David Wesley Colby

TitleAssistant Professor
InstitutionUniversity of Delaware
DepartmentChemical and Biomolecular Engineering
Address150 Academy St.
Newark DE 19716
Phone302-831-3649
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    K99NS064173     (COLBY, DAVID W)Jan 1, 2009 - Dec 31, 2010
    NIH
    Detection and structural analysis of misfolded proteins causing neurodegeneration
    Role: Principal Investigator

    R00NS064173     (COLBY, DAVID W)Jan 1, 2009 - Jun 30, 2013
    NIH
    Detection and structural analysis of misfolded proteins causing neurodegeneration
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mirbaha H, Chen D, Morazova OA, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak LA, Diamond MI. Inert and seed-competent tau monomers suggest structural origins of aggregation. Elife. 2018 Jul 10; 7. PMID: 29988016.
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    2. Ovadia EM, Colby DW, Kloxin AM. Designing well-defined photopolymerized synthetic matrices for three-dimensional culture and differentiation of induced pluripotent stem cells. Biomater Sci. 2018 Apr 20. PMID: 29675520.
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    3. Wu B, McDonald AJ, Markham K, Rich CB, McHugh KP, Tatzelt J, Colby DW, Millhauser GL, Harris DA. The N-terminus of the prion protein is a toxic effector regulated by the C-terminus. Elife. 2017 May 20; 6. PMID: 28527237.
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    4. Morozova OA, Gupta S, Colby DW. Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation. FEBS Lett. 2015 Jul 8; 589(15):1897-903. PMID: 26037141.
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    5. Doolan KM, Colby DW. Conformation-dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencing. J Mol Biol. 2015 Jan 30; 427(2):328-40. PMID: 25451031.
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    6. Barbaro BA, Lukacsovich T, Agrawal N, Burke J, Bornemann DJ, Purcell JM, Worthge SA, Caricasole A, Weiss A, Song W, Morozova OA, Colby DW, Marsh JL. Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease. Hum Mol Genet. 2015 Feb 15; 24(4):913-25. PMID: 25305076.
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    7. Morozova OA, March ZM, Robinson AS, Colby DW. Conformational features of tau fibrils from Alzheimer's disease brain are faithfully propagated by unmodified recombinant protein. Biochemistry. 2013 Oct 8; 52(40):6960-7. PMID: 24033133.
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    8. Ghaemmaghami S, Colby DW, Nguyen HO, Hayashi S, Oehler A, Dearmond SJ, Prusiner SB. Convergent replication of mouse synthetic prion strains. Am J Pathol. 2013 Mar; 182(3):866-74. PMID: 23438476.
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    9. Gupta S, Jie S, Colby DW. Protein misfolding detected early in pathogenesis of transgenic mouse model of Huntington disease using amyloid seeding assay. J Biol Chem. 2012 Mar 23; 287(13):9982-9. PMID: 22187438.
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    10. Colby DW, Prusiner SB. De novo generation of prion strains. Nat Rev Microbiol. 2011 Nov; 9(11):771-7. PMID: 21947062.
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    11. Schiefner A, Chatwell L, Körner J, Neumaier I, Colby DW, Volkmer R, Wittrup KD, Skerra A. A disulfide-free single-domain V(L) intrabody with blocking activity towards huntingtin reveals a novel mode of epitope recognition. J Mol Biol. 2011 Dec 2; 414(3):337-55. PMID: 21968397.
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    12. Colby DW, Prusiner SB. Prions. Cold Spring Harb Perspect Biol. 2011 Jan; 3(1):a006833. PMID: 21421910.
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    13. Colby DW, Wain R, Baskakov IV, Legname G, Palmer CG, Nguyen HO, Lemus A, Cohen FE, DeArmond SJ, Prusiner SB. Protease-sensitive synthetic prions. PLoS Pathog. 2010 Jan; 6(1):e1000736. PMID: 20107515.
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    14. Colby DW, Giles K, Legname G, Wille H, Baskakov IV, DeArmond SJ, Prusiner SB. Design and construction of diverse mammalian prion strains. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20417-22. PMID: 19915150.
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    15. Wille H, Bian W, McDonald M, Kendall A, Colby DW, Bloch L, Ollesch J, Borovinskiy AL, Cohen FE, Prusiner SB, Stubbs G. Natural and synthetic prion structure from X-ray fiber diffraction. Proc Natl Acad Sci U S A. 2009 Oct 6; 106(40):16990-5. PMID: 19805070.
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    16. Feng BY, Toyama BH, Wille H, Colby DW, Collins SR, May BC, Prusiner SB, Weissman J, Shoichet BK. Small-molecule aggregates inhibit amyloid polymerization. Nat Chem Biol. 2008 Mar; 4(3):197-9. PMID: 18223646.
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    17. Colby DW, Zhang Q, Wang S, Groth D, Legname G, Riesner D, Prusiner SB. Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20914-9. PMID: 18096717.
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    18. Colby DW, Cassady JP, Lin GC, Ingram VM, Wittrup KD. Stochastic kinetics of intracellular huntingtin aggregate formation. Nat Chem Biol. 2006 Jun; 2(6):319-23. PMID: 16699519.
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    19. Colby DW, Chu Y, Cassady JP, Duennwald M, Zazulak H, Webster JM, Messer A, Lindquist S, Ingram VM, Wittrup KD. Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17616-21. PMID: 15598740.
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    20. Colby DW, Garg P, Holden T, Chao G, Webster JM, Messer A, Ingram VM, Wittrup KD. Development of a human light chain variable domain (V(L)) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display. J Mol Biol. 2004 Sep 17; 342(3):901-12. PMID: 15342245.
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    21. Colby DW, Kellogg BA, Graff CP, Yeung YA, Swers JS, Wittrup KD. Engineering antibody affinity by yeast surface display. Methods Enzymol. 2004; 388:348-58. PMID: 15289082.
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    22. Feldhaus MJ, Siegel RW, Opresko LK, Coleman JR, Feldhaus JM, Yeung YA, Cochran JR, Heinzelman P, Colby D, Swers J, Graff C, Wiley HS, Wittrup KD. Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nat Biotechnol. 2003 Feb; 21(2):163-70. PMID: 12536217.
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