Theresa Freeman

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentOrthopedic Surgery
Address1015 Walnut St.
Philadelphia PA 19107
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    Collapse Overview 
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    Industry Associated Positions:

    1997 - 2004 Applications Scientist, Phase 3 Imaging Systems, Inc., Glen Mills, PA

    Postgraduate Training and Fellowship Appointments:
    1996 Post-Doctoral Fellow, New Jersey Department of Human Services
    1997 - 1998 Director, Cell Morphology Core, Institute of Human Gene Therapy
    1998 - 2004 Applications Scientist, Phase 3 Imaging Systems, Inc., Glen Mills, PA
    2004 - 2005 Research Associate, Department of Orthopaedic Surgery at Thomas Jefferson University

    Faculty Appointments:
    1997 - 1998 Research Assistant Professor, Department of Molecular Genetics, Univ. of Penn
    2006 - Present Tenure-track Assistant Professor, Department of Orthopaedic Surgery

    Memberships in Professional and Scientific Societies:
    1994 - Present American Association for the Advancement of Science
    2005 - 2009 American Society for Bone and Mineral Research
    2006 - Present Orthopaedic Research Society

    Academic Committees at Thomas Jefferson University:
    Thomas Jefferson University Research Strategic Planning Committee Member 2010 - 2011
    Thomas Jefferson University Graduate School Faculty - Tissue Engineering and Regenerative Medicine and Cell and Developmental Biology

    Major Teaching Responsibilities at Thomas Jefferson University and other Universities:
    2006 - Present - Lecturer Tissue Engineering and Regenerative Medicine Courses
    2006 - Present - Host Laboratory for School of Health Sciences Student Rotations
    1996-97 - Functional Histology, Jefferson College of Health Professions
    1995-96 - Histology Laboratory, UMDNJ
    1994-96 - Comparative Anatomy, Lecture and Lab, Rutgers University
    1986-1992 - Anatomy and Physiology, Chemistry, Biology Lab, Burl. County Comm. College



    Collapse Research 
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    R03DE020840     (FREEMAN, THERESA)Sep 1, 2010 - Aug 31, 2013
    NIH
    ROS activation of Apoptosis Signal-regulated Kinase1 (Ask1) in chondrocytes
    Role: Principal Investigator

    R01EB013011     (FREEMAN, THERESA A)Apr 1, 2011 - Jan 31, 2016
    NIH
    Non-Thermal Plasma in Biomedicine: A New Paradigm for Redox Cell Activation
    Role: Principal Investigator

