Keywords
Last Name
Institution

Sergio Jimenez

TitleProfessor
InstitutionThomas Jefferson University
DepartmentDermatology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-5042
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01AM015091     (JIMENEZ, SERGIO A)Apr 1, 1977 - Nov 30, 1987
    NIH/NIADDK
    ARTICULAR CARTILAGE PRESERVATION AND TRANSPLANTATION
    Role: Principal Investigator
    R01AR015091     (JIMENEZ, SERGIO A)Apr 1, 1977 - Nov 30, 1987
    NIH/NIAMS
    ARTICULAR CARTILAGE PRESERVATION AND TRANSPLANTATION
    Role: Principal Investigator
    R01AM019616     (JIMENEZ, SERGIO A)Jul 1, 1978 - Jun 30, 1990
    NIH/NIADDK
    BIOCHEMICAL AND VASCULAR ALTERATIONS IN SCLERODERMA
    Role: Principal Investigator
    R01AR019616     (JIMENEZ, SERGIO A)Jul 1, 1978 - Mar 31, 2012
    NIH/NIAMS
    Biochemical and Vascular Alterations in Scleroderma
    Role: Principal Investigator
    R01HL031650     (JIMENEZ, SERGIO A)Sep 30, 1983 - Sep 29, 1986
    NIH/NHLBI
    CONNECTIVE TISSUE REGULATION IN PULMONARY FIBROSIS
    Role: Principal Investigator
    R01AM032564     (JIMENEZ, SERGIO A)Dec 1, 1984 - Nov 30, 1987
    NIH/NIADDK
    COLLAGEN METABOLISM IN A MODEL FOR SCLERODERMA
    Role: Principal Investigator
    R01AR032564     (JIMENEZ, SERGIO A)Dec 1, 1984 - Jun 30, 2005
    NIH/NIAMS
    COLLAGEN METABOLISM IN A MODEL FOR SCLERODERMA
    Role: Principal Investigator
    R01HL041214     (JIMENEZ, SERGIO A)Jul 1, 1988 - Apr 30, 1994
    NIH/NHLBI
    LUNG FIBROSIS--MECHANISMS OF COLLAGEN GENE EXPRESSION
    Role: Principal Investigator
    P01AR039740     (JIMENEZ, SERGIO A)Dec 1, 1988 - Mar 31, 2008
    NIH/NIAMS
    Molecular Biology of Osteoarthritis
    Role: Principal Investigator
    T32AR007583     (JIMENEZ, SERGIO A)Jul 1, 1994 - Dec 29, 2009
    NIH/NIAMS
    TRAINING IN MOLECULAR RHEUMATOLOGY AND ORTHOPEDICS
    Role: Principal Investigator
    R01AR055660     (JIMENEZ, SERGIO A)Jul 1, 2008 - May 31, 2014
    NIH/NIAMS
    Role of Caveolin in Scleroderma Tissue Fibrosis and Vasculopathy
    Role: Principal Investigator
    R21AR059970     (JIMENEZ, SERGIO A)Aug 9, 2010 - Dec 31, 2012
    NIH/NIAMS
    Identification of Novel Markers for Systemic Sclerosis Employing Proteomics
    Role: Principal Investigator
    R21AR061680     (JIMENEZ, SERGIO A)Sep 24, 2012 - Aug 31, 2014
    NIH/NIAMS
    Role of toll like receptors (TLRs)in Gd contrast agent induced skin fibrosis
    Role: Principal Investigator
    R21AR065638     (JIMENEZ, SERGIO A)Apr 1, 2014 - Mar 31, 2016
    NIH/NIAMS
    Role of TRPV channels in the pathogenesis of Systemic Sclerosis vasculopathy
    Role: Principal Investigator
    R21AR071644     (JIMENEZ, SERGIO A)Apr 10, 2017 - Feb 28, 2019
    NIH/NIAMS
    Serum Exosome MicroRNA in Systemic Sclerosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Wermuth PJ, Piera-Velazquez S, Rosenbloom J, Jimenez SA. Existing and novel biomarkers for precision medicine in systemic sclerosis. Nat Rev Rheumatol. 2018 Jul; 14(7):421-432. PMID: 29789665.
