Theodore Christopher

TitleProfessor & Chair JMC
InstitutionThomas Jefferson University
DepartmentChair SKMC
Address1020 Sansom St.
Philadelphia PA 19107
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu D, Gu G, Gan L, Yan W, Zhang Z, Yao P, Zhu D, Lau WB, Xie D, Wu S, Meng Z, Tsukuda J, Christopher T, Lopez B, Zhao J, Gao E, Koch W, Ma XL, Wang Y. Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production. Redox Biol. 2021 May; 41:101929. PMID: 33714738.
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    2. Xie Y, Meng Z, Gao J, Liu C, Wang J, Guo R, Zhao J, Lopez B, Christopher T, Lee D, Ma X, Wang Y. C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19. Proteomes. 2021 Mar 01; 9(1). PMID: 33804408.
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    3. Jia G, Meng Z, Liu C, Ma X, Gao J, Liu J, Guo R, Yan Z, Christopher T, Lopez B, Liu W, Dai H, Lau WB, Jiao X, Zhao J, Wang ZX, Cao J, Wang Y. Nicotine induces cardiac toxicity through blocking mitophagic clearance in young adult rat. Life Sci. 2020 Sep 15; 257:118084. PMID: 32663572.
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    4. He Y, Liu B, Yao P, Shao Y, Cheng Y, Zhao J, Wu J, Zhao ZW, Huang W, Christopher TA, Lopez B, Ma X, Cao Y. Adiponectin inhibits cardiac arrest/cardiopulmonary resuscitation-induced apoptosis in brain by increasing autophagy involved in AdipoR1-AMPK signaling. Mol Med Rep. 2020 Aug; 22(2):870-878. PMID: 32468051.
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    5. Liu J, Meng Z, Gan L, Guo R, Gao J, Liu C, Zhu D, Liu D, Zhang L, Zhang Z, Xie D, Jiao X, Lau WB, Lopez BL, Christopher TA, Ma X, Cao J, Wang Y. C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling. Redox Biol. 2020 Feb 24; 101476. PMID: 32122792.
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    6. Gan L, Xie D, Liu J, Lau WB, Christopher TA, Lopez B, Zhang L, Gao E, Koch W, Ma XL, Wang Y. Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice. Circulation. 2020 Jan 10. PMID: 31918577.
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    7. Xie D, Zhao J, Guo R, Jiao L, Zhang Y, Lau WB, Lopez B, Christopher T, Gao E, Cao J, Ma X, Wang Y. Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. Sci Rep. 2020 Jan 08; 10(1):23. PMID: 31913350.
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    8. Du Y, Wang X, Li LY, Hao W, Zhang H, Li Y, Qin Y, Nie S, Christopher T, Lopez B, Wang Y, Lau WB, Wei YX, Ma XL. miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders. Circ Res. 2019 Nov 07. PMID: 31694459.
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    9. Guo R, Gan L, Lau WB, Yan Z, Xie D, Gao E, Christopher TA, Lopez BL, Ma X, Wang Y. Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling. Circ J. 2019 Jul 25; 83(8):1726-1736. PMID: 31217391.
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    10. Yan Z, Guo R, Gan L, Lau WB, Cao X, Zhao J, Ma X, Christopher TA, Lopez BL, Wang Y. Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress. Life Sci. 2018 Oct 15; 211:91-101. PMID: 30213729.
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    11. Du Y, Li R, Lau WB, Zhao J, Lopez B, Christopher TA, Ma XL, Wang Y. Adiponectin at Physiologically Relevant Concentrations Enhances the Vasorelaxative Effect of Acetylcholine via Cav-1/AdipoR-1 Signaling. PLoS One. 2016; 11(3):e0152247. PMID: 27023866.
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    12. Liu GZ, Liang B, Lau WB, Wang Y, Zhao J, Li R, Wang X, Yuan Y, Lopez BL, Christopher TA, Xiao C, Ma XL, Wang Y. High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation. Free Radic Biol Med. 2015 Dec; 89:473-85. PMID: 26453924.
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    13. Yuan Y, Lau WB, Su H, Sun Y, Yi W, Du Y, Christopher T, Lopez B, Wang Y, Ma XL. C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform. Am J Physiol Endocrinol Metab. 2015 May 15; 308(10):E891-8. PMID: 25783894.