    R01AR076941     (FREEMAN, THERESA A)Feb 1, 2020 - Jan 31, 2025
    NIH
    Plasma-based therapies for bone infection: A tripartite USA/Northern Ireland/Republic of Ireland consortium
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Falcon JM, Chirman D, Veneziale A, Morman J, Bolten K, Kandel S, Querido W, Freeman T, Pleshko N. DMOG Negatively Impacts Tissue Engineered Cartilage Development. Cartilage. 2020 Oct 26; 1947603520967060. PMID: 33100027.
      Citations:    
    2. Feldman G, Kappes D, Mookerjee-Basu J, Freeman T, Fertala A, Parvizi J. Novel mutation in Teneurin 3 found to co-segregate in all affecteds in a multi-generation family with developmental dysplasia of the hip. J Orthop Res. 2018 Oct 01. PMID: 30273960.
      Citations:    
    3. Nguyen L, Lu P, Boehm D, Bourke P, Gilmore BF, Hickok NJ, Freeman TA. Cold atmospheric plasma is a viable solution for treating orthopedic infection: a review. Biol Chem. 2018 Sep 19. PMID: 30138104.
      Citations:    
    4. Cooper F, Overmiller AM, Loder A, Brennan-Crispi DM, McGuinn KP, Marous MR, Freeman TA, Riobo-Del Galdo NA, Siracusa LD, Wahl JK, Mahoney MG. Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion. J Invest Dermatol. 2018 May 09. PMID: 29753032.
      Citations:    
    5. Gilmore BF, Flynn PB, O'Brien S, Hickok N, Freeman T, Bourke P. Cold Plasmas for Biofilm Control: Opportunities and Challenges. Trends Biotechnol. 2018 Jun; 36(6):627-638. PMID: 29729997.
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    6. Munsell EV, Kurpad DS, Freeman TA, Sullivan MO. Histone-targeted gene transfer of bone morphogenetic protein-2 enhances mesenchymal stem cell chondrogenic differentiation. Acta Biomater. 2018 Mar 02. PMID: 29481871.
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    7. Feldman G, Offemaria A, Sawan H, Parvizi J, Freeman TA. A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait. J Transl Med. 2017 Nov 10; 15(1):233. PMID: 29126427.
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    8. Zhang QS, Kurpad DS, Mahoney MG, Steinbeck MJ, Freeman TA. Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration. PLoS One. 2017; 12(10):e0185803. PMID: 29045420.
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    9. Veruva SY, Lanman TH, Isaza JE, Freeman TA, Kurtz SM, Steinbeck MJ. Periprosthetic UHMWPE Wear Debris Induces Inflammation, Vascularization, and Innervation After Total Disc Replacement in the Lumbar Spine. Clin Orthop Relat Res. 2017 May; 475(5):1369-1381. PMID: 27488379.
      Citations:    
    10. Zhang J, Eisenhauer P, Kaya O, Vaccaro AR, Diallo C, Fertala A, Freeman TA. P15 peptide stimulates chondrogenic commitment and endochondral ossification. Int Orthop. 2017 Jul; 41(7):1413-1422. PMID: 28389839.
      Citations:    
    11. Acharya NK, Qi X, Goldwaser EL, Godsey GA, Wu H, Kosciuk MC, Freeman TA, Macphee CH, Wilensky RL, Venkataraman V, Nagele RG. Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA2 inhibitor Darapladib. Diab Vasc Dis Res. 2017 May; 14(3):200-213. PMID: 28301218.
      Citations:    
    12. Eisenhauer P, Chernets N, Song Y, Dobrynin D, Pleshko N, Steinbeck MJ, Freeman TA. Chemical modification of extracellular matrix by cold atmospheric plasma-generated reactive species affects chondrogenesis and bone formation. J Tissue Eng Regen Med. 2016 Sep; 10(9):772-82. PMID: 27510797.
      Citations:    
    13. Chernets N, Kurpad DS, Alexeev V, Rodrigues DB, Freeman TA. Reaction Chemistry Generated by Nanosecond Pulsed Dielectric Barrier Discharge Treatment is Responsible for the Tumor Eradication in the B16 Melanoma Mouse Model. Plasma Process Polym. 2015 Dec; 12(12):1400-1409. PMID: 29104522.