      View in: PubMed
    2. Wermuth PJ, Jimenez SA. Abrogation of transforming growth factor-ß-induced tissue fibrosis in TBRIcaCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib). PLoS One. 2018; 13(5):e0196559. PMID: 29718973.
      View in: PubMed
    3. Wermuth PJ, Piera-Velazquez S, Jimenez SA. Identification of novel systemic sclerosis biomarkers employing aptamer proteomic analysis. Rheumatology (Oxford). 2017 Nov 13. PMID: 29140474.
      View in: PubMed
    4. Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N. PTP4A1 promotes TGFß signaling and fibrosis in systemic sclerosis. Nat Commun. 2017 Oct 20; 8(1):1060. PMID: 29057934.
      View in: PubMed
    5. Wermuth PJ, Carney KR, Mendoza FA, Piera-Velazquez S, Jimenez SA. Endothelial cell-specific activation of transforming growth factor-ß signaling in mice induces cutaneous, visceral, and microvascular fibrosis. Lab Invest. 2017 Jul; 97(7):806-818. PMID: 28346399.
      View in: PubMed
    6. Cox LA, Webster GF, Piera-Velazquez S, Jimenez SA. Multiplex assessment of serum cytokine and chemokine levels in idiopathic morphea and vitamin K1-induced morphea. Clin Rheumatol. 2017 May; 36(5):1173-1178. PMID: 28220270.
      View in: PubMed
    7. Wermuth PJ, Piera-Velazquez S, Jimenez SA. Exosomes isolated from serum of systemic sclerosis patients display alterations in their content of profibrotic and antifibrotic microRNA and induce a profibrotic phenotype in cultured normal dermal fibroblasts. Clin Exp Rheumatol. 2017 Jan 13. PMID: 28094758.
      View in: PubMed
    8. Rosenbloom J, Macarak E, Piera-Velazquez S, Jimenez SA. Human Fibrotic Diseases: Current Challenges in Fibrosis Research. Methods Mol Biol. 2017; 1627:1-23. PMID: 28836191.
      View in: PubMed
    9. Wermuth PJ, Li Z, Mendoza FA, Jimenez SA. Stimulation of Transforming Growth Factor-ß1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1. PLoS One. 2016; 11(9):e0161988. PMID: 27583804.
      View in: PubMed
    10. Kumar S, Singh J, Kedika R, Mendoza F, Jimenez SA, Blomain ES, DiMarino AJ, Cohen S, Rattan S. Role of muscarinic-3 receptor antibody in systemic sclerosis: correlation with disease duration and effects of IVIG. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1; 310(11):G1052-60. PMID: 27173508.
      View in: PubMed
    11. Piera-Velazquez S, Mendoza FA, Jimenez SA. Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases. J Clin Med. 2016; 5(4). PMID: 27077889.
      View in: PubMed
    12. Jimenez SA, Piera-Velazquez S. Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of Systemic Sclerosis-associated pulmonary fibrosis and pulmonary arterial hypertension. Myth or reality? Matrix Biol. 2016 Apr; 51:26-36. PMID: 26807760.
      View in: PubMed
    13. Mendoza FA, Mansoor M, Jimenez SA. Treatment of Rapidly Progressive Systemic Sclerosis: Current and Futures Perspectives. Expert Opin Orphan Drugs. 2016; 4(1):31-47. PMID: 27812432.
      View in: PubMed
    14. Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):E1106-15. PMID: 25713380.
      View in: PubMed
    15. Wermuth PJ, Jimenez SA. The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. Clin Transl Med. 2015; 4:2. PMID: 25852818.