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    14. Beeson MS, Carter WA, Christopher TA, Heidt JW, Jones JH, Meyer LE, Promes SB, Rodgers KG, Shayne PH, Swing SR, Wagner MJ. The development of the emergency medicine milestones. Acad Emerg Med. 2013 Jul; 20(7):724-9. PMID: 23782404.
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    15. Beeson MS, Carter WA, Christopher TA, Heidt JW, Jones JH, Meyer LE, Promes SB, Rodgers KG, Shayne PH, Wagner MJ, Swing SR. Emergency medicine milestones. J Grad Med Educ. 2013 Mar; 5(1 Suppl 1):5-13. PMID: 24404210.
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    16. Lau WB, Zhang Y, Zhao J, Liu B, Wang X, Yuan Y, Christopher TA, Lopez B, Gao E, Koch WJ, Ma XL, Wang Y. Lymphotoxin-a is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion. Am J Physiol Endocrinol Metab. 2013 Mar; 304(6):E661-7. PMID: 23360826.
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    17. Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, Wang X, Sun Y, Lopez BL, Christopher TA, Peterson JM, Wong GW, Yu S, Yi D, Ma XL. C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2616-23. PMID: 21836066.
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    18. Rogers RL, Wald DA, Lin M, Zun LS, Christopher T, Manthey DE. Expectations of an emergency medicine clerkship director. Acad Emerg Med. 2011 May; 18(5):513-8. PMID: 21521403.
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    19. Wald DA, Lin M, Manthey DE, Rogers RL, Zun LS, Christopher T. Emergency medicine in the medical school curriculum. Acad Emerg Med. 2010 Oct; 17 Suppl 2:S26-30. PMID: 21199080.
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    20. Schneider SM, Gardner AF, Weiss LD, Wood JP, Ybarra M, Beck DM, Stauffer AR, Wilkerson D, Brabson T, Jennings A, Mitchell M, McGrath RB, Christopher TA, King B, Muelleman RL, Wagner MJ, Char DM, McGee DL, Pilgrim RL, Moskovitz JB, Zinkel AR, Byers M, Briggs WT, Hobgood CD, Kupas DF, Kruger J, Stratford CJ, Jouriles N. The future of emergency medicine. Acad Emerg Med. 2010 Sep; 17(9):998-1003. PMID: 20836784.
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    21. Schneider SM, Gardner AF, Weiss LD, Wood JP, Ybarra M, Beck DM, Stauffer AR, Wilkerson D, Brabson T, Jennings A, Mitchell M, McGrath RB, Christopher TA, King B, Muelleman RL, Wagner MJ, Char DM, McGee DL, Pilgrim RL, Moskovitz JB, Zinkel AR, Byers M, Briggs WT, Hobgood CD, Kupas DF, Krueger J, Stratford CJ, Jouriles NJ. The future of emergency medicine. J Emerg Med. 2010 Aug; 39(2):210-5. PMID: 20634023.
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    22. Schneider SM, Gardner AF, Weiss LD, Wood JP, Ybarra M, Beck DM, Stauffer AR, Wilkerson D, Brabson T, Jennings A, Mitchell M, McGrath RB, Christopher TA, King B, Muelleman RL, Wagner MJ, Char DM, McGee DL, Pilgrim RL, Moskovitz JB, Zinkel AR, Byers M, Briggs WT, Hobgood CD, Kupas DF, Kruger J, Stratford CJ, Jouriles N. The future of emergency medicine. J Emerg Nurs. 2010 Jul; 36(4):330-5. PMID: 20624567.
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    23. Schneider SM, Gardner AF, Weiss LD, Wood JP, Ybarra M, Beck DM, Stauffer AR, Wilkerson D, Brabson T, Jennings A, Mitchell M, McGrath RB, Christopher TA, King B, Muelleman RL, Wagner MJ, Char DM, McGee DL, Pilgrim RL, Moskovitz JB, Zinkel AR, Byers M, Briggs WT, Hobgood CD, Kupas DF, Kruger J, Stratford CJ, Jouriles N. The future of emergency medicine. Ann Emerg Med. 2010 Aug; 56(2):178-83. PMID: 20580128.
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    24. Wang XL, Lau WB, Yuan YX, Wang YJ, Yi W, Christopher TA, Lopez BL, Liu HR, Ma XL. Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity. Am J Physiol Endocrinol Metab. 2010 Aug; 299(2):E207-14. PMID: 20460580.