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    14. Zhang QS, Eaton GJ, Diallo C, Freeman TA. Stress-Induced Activation of Apoptosis Signal-Regulating Kinase 1 Promotes Osteoarthritis. J Cell Physiol. 2016 Apr; 231(4):944-53. PMID: 26405834.
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    15. Steinbeck MJ, Eisenhauer PT, Maltenfort MG, Parvizi J, Freeman TA. Identifying Patient-Specific Pathology in Osteoarthritis Development Based on MicroCT Analysis of Subchondral Trabecular Bone. J Arthroplasty. 2016 Jan; 31(1):269-77. PMID: 26411393.
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    16. O'Brien MP, Penmatsa M, Palukuru U, West P, Yang X, Bostrom MP, Freeman T, Pleshko N. Monitoring the Progression of Spontaneous Articular Cartilage Healing with Infrared Spectroscopy. Cartilage. 2015 Jul; 6(3):174-84. PMID: 26175863.
      Citations:    
    17. Chernets N, Zhang J, Steinbeck MJ, Kurpad DS, Koyama E, Friedman G, Freeman TA. Nonthermal atmospheric pressure plasma enhances mouse limb bud survival, growth, and elongation. Tissue Eng Part A. 2015 Jan; 21(1-2):300-9. PMID: 25102046.
      Citations:    
    18. Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. Nat Commun. 2014; 5:3891. PMID: 24852344.
      Citations:    
    19. Steinbeck MJ, Chernets N, Zhang J, Kurpad DS, Fridman G, Fridman A, Freeman TA. Skeletal cell differentiation is enhanced by atmospheric dielectric barrier discharge plasma treatment. PLoS One. 2013; 8(12):e82143. PMID: 24349203.
      Citations:    
    20. Steinbeck MJ, Jablonowski LJ, Parvizi J, Freeman TA. The role of oxidative stress in aseptic loosening of total hip arthroplasties. J Arthroplasty. 2014 Apr; 29(4):843-9. PMID: 24290740.
      Citations:    
    21. Zhou J, Freeman TA, Ahmad F, Shang X, Mangano E, Gao E, Farber J, Wang Y, Ma XL, Woodgett J, Vagnozzi RJ, Lal H, Force T. GSK-3a is a central regulator of age-related pathologies in mice. J Clin Invest. 2013 Apr 1; 123(4):1821-32. PMID: 23549082.
      Citations:    
    22. Acharya NK, Levin EC, Clifford PM, Han M, Tourtellotte R, Chamberlain D, Pollaro M, Coretti NJ, Kosciuk MC, Nagele EP, Demarshall C, Freeman T, Shi Y, Guan C, Macphee CH, Wilensky RL, Nagele RG. Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib. J Alzheimers Dis. 2013; 35(1):179-98. PMID: 23388174.
      Citations:    
    23. Liu Q, Limthongkul W, Sidhu G, Zhang J, Vaccaro A, Shenck R, Hickok N, Shapiro I, Freeman T. Covalent attachment of P15 peptide to titanium surfaces enhances cell attachment, spreading, and osteogenic gene expression. J Orthop Res. 2012 Oct; 30(10):1626-33. PMID: 22504956.
      Citations:    
    24. Casper DS, Kim GK, Parvizi J, Freeman TA. Morphology of the proximal femur differs widely with age and sex: relevance to design and selection of femoral prostheses. J Orthop Res. 2012 Jul; 30(7):1162-6. PMID: 22570223.
      Citations:    
    25. Baxter RM, Freeman TA, Kurtz SM, Steinbeck MJ. Do tissues from THA revision of highly crosslinked UHMWPE liners contain wear debris and associated inflammation? Clin Orthop Relat Res. 2011 Aug; 469(8):2308-17. PMID: 21136220.
      Citations:    
    26. Baxter RM, Ianuzzi A, Freeman TA, Kurtz SM, Steinbeck MJ. Distinct immunohistomorphologic changes in periprosthetic hip tissues from historical and highly crosslinked UHMWPE implant retrievals. J Biomed Mater Res A. 2010 Oct; 95(1):68-78. PMID: 20740602.
      Citations:    
    27. Freeman TA, Parvizi J, Dela Valle CJ, Steinbeck MJ. Mast cells and hypoxia drive tissue metaplasia and heterotopic ossification in idiopathic arthrofibrosis after total knee arthroplasty. Fibrogenesis Tissue Repair. 2010; 3:17. PMID: 20809936.
      Citations:    
    28. Skubutyte R, Markova D, Freeman TA, Anderson DG, Dion AS, Williams CJ, Shapiro IM, Risbud MV. Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc. Arthritis Rheum. 2010 Sep; 62(9):2707-15. PMID: 20496369.