      View in: PubMed
    16. Piera-Velazquez S, Jimenez SA. Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis. Curr Rheumatol Rep. 2015 Jan; 17(1):473. PMID: 25475596.
      View in: PubMed
    17. Elhai M, Avouac J, Walker UA, Matucci-Cerinic M, Riemekasten G, Airò P, Hachulla E, Valentini G, Carreira PE, Cozzi F, Balbir Gurman A, Braun-Moscovici Y, Damjanov N, Ananieva LP, Scorza R, Jimenez S, Busquets J, Li M, Müller-Ladner U, Kahan A, Distler O, Allanore Y. A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study. Ann Rheum Dis. 2016 Jan; 75(1):163-9. PMID: 25342760.
      View in: PubMed
    18. Dumit VI, Küttner V, Käppler J, Piera-Velazquez S, Jimenez SA, Bruckner-Tuderman L, Uitto J, Dengjel J. Altered MCM Protein Levels and Autophagic Flux in Aged and Systemic Sclerosis Dermal Fibroblasts. J Invest Dermatol. 2014 Sep; 134(9):2321-30. PMID: 24496236.
      View in: PubMed
    19. van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Ellen Csuka M, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE. 2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative. Ann Rheum Dis. 2013 Nov 1; 72(11):1747-55. PMID: 24092682.
      View in: PubMed
    20. Manne J, Markova M, Siracusa LD, Jimenez SA. Collagen content in skin and internal organs of the tight skin mouse: an animal model of scleroderma. Biochem Res Int. 2013; 2013:436053. PMID: 24260716.
      View in: PubMed
    21. van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, Matucci-Cerinic M, Naden RP, Medsger TA, Carreira PE, Riemekasten G, Clements PJ, Denton CP, Distler O, Allanore Y, Furst DE, Gabrielli A, Mayes MD, van Laar JM, Seibold JR, Czirjak L, Steen VD, Inanc M, Kowal-Bielecka O, Müller-Ladner U, Valentini G, Veale DJ, Vonk MC, Walker UA, Chung L, Collier DH, Csuka ME, Fessler BJ, Guiducci S, Herrick A, Hsu VM, Jimenez S, Kahaleh B, Merkel PA, Sierakowski S, Silver RM, Simms RW, Varga J, Pope JE. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum. 2013 Nov; 65(11):2737-47. PMID: 24122180.
      View in: PubMed
    22. Jimenez SA. Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis. ISRN Rheumatol. 2013; 2013:835948. PMID: 24175099.
      View in: PubMed
    23. Jimenez SA, Piera-Velazquez S. Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of Systemic Sclerosis and Sjögren's Syndrome. Autoimmun Rev. 2013 Sep; 12(11):1046-51. PMID: 23684698.
      View in: PubMed
    24. Busquets J, Lee Y, Santamarina L, Federman JL, Abel A, Del Galdo F, Eagle RC, Jimenez SA. Acute retinal artery occlusion in systemic sclerosis: a rare manifestation of systemic sclerosis fibroproliferative vasculopathy. Semin Arthritis Rheum. 2013 Oct; 43(2):204-8. PMID: 23433487.
      View in: PubMed
    25. Rosenbloom J, Mendoza FA, Jimenez SA. Strategies for anti-fibrotic therapies. Biochim Biophys Acta. 2013 Jul; 1832(7):1088-103. PMID: 23266403.
      View in: PubMed
    26. Mendoza FA, Purohit S, Kenyon L, Jimenez SA. Severe eosinophilic syndrome associated with the use of probiotic supplements: a new entity? Case Report Rheumatol. 2012; 2012:934324. PMID: 23259129.
      View in: PubMed
    27. Li Z, Wermuth PJ, Benn BS, Lisanti MP, Jimenez SA. Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro. Am J Pathol. 2013 Feb; 182(2):325-31. PMID: 23195429.
