Last Name

Theresa Freeman

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentOrthopedic Surgery
Address1015 Walnut St.
Philadelphia PA 19107

Industry Associated Positions:

1997 - 2004 Applications Scientist, Phase 3 Imaging Systems, Inc., Glen Mills, PA

Postgraduate Training and Fellowship Appointments:
1996 Post-Doctoral Fellow, New Jersey Department of Human Services
1997 - 1998 Director, Cell Morphology Core, Institute of Human Gene Therapy
1998 - 2004 Applications Scientist, Phase 3 Imaging Systems, Inc., Glen Mills, PA
2004 - 2005 Research Associate, Department of Orthopaedic Surgery at Thomas Jefferson University

Faculty Appointments:
1997 - 1998 Research Assistant Professor, Department of Molecular Genetics, Univ. of Penn
2006 - Present Tenure-track Assistant Professor, Department of Orthopaedic Surgery

Memberships in Professional and Scientific Societies:
1994 - Present American Association for the Advancement of Science
2005 - 2009 American Society for Bone and Mineral Research
2006 - Present Orthopaedic Research Society

Academic Committees at Thomas Jefferson University:
Thomas Jefferson University Research Strategic Planning Committee Member 2010 - 2011
Thomas Jefferson University Graduate School Faculty - Tissue Engineering and Regenerative Medicine and Cell and Developmental Biology

Major Teaching Responsibilities at Thomas Jefferson University and other Universities:
2006 - Present - Lecturer Tissue Engineering and Regenerative Medicine Courses
2006 - Present - Host Laboratory for School of Health Sciences Student Rotations
1996-97 - Functional Histology, Jefferson College of Health Professions
1995-96 - Histology Laboratory, UMDNJ
1994-96 - Comparative Anatomy, Lecture and Lab, Rutgers University
1986-1992 - Anatomy and Physiology, Chemistry, Biology Lab, Burl. County Comm. College