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    25. Yuan Y, Jiao X, Lau WB, Wang Y, Christopher TA, Lopez BL, Ramachandrarao SP, Tao L, Ma XL. Thioredoxin glycation: A novel posttranslational modification that inhibits its antioxidant and organ protective actions. Free Radic Biol Med. 2010 Aug 1; 49(3):332-8. PMID: 20416371.
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    26. Li R, Xu M, Wang X, Wang Y, Lau WB, Yuan Y, Yi W, Wei X, Lopez BL, Christopher TA, Wang XM, Ma XL. Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance. J Mol Cell Cardiol. 2010 Sep; 49(3):508-15. PMID: 20303976.
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    27. Chen G, Lai W, Liu F, Mao Q, Tu F, Wen J, Xiao H, Zhang JC, Zhu T, Chen B, Hu ZY, Li RM, Liang Z, Nie H, Yan H, Yang BX, Du Q, Huang WX, Jiang YW, Kwan AS, Song L, Wu CM, Xiang T, Xu HW, Lau WB, Song HB, Wen CB, Yao ZH, Zhang L, Zeng J, Dai YE, Lopez BL, Zheng JQ, Zhou J, Christopher TA, Ma XL, Yu H, Xu LL, Guo Q, Song ZP, Volinn E, Kryger K, Cao Y, Ge H, Liu H, Luo CZ, Tao W, Zuo YX, Liu J. The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg. 2010 Mar 1; 110(3):908-15. PMID: 20185667.
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    28. Nie H, Tang SY, Lau WB, Zhang JC, Jiang YW, Lopez BL, Ma XL, Cao Y, Christopher TA. Triage during the week of the Sichuan earthquake: a review of utilized patient triage, care, and disposition procedures. Injury. 2011 May; 42(5):515-20. PMID: 20153857.
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    29. Hemphill RR, Sklar DP, Christopher T, Kellermann AL, Tarrant JR. Emergency medicine and political influence. Acad Emerg Med. 2009 Oct; 16(10):1019-24. PMID: 19754861.
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    30. Wang Y, Tao L, Yuan Y, Lau WB, Li R, Lopez BL, Christopher TA, Tian R, Ma XL. Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E384-91. PMID: 19470831.
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    31. Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17; 119(6):835-44. PMID: 19188503.
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    32. Liu HR, Tao L, Gao E, Qu Y, Lau WB, Lopez BL, Christopher TA, Koch W, Yue TL, Ma XL. Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists. Cardiovasc Res. 2009 Feb 1; 81(2):344-52. PMID: 19010810.
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    33. Cao Y, Tao L, Yuan Y, Jiao X, Lau WB, Wang Y, Christopher T, Lopez B, Chan L, Goldstein B, Ma XL. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol. 2009 Mar; 46(3):413-9. PMID: 19027750.
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    34. Zhang H, Li J, Li R, Zhang Q, Ma H, Ji Q, Guo W, Wang H, Lopez BL, Christopher TA, Ma X, Gao F. Reduced cardiotropic response to insulin in spontaneously hypertensive rats: role of peroxisome proliferator-activated receptor-gamma-initiated signaling. J Hypertens. 2008 Mar; 26(3):560-9. PMID: 18300869.
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    35. Li S, Tao L, Jiao X, Liu H, Cao Y, Lopez B, Luan RH, Christopher T, Ma XL. TNFalpha-initiated oxidative/nitrative stress mediates cardiomyocyte apoptosis in traumatic animals. Apoptosis. 2007 Oct; 12(10):1795-802. PMID: 17701456.
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    36. Li R, Wang WQ, Zhang H, Yang X, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein BJ, Gao F, Ma XL. Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1703-8. PMID: 17895290.
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    37. Li S, Jiao X, Tao L, Liu H, Cao Y, Lopez BL, Christopher TA, Ma XL. Tumor necrosis factor-alpha in mechanic trauma plasma mediates cardiomyocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1847-52. PMID: 17616742.
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    38. Wang XL, Liu HR, Tao L, Liang F, Yan L, Zhao RR, Lopez BL, Christopher TA, Ma XL. Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion. Apoptosis. 2007 Jul; 12(7):1209-17. PMID: 17333318.
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    39. Huang Z, Shi G, Gao F, Zhang Y, Liu X, Christopher TA, Lopez B, Ma X. Effects of N-n-butyl haloperidol iodide on L-type calcium channels and intracellular free calcium in rat ventricular myocytes. Biochem Cell Biol. 2007 Apr; 85(2):182-8. PMID: 17534398.