      View in: PubMed
    28. Singh J, Cohen S, Mehendiratta V, Mendoza F, Jimenez SA, Dimarino AJ, Rattan S. Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function. Gastroenterology. 2012 Nov; 143(5):1308-18. PMID: 22864255.
      View in: PubMed
    29. Lee CG, Herzog EL, Ahangari F, Zhou Y, Gulati M, Lee CM, Peng X, Feghali-Bostwick C, Jimenez SA, Varga J, Elias JA. Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-ß1 signaling. J Immunol. 2012 Sep 1; 189(5):2635-44. PMID: 22826322.
      View in: PubMed
    30. Mendoza FA, Keyes-Elstein LL, Jimenez SA. Systemic sclerosis disease modification clinical trials design: quo vadis? Arthritis Care Res (Hoboken). 2012 Jul; 64(7):945-54. PMID: 22422541.
      View in: PubMed
    31. Piera-Velazquez S, Jimenez SA. Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S7. PMID: 23259736.
      View in: PubMed
    32. Wermuth PJ, Jimenez SA. Gadolinium compounds signaling through TLR4 and TLR7 in normal human macrophages: establishment of a proinflammatory phenotype and implications for the pathogenesis of nephrogenic systemic fibrosis. J Immunol. 2012 Jul 1; 189(1):318-27. PMID: 22649203.
      View in: PubMed
    33. Mendoza FA, Nagle SJ, Lee JB, Jimenez SA. A prospective observational study of mycophenolate mofetil treatment in progressive diffuse cutaneous systemic sclerosis of recent onset. J Rheumatol. 2012 Jun; 39(6):1241-7. PMID: 22467932.
      View in: PubMed
    34. Fransen J, Johnson SR, van den Hoogen F, Baron M, Allanore Y, Carreira PE, Czirják L, Denton CP, Distler O, Furst DE, Gabrielli A, Herrick A, Inanc M, Kahaleh B, Kowal-Bielecka O, Medsger TA, Mueller-Ladner U, Riemekasten G, Sierakowski S, Valentini G, Veale D, Vonk MC, Walker U, Chung L, Clements PJ, Collier DH, Csuka ME, Jimenez S, Merkel PA, Seibold JR, Silver R, Steen V, Tyndall A, Matucci-Cerinic M, Pope JE, Khanna D. Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise. Arthritis Care Res (Hoboken). 2012 Mar; 64(3):351-7. PMID: 22052558.
      View in: PubMed
    35. Derk CT, Huaman G, Littlejohn J, Otieno F, Jimenez S. Predictors of early mortality in systemic sclerosis: a case-control study comparing early versus late mortality in systemic sclerosis. Rheumatol Int. 2012 Dec; 32(12):3841-4. PMID: 22193226.
      View in: PubMed
    36. Tsou PS, Talia NN, Pinney AJ, Kendzicky A, Piera-Velazquez S, Jimenez SA, Seibold JR, Phillips K, Koch AE. Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts. Arthritis Rheum. 2012 Jun; 64(6):1978-89. PMID: 22161819.
      View in: PubMed
    37. Wermuth PJ, Addya S, Jimenez SA. Effect of protein kinase C delta (PKC-d) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro. PLoS One. 2011; 6(11):e27110. PMID: 22096525.
      View in: PubMed
    38. Lee YH, Sahu J, O'Brien MS, D'Agati VD, Jimenez SA. Scleroderma renal crisis-like acute renal failure associated with mucopolysaccharide accumulation in renal vessels in a patient with scleromyxedema. J Clin Rheumatol. 2011 Sep; 17(6):318-22. PMID: 21869708.
      View in: PubMed
    39. Li Z, Jimenez SA. Protein kinase Cd and c-Abl kinase are required for transforming growth factor ß induction of endothelial-mesenchymal transition in vitro. Arthritis Rheum. 2011 Aug; 63(8):2473-83. PMID: 21425122.
