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Ya-Ming Hou

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-4480
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Masuda I, Igarashi T, Sakaguchi R, Nitharwal RG, Takase R, Han KY, Leslie BJ, Liu C, Gamper H, Ha T, Sanyal S, Hou YM. A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Res. 2017 Apr 20; 45(7):4081-4093. PMID: 27956502.
      View in: PubMed
    2. Hou YM, Matsubara R, Takase R, Masuda I, Sulkowska JI. TrmD: A Methyl Transferase for tRNA Methylation With m1G37. Enzymes. 2017; 41:89-115. PMID: 28601227.
      View in: PubMed
    3. Christian T, Sakaguchi R, Perlinska AP, Lahoud G, Ito T, Taylor EA, Yokoyama S, Sulkowska JI, Hou YM. Methyl transfer by substrate signaling from a knotted protein fold. Nat Struct Mol Biol. 2016 Oct; 23(10):941-948. PMID: 27571175.
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    4. Liu C, Stonestrom AJ, Christian T, Yong J, Takase R, Hou YM, Yang X. Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. J Biol Chem. 2016 May 6; 291(19):10426-36. PMID: 26961879.
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    5. Hou YM. Single-Turnover Kinetics of Methyl Transfer to tRNA by Methyltransferases. Methods Mol Biol. 2016; 1421:79-96. PMID: 26965259.
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    6. Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM. The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts. Int J Mol Sci. 2015; 16(7):14866-83. PMID: 26140378.
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    7. Hou YM, Masuda I. Kinetic Analysis of tRNA Methyltransferases. Methods Enzymol. 2015; 560:91-116. PMID: 26253967.
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    8. Gamper HB, Masuda I, Frenkel-Morgenstern M, Hou YM. Maintenance of protein synthesis reading frame by EF-P and m(1)G37-tRNA. Nat Commun. 2015; 6:7226. PMID: 26009254.
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    9. Hou YM, Gamper H, Yang W. Post-transcriptional modifications to tRNA-a response to the genetic code degeneracy. RNA. 2015 Apr; 21(4):642-4. PMID: 25780173.
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    10. Sakaguchi R, Lahoud G, Christian T, Gamper H, Hou YM. A Divalent Metal Ion-Dependent N(1)-Methyl Transfer to G37-tRNA. Chem Biol. 2014 Oct 23; 21(10):1351-60. PMID: 25219964.
      View in: PubMed
    11. Peacock JR, Walvoord RR, Chang AY, Kozlowski MC, Gamper H, Hou YM. Amino acid-dependent stability of the acyl linkage in aminoacyl-tRNA. RNA. 2014 Jun; 20(6):758-64. PMID: 24751649.
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    12. Masuda I, Sakaguchi R, Liu C, Gamper H, Hou YM. The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD). J Biol Chem. 2013 Oct 4; 288(40):28987-96. PMID: 23986443.
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    13. Christian T, Gamper H, Hou YM. Conservation of structure and mechanism by Trm5 enzymes. RNA. 2013 Sep; 19(9):1192-9. PMID: 23887145.
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    14. Hou YM, Yang X. Regulation of cell death by transfer RNA. Antioxid Redox Signal. 2013 Aug 20; 19(6):583-94. PMID: 23350625.
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    15. Sakaguchi R, Giessing A, Dai Q, Lahoud G, Liutkeviciute Z, Klimasauskas S, Piccirilli J, Kirpekar F, Hou YM. Recognition of guanosine by dissimilar tRNA methyltransferases. RNA. 2012 Sep; 18(9):1687-701. PMID: 22847817.
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    16. Hou YM. High-Purity Enzymatic Synthesis of Site-Specifically Modified tRNA. Methods Mol Biol. 2012; 941:195-212. PMID: 23065563.
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    17. Liu C, Sanders JM, Pascal JM, Hou YM. Adaptation to tRNA acceptor stem structure by flexible adjustment in the catalytic domain of class I tRNA synthetases. RNA. 2012 Feb; 18(2):213-21. PMID: 22184460.
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    18. Igarashi T, Liu C, Morinaga H, Kim S, Hou YM. Pyrophosphorolysis of CCA addition: implication for fidelity. J Mol Biol. 2011 Nov 18; 414(1):28-43. PMID: 22001019.
