Carson MC, Duncan RL, Jia X. Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks. Soft Matter. 2010 Jun 15; 6(20):5045-5055.
    View in: PubMed
  35. Farran AJ, Teller SS, Jha AK, Jiao T, Hule RA, Clifton RJ, Pochan DP, Duncan RL, Jia X. Effects of matrix composition, microstructure, and viscoelasticity on the behaviors of vocal fold fibroblasts cultured in three-dimensional hydrogel networks. Tissue Eng Part A. 2010 Apr; 16(4):1247-61.
    View in: PubMed
  36. Gardinier JD, Townend CW, Jen KP, Wu Q, Duncan RL, Wang L. In situ permeability measurement of the mammalian lacunar-canalicular system. Bone. 2010 Apr; 46(4):1075-81.
    View in: PubMed
  37. Li J, Meyer R, Duncan RL, Turner CH. P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair. Calcif Tissue Int. 2009 May; 84(5):405-12.
    View in: PubMed
  38. Shao Y, Czymmek KJ, Jones PA, Fomin VP, Akanbi K, Duncan RL, Farach-Carson MC. Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells. Am J Physiol Cell Physiol. 2009 May; 296(5):C1067-78.
    View in: PubMed
  39. Gardinier JD, Majumdar S, Duncan RL, Wang L. Cyclic Hydraulic Pressure and Fluid Flow Differentially Modulate Cytoskeleton Re-Organization in MC3T3 Osteoblasts. Cell Mol Bioeng. 2009 Mar 1; 2(1):133-143.
    View in: PubMed
  40. Jha AK, Hule RA, Jiao T, Teller SS, Clifton RJ, Duncan RL, Pochan DJ, Jia X. Structural Analysis and Mechanical Characterization of Hyaluronic Acid-Based Doubly Cross-Linked Networks. Macromolecules. 2009; 42(2):537-546.
    View in: PubMed
  41. Fomin VP, Kronbergs A, Gunst S, Tang D, Simirskii V, Hoffman M, Duncan RL. Role of protein kinase Calpha in regulation of [Ca2+](I) and force in human myometrium. Reprod Sci. 2009 Jan; 16(1):71-9.
    View in: PubMed
  42. Zhang J, Ryder KD, Bethel JA, Ramirez R, Duncan RL. PTH-induced actin depolymerization increases mechanosensitive channel activity to enhance mechanically stimulated Ca2+ signaling in osteoblasts. J Bone Miner Res. 2006 Nov; 21(11):1729-37.
    View in: PubMed
  43. Fiske JL, Fomin VP, Brown ML, Duncan RL, Sikes RA. Voltage-sensitive ion channels and cancer. Cancer Metastasis Rev. 2006 Sep; 25(3):493-500.
    View in: PubMed
  44. Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML, Turner CH. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006 Aug 18; 281(33):23698-711.
    View in: PubMed
  45. Li J, Liu D, Ke HZ, Duncan RL, Turner CH. The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem. 2005 Dec 30; 280(52):42952-9.
    View in: PubMed
  46. Bergh JJ, Shao Y, Puente E, Duncan RL, Farach-Carson MC. Osteoblast Ca(2+) permeability and voltage-sensitive Ca(2+) channel expression is temporally regulated by 1,25-dihydroxyvitamin D(3). Am J Physiol Cell Physiol. 2006 Mar; 290(3):C822-31.
    View in: PubMed
  47. Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res. 2005 Jan; 20(1):41-9.
    View in: PubMed
  48. Chen NX, Geist DJ, Genetos DC, Pavalko FM, Duncan RL. Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release. Bone. 2003 Sep; 33(3):399-410.
    View in: PubMed
  49. Li J, Duncan RL, Burr DB, Gattone VH, Turner CH. Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels. Endocrinology. 2003 Apr; 144(4):1226-33.
    View in: PubMed
  50. Pavalko FM, Norvell SM, Burr DB, Turner CH, Duncan RL, Bidwell JP. A model for mechanotransduction in bone cells: the load-bearing mechanosomes. J Cell Biochem. 2003 Jan 1; 88(1):104-12.
    View in: PubMed
  51. Tanaka SM, Li J, Duncan RL, Yokota H, Burr DB, Turner CH. Effects of broad frequency vibration on cultured osteoblasts. J Biomech. 2003 Jan; 36(1):73-80.
    View in: PubMed
  52. Li J, Duncan RL, Burr DB, Turner CH. L-type calcium channels mediate mechanically induced bone formation in vivo. J Bone Miner Res. 2002 Oct; 17(10):1795-800.
    View in: PubMed
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