Ya-Ming Hou

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gamper H, Li H, Masuda I, Miklos Robkis D, Christian T, Conn AB, Blaha G, Petersson EJ, Gonzalez RL, Hou YM. Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA. Nat Commun. 2021 01 12; 12(1):328. PMID: 33436566.
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    2. Gamper H, Hou YM. A Label-Free Assay for Aminoacylation of tRNA. Genes (Basel). 2020 Oct 07; 11(10). PMID: 33036365.
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    3. Hou YM, Masuda I, Foster LJ. tRNA methylation: An unexpected link to bacterial resistance and persistence to antibiotics and beyond. Wiley Interdiscip Rev RNA. 2020 Jun 13; e1608. PMID: 32533808.
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    4. Yin S, Dhital B, Hou YM. How to Untie a Protein Knot. Structure. 2019 Aug 06; 27(8):1190-1191. PMID: 31390544.
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    5. Sun C, Song J, Jiang Y, Zhao C, Lu J, Li Y, Wang Y, Gao M, Xi J, Luo S, Li M, Donaldson K, Oprescu SN, Slavin TP, Lee S, Magoulas PL, Lewis AM, Emrick L, Lalani SR, Niu Z, Landsverk ML, Walkiewicz M, Person RE, Mei H, Rosenfeld JA, Yang Y, Antonellis A, Hou YM, Lin J, Zhang VW. Loss-of-function mutations in Lysyl-tRNA synthetase cause various leukoencephalopathy phenotypes. Neurol Genet. 2019 Apr; 5(2):e565. PMID: 31192300.
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    6. Masuda I, Matsubara R, Christian T, Rojas ER, Yadavalli SS, Zhang L, Goulian M, Foster LJ, Huang KC, Hou YM. tRNA Methylation Is a Global Determinant of Bacterial Multi-drug Resistance. Cell Syst. 2019 Apr 24; 8(4):302-314.e8. PMID: 30981730.
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    7. Hou YM, Masuda I, Gamper H. Codon-Specific Translation by m1G37 Methylation of tRNA. Front Genet. 2018; 9:713. PMID: 30687389.
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    8. Gamper H, Hou YM. tRNA 3'-Amino-Tailing for Stable Amino Acid Attachment. RNA. 2018 Sep 14. PMID: 30217865.
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    9. Masuda I, Takase R, Matsubara R, Paulines MJ, Gamper H, Limbach PA, Hou YM. Selective terminal methylation of a tRNA wobble base. Nucleic Acids Res. 2018 Jan 18. PMID: 29361055.
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    10. Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Res. 2017 Apr 20; 45(7):4081-4093. PMID: 27956502.
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    11. Hou YM, Matsubara R, Takase R, Masuda I, Sulkowska JI. TrmD: A Methyl Transferase for tRNA Methylation With m1G37. Enzymes. 2017; 41:89-115. PMID: 28601227.
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    12. Christian T, Sakaguchi R, Perlinska AP, Lahoud G, Ito T, Taylor EA, Yokoyama S, Sulkowska JI, Hou YM. Methyl transfer by substrate signaling from a knotted protein fold. Nat Struct Mol Biol. 2016 Oct; 23(10):941-948. PMID: 27571175.
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    13. Liu C, Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X. Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. J Biol Chem. 2016 May 6; 291(19):10426-36. PMID: 26961879.
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    14. Hou YM. Single-Turnover Kinetics of Methyl Transfer to tRNA by Methyltransferases. Methods Mol Biol. 2016; 1421:79-96. PMID: 26965259.
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    15. Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM. The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts. Int J Mol Sci. 2015; 16(7):14866-83. PMID: 26140378.
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    16. Hou YM, Masuda I. Kinetic Analysis of tRNA Methyltransferases. Methods Enzymol. 2015; 560:91-116. PMID: 26253967.
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    17. Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM. Maintenance of protein synthesis reading frame by EF-P and m(1)G37-tRNA. Nat Commun. 2015; 6:7226. PMID: 26009254.
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    18. Hou YM, Gamper H, Yang W. Post-transcriptional modifications to tRNA-a response to the genetic code degeneracy. RNA. 2015 Apr; 21(4):642-4. PMID: 25780173.
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    19. Sakaguchi R, Lahoud G, Christian T, Gamper H, Hou YM. A Divalent Metal Ion-Dependent N(1)-Methyl Transfer to G37-tRNA. Chem Biol. 2014 Oct 23; 21(10):1351-60. PMID: 25219964.
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    20. Peacock JR, Walvoord RR, Chang AY, Kozlowski MC, Gamper H, Hou YM. Amino acid-dependent stability of the acyl linkage in aminoacyl-tRNA. RNA. 2014 Jun; 20(6):758-64. PMID: 24751649.