      Citations:    
    29. Oca P, Zaka R, Dion AS, Freeman TA, Williams CJ. Phosphate and calcium are required for TGFbeta-mediated stimulation of ANK expression and function during chondrogenesis. J Cell Physiol. 2010 Aug; 224(2):540-8. PMID: 20432454.
      Citations:    
    30. Freeman TA, Parvizi J, Della Valle CJ, Steinbeck MJ. Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty. Fibrogenesis Tissue Repair. 2009; 2(1):5. PMID: 19912645.
      Citations:    
    31. Zaka R, Dion AS, Kusnierz A, Bohensky J, Srinivas V, Freeman T, Williams CJ. Oxygen tension regulates the expression of ANK (progressive ankylosis) in an HIF-1-dependent manner in growth plate chondrocytes. J Bone Miner Res. 2009 Nov; 24(11):1869-78. PMID: 19419319.
      Citations:    
    32. Freeman TA, Patel P, Parvizi J, Antoci V, Shapiro IM. Micro-CT analysis with multiple thresholds allows detection of bone formation and resorption during ultrasound-treated fracture healing. J Orthop Res. 2009 May; 27(5):673-9. PMID: 19016539.
      Citations:    
    33. Bohensky J, Terkhorn SP, Freeman TA, Adams CS, Garcia JA, Shapiro IM, Srinivas V. Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy. Arthritis Rheum. 2009 May; 60(5):1406-15. PMID: 19404942.
      Citations:    
    34. Antoci V, Adams CS, Parvizi J, Davidson HM, Composto RJ, Freeman TA, Wickstrom E, Ducheyne P, Jungkind D, Shapiro IM, Hickok NJ. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials. 2008 Dec; 29(35):4684-90. PMID: 18814909.
      Citations:    
    35. Watanabe H, Bohensky J, Freeman T, Srinivas V, Shapiro IM. Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy. J Cell Physiol. 2008 Aug; 216(2):419-25. PMID: 18288636.
      Citations:    
    36. Kerr BA, Otani T, Koyama E, Freeman TA, Enomoto-Iwamoto M. Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytes. Exp Cell Res. 2008 Apr 1; 314(6):1301-12. PMID: 18261726.
      Citations:    
    37. Antoci V, King SB, Jose B, Parvizi J, Zeiger AR, Wickstrom E, Freeman TA, Composto RJ, Ducheyne P, Shapiro IM, Hickok NJ, Adams CS. Vancomycin covalently bonded to titanium alloy prevents bacterial colonization. J Orthop Res. 2007 Jul; 25(7):858-66. PMID: 17415753.
      Citations:    
    38. Pucci B, Adams CS, Fertala J, Snyder BC, Mansfield KD, Tafani M, Freeman T, Shapiro IM. Development of the terminally differentiated state sensitizes epiphyseal chondrocytes to apoptosis through caspase-3 activation. J Cell Physiol. 2007 Mar; 210(3):609-15. PMID: 17133357.
      Citations:    
    39. Han F, Gilbert JR, Harrison G, Adams CS, Freeman T, Tao Z, Zaka R, Liang H, Williams C, Tuan RS, Norton PA, Hickok NJ. Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation. Exp Cell Res. 2007 May 1; 313(8):1518-32. PMID: 17391668.
      Citations:    
    40. Jacob S, Wu C, Freeman TA, Koyama E, Kirschner RE. Expression of Indian Hedgehog, BMP-4 and Noggin in craniosynostosis induced by fetal constraint. Ann Plast Surg. 2007 Feb; 58(2):215-21. PMID: 17245153.
      Citations:    
    41. Shapiro IM, Adams CS, Freeman T, Srinivas V. Fate of the hypertrophic chondrocyte: microenvironmental perspectives on apoptosis and survival in the epiphyseal growth plate. Birth Defects Res C Embryo Today. 2005 Dec; 75(4):330-9. PMID: 16425255.
      Citations:    
    42. Pacifici M, Shimo T, Gentili C, Kirsch T, Freeman TA, Enomoto-Iwamoto M, Iwamoto M, Koyama E. Syndecan-3: a cell-surface heparan sulfate proteoglycan important for chondrocyte proliferation and function during limb skeletogenesis. J Bone Miner Metab. 2005; 23(3):191-9. PMID: 15838620.
      Citations:    
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