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Last Name
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Randall Lyle Duncan

TitleChairperson
InstitutionUniversity of Delaware
DepartmentBiological Sciences
Address105 The Green
Newark DE 19716
Phone302-831-4296
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Delaware
    DepartmentBiological Sciences

    TitleProfessor
    InstitutionUniversity of Delaware
    DepartmentMechanical Engineering


    Collapse Research 
    Collapse research activities and funding
    R01AR043222     (DUNCAN, RANDALL L)Aug 1, 1996 - Jul 31, 2007
    NIH/NIAMS
    Issues of Mechanosensitivity in Osteoblasts
    Role: Principal Investigator

    R01DK058246     (DUNCAN, RANDALL L)Aug 15, 2000 - Mar 31, 2011
    NIH/NIDDK
    PTH Reduces the Mechanical Threshold in Osteoblasts
    Role: Principal Investigator

    R01AR051901     (DUNCAN, RANDALL L)Sep 5, 2005 - Aug 31, 2011
    NIH/NIAMS
    Mechanotransduction: Puringergic Signaling in Bone
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL. Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophys J. 2016 Aug 23; 111(4):864-74. PMID: 27558729.
      View in: PubMed
    2. DeLucca JF, Cortes DH, Jacobs NT, Vresilovic EJ, Duncan RL, Elliott DM. Human cartilage endplate permeability varies with degeneration and intervertebral disc site. J Biomech. 2016 Feb 29; 49(4):550-7. PMID: 26874969.
      View in: PubMed
    3. Han WM, Heo SJ, Driscoll TP, Delucca JF, McLeod CM, Smith LJ, Duncan RL, Mauck RL, Elliott DM. Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage. Nat Mater. 2016 Apr; 15(4):477-84. PMID: 26726994.
      View in: PubMed
    4. Heo SJ, Thorpe SD, Driscoll TP, Duncan RL, Lee DA, Mauck RL. Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep. 2015; 5:16895. PMID: 26592929.
      View in: PubMed
    5. Hurd L, Kirwin SM, Boggs M, Mackenzie WG, Bober MB, Funanage VL, Duncan RL. A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. Am J Med Genet A. 2015 Oct; 167(10):2286-93. PMID: 26249260.
      View in: PubMed
    6. Zhou Y, David MA, Chen X, Wan LQ, Duncan RL, Wang L, Lu XL. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Ann Biomed Eng. 2016 Apr; 44(4):1138-47. PMID: 26219403.
      View in: PubMed
    7. Kim HS, Kim JE, Frailey D, Nohe A, Duncan R, Czymmek KJ, Kang S. Roles of three Fusarium oxysporum calcium ion (Ca(2+)) channels in generating Ca(2+) signatures and controlling growth. Fungal Genet Biol. 2015 Sep; 82:145-57. PMID: 26162966.
      View in: PubMed
    8. Srinivasan PP, Parajuli A, Price C, Wang L, Duncan RL, Kirn-Safran CB. Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes. PLoS One. 2015; 10(5):e0127290. PMID: 26011709.
      View in: PubMed
    9. Rohe BG, Carter R, Thompson WR, Duncan RL, Cooper CR. Experimental integrative muscular movement technique enhances cervical range of motion in patients with chronic neck pain: a pilot study. J Altern Complement Med. 2015 Apr; 21(4):223-8. PMID: 25839390.
      View in: PubMed
    10. Balasubramaniam SL, Gopalakrishnapillai A, Gangadharan V, Duncan RL, Barwe SP. Sodium-Calcium Exchanger 1 Regulates Epithelial Cell Migration via Calcium-dependent Extracellular Signal-regulated Kinase Signaling. J Biol Chem. 2015 May 15; 290(20):12463-73. PMID: 25770213.
      View in: PubMed
    11. Akkiraju H, Bonor J, Olli K, Bowen C, Bragdon B, Coombs H, Donahue LR, Duncan R, Nohe A. Systemic Injection of CK2.3, a Novel Peptide Acting Downstream of Bone Morphogenetic Protein Receptor BMPRIa, Leads to Increased Trabecular Bone Mass. J Orthop Res. 2015 Feb; 33(2):208-15. PMID: 25331517.
      View in: PubMed
    12. Gangadharan V, Nohe A, Caplan J, Czymmek K, Duncan RL. Caveolin-1 regulates P2X7 receptor signaling in osteoblasts. Am J Physiol Cell Physiol. 2015 Jan 1; 308(1):C41-50. PMID: 25318104.
