Alexander Mazo

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address1020 Locust St.
Philadelphia PA 19107
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    R01GM075141     (MAZO, ALEXANDER M)Aug 1, 2005 - Apr 30, 2022
    NIH
    Transcriptional Regulation by Epigenetic Factors
    Role: Principal Investigator

    R01HL127895     (CALABRETTA, BRUNO)Mar 1, 2016 - Feb 28, 2021
    NIH
    The role of chromatin structure in differentiation of hematopoietic stem cells
    Role: Co-Principal Investigator

    R01AI125650     (MAZO, ALEXANDER M)Feb 3, 2017 - Jan 31, 2022
    NIH
    The Role of the De-condensed Structure of Nascent Chromatin During T Cell Differentiation
    Role: Principal Investigator

    R01EY026159     (WALKER, JANICE LYNN)Apr 1, 2017 - Mar 31, 2021
    NIH
    Structure of post-replicative chromatin during cell reprogramming in fibrotic disease
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De Dominici M, Porazzi P, Xiao Y, Chao A, Tang HY, Kumar G, Fortina P, Spinelli O, Rambaldi A, Peterson LF, Petruk S, Barletta C, Mazo A, Cingolani G, Salvino JM, Calabretta B. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and independent effects by CDK6-specific PROTACs. Blood. 2020 Feb 07. PMID: 32040545.
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    2. Kohzaki H, Asano M, Murakami Y, Mazo A. Epigenetic regulation affects gene amplification in Drosophila development. Front Biosci (Landmark Ed). 2020 Jan 01; 25:632-645. PMID: 31585908.
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    3. Fenstermaker TK, Sun G, Mazo A, Petruk S. A Proximity Ligation-