      View in: PubMed
    40. Piera-Velazquez S, Li Z, Jimenez SA. Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders. Am J Pathol. 2011 Sep; 179(3):1074-80. PMID: 21763673.
      View in: PubMed
    41. Velasco G, Savarese V, Sandorfi N, Jimenez SA, Jabbour S. 46, XX SRY-positive male syndrome presenting with primary hypogonadism in the setting of scleroderma. Endocr Pract. 2011 Jan-Feb; 17(1):95-8. PMID: 20841307.
      View in: PubMed
    42. Del Galdo F, Wermuth PJ, Addya S, Fortina P, Jimenez SA. NF?B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. Ann Rheum Dis. 2010 Nov; 69(11):2024-33. PMID: 20959327.
      View in: PubMed
    43. Del Galdo F, Shaw MA, Jimenez SA. Proteomic analysis identification of a pattern of shared alterations in the secretome of dermal fibroblasts from systemic sclerosis and nephrogenic systemic fibrosis. Am J Pathol. 2010 Oct; 177(4):1638-46. PMID: 20724591.
      View in: PubMed
    44. Piera-Velazquez S, Louneva N, Fertala J, Wermuth PJ, Del Galdo F, Jimenez SA. Persistent activation of dermal fibroblasts from patients with gadolinium-associated nephrogenic systemic fibrosis. Ann Rheum Dis. 2010 Nov; 69(11):2017-23. PMID: 20570839.
      View in: PubMed
    45. Busquets J, Del Galdo F, Kissin EY, Jimenez SA. Assessment of tissue fibrosis in skin biopsies from patients with systemic sclerosis employing confocal laser scanning microscopy: an objective outcome measure for clinical trials? Rheumatology (Oxford). 2010 Jun; 49(6):1069-75. PMID: 20202926.
      View in: PubMed
    46. Rosenbloom J, Castro SV, Jimenez SA. Narrative review: fibrotic diseases: cellular and molecular mechanisms and novel therapies. Ann Intern Med. 2010 Feb 2; 152(3):159-66. PMID: 20124232.
      View in: PubMed
    47. Castro SV, Jimenez SA. Biomarkers in systemic sclerosis. Biomark Med. 2010 Feb; 4(1):133-47. PMID: 20387310.
      View in: PubMed
    48. Newton BB, Jimenez SA. Mechanism of NSF: New evidence challenging the prevailing theory. J Magn Reson Imaging. 2009 Dec; 30(6):1277-83. PMID: 19937925.
      View in: PubMed
    49. Singh J, Mehendiratta V, Del Galdo F, Jimenez SA, Cohen S, DiMarino AJ, Rattan S. Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1206-13. PMID: 19779020.
      View in: PubMed
    50. Schulz SW, O'Brien M, Maqsood M, Sandorfi N, Del Galdo F, Jimenez SA. Improvement of severe systemic sclerosis-associated gastric antral vascular ectasia following immunosuppressive treatment with intravenous cyclophosphamide. J Rheumatol. 2009 Aug; 36(8):1653-6. PMID: 19605670.
      View in: PubMed
    51. Herrero-Beaumont G, Roman-Blas JA, Castañeda S, Jimenez SA. Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics. Semin Arthritis Rheum. 2009 Oct; 39(2):71-80. PMID: 19589561.
      View in: PubMed
    52. Rabquer BJ, Hou Y, Del Galdo F, Kenneth Haines G, Gerber ML, Jimenez SA, Seibold JR, Koch AE. The proadhesive phenotype of systemic sclerosis skin promotes myeloid cell adhesion via ICAM-1 and VCAM-1. Rheumatology (Oxford). 2009 Jul; 48(7):734-40. PMID: 19439502.