      View in: PubMed
    13. Gardinier JD, Gangadharan V, Wang L, Duncan RL. Hydraulic Pressure during Fluid Flow Regulates Purinergic Signaling and Cytoskeleton Organization of Osteoblasts. Cell Mol Bioeng. 2014 Jun 1; 7(2):266-277. PMID: 24910719.
      View in: PubMed
    14. Gardinier J, Yang W, Madden GR, Kronbergs A, Gangadharan V, Adams E, Czymmek K, Duncan RL. P2Y2 receptors regulate osteoblast mechanosensitivity during fluid flow. Am J Physiol Cell Physiol. 2014 Jun 1; 306(11):C1058-67. PMID: 24696143.
      View in: PubMed
    15. Tong Z, Zerdoum AB, Duncan RL, Jia X. Dynamic vibration cooperates with connective tissue growth factor to modulate stem cell behaviors. Tissue Eng Part A. 2014 Jul; 20(13-14):1922-34. PMID: 24456068.
      View in: PubMed
    16. Katiyar A, Duncan RL, Sarkar K. Ultrasound stimulation increases proliferation of MC3T3-E1 preosteoblast-like cells. J Ther Ultrasound. 2014; 2:1. PMID: 25516803.
      View in: PubMed
    17. Gong X, Yang W, Wang L, Duncan RL, Pan J. Prostaglandin E2 modulates F-actin stress fiber in FSS-stimulated MC3T3-E1 cells in a PKA-dependent manner. Acta Biochim Biophys Sin (Shanghai). 2014 Jan; 46(1):40-7. PMID: 24296051.
      View in: PubMed
    18. Greaney JL, Matthews EL, Boggs ME, Edwards DG, Duncan RL, Farquhar WB. Exaggerated exercise pressor reflex in adults with moderately elevated systolic blood pressure: role of purinergic receptors. Am J Physiol Heart Circ Physiol. 2014 Jan; 306(1):H132-41. PMID: 24163081.
      View in: PubMed
    19. Pradhan-Bhatt S, Harrington DA, Duncan RL, Farach-Carson MC, Jia X, Witt RL. A novel in vivo model for evaluating functional restoration of a tissue-engineered salivary gland. Laryngoscope. 2014 Feb; 124(2):456-61. PMID: 23832678.
      View in: PubMed
    20. Pradhan-Bhatt S, Harrington DA, Duncan RL, Jia X, Witt RL, Farach-Carson MC. Implantable three-dimensional salivary spheroid assemblies demonstrate fluid and protein secretory responses to neurotransmitters. Tissue Eng Part A. 2013 Jul; 19(13-14):1610-20. PMID: 23442148.
      View in: PubMed
    21. Moseychuk O, Akkiraju H, Dutta J, D'Angelo A, Bragdon B, Duncan RL, Nohe A. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes. J Cell Commun Signal. 2013 Dec; 7(4):265-78. PMID: 23637019.
      View in: PubMed
    22. Tong Z, Duncan RL, Jia X. Modulating the behaviors of mesenchymal stem cells via the combination of high-frequency vibratory stimulations and fibrous scaffolds. Tissue Eng Part A. 2013 Aug; 19(15-16):1862-78. PMID: 23516973.
      View in: PubMed
    23. Teller SS, Farran AJ, Xiao L, Jiao T, Duncan RL, Clifton RJ, Jia X. High-frequency viscoelastic shear properties of vocal fold tissues: implications for vocal fold tissue engineering. Tissue Eng Part A. 2012 Oct; 18(19-20):2008-19. PMID: 22741523.
      View in: PubMed
    24. Aravindan RG, Fomin VP, Naik UP, Modelski MJ, Naik MU, Galileo DS, Duncan RL, Martin-Deleon PA. CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility. J Cell Physiol. 2012 Aug; 227(8):3138-50. PMID: 22020416.
      View in: PubMed
    25. Kim HS, Czymmek KJ, Patel A, Modla S, Nohe A, Duncan R, Gilroy S, Kang S. Expression of the Cameleon calcium biosensor in fungi reveals distinct Ca(2+) signatures associated with polarized growth, development, and pathogenesis. Fungal Genet Biol. 2012 Aug; 49(8):589-601. PMID: 22683653.
