Satish Rattan

TitleProfessor
InstitutionThomas Jefferson University
DepartmentGastroenterology
Address1025 Walnut St.
Philadelphia PA 19107
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    1. Singh A, Singh J, Rattan S. Evidence for the presence and release of BDNF in the neuronal and non-neuronal structures of the internal anal sphincter. Neurogastroenterol Motil. 2021 Feb 24; e14099. PMID: 33624396.
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    2. Javed E, Thangavel C, Frara N, Singh J, Mohanty I, Hypolite J, Birbe R, Braverman AS, Den RB, Rattan S, Zderic SA, Deshpande DA, Penn RB, Ruggieri MR, Chacko S, Boopathi E. Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2. FASEB J. 2019 Dec 16. PMID: 31909533.
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    3. Singh A, Mohanty I, Singh J, Rattan S. BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling, and non-adrenergic, non-cholinergic relaxation via increased NO release. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 04. PMID: 31682160.
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    4. Mohanty I, Singh J, Rattan S. Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. Sci Rep. 2019 May 01; 9(1):6759. PMID: 31043680.
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    5. Thangavel C, Gomes CM, Zderic SA, Javed E, Addya S, Singh J, Das S, Birbe R, Den RB, Rattan S, Deshpande DA, Penn RB, Chacko S, Boopathi E. NF-?B and GATA-6 Repress Transcription of Caveolins in Bladder Smooth Muscle Hypertrophy. Am J Pathol. 2019 Jan 29. PMID: 30707892.
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    6. Mohanty I, Parija SC, Suklabaidya S, Rattan S. Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. Eur J Pharmacol. 2018 Mar 07; 827:22-31. PMID: 29524386.
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    7. Singh J, Mohanty I, Rattan S. In vivo magnetofection: a novel approach for targeted topical delivery of nucleic acids for rectoanal motility disorders. Am J Physiol Gastrointest Liver Physiol. 2018 01 01; 314(1):G109-G118. PMID: 29051187.
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    8. Singh J, Mohanty I, Addya S, Phillips B, Mee Yong H, An SS, Penn RB, Rattan S. Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone. Sci Rep. 2017 May 03; 7(1):1477. PMID: 28469189.
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    9. Rattan S. Ca2+/calmodulin/MLCK pathway initiates, and RhoA/ROCK maintains the internal anal sphincter smooth muscle tone. Am J Physiol Gastrointest Liver Physiol. 2016 Dec 08; ajpgi.00370.2016. PMID: 27932502.
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    10. Singh J, Boopathi E, Addya S, Phillips B, Rigoutsos I, Penn RB, Rattan S. Aging-associated changes in microRNA expression profile of internal anal sphincter smooth muscle: Role of microRNA-133a. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 01; 311(5):G964-G973. PMID: 27634012.
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    11. Kumar S, Singh J, Kedika R, Mendoza F, Jimenez SA, Blomain ES, DiMarino AJ, Cohen S, Rattan S. Role of muscarinic-3 receptor antibody in systemic sclerosis: correlation with disease duration and effects of IVIG. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1; 310(11):G1052-60. PMID: 27173508.
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    12. Mandaliya R, Burkart AL, DiMarino AJ, Rattan S, Cohen S. Association between common variable immunodeficiency and collagenous infiltrative disorders of the gastrointestinal tract: A series of four patients. Indian J Gastroenterol. 2016 Mar; 35(2):133-8. PMID: 27053352.
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    13. Krishna CV, Singh J, Thangavel C, Rattan S. Role of microRNAs in gastrointestinal smooth muscle fibrosis and dysfunction: novel molecular perspectives on the pathophysiology and therapeutic targeting. Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1; 310(7):G449-59. PMID: 26822916.
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    14. Mandaliya R, DiMarino AJ, Moleski S, Rattan S, Cohen S. Survey of anal sphincter dysfunction using anal manometry in patients with fecal incontinence: a possible guide to therapy. Ann Gastroenterol. 2015 Oct-Dec; 28(4):469-74. PMID: 26423466.
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    15. Singh J, Kumar S, Rattan S. Bimodal effect of oxidative stress in internal anal sphincter smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1; 309(5):G292-300. PMID: 26138467.
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    16. Rattan S, Singh J, Kumar S, Phillips B. Nature of extracellular signal that triggers RhoA/ROCK activation for the basal internal anal sphincter tone in humans. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1; 308(11):G924-33. PMID: 25882611.
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    17. Rattan S, Ali M. Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 1; 308(7):G605-12. PMID: 25617350.
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    18. Krishna CV, Singh J, Kumar S, Rattan S. Heme oxygenase-1 upregulation modulates tone and fibroelastic properties of internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 15; 307(6):G595-601. PMID: 25035109.
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    19. Singh J, Kumar S, Krishna CV, Rattan S. Aging-associated oxidative stress leads to decrease in IAS tone via RhoA/ROCK downregulation. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1; 306(11):G983-91. PMID: 24742984.