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    40. Zhang H, Tao L, Jiao X, Gao E, Lopez BL, Christopher TA, Koch W, Ma XL. Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart. Free Radic Biol Med. 2007 Jul 1; 43(1):39-47. PMID: 17561092.
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    41. Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation. 2007 Mar 20; 115(11):1408-16. PMID: 17339545.
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    42. Tao L, Jiao X, Gao E, Lau WB, Yuan Y, Lopez B, Christopher T, RamachandraRao SP, Williams W, Southan G, Sharma K, Koch W, Ma XL. Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis. Circulation. 2006 Sep 26; 114(13):1395-402. PMID: 16966583.
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    43. Wang HC, Zhang HF, Guo WY, Su H, Zhang KR, Li QX, Yan W, Ma XL, Lopez BL, Christopher TA, Gao F. Hypoxic postconditioning enhances the survival and inhibits apoptosis of cardiomyocytes following reoxygenation: role of peroxynitrite formation. Apoptosis. 2006 Aug; 11(8):1453-60. PMID: 16761110.
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    44. Manthey DE, Coates WC, Ander DS, Ankel FK, Blumstein H, Christopher TA, Courtney JM, Hamilton GC, Kaiyala EK, Rodgers K, Schneir AB, Thomas SH. Report of the Task Force on National Fourth Year Medical Student Emergency Medicine Curriculum Guide. Ann Emerg Med. 2006 Mar; 47(3):e1-7. PMID: 16492483.
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    45. Tao L, Liu HR, Gao F, Qu Y, Christopher TA, Lopez BL, Ma XL. Mechanical traumatic injury without circulatory shock causes cardiomyocyte apoptosis: role of reactive nitrogen and reactive oxygen species. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2811-8. PMID: 15695560.
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    46. Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation. 2005 Jan 4; 111(1):90-6. PMID: 15611365.
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    47. Tao L, Gao E, Bryan NS, Qu Y, Liu HR, Hu A, Christopher TA, Lopez BL, Yodoi J, Koch WJ, Feelisch M, Ma XL. Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A. 2004 Aug 3; 101(31):11471-6. PMID: 15277664.
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    48. Liang F, Gao E, Tao L, Liu H, Qu Y, Christopher TA, Lopez BL, Ma XL. Critical timing of L-arginine treatment in post-ischemic myocardial apoptosis-role of NOS isoforms. Cardiovasc Res. 2004 Jun 1; 62(3):568-77. PMID: 15158149.
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    49. Liu HR, Gao F, Tao L, Yan WL, Gao E, Christopher TA, Lopez BL, Hu A, Ma XL. Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart. Br J Pharmacol. 2004 Jun; 142(4):627-34. PMID: 15172961.
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    50. Liu HR, Tao L, Gao E, Lopez BL, Christopher TA, Willette RN, Ohlstein EH, Yue TL, Ma XL. Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. Cardiovasc Res. 2004 Apr 1; 62(1):135-44. PMID: 15023560.
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    51. Tao L, Liu HR, Gao E, Teng ZP, Lopez BL, Christopher TA, Ma XL, Batinic-Haberle I, Willette RN, Ohlstein EH, Yue TL. Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. Circulation. 2003 Dec 2; 108(22):2805-11. PMID: 14610009.
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    52. Lopez BL, Davis-Moon L, Sterious W, Bulette M, Liang-Ma X, Christopher TA. The Power Infuser: a new device for rapid fluid infusion. Am J Emerg Med. 2003 Mar; 21(2):129-32. PMID: 12671814.
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    53. Christopher TA, Lopez BL, Stillwagon JC, Gao F, Gao E, Ma XL, Ohlstein EH, Yue TL. Idoxifene causes endothelium-dependent, nitric oxide-mediated vasorelaxation in male rats. Eur J Pharmacol. 2002 Jun 20; 446(1-3):139-43. PMID: 12098595.
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    54. Gao F, Yao CL, Gao E, Mo QZ, Yan WL, McLaughlin R, Lopez BL, Christopher TA, Ma XL. Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury. J Pharmacol Exp Ther. 2002 May; 301(2):543-50. PMID: 11961055.
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    55. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002 Mar 26; 105(12):1497-502. PMID: 11914261.
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    56. Gao F, Yue TL, Shi DW, Christopher TA, Lopez BL, Ohlstein EH, Barone FC, Ma XL. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation. Cardiovasc Res. 2002 Feb 1; 53(2):414-22. PMID: 11827692.
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