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Eisenhauer P, Chernets N, Song Y, Dobrynin D, Pleshko N, Steinbeck MJ, Freeman TA. Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation. J Tissue Eng Regen Med. 2016 Sep; 10(9):772-82.
    View in: PubMed
  2. Steinbeck MJ, Eisenhauer PT, Maltenfort MG, Parvizi J, Freeman TA. Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone. J Arthroplasty. 2016 Jan; 31(1):269-77.
    View in: PubMed
  3. O'Brien MP, Penmatsa M, Palukuru U, West P, Yang X, Bostrom MP, Freeman T, Pleshko N. Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy. Cartilage. 2015 Jul; 6(3):174-84.
    View in: PubMed
  4. Chernets N, Zhang J, Steinbeck MJ, Kurpad DS, Koyama E, Friedman G, Freeman TA. Nonthermal atmospheric pressure plasma enhances mouse limb bud survival, growth, and elongation. Tissue Eng Part A. 2015 Jan; 21(1-2):300-9.
    View in: PubMed
  5. Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. Nat Commun. 2014; 5:3891.
    View in: PubMed
  6. Steinbeck MJ, Chernets N, Zhang J, Kurpad DS, Fridman G, Fridman A, Freeman TA. Skeletal cell differentiation is enhanced by atmospheric dielectric barrier discharge plasma treatment. PLoS One. 2013; 8(12):e82143.
    View in: PubMed
  7. Steinbeck MJ, Jablonowski LJ, Parvizi J, Freeman TA. The role of oxidative stress in aseptic loosening of total hip arthroplasties. J Arthroplasty. 2014 Apr; 29(4):843-9.
    View in: PubMed
  8. Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T. GSK-3a is a central regulator of age-related pathologies in mice. J Clin Invest. 2013 Apr 1; 123(4):1821-32.
    View in: PubMed
  9. Liu Q, Limthongkul W, Sidhu G, Zhang J, Vaccaro A, Shenck R, Hickok N, Shapiro I, Freeman T. Covalent attachment of P15 peptide to titanium surfaces enhances cell attachment, spreading, and osteogenic gene expression. J Orthop Res. 2012 Oct; 30(10):1626-33.
    View in: PubMed
  10. Casper DS, Kim GK, Parvizi J, Freeman TA. Morphology of the proximal femur differs widely with age and sex: relevance to design and selection of femoral prostheses. J Orthop Res. 2012 Jul; 30(7):1162-6.
    View in: PubMed
  11. Baxter RM, Freeman TA, Kurtz SM, Steinbeck MJ. Do tissues from THA revision of highly crosslinked UHMWPE liners contain wear debris and associated inflammation? Clin Orthop Relat Res. 2011 Aug; 469(8):2308-17.
    View in: PubMed
  12. Baxter RM, Ianuzzi A, Freeman TA, Kurtz SM, Steinbeck MJ. Distinct immunohistomorphologic changes in periprosthetic hip tissues from historical and highly crosslinked UHMWPE implant retrievals. J Biomed Mater Res A. 2010 Oct; 95(1):68-78.
    View in: PubMed
  13. Freeman TA, Parvizi J, Dela Valle CJ, Steinbeck MJ. Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty. Fibrogenesis Tissue Repair. 2010; 3:17.
    View in: PubMed
  14. Skubutyte R, Markova D, Freeman TA, Anderson DG, Dion AS, Williams CJ, Shapiro IM, Risbud MV. Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc. Arthritis Rheum. 2010 Sep; 62(9):2707-15.
    View in: PubMed
  15. Oca P, Zaka R, Dion AS, Freeman TA, Williams CJ. Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesis. J Cell Physiol. 2010 Aug; 224(2):540-8.
    View in: PubMed
  16. Freeman TA, Parvizi J, Della Valle CJ, Steinbeck MJ. Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty. Fibrogenesis Tissue Repair. 2009; 2(1):5.
    View in: PubMed
  17. Zaka R, Dion AS, Kusnierz A, Bohensky J, Srinivas V, Freeman T, Williams CJ. Oxygen tension regulates the expression of ANK (progressive ankylosis) in an HIF-1-dependent manner in growth plate chondrocytes. J Bone Miner Res. 2009 Nov; 24(11):1869-78.
    View in: PubMed
  18. Freeman TA, Patel P, Parvizi J, Antoci V, Shapiro IM. Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healing. J Orthop Res. 2009 May; 27(5):673-9.
    View in: PubMed
  19. Bohensky J, Terkhorn SP, Freeman TA, Adams CS, Garcia JA, Shapiro IM, Srinivas V. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009 May; 60(5):1406-15.
    View in: PubMed
  20. Antoci V, Adams CS, Parvizi J, Davidson HM, Composto RJ, Freeman TA, Wickstrom E, Ducheyne P, Jungkind D, Shapiro IM, Hickok NJ. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials. 2008 Dec; 29(35):4684-90.
    View in: PubMed
  21. Watanabe H, Bohensky J, Freeman T, Srinivas V, Shapiro IM. Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy. J Cell Physiol. 2008 Aug; 216(2):419-25.
    View in: PubMed
  22. Kerr BA, Otani T, Koyama E, Freeman TA, Enomoto-Iwamoto M. Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes. Exp Cell Res. 2008 Apr 1; 314(6):1301-12.
    View in: PubMed
  23. Antoci V, King SB, Jose B, Parvizi J, Zeiger AR, Wickstrom E, Freeman TA, Composto RJ, Ducheyne P, Shapiro IM, Hickok NJ, Adams CS. Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J Orthop Res. 2007 Jul; 25(7):858-66.
    View in: PubMed
  24. Pucci B, Adams CS, Fertala J, Snyder BC, Mansfield KD, Tafani M, Freeman T, Shapiro IM. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. J Cell Physiol. 2007 Mar; 210(3):609-15.
    View in: PubMed
  25. Han F, Gilbert JR, Harrison G, Adams CS, Freeman T, Tao Z, Zaka R, Liang H, Williams C, Tuan RS, Norton PA, Hickok NJ. Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation. Exp Cell Res. 2007 May 1; 313(8):1518-32.
    View in: PubMed
  26. Jacob S, Wu C, Freeman TA, Koyama E, Kirschner RE. Expression of Indian Hedgehog, BMP-4 and Noggin in craniosynostosis induced by fetal constraint. Ann Plast Surg. 2007 Feb; 58(2):215-21.
    View in: PubMed
  27. Shapiro IM, Adams CS, Freeman T, Srinivas V. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res C Embryo Today. 2005 Dec; 75(4):330-9.
    View in: PubMed
  28. Pacifici M, Shimo T, Gentili C, Kirsch T, Freeman TA, Enomoto-Iwamoto M, Iwamoto M, Koyama E. Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis. J Bone Miner Metab. 2005; 23(3):191-9.
    View in: PubMed
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