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    20. Rattan S. Smooth Muscle-Specific Myosin Phosphatase Target Subunit 1 (MYPT1): An Important Piece of the Puzzle. Gastroenterology. 2013 Dec; 145(6):1494-5. PMID: 24172015.
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    21. Gibbons AV, Lin JE, Kim GW, Marszalowicz GP, Li P, Stoecker BA, Blomain ES, Rattan S, Snook AE, Schulz S, Waldman SA. Intestinal GUCY2C Prevents TGF-ß Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer. Cancer Res. 2013 Nov 15; 73(22):6654-66. PMID: 24085786.
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    22. Romer AI, Singh J, Rattan S, Krauss RS. Smooth muscle fascicular reorientation is required for esophageal morphogenesis and dependent on Cdo. J Cell Biol. 2013 Apr 15; 201(2):309-23. PMID: 23569214.
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    23. Singh J, Rattan S. Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2013 Apr; 304(8):G723-31. PMID: 23413252.
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    24. Singh J, Cohen S, Mehendiratta V, Mendoza F, Jimenez SA, Dimarino AJ, Rattan S. Effects of scleroderma antibodies and pooled human immunoglobulin on anal sphincter and colonic smooth muscle function. Gastroenterology. 2012 Nov; 143(5):1308-18. PMID: 22864255.
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    25. Singh J, Rattan S. Bioengineered human IAS reconstructs with functional and molecular properties similar to intact IAS. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 15; 303(6):G713-22. PMID: 22790596.
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    26. Rattan S, Singh J. RhoA/ROCK pathway is the major molecular determinant of basal tone in intact human internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2012 Apr; 302(7):G664-75. PMID: 22241857.
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    27. Fressatto de Godoy MA, Pernomian L, de Oliveira AM, Rattan S. Biosynthetic pathways and the role of the MAS receptor in the effects of Angiotensin-(1-7) in smooth muscles. Int J Hypertens. 2012; 2012:121740. PMID: 22164327.
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    28. Singh J, Maxwell PJ, Rattan S. Immunocytochemical evidence for PDBu-induced activation of RhoA/ROCK in human internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G317-25. PMID: 21566015.
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    29. de Godoy MA, Rattan S. Role of rho kinase in the functional and dysfunctional tonic smooth muscles. Trends Pharmacol Sci. 2011 Jul; 32(7):384-93. PMID: 21497405.
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    30. Rattan S. 3-Hydroxymethyl coenzyme A reductase inhibition attenuates spontaneous smooth muscle tone via RhoA/ROCK pathway regulated by RhoA prenylation. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G962-9. PMID: 20378830.
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    31. Rattan S, Phillips BR, Maxwell PJ. RhoA/Rho-kinase: pathophysiologic and therapeutic implications in gastrointestinal smooth muscle tone and relaxation. Gastroenterology. 2010 Jan; 138(1):13-8.e1-3. PMID: 19931260.
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    32. Singh J, Mehendiratta V, Del Galdo F, Jimenez SA, Cohen S, DiMarino AJ, Rattan S. Immunoglobulins from scleroderma patients inhibit the muscarinic receptor activation in internal anal sphincter smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1206-13. PMID: 19779020.
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    33. de Godoy MA, Rattan N, Rattan S. Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G727-34. PMID: 19221012.
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    34. Rattan S. Role of RHO kinase in gastrointestinal motility. Gastroenterology. 2009 Mar; 136(3):1109-12; discussion 1112. PMID: 19167398.
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    35. de Godoy MA, Rattan N, Rattan S. COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2009 Feb; 296(2):G219-25. PMID: 19056763.
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    36. Rattan S. Sympathetic (adrenergic) innervation modulates but does not generate basal tone in the internal anal sphincter smooth muscle. Gastroenterology. 2008 Jun; 134(7):2179-81; author reply 2181-2. PMID: 18485916.
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    37. Rattan S, Patel CA. Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G687-93. PMID: 18187514.
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    38. Zhang K, Aruva MR, Shanthly N, Cardi CA, Rattan S, Patel C, Kim C, McCue PA, Wickstrom E, Thakur ML. PET imaging of VPAC1 expression in experimental and spontaneous prostate cancer. J Nucl Med. 2008 Jan; 49(1):112-21. PMID: 18077536.
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    39. de Godoy MA, Rattan S. Role of phospholipase A2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2007 Nov; 293(5):G979-86. PMID: 17717042.
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    40. Zhang K, Aruva MR, Shanthly N, Cardi CA, Patel CA, Rattan S, Cesarone G, Wickstrom E, Thakur ML. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation. Regul Pept. 2007 Dec 4; 144(1-3):91-100. PMID: 17727979.
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    41. Patel CA, Rattan S. Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1747-56. PMID: 17379756.
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    42. Patel CA, Rattan S. RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J Pharmacol Exp Ther. 2007 May; 321(2):501-8. PMID: 17322025.
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    43. de Godoy MA, Patel CA, Waldman SA, Katsuki M, Regan RF, Rattan S. H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter. Gastroenterology. 2007 Apr; 132(4):1401-9. PMID: 17408635.
