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Timothy Manser

TitleProfessor & Chair JMC
InstitutionThomas Jefferson University
DepartmentChair SKMC
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-4672
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    Collapse Overview 
    Collapse overview
    RECENT TEACHING EXPERIENCE
    1991-present, Graduate and Medical School Courses in Immunology, Thomas Jefferson University

    STUDY SECTIONS AND EDITORSHIPS
    - Advisory Editor, The Journal of Experimental Medicine, 1991-1997
    - Associate Editor, The Journal of Immunology, 1993-1999
    - Permanent Member, NIH, NIAID Experimental Immunology Study Section, 1995-1999.
    - Section Editor, The Journal of Immunology, 1999-2003
    - Editor, BMC Immunology, 2004-present
    - Associate Editor, Frontiers in B Cell Biology, 2010-present


    Collapse Research 
    Collapse research activities and funding
    R01AI023739     (MANSER, TIMOTHY L)Apr 1, 1986 - Mar 31, 2003
    NIH/NIAID
    EXPRESSION OF ANTIBODY DIVERSITY DURING IMMUNE RESPONSES
    Role: Principal Investigator

    R01AI033684     (MANSER, TIMOTHY L)May 1, 1992 - Apr 30, 1996
    NIH/NIAID
    PEPTIDE INDUCED IMMEDIATE HYPERSENSITIVITY IN MICE
    Role: Principal Investigator

    R01AI038965     (MANSER, TIMOTHY L)May 1, 1996 - Aug 14, 2012
    NIH/NIAID
    Negative Selective of Autoreactive Antibodies
    Role: Principal Investigator

    R56AI038965     (MANSER, TIMOTHY L)May 1, 1996 - Aug 14, 2013
    NIH/NIAID
    Negative selection of autoreactive antibodies
    Role: Principal Investigator

    T32AI007492     (MANSER, TIMOTHY L)Jul 1, 1996 - Jun 30, 2007
    NIH/NIAID
    Training Program in Developmental Immunolgy
    Role: Principal Investigator

    R21AI040668     (MANSER, TIMOTHY L)Sep 1, 1997 - Mar 31, 1999
    NIH/NIAID
    REGULATION OF PERSISTENT AB RESPONSE BY FC RECEPTORS
    Role: Principal Investigator

    R01AI046806     (MANSER, TIMOTHY L)May 15, 1999 - Jan 31, 2012
    NIH/NIAID
    Regulation of Persistent Ab Responses by Fc Receptors
    Role: Principal Investigator

    R56AI046806     (MANSER, TIMOTHY L)May 15, 1999 - Jul 31, 2014
    NIH/NIAID
    Regulation of Persistent Antibody Responses by FC Receptors
    Role: Principal Investigator

    R03AI057510     (MANSER, TIMOTHY L)Mar 15, 2005 - Feb 28, 2007
    NIH/NIAID
    A New Model for Studying Antigen-driven B cell Tolerance
    Role: Principal Investigator

    R03AI059730     (MANSER, TIMOTHY L)Mar 15, 2005 - Feb 28, 2007
    NIH/NIAID
    A Vh gene that blocks development of follicular B cells
    Role: Principal Investigator

    R03AI099316     (MANSER, TIMOTHY L)Apr 1, 2012 - Mar 31, 2014
    NIH/NIAID
    Antigen-driven B cell development at the follicular perimeter
    Role: Principal Investigator

