Roberta Colman

TitleProfessor Emerita
InstitutionUniversity of Delaware
DepartmentChemistry & Biochemistry
Address163 The Green
Newark DE 19716
Phone302-831-2973
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    Other Positions
    TitleWillis Harrington Professor
    InstitutionUniversity of Delaware
    DepartmentChemistry & Biochemistry


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thévenin AF, Zony CL, Bahnson BJ, Colman RF. GST pi modulates JNK activity through a direct interaction with JNK substrate, ATF2. Protein Sci. 2011 May; 20(5):834-48. PMID: 21384452.
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    2. De Zoysa Ariyananda L, Antonopoulos C, Currier J, Colman RF. In vitro hybridization and separation of hybrids of human adenylosuccinate lyase from wild-type and disease-associated mutant enzymes. Biochemistry. 2011 Mar 1; 50(8):1336-46. PMID: 21210713.
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    3. Thévenin AF, Zony CL, Bahnson BJ, Colman RF. Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts. Protein Expr Purif. 2011 Feb; 75(2):138-46. PMID: 20709173.
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    4. Dange M, Colman RF. Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function. J Biol Chem. 2010 Jul 2; 285(27):20520-5. PMID: 20435888.
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    5. Ariyananda Lde Z, Lee P, Antonopoulos C, Colman RF. Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants. Biochemistry. 2009 Jun 16; 48(23):5291-302. PMID: 19405474.
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    6. Huang YC, Misquitta S, Blond SY, Adams E, Colman RF. Catalytically active monomer of glutathione S-transferase pi and key residues involved in the electrostatic interaction between subunits. J Biol Chem. 2008 Nov 21; 283(47):32880-8. PMID: 18796433.
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    7. Sivendran S, Colman RF. Effect of a new non-cleavable substrate analog on wild-type and serine mutants in the signature sequence of adenylosuccinate lyase of Bacillus subtilis and Homo sapiens. Protein Sci. 2008 Jul; 17(7):1162-74. PMID: 18469177.
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    8. Ralat LA, Misquitta SA, Manevich Y, Fisher AB, Colman RF. Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin. Arch Biochem Biophys. 2008 Jun 1; 474(1):109-18. PMID: 18358825.
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    9. De Zoysa Ariyananda L, Colman RF. Evaluation of types of interactions in subunit association in Bacillus subtilis adenylosuccinate lyase. Biochemistry. 2008 Mar 4; 47(9):2923-34. PMID: 18237141.
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    10. Sivendran S, Segall ML, Rancy PC, Colman RF. Effect of Asp69 and Arg310 on the pK of His68, a key catalytic residue of adenylosuccinate lyase. Protein Sci. 2007 Aug; 16(8):1700-7. PMID: 17600142.
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    11. Tsai M, Koo J, Yip P, Colman RF, Segall ML, Howell PL. Substrate and product complexes of Escherichia coli adenylosuccinate lyase provide new insights into the enzymatic mechanism. J Mol Biol. 2007 Jul 13; 370(3):541-54. PMID: 17531264.
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    12. Bzymek KP, Colman RF. Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. Biochemistry. 2007 May 8; 46(18):5391-7. PMID: 17432878.
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    13. Segall ML, Cashman MA, Colman RF. Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase. Protein Sci. 2007 Mar; 16(3):441-8. PMID: 17322529.
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    14. Ralat LA, Colman RF. Identification of tyrosine 79 in the tocopherol binding site of glutathione S-transferase pi. Biochemistry. 2006 Oct 17; 45(41):12491-9. PMID: 17029404.
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    15. Lee P, Colman RF. Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase. Protein Expr Purif. 2007 Feb; 51(2):227-34. PMID: 16973378.
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    16. Soundar S, O'hagan M, Fomulu KS, Colman RF. Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28; 281(30):21073-81. PMID: 16737955.
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    17. Hearne JL, Colman RF. Catalytically active monomer of class mu glutathione transferase from rat. Biochemistry. 2006 May 16; 45(19):5974-84. PMID: 16681369.
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    18. Lee P, Colman RF. Thr373, Asp375, and Lys260 are in the coenzyme site of porcine NADP-dependent isocitrate dehydrogenase. Arch Biochem Biophys. 2006 Jun 15; 450(2):183-90. PMID: 16712772.
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    19. Hearne JL, Colman RF. Contribution of the mu loop to the structure and function of rat glutathione transferase M1-1. Protein Sci. 2006 Jun; 15(6):1277-89. PMID: 16672236.
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    20. Ralat LA, Manevich Y, Fisher AB, Colman RF. Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes. Biochemistry. 2006 Jan 17; 45(2):360-72. PMID: 16401067.
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    21. Hearne JL, Colman RF. Delineation of xenobiotic substrate sites in rat glutathione S-transferase M1-1. Protein Sci. 2005 Oct; 14(10):2526-36. PMID: 16195544.
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    22. Huang YC, Colman RF. Location of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase. J Biol Chem. 2005 Aug 26; 280(34):30349-53. PMID: 15975917.