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    21. Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD). J Biol Chem. 2013 Oct 4; 288(40):28987-96. PMID: 23986443.
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    22. Christian T, Gamper H, Hou YM. Conservation of structure and mechanism by Trm5 enzymes. RNA. 2013 Sep; 19(9):1192-9. PMID: 23887145.
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    23. Hou YM, Yang X. Regulation of cell death by transfer RNA. Antioxid Redox Signal. 2013 Aug 20; 19(6):583-94. PMID: 23350625.
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    24. Sakaguchi R, Giessing A, Dai Q, Lahoud G, Liutkeviciute Z, Klimasauskas S, Piccirilli J, Kirpekar F, Hou YM. Recognition of guanosine by dissimilar tRNA methyltransferases. RNA. 2012 Sep; 18(9):1687-701. PMID: 22847817.
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    25. Hou YM. High-Purity Enzymatic Synthesis of Site-Specifically Modified tRNA. Methods Mol Biol. 2012; 941:195-212. PMID: 23065563.
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    26. Liu C, Sanders JM, Pascal JM, Hou YM. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases. RNA. 2012 Feb; 18(2):213-21. PMID: 22184460.
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    27. Igarashi T, Liu C, Morinaga H, Kim S, Hou YM. Pyrophosphorolysis of CCA addition: implication for fidelity. J Mol Biol. 2011 Nov 18; 414(1):28-43. PMID: 22001019.
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    28. Silver HR, Nissley JA, Reed SH, Hou YM, Johnson ES. A role for SUMO in nucleotide excision repair. DNA Repair (Amst). 2011 Dec 10; 10(12):1243-51. PMID: 21968059.
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    29. Lahoud G, Goto-Ito S, Yoshida K, Ito T, Yokoyama S, Hou YM. Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. RNA. 2011 Jul; 17(7):1236-46. PMID: 21602303.
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    30. Liu C, Gamper H, Liu H, Cooperman BS, Hou YM. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding. Nat Commun. 2011; 2:329. PMID: 21629262.
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    31. Christian T, Lahoud G, Liu C, Hoffmann K, Perona JJ, Hou YM. Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. RNA. 2010 Dec; 16(12):2484-92. PMID: 20980671.
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    32. Christian T, Lahoud G, Liu C, Hou YM. Control of catalytic cycle by a pair of analogous tRNA modification enzymes. J Mol Biol. 2010 Jul 9; 400(2):204-17. PMID: 20452364.
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    33. Hou YM. CCA addition to tRNA: implications for tRNA quality control. IUBMB Life. 2010 Apr; 62(4):251-60. PMID: 20101632.
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    34. Hou YM, Perona JJ. Stereochemical mechanisms of tRNA methyltransferases. FEBS Lett. 2010 Jan 21; 584(2):278-86. PMID: 19944101.
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    35. Kim S, Liu C, Halkidis K, Gamper HB, Hou YM. Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA. 2009 Oct; 15(10):1827-36. PMID: 19696158.
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    36. Liu C, Betteridge T, Hou YM. Fluorophore labeling to monitor tRNA dynamics. Methods Enzymol. 2009; 469:69-93. PMID: 20946785.
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    37. Lahoud G, Timoshchuk V, Lebedev A, Arar K, Hou YM, Gamper H. Properties of pseudo-complementary DNA substituted with weakly pairing analogs of guanine or cytosine. Nucleic Acids Res. 2008 Dec; 36(22):6999-7008. PMID: 18987000.
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    38. Lahoud G, Arar K, Hou YM, Gamper H. RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine. Nucleic Acids Res. 2008 Dec; 36(21):6806-15. PMID: 18953036.
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    39. Zhang CM, Liu C, Christian T, Gamper H, Rozenski J, Pan D, Randolph JB, Wickstrom E, Cooperman BS, Hou YM. Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end. RNA. 2008 Oct; 14(10):2245-53. PMID: 18755841.
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    40. Lahoud G, Timoshchuk V, Lebedev A, de Vega M, Salas M, Arar K, Hou YM, Gamper H. Enzymatic synthesis of structure-free DNA with pseudo-complementary properties. Nucleic Acids Res. 2008 Jun; 36(10):3409-19. PMID: 18448471.
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    41. Zhang CM, Liu C, Slater S, Hou YM. Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys). Nat Struct Mol Biol. 2008 May; 15(5):507-14. PMID: 18425141.
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    42. Dupasquier M, Kim S, Halkidis K, Gamper H, Hou YM. tRNA integrity is a prerequisite for rapid CCA addition: implication for quality control. J Mol Biol. 2008 Jun 6; 379(3):579-88. PMID: 18466919.
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    43. Christian T, Hou YM. Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases. J Mol Biol. 2007 Oct 26; 373(3):623-32. PMID: 17868690.