      View in: PubMed
    53. Sotgia F, Del Galdo F, Casimiro MC, Bonuccelli G, Mercier I, Whitaker-Menezes D, Daumer KM, Zhou J, Wang C, Katiyar S, Xu H, Bosco E, Quong AA, Aronow B, Witkiewicz AK, Minetti C, Frank PG, Jimenez SA, Knudsen ES, Pestell RG, Lisanti MP. Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol. 2009 Mar; 174(3):746-61. PMID: 19234134.
      View in: PubMed
    54. Schulz SW, Bober M, Johnson C, Braverman N, Jimenez SA. Maternal mixed connective tissue disease and offspring with chondrodysplasia punctata. Semin Arthritis Rheum. 2010 Apr; 39(5):410-6. PMID: 19110299.
      View in: PubMed
    55. Del Galdo F, Lisanti MP, Jimenez SA. Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis. Curr Opin Rheumatol. 2008 Nov; 20(6):713-9. PMID: 18949888.
      View in: PubMed
    56. Roman-Blas JA, Jimenez SA. Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis. Int Rev Immunol. 2008; 27(5):351-74. PMID: 18853343.
      View in: PubMed
    57. Kypriotou M, Beauchef G, Chadjichristos C, Widom R, Renard E, Jimenez SA, Korn J, Maquart FX, Oddos T, Von Stetten O, Pujol JP, Galéra P. Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors. J Biol Chem. 2007 Nov 2; 282(44):32000-14. PMID: 17698844.
      View in: PubMed
    58. Shah RM, Jimenez S, Wechsler R. Significance of ground-glass opacity on HRCT in long-term follow-up of patients with systemic sclerosis. J Thorac Imaging. 2007 May; 22(2):120-4. PMID: 17527113.
      View in: PubMed
    59. Piera-Velazquez S, Hawkins DF, Whitecavage MK, Colter DC, Stokes DG, Jimenez SA. Regulation of the human SOX9 promoter by Sp1 and CREB. Exp Cell Res. 2007 Apr 1; 313(6):1069-79. PMID: 17289023.
      View in: PubMed
    60. Del Galdo F, Artlett CM, Jimenez SA. The role of allograft inflammatory factor 1 in systemic sclerosis. Curr Opin Rheumatol. 2006 Nov; 18(6):588-93. PMID: 17053503.
      View in: PubMed
    61. Derk CT, Rasheed M, Artlett CM, Jimenez SA. A cohort study of cancer incidence in systemic sclerosis. J Rheumatol. 2006 Jun; 33(6):1113-6. PMID: 16622904.
      View in: PubMed
    62. Derk CT, Jimenez SA. Acute myocardial infarction in systemic sclerosis patients: a case series. Clin Rheumatol. 2007 Jun; 26(6):965-8. PMID: 16521051.
      View in: PubMed
    63. Mendoza FA, Artlett CM, Sandorfi N, Latinis K, Piera-Velazquez S, Jimenez SA. Description of 12 cases of nephrogenic fibrosing dermopathy and review of the literature. Semin Arthritis Rheum. 2006 Feb; 35(4):238-49. PMID: 16461069.
      View in: PubMed
    64. Derk CT, Artlett CM, Jimenez SA. Morbidity and mortality of patients diagnosed with systemic sclerosis after the age of 75: a nested case-control study. Clin Rheumatol. 2006 Nov; 25(6):831-4. PMID: 16435160.
      View in: PubMed
    65. Steplewski A, Brittingham R, Jimenez SA, Fertala A. Single amino acid substitutions in the C-terminus of collagen II alter its affinity for collagen IX. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):749-55. PMID: 16087158.
      View in: PubMed
    66. Derk CT, Jimenez SA. Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? Autoimmun Rev. 2006 Jan; 5(1):25-32. PMID: 16338208.
      View in: PubMed
    67. Gentiletti J, McCloskey LJ, Artlett CM, Peters J, Jimenez SA, Christner PJ. Demonstration of autoimmunity in the tight skin-2 mouse: a model for scleroderma. J Immunol. 2005 Aug 15; 175(4):2418-26. PMID: 16081813.