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    23. Misquitta SA, Colman RF. Communication between the two active sites of glutathione S-transferase A1-1, probed using wild-type-mutant heterodimers. Biochemistry. 2005 Jun 21; 44(24):8608-19. PMID: 15952767.
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    24. Lee P, Colman RF. Adenosine 2'-monophosphate, 5'-O-[S-(4-succinimidylbenzophenone)-thiophosphate]: a new photoaffinity label for the coenzyme site of porcine NADP-specific isocitrate dehydrogenase. Bioconjug Chem. 2005 May-Jun; 16(3):650-9. PMID: 15898734.
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    25. Kim TK, Colman RF. Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase. Protein Sci. 2005 Jan; 14(1):140-7. PMID: 15576556.
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    26. Sivendran S, Patterson D, Spiegel E, McGown I, Cowley D, Colman RF. Two novel mutant human adenylosuccinate lyases (ASLs) associated with autism and characterization of the equivalent mutant Bacillus subtilis ASL. J Biol Chem. 2004 Dec 17; 279(51):53789-97. PMID: 15471876.
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    27. Ralat LA, Colman RF. Glutathione S-transferase Pi has at least three distinguishable xenobiotic substrate sites close to its glutathione-binding site. J Biol Chem. 2004 Nov 26; 279(48):50204-13. PMID: 15347687.
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    28. Segall ML, Colman RF. Gln212, Asn270, and Arg301 are critical for catalysis by adenylosuccinate lyase from Bacillus subtilis. Biochemistry. 2004 Jun 15; 43(23):7391-402. PMID: 15182182.
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    29. Vargo MA, Colman RF. Heterodimers of wild-type and subunit interface mutant enzymes of glutathione S-transferase A1-1: interactive or independent active sites? Protein Sci. 2004 Jun; 13(6):1586-93. PMID: 15152091.
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    30. Vargo MA, Nguyen L, Colman RF. Subunit interface residues of glutathione S-transferase A1-1 that are important in the monomer-dimer equilibrium. Biochemistry. 2004 Mar 30; 43(12):3327-35. PMID: 15035604.
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    31. Huang YC, Grodsky NB, Kim TK, Colman RF. Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis. Biochemistry. 2004 Mar 16; 43(10):2821-8. PMID: 15005617.
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    32. Ralat LA, Colman RF. Monobromobimane occupies a distinct xenobiotic substrate site in glutathione S-transferase pi. Protein Sci. 2003 Nov; 12(11):2575-87. PMID: 14573868.
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    33. Soundar S, Park JH, Huh TL, Colman RF. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2003 Dec 26; 278(52):52146-53. PMID: 14555658.
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    34. Kim TK, Lee P, Colman RF. Critical role of Lys212 and Tyr140 in porcine NADP-dependent isocitrate dehydrogenase. J Biol Chem. 2003 Dec 5; 278(49):49323-31. PMID: 14512428.
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    35. Palenchar JB, Crocco JM, Colman RF. The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies. Protein Sci. 2003 Aug; 12(8):1694-705. PMID: 12876319.
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    36. Palenchar JB, Colman RF. Characterization of a mutant Bacillus subtilis adenylosuccinate lyase equivalent to a mutant enzyme found in human adenylosuccinate lyase deficiency: asparagine 276 plays an important structural role. Biochemistry. 2003 Feb 25; 42(7):1831-41. PMID: 12590570.
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    37. Ceccarelli C, Grodsky NB, Ariyaratne N, Colman RF, Bahnson BJ. Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism. J Biol Chem. 2002 Nov 8; 277(45):43454-62. PMID: 12207025.
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    38. Lee P, Colman RF. Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase. Arch Biochem Biophys. 2002 May 1; 401(1):81-90. PMID: 12054490.
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    39. Huang YC, Colman RF. Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase. Biochemistry. 2002 Apr 30; 41(17):5637-43. PMID: 11969425.
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    40. Hung SH, Madhusoodanan KS, Boyd RL, Baldwin JL, Colman RF, Colman RW. A nonhydrolyzable reactive cAMP analogue, (S(p))-8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 3',5'-cyclic S-(methyl)monophosphorothioate, irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase at micromolar concentrations. Biochemistry. 2002 Mar 5; 41(9):2962-9. PMID: 11863434.
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    41. Brosius JL, Colman RF. Three subunits contribute amino acids to the active site of tetrameric adenylosuccinate lyase: Lys268 and Glu275 are required. Biochemistry. 2002 Feb 19; 41(7):2217-26. PMID: 11841213.
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    42. Hung SH, Madhusoodanan KS, Beres JA, Boyd RL, Baldwin JL, Zhang W, Colman RW, Colman RF. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3',5'-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb; 30(1):16-31. PMID: 11955000.
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    43. Brosius JL, Colman RF. A key role in catalysis for His89 of adenylosuccinate lyase of Bacillus subtilis. Biochemistry. 2000 Nov 7; 39(44):13336-43. PMID: 11063569.
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