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    44. Betteridge T, Liu H, Gamper H, Kirillov S, Cooperman BS, Hou YM. Fluorescent labeling of tRNAs for dynamics experiments. RNA. 2007 Sep; 13(9):1594-601. PMID: 17652134.
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    45. Liu C, Gamper H, Shtivelband S, Hauenstein S, Perona JJ, Hou YM. Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. J Mol Biol. 2007 Apr 6; 367(4):1063-78. PMID: 17303165.
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    46. Zhang CM, Perona JJ, Ryu K, Francklyn C, Hou YM. Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases. J Mol Biol. 2006 Aug 11; 361(2):300-11. PMID: 16843487.
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    47. Christian T, Evilia C, Hou YM. Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. Biochemistry. 2006 Jun 20; 45(24):7463-73. PMID: 16768442.
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    48. Evilia C, Hou YM. Acquisition of an insertion peptide for efficient aminoacylation by a halophile tRNA synthetase. Biochemistry. 2006 Jun 6; 45(22):6835-45. PMID: 16734420.
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    49. Gamper HB, Arar K, Gewirtz A, Hou YM. Unrestricted hybridization of oligonucleotides to structure-free DNA. Biochemistry. 2006 Jun 6; 45(22):6978-86. PMID: 16734433.
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    50. Hou YM, Li Z, Gamper H. Isolation of a site-specifically modified RNA from an unmodified transcript. Nucleic Acids Res. 2006; 34(3):e21. PMID: 16473844.
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    51. Hou YM, Gu SQ, Zhou H, Ingerman L. Metal-ion-dependent catalysis and specificity of CCA-adding enzymes: a comparison of two classes. Biochemistry. 2005 Sep 27; 44(38):12849-59. PMID: 16171400.
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    52. Gamper HB, Arar K, Gewirtz A, Hou YM. Unrestricted accessibility of short oligonucleotides to RNA. RNA. 2005 Sep; 11(9):1441-7. PMID: 16120834.
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    53. Zhang CM, Hou YM. Domain-domain communication for tRNA aminoacylation: the importance of covalent connectivity. Biochemistry. 2005 May 17; 44(19):7240-9. PMID: 15882062.
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    54. Shitivelband S, Hou YM. Breaking the stereo barrier of amino acid attachment to tRNA by a single nucleotide. J Mol Biol. 2005 May 6; 348(3):513-21. PMID: 15826650.
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    55. Christian T, Evilia C, Williams S, Hou YM. Distinct origins of tRNA(m1G37) methyltransferase. J Mol Biol. 2004 Jun 11; 339(4):707-19. PMID: 15165845.
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    56. Zhang CM, Hou YM. Synthesis of cysteinyl-tRNACys by a prolyl-tRNA synthetase. RNA Biol. 2004 May; 1(1):35-41. PMID: 17194940.
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    57. Zhang CM, Perona JJ, Hou YM. Amino acid discrimination by a highly differentiated metal center of an aminoacyl-tRNA synthetase. Biochemistry. 2003 Sep 23; 42(37):10931-7. PMID: 12974627.
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    58. Evilia C, Ming X, DasSarma S, Hou YM. Aminoacylation of an unusual tRNA(Cys) from an extreme halophile. RNA. 2003 Jul; 9(7):794-801. PMID: 12810913.
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    59. Lipman RS, Chen J, Evilia C, Vitseva O, Hou YM. Association of an aminoacyl-tRNA synthetase with a putative metabolic protein in archaea. Biochemistry. 2003 Jun 24; 42(24):7487-96. PMID: 12809505.
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    60. Zhang CM, Christian T, Newberry KJ, Perona JJ, Hou YM. Zinc-mediated amino acid discrimination in cysteinyl-tRNA synthetase. J Mol Biol. 2003 Apr 11; 327(5):911-7. PMID: 12662918.
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    61. Ming X, Smith K, Suga H, Hou YM. Recognition of tRNA backbone for aminoacylation with cysteine: evolution from Escherichia coli to human. J Mol Biol. 2002 May 17; 318(5):1207-20. PMID: 12083512.
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    62. Seth M, Thurlow DL, Hou YM. Poly(C) synthesis by class I and class II CCA-adding enzymes. Biochemistry. 2002 Apr 9; 41(14):4521-32. PMID: 11926813.
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    63. Lipman RS, Beuning PJ, Musier-Forsyth K, Hou YM. Amino acid activation of a dual-specificity tRNA synthetase is independent of tRNA. J Mol Biol. 2002 Feb 22; 316(3):421-7. PMID: 11866507.
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    64. Lipman RS, Wang J, Sowers KR, Hou YM. Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase. J Mol Biol. 2002 Feb 1; 315(5):943-9. PMID: 11827467.
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