      View in: PubMed
    26. Boggs ME, Thompson WR, Farach-Carson MC, Duncan RL, Beebe TP. Co-culture of osteocytes and neurons on a unique patterned surface. Biointerphases. 2011 Dec; 6(4):200-9. PMID: 22239813.
      View in: PubMed
    27. Jansson KH, Lynch JE, Lepori-Bui N, Czymmek KJ, Duncan RL, Sikes RA. Overexpression of the VSSC-associated CAM, ß-2, enhances LNCaP cell metastasis associated behavior. Prostate. 2012 Jul 1; 72(10):1080-92. PMID: 22127840.
      View in: PubMed
    28. Farran AJ, Teller SS, Jia F, Clifton RJ, Duncan RL, Jia X. Design and characterization of a dynamic vibrational culture system. J Tissue Eng Regen Med. 2013 Mar; 7(3):213-25. PMID: 22095782.
      View in: PubMed
    29. Thompson WR, Carter R, Rohe B, Duncan RL, Cooper CR. A novel massage therapy technique for management of chronic cervical pain: a case series. Int J Ther Massage Bodywork. 2011; 4(3):1-7. PMID: 22016757.
      View in: PubMed
    30. Thompson WR, Majid AS, Czymmek KJ, Ruff AL, García J, Duncan RL, Farach-Carson MC. Association of the a(2)d(1) subunit with Ca(v)3.2 enhances membrane expression and regulates mechanically induced ATP release in MLO-Y4 osteocytes. J Bone Miner Res. 2011 Sep; 26(9):2125-39. PMID: 21638318.
      View in: PubMed
    31. Xu X, Jha AK, Duncan RL, Jia X. Heparin-decorated, hyaluronic acid-based hydrogel particles for the controlled release of bone morphogenetic protein 2. Acta Biomater. 2011 Aug; 7(8):3050-9. PMID: 21550426.
      View in: PubMed
    32. Thompson WR, Modla S, Grindel BJ, Czymmek KJ, Kirn-Safran CB, Wang L, Duncan RL, Farach-Carson MC. Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res. 2011 Mar; 26(3):618-29. PMID: 20814969.
      View in: PubMed
    33. Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL. Purinergic signaling is required for fluid shear stress-induced NF-?B translocation in osteoblasts. Exp Cell Res. 2011 Apr 1; 317(6):737-44. PMID: 21237152.
      View in: PubMed
    34. Jha AK, Xu X, Duncan RL, Jia X. Controlling the adhesion and differentiation of mesenchymal stem cells using hyaluronic acid-based, doubly crosslinked networks. Biomaterials. 2011 Apr; 32(10):2466-78. PMID: 21216457.
      View in: PubMed
    35. Jha AK, Malik MS, Farach-Carson MC, Duncan RL, Jia X. Hierarchically structured, hyaluronic acid-based hydrogel matrices via the covalent integration of microgels into macroscopic networks. Soft Matter. 2010 Jun 15; 6(20):5045-5055. PMID: 20936090.
      View in: PubMed
    36. Farran AJ, Teller SS, Jha AK, Jiao T, Hule RA, Clifton RJ, Pochan DP, Duncan RL, Jia X. Effects of matrix composition, microstructure, and viscoelasticity on the behaviors of vocal fold fibroblasts cultured in three-dimensional hydrogel networks. Tissue Eng Part A. 2010 Apr; 16(4):1247-61. PMID: 20064012.
      View in: PubMed
    37. Gardinier JD, Townend CW, Jen KP, Wu Q, Duncan RL, Wang L. In situ permeability measurement of the mammalian lacunar-canalicular system. Bone. 2010 Apr; 46(4):1075-81. PMID: 20080221.
      View in: PubMed
    38. Li J, Meyer R, Duncan RL, Turner CH. P2X7 nucleotide receptor plays an important role in callus remodeling during fracture repair. Calcif Tissue Int. 2009 May; 84(5):405-12. PMID: 19308630.
      View in: PubMed
    39. Shao Y, Czymmek KJ, Jones PA, Fomin VP, Akanbi K, Duncan RL, Farach-Carson MC. Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells. Am J Physiol Cell Physiol. 2009 May; 296(5):C1067-78. PMID: 19261907.
      View in: PubMed
    40. Gardinier JD, Majumdar S, Duncan RL, Wang L. Cyclic Hydraulic Pressure and Fluid Flow Differentially Modulate Cytoskeleton Re-Organization in MC3T3 Osteoblasts. Cell Mol Bioeng. 2009 Mar 1; 2(1):133-143. PMID: 20161062.