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    19. Silver HR, Nissley JA, Reed SH, Hou YM, Johnson ES. A role for SUMO in nucleotide excision repair. DNA Repair (Amst). 2011 Dec 10; 10(12):1243-51. PMID: 21968059.
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    20. Lahoud G, Goto-Ito S, Yoshida K, Ito T, Yokoyama S, Hou YM. Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. RNA. 2011 Jul; 17(7):1236-46. PMID: 21602303.
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    21. Liu C, Gamper H, Liu H, Cooperman BS, Hou YM. Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding. Nat Commun. 2011; 2:329. PMID: 21629262.
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    22. Christian T, Lahoud G, Liu C, Hoffmann K, Perona JJ, Hou YM. Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. RNA. 2010 Dec; 16(12):2484-92. PMID: 20980671.
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    23. Christian T, Lahoud G, Liu C, Hou YM. Control of catalytic cycle by a pair of analogous tRNA modification enzymes. J Mol Biol. 2010 Jul 9; 400(2):204-17. PMID: 20452364.
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    24. Hou YM. CCA addition to tRNA: implications for tRNA quality control. IUBMB Life. 2010 Apr; 62(4):251-60. PMID: 20101632.
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    25. Hou YM, Perona JJ. Stereochemical mechanisms of tRNA methyltransferases. FEBS Lett. 2010 Jan 21; 584(2):278-86. PMID: 19944101.
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    26. Kim S, Liu C, Halkidis K, Gamper HB, Hou YM. Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA. 2009 Oct; 15(10):1827-36. PMID: 19696158.
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    27. Liu C, Betteridge T, Hou YM. Fluorophore labeling to monitor tRNA dynamics. Methods Enzymol. 2009; 469:69-93. PMID: 20946785.
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    28. Lahoud G, Timoshchuk V, Lebedev A, Arar K, Hou YM, Gamper H. Properties of pseudo-complementary DNA substituted with weakly pairing analogs of guanine or cytosine. Nucleic Acids Res. 2008 Dec; 36(22):6999-7008. PMID: 18987000.
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    29. Lahoud G, Arar K, Hou YM, Gamper H. RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine. Nucleic Acids Res. 2008 Dec; 36(21):6806-15. PMID: 18953036.
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    30. Zhang CM, Liu C, Christian T, Gamper H, Rozenski J, Pan D, Randolph JB, Wickstrom E, Cooperman BS, Hou YM. Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end. RNA. 2008 Oct; 14(10):2245-53. PMID: 18755841.
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    31. Lahoud G, Timoshchuk V, Lebedev A, de Vega M, Salas M, Arar K, Hou YM, Gamper H. Enzymatic synthesis of structure-free DNA with pseudo-complementary properties. Nucleic Acids Res. 2008 Jun; 36(10):3409-19. PMID: 18448471.
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    32. Zhang CM, Liu C, Slater S, Hou YM. Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys). Nat Struct Mol Biol. 2008 May; 15(5):507-14. PMID: 18425141.
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    33. Dupasquier M, Kim S, Halkidis K, Gamper H, Hou YM. tRNA integrity is a prerequisite for rapid CCA addition: implication for quality control. J Mol Biol. 2008 Jun 6; 379(3):579-88. PMID: 18466919.
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    34. Christian T, Hou YM. Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases. J Mol Biol. 2007 Oct 26; 373(3):623-32. PMID: 17868690.
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    35. Betteridge T, Liu H, Gamper H, Kirillov S, Cooperman BS, Hou YM. Fluorescent labeling of tRNAs for dynamics experiments. RNA. 2007 Sep; 13(9):1594-601. PMID: 17652134.
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    36. Liu C, Gamper H, Shtivelband S, Hauenstein S, Perona JJ, Hou YM. Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. J Mol Biol. 2007 Apr 6; 367(4):1063-78. PMID: 17303165.
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    37. Zhang CM, Perona JJ, Ryu K, Francklyn C, Hou YM. Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases. J Mol Biol. 2006 Aug 11; 361(2):300-11. PMID: 16843487.