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    44. de Godoy MA, Rattan S. Translocation of AT1- and AT2-receptors by higher concentrations of angiotensin II in the smooth muscle cells of rat internal anal sphincter. J Pharmacol Exp Ther. 2006 Dec; 319(3):1088-95. PMID: 16985169.
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    45. Rattan S, De Godoy MA, Patel CA. Rho kinase as a novel molecular therapeutic target for hypertensive internal anal sphincter. Gastroenterology. 2006 Jul; 131(1):108-16. PMID: 16831595.
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    46. Patel CA, Rattan S. Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291(5):G830-7. PMID: 16763289.
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    47. De Godoy MA, Rattan S. Angiotensin-converting enzyme and angiotensin II receptor subtype 1 inhibitors restitute hypertensive internal anal sphincter in the spontaneously hypertensive rats. J Pharmacol Exp Ther. 2006 Aug; 318(2):725-34. PMID: 16648368.
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    48. Rattan S, Regan RF, Patel CA, De Godoy MA. Nitric oxide not carbon monoxide mediates nonadrenergic noncholinergic relaxation in the murine internal anal sphincter. Gastroenterology. 2005 Dec; 129(6):1954-66. PMID: 16344064.
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    49. De Godoy MA, Rattan S. Autocrine regulation of internal anal sphincter tone by renin-angiotensin system: comparison with phasic smooth muscle. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 289(6):G1164-75. PMID: 16020656.
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    50. Rattan S, Al Haj R, De Godoy MA. Mechanism of internal anal sphincter relaxation by CORM-1, authentic CO, and NANC nerve stimulation. Am J Physiol Gastrointest Liver Physiol. 2004 Sep; 287(3):G605-11. PMID: 15331353.
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    51. Thakur ML, Aruva MR, Gariepy J, Acton P, Rattan S, Prasad S, Wickstrom E, Alavi A. PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog. J Nucl Med. 2004 Aug; 45(8):1381-9. PMID: 15299065.
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    52. Said SI, Rattan S. The multiple mediators of neurogenic smooth muscle relaxation. Trends Endocrinol Metab. 2004 Jul; 15(5):189-91. PMID: 15223046.
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    53. De Godoy MA, Dunn S, Rattan S. Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone. Gastroenterology. 2004 Jul; 127(1):127-38. PMID: 15236179.
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    54. de Godoy MA, de Oliveira AM, Rattan S. Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway. J Pharmacol Exp Ther. 2004 Oct; 311(1):394-401. PMID: 15178697.
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    55. Heyt GJ, Oh MK, Alemzadeh N, Rivera S, Jimenez SA, Rattan S, Cohen S, Dimarino AJ. Impaired rectoanal inhibitory response in scleroderma (systemic sclerosis): an association with fecal incontinence. Dig Dis Sci. 2004 Jun; 49(6):1040-5. PMID: 15309898.
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    56. Li F, De Godoy M, Rattan S. Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. J Pharmacol Exp Ther. 2004 Mar; 308(3):1111-20. PMID: 14711933.
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    57. Rattan S, Puri RN, Fan YP. Involvement of rho and rho-associated kinase in sphincteric smooth muscle contraction by angiotensin II. Exp Biol Med (Maywood). 2003 Sep; 228(8):972-81. PMID: 12968070.
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    58. Banwait KS, Rattan S. Role of nitric oxide in beta3-adrenoceptor activation on basal tone of internal anal sphincter. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G547-55. PMID: 12736154.
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    59. Rathi S, Kazerounian S, Banwait K, Schulz S, Waldman SA, Rattan S. Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter. J Pharmacol Exp Ther. 2003 May; 305(2):615-24. PMID: 12606629.
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    60. Sarma DN, Banwait K, Basak A, DiMarino AJ, Rattan S. Inhibitory effect of beta3-adrenoceptor agonist in lower esophageal sphincter smooth muscle: in vitro studies. J Pharmacol Exp Ther. 2003 Jan; 304(1):48-55. PMID: 12490574.
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    61. Dimarino M, Banwait K, Rattan S, Cohen S, DiMarino AJ. Beta3 adrenergic stimulation inhibits the opossum lower esophageal sphincter. Gastroenterology. 2002 Nov; 123(5):1508-15. PMID: 12404226.
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    62. Puri RN, Fan YP, Rattan S. Role of pp60(c-src) and p(44/42) MAPK in ANG II-induced contraction of rat tonic gastrointestinal smooth muscles. Am J Physiol Gastrointest Liver Physiol. 2002 Aug; 283(2):G390-9. PMID: 12121887.
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    63. Rattan S, Fan YP, Puri RN. Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles. Life Sci. 2002 Mar 22; 70(18):2147-64. PMID: 12002807.
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    64. Fan YP, Puri RN, Rattan S. Animal model for angiotensin II effects in the internal anal sphincter smooth muscle: mechanism of action. Am J Physiol Gastrointest Liver Physiol. 2002 Mar; 282(3):G461-9. PMID: 11841996.
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