      View in: PubMed
    41. Jha AK, Hule RA, Jiao T, Teller SS, Clifton RJ, Duncan RL, Pochan DJ, Jia X. Structural Analysis and Mechanical Characterization of Hyaluronic Acid-Based Doubly Cross-Linked Networks. Macromolecules. 2009; 42(2):537-546. PMID: 20046226.
      View in: PubMed
    42. Fomin VP, Kronbergs A, Gunst S, Tang D, Simirskii V, Hoffman M, Duncan RL. Role of protein kinase Calpha in regulation of [Ca2+](I) and force in human myometrium. Reprod Sci. 2009 Jan; 16(1):71-9. PMID: 19087983.
      View in: PubMed
    43. Liu D, Genetos DC, Shao Y, Geist DJ, Li J, Ke HZ, Turner CH, Duncan RL. Activation of extracellular-signal regulated kinase (ERK1/2) by fluid shear is Ca(2+)- and ATP-dependent in MC3T3-E1 osteoblasts. Bone. 2008 Apr; 42(4):644-52. PMID: 18291742.
      View in: PubMed
    44. Zhang J, Ryder KD, Bethel JA, Ramirez R, Duncan RL. PTH-induced actin depolymerization increases mechanosensitive channel activity to enhance mechanically stimulated Ca2+ signaling in osteoblasts. J Bone Miner Res. 2006 Nov; 21(11):1729-37. PMID: 17002579.
      View in: PubMed
    45. Fiske JL, Fomin VP, Brown ML, Duncan RL, Sikes RA. Voltage-sensitive ion channels and cancer. Cancer Metastasis Rev. 2006 Sep; 25(3):493-500. PMID: 17111226.
      View in: PubMed
    46. Sawakami K, Robling AG, Ai M, Pitner ND, Liu D, Warden SJ, Li J, Maye P, Rowe DW, Duncan RL, Warman ML, Turner CH. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment. J Biol Chem. 2006 Aug 18; 281(33):23698-711. PMID: 16790443.
      View in: PubMed
    47. Li J, Liu D, Ke HZ, Duncan RL, Turner CH. The P2X7 nucleotide receptor mediates skeletal mechanotransduction. J Biol Chem. 2005 Dec 30; 280(52):42952-9. PMID: 16269410.
      View in: PubMed
    48. Bergh JJ, Shao Y, Puente E, Duncan RL, Farach-Carson MC. Osteoblast Ca(2+) permeability and voltage-sensitive Ca(2+) channel expression is temporally regulated by 1,25-dihydroxyvitamin D(3). Am J Physiol Cell Physiol. 2006 Mar; 290(3):C822-31. PMID: 16221734.
      View in: PubMed
    49. Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res. 2005 Jan; 20(1):41-9. PMID: 15619668.
      View in: PubMed
    50. Chen NX, Geist DJ, Genetos DC, Pavalko FM, Duncan RL. Fluid shear-induced NFkappaB translocation in osteoblasts is mediated by intracellular calcium release. Bone. 2003 Sep; 33(3):399-410. PMID: 13678782.
      View in: PubMed
    51. Li J, Duncan RL, Burr DB, Gattone VH, Turner CH. Parathyroid hormone enhances mechanically induced bone formation, possibly involving L-type voltage-sensitive calcium channels. Endocrinology. 2003 Apr; 144(4):1226-33. PMID: 12639904.
      View in: PubMed
    52. Pavalko FM, Norvell SM, Burr DB, Turner CH, Duncan RL, Bidwell JP. A model for mechanotransduction in bone cells: the load-bearing mechanosomes. J Cell Biochem. 2003 Jan 1; 88(1):104-12. PMID: 12461779.
      View in: PubMed
    53. Tanaka SM, Li J, Duncan RL, Yokota H, Burr DB, Turner CH. Effects of broad frequency vibration on cultured osteoblasts. J Biomech. 2003 Jan; 36(1):73-80. PMID: 12485640.
      View in: PubMed
    54. Li J, Duncan RL, Burr DB, Turner CH. L-type calcium channels mediate mechanically induced bone formation in vivo. J Bone Miner Res. 2002 Oct; 17(10):1795-800. PMID: 12369783.
      View in: PubMed
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