      View in: PubMed
    68. Colter DC, Piera-Velazquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG. Regulation of the human Sox9 promoter by the CCAAT-binding factor. Matrix Biol. 2005 May; 24(3):185-97. PMID: 15908194.
      View in: PubMed
    69. Taylor RA, Levine JM, Jimenez SA. Case 35-2004: nephrogenic fibrosing dermopathy. N Engl J Med. 2005 Apr 21; 352(16):1723-4; author reply 1723-4. PMID: 15843679.
      View in: PubMed
    70. Derk CT, Rasheed M, Spiegel JR, Jimenez SA. Increased incidence of carcinoma of the tongue in patients with systemic sclerosis. J Rheumatol. 2005 Apr; 32(4):637-41. PMID: 15801018.
      View in: PubMed
    71. Sandorfi N, Jimenez SA. Scleroderma fibroblast survival in Aktion. J Invest Dermatol. 2005 Feb; 124(2):viii-xi. PMID: 15675944.
      View in: PubMed
    72. Jimenez SA, Artlett CM. Microchimerism and systemic sclerosis. Curr Opin Rheumatol. 2005 Jan; 17(1):86-90. PMID: 15604910.
      View in: PubMed
    73. Markova MS, Zeskand J, McEntee B, Rothstein J, Jimenez SA, Siracusa LD. A role for the androgen receptor in collagen content of the skin. J Invest Dermatol. 2004 Dec; 123(6):1052-6. PMID: 15610513.
      View in: PubMed
    74. Steplewski A, Ito H, Rucker E, Brittingham RJ, Alabyeva T, Gandhi M, Ko FK, Birk DE, Jimenez SA, Fertala A. Position of single amino acid substitutions in the collagen triple helix determines their effect on structure of collagen fibrils. J Struct Biol. 2004 Dec; 148(3):326-37. PMID: 15522781.
      View in: PubMed
    75. Christner PJ, Jimenez SA. Animal models of systemic sclerosis: insights into systemic sclerosis pathogenesis and potential therapeutic approaches. Curr Opin Rheumatol. 2004 Nov; 16(6):746-52. PMID: 15577614.
      View in: PubMed
    76. Levine JM, Taylor RA, Elman LB, Bird SJ, Lavi E, Stolzenberg ED, McGarvey ML, Asbury AK, Jimenez SA. Involvement of skeletal muscle in dialysis-associated systemic fibrosis (nephrogenic fibrosing dermopathy). Muscle Nerve. 2004 Nov; 30(5):569-77. PMID: 15389718.
      View in: PubMed
    77. Heyt GJ, Oh MK, Alemzadeh N, Rivera S, Jimenez SA, Rattan S, Cohen S, Dimarino AJ. Impaired rectoanal inhibitory response in scleroderma (systemic sclerosis): an association with fecal incontinence. Dig Dis Sci. 2004 Jun; 49(6):1040-5. PMID: 15309898.
      View in: PubMed
    78. Steplewski A, Majsterek I, McAdams E, Rucker E, Brittingham RJ, Ito H, Hirai K, Adachi E, Jimenez SA, Fertala A. Thermostability gradient in the collagen triple helix reveals its multi-domain structure. J Mol Biol. 2004 May 14; 338(5):989-98. PMID: 15111062.
      View in: PubMed
    79. Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velazquez S, Stokes DG. Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cartilage. 2004 Apr; 12(4):336-45. PMID: 15023385.
      View in: PubMed
    80. Cicchillitti L, Jimenez SA, Sala A, Saitta B. B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts. Biochem J. 2004 Mar 1; 378(Pt 2):609-16. PMID: 14613485.
      View in: PubMed
    81. Jimenez SA, Derk CT. Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis. Ann Intern Med. 2004 Jan 6; 140(1):37-50. PMID: 14706971.