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    38. Christian T, Evilia C, Hou YM. Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. Biochemistry. 2006 Jun 20; 45(24):7463-73. PMID: 16768442.
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    39. Evilia C, Hou YM. Acquisition of an insertion peptide for efficient aminoacylation by a halophile tRNA synthetase. Biochemistry. 2006 Jun 6; 45(22):6835-45. PMID: 16734420.
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    40. Gamper HB, Arar K, Gewirtz A, Hou YM. Unrestricted hybridization of oligonucleotides to structure-free DNA. Biochemistry. 2006 Jun 6; 45(22):6978-86. PMID: 16734433.
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    41. Hou YM, Li Z, Gamper H. Isolation of a site-specifically modified RNA from an unmodified transcript. Nucleic Acids Res. 2006; 34(3):e21. PMID: 16473844.
      View in: PubMed
    42. Hou YM, Gu SQ, Zhou H, Ingerman L. Metal-ion-dependent catalysis and specificity of CCA-adding enzymes: a comparison of two classes. Biochemistry. 2005 Sep 27; 44(38):12849-59. PMID: 16171400.
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    43. Gamper HB, Arar K, Gewirtz A, Hou YM. Unrestricted accessibility of short oligonucleotides to RNA. RNA. 2005 Sep; 11(9):1441-7. PMID: 16120834.
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    44. Zhang CM, Hou YM. Domain-domain communication for tRNA aminoacylation: the importance of covalent connectivity. Biochemistry. 2005 May 17; 44(19):7240-9. PMID: 15882062.
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    45. Shitivelband S, Hou YM. Breaking the stereo barrier of amino acid attachment to tRNA by a single nucleotide. J Mol Biol. 2005 May 6; 348(3):513-21. PMID: 15826650.
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    46. Christian T, Evilia C, Williams S, Hou YM. Distinct origins of tRNA(m1G37) methyltransferase. J Mol Biol. 2004 Jun 11; 339(4):707-19. PMID: 15165845.
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    47. Zhang CM, Hou YM. Synthesis of cysteinyl-tRNACys by a prolyl-tRNA synthetase. RNA Biol. 2004 May; 1(1):35-41. PMID: 17194940.
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    48. Zhang CM, Perona JJ, Hou YM. Amino acid discrimination by a highly differentiated metal center of an aminoacyl-tRNA synthetase. Biochemistry. 2003 Sep 23; 42(37):10931-7. PMID: 12974627.
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    49. Evilia C, Ming X, DasSarma S, Hou YM. Aminoacylation of an unusual tRNA(Cys) from an extreme halophile. RNA. 2003 Jul; 9(7):794-801. PMID: 12810913.
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    50. Lipman RS, Chen J, Evilia C, Vitseva O, Hou YM. Association of an aminoacyl-tRNA synthetase with a putative metabolic protein in archaea. Biochemistry. 2003 Jun 24; 42(24):7487-96. PMID: 12809505.
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    51. Zhang CM, Christian T, Newberry KJ, Perona JJ, Hou YM. Zinc-mediated amino acid discrimination in cysteinyl-tRNA synthetase. J Mol Biol. 2003 Apr 11; 327(5):911-7. PMID: 12662918.
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    52. Ming X, Smith K, Suga H, Hou YM. Recognition of tRNA backbone for aminoacylation with cysteine: evolution from Escherichia coli to human. J Mol Biol. 2002 May 17; 318(5):1207-20. PMID: 12083512.
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    53. Seth M, Thurlow DL, Hou YM. Poly(C) synthesis by class I and class II CCA-adding enzymes. Biochemistry. 2002 Apr 9; 41(14):4521-32. PMID: 11926813.
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    54. Lipman RS, Beuning PJ, Musier-Forsyth K, Hou YM. Amino acid activation of a dual-specificity tRNA synthetase is independent of tRNA. J Mol Biol. 2002 Feb 22; 316(3):421-7. PMID: 11866507.
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    55. Lipman RS, Wang J, Sowers KR, Hou YM. Prevention of mis-aminoacylation of a dual-specificity aminoacyl-tRNA synthetase. J Mol Biol. 2002 Feb 1; 315(5):943-9. PMID: 11827467.
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