    R21AI097677     (MANSER, TIMOTHY L)Jan 18, 2013 - Dec 31, 2014
    NIH/NIAID
    Anti-polysaccharide antibody responses in humanized mice
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ozaki S, Vuyyuru R, Kageyama K, Terai M, Ohara M, Cheng H, Manser T, Mastrangelo MJ, Aplin AE, Sato T. Establishment and Characterization of Orthotopic Mouse Models for Human Uveal Melanoma Hepatic Colonization. Am J Pathol. 2016 Jan; 186(1):43-56. PMID: 26613897.
      View in: PubMed
    2. Vuyyuru R, Shen S, Manser T. Testing the role of the Fc?RIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response. Immun Inflamm Dis. 2015 Sep; 3(3):247-64. PMID: 26417440.
      View in: PubMed
    3. Patton J, Vuyyuru R, Siglin A, Root M, Manser T. Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources. J Immunol Methods. 2015 Jul; 422:13-21. PMID: 25776756.
      View in: PubMed
    4. Nikbakht N, Shen S, Manser T. Cutting edge: macrophages are required for localization of antigen-activated B cells to the follicular perimeter and the subsequent germinal center response. J Immunol. 2013 May 15; 190(10):4923-7. PMID: 23567932.
      View in: PubMed
    5. Landel CP, Dunlap J, Patton JB, Manser T. A germline-competent embryonic stem cell line from NOD.Cg-Prkdc ( scid ) Il2rg ( tm1Wjl )/SzJ (NSG) mice. Transgenic Res. 2013 Feb; 22(1):179-85. PMID: 22767020.
      View in: PubMed
    6. Vuyyuru R, Liu H, Manser T, Alugupalli KR. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20707-12. PMID: 22143787.
      View in: PubMed
    7. Manser TL. Immunologic research at Thomas Jefferson University: a recent history. Immunol Res. 2011 Dec; 51(2-3):123-4. PMID: 22160837.
      View in: PubMed
    8. Vuyyuru R, Patton J, Manser T. Human immune system mice: current potential and limitations for translational research on human antibody responses. Immunol Res. 2011 Dec; 51(2-3):257-66. PMID: 22038527.
      View in: PubMed
    9. Shen S, Manser T. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing. J Immunol. 2012 Jan 1; 188(1):47-56. PMID: 22131331.
      View in: PubMed
    10. Nikbakht N, Migone TS, Ward CP, Manser T. Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments. J Immunol. 2011 Jul 1; 187(1):37-46. PMID: 21632709.
      View in: PubMed
    11. Coffey F, Manser T. Expression of cellular FLIP by B cells is required for their participation in an immune response. J Immunol. 2010 May 1; 184(9):4871-9. PMID: 20335528.
      View in: PubMed
    12. Vuyyuru R, Mohan C, Manser T, Rahman ZS. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints. J Immunol. 2009 Nov 1; 183(9):5716-27. PMID: 19828626.
      View in: PubMed
    13. Coffey F, Alabyev B, Manser T. Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. Immunity. 2009 Apr 17; 30(4):599-609. PMID: 19303334.
      View in: PubMed
    14. Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009 Jan 1; 182(1):207-15. PMID: 19109151.
      View in: PubMed
    15. Liu X, Shen S, Manser T. Influence of B cell antigen receptor expression level on pathways of B cell tolerance induction. J Immunol. 2009 Jan 1; 182(1):398-407. PMID: 19109171.
      View in: PubMed
    16. Alabyev B, Vuyyuru R, Manser T. Influence of Fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen. Int Immunol. 2008 Oct; 20(10):1279-87. PMID: 18689725.
      View in: PubMed
    17. Coffey F, Liu X, Manser T. Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype are not influenced by TLR9 or other MyD88-dependent TLRs. J Immunol. 2007 Nov 15; 179(10):6663-72. PMID: 17982056.
      View in: PubMed
    18. Alabyev B, Rahman ZS, Manser T. Quantitatively reduced participation of anti-nuclear antigen B cells that down-regulate B cell receptor during primary development in the germinal center/memory B cell response to foreign antigen. J Immunol. 2007 May 1; 178(9):5623-34. PMID: 17442945.
      View in: PubMed
    19. Liu X, Wysocki LJ, Manser T. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci. J Immunol. 2007 Apr 15; 178(8):5035-47. PMID: 17404286.
      View in: PubMed
    20. Rahman ZS, Alabyev B, Manser T. FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity. J Immunol. 2007 Jan 15; 178(2):897-907. PMID: 17202351.
      View in: PubMed
    21. Imtiyaz HZ, Rosenberg S, Zhang Y, Rahman ZS, Hou YJ, Manser T, Zhang J. The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells. J Immunol. 2006 Jun 1; 176(11):6852-61. PMID: 16709845.
      View in: PubMed
    22. Heltemes-Harris L, Liu X, Manser T. An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol. 2005 Nov; 17(11):1447-61. PMID: 16204304.
      View in: PubMed
    23. Rahman ZS, Manser T. Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene. J Immunol. 2005 Aug 1; 175(3):1440-9. PMID: 16034080.
      View in: PubMed
    24. Liu X, Manser T. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol. 2005 Apr 15; 174(8):4505-15. PMID: 15814671.
      View in: PubMed
    25. Rahman ZS, Manser T. B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers. J Immunol. 2004 Nov 15; 173(10):6179-88. PMID: 15528355.
      View in: PubMed
    26. Mareeva T, Lebedeva T, Anikeeva N, Manser T, Sykulev Y. Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like? J Biol Chem. 2004 Oct 22; 279(43):44243-9. PMID: 15302863.
      View in: PubMed
    27. Manser T. Textbook germinal centers? J Immunol. 2004 Mar 15; 172(6):3369-75. PMID: 15004133.
      View in: PubMed
    28. Heltemes-Harris L, Liu X, Manser T. Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype. J Immunol. 2004 Jan 15; 172(2):823-33. PMID: 14707052.
      View in: PubMed
    29. Rahman ZS, Rao SP, Kalled SL, Manser T. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med. 2003 Oct 20; 198(8):1157-69. PMID: 14557413.
      View in: PubMed
    30. Alabyev B, Manser T. Bcl-2 rescues the germinal center response but does not alter the V gene somatic hypermutation spectrum in MSH2-deficient mice. J Immunol. 2002 Oct 1; 169(7):3819-24. PMID: 12244177.
      View in: PubMed
    31. Notidis E, Heltemes L, Manser T. Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development. Immunity. 2002 Sep; 17(3):317-27. PMID: 12354384.
      View in: PubMed
    32. Rao SP, Vora KA, Manser T. Differential expression of the inhibitory IgG Fc receptor FcgammaRIIB on germinal center cells: implications for selection of high-affinity B cells. J Immunol. 2002 Aug 15; 169(4):1859-68. PMID: 12165510.
      View in: PubMed
    33. Heltemes LM, Manser T. Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development. J Immunol. 2002 Aug 1; 169(3):1283-92. PMID: 12133950.
      View in: PubMed
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