      View in: PubMed
    82. Derk CT, Conway RT, Jimenez SA. Primary B-cell lymphoma of the tongue in a patient with systemic sclerosis. Oral Oncol. 2004 Jan; 40(1):103-6. PMID: 14662423.
      View in: PubMed
    83. Williams CJ, Jimenez SA. Skeletal dysplasias and the osteoarthritic phenotype. Best Pract Res Clin Rheumatol. 2003 Dec; 17(6):1005-18. PMID: 15123048.
      View in: PubMed
    84. Derk CT, Sakkas LI, Rasheed M, Artlett C, Jimenez SA. Autoantibodies in patients with systemic sclerosis and cancer: a case-control study. J Rheumatol. 2003 Sep; 30(9):1994-6. PMID: 12966604.
      View in: PubMed
    85. Louneva N, Saitta B, Herrick DJ, Jimenez SA. Transcriptional inhibition of type I collagen gene expression in scleroderma fibroblasts by the antineoplastic drug ecteinascidin 743. J Biol Chem. 2003 Oct 10; 278(41):40400-7. PMID: 12881530.
      View in: PubMed
    86. Derk CT, Jimenez SA. Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature. J Rheumatol. 2003 Jul; 30(7):1616-20. PMID: 12858467.
      View in: PubMed
    87. Atamas SP, Luzina IG, Choi J, Tsymbalyuk N, Carbonetti NH, Singh IS, Trojanowska M, Jimenez SA, White B. Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts. Am J Respir Cell Mol Biol. 2003 Dec; 29(6):743-9. PMID: 12805086.
      View in: PubMed
    88. Derk CT, Jimenez SA. Systemic sclerosis: current views of its pathogenesis. Autoimmun Rev. 2003 Jun; 2(4):181-91. PMID: 12848944.
      View in: PubMed
    89. Cox LA, Ramos RC, Dennis TN, Jimenez SA, Smith JB, Artlett CM. Detection of microchimeric cells in the peripheral blood of nonpregnant women is enhanced by magnetic cell sorting before PCR. Clin Chem. 2003 Feb; 49(2):309-12. PMID: 12560357.
      View in: PubMed
    90. Jimenez SA, Christner PJ. Murine animal models of systemic sclerosis. Curr Opin Rheumatol. 2002 Nov; 14(6):671-80. PMID: 12410090.
      View in: PubMed
    91. Zhang P, Jimenez SA, Stokes DG. Regulation of human COL9A1 gene expression. Activation of the proximal promoter region by SOX9. J Biol Chem. 2003 Jan 3; 278(1):117-23. PMID: 12399468.
      View in: PubMed
    92. Artlett CM, Cox LA, Ramos RC, Dennis TN, Fortunato RA, Hummers LK, Jimenez SA, Smith JB. Increased microchimeric CD4+ T lymphocytes in peripheral blood from women with systemic sclerosis. Clin Immunol. 2002 Jun; 103(3 Pt 1):303-8. PMID: 12173305.
      View in: PubMed
    93. Sakkas LI, Xu B, Artlett CM, Lu S, Jimenez SA, Platsoucas CD. Oligoclonal T cell expansion in the skin of patients with systemic sclerosis. J Immunol. 2002 Apr 1; 168(7):3649-59. PMID: 11907131.
      View in: PubMed
    94. Piera-Velazquez S, Jimenez SA, Stokes D. Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase. Arthritis Rheum. 2002 Mar; 46(3):683-93. PMID: 11920404.
      View in: PubMed
    95. Agha B, Rasheed M, Kenyon L, Jimenez SA. Hepatitis C virus infection, inflammatory myopathy, and pulmonary fibrosis: are they related? J Clin Rheumatol. 2002 Feb; 8(1):44-9. PMID: 17039200.
      View in: PubMed
    Jimenez's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (383) concept(s)
    _
    Co-Authors Expand Description
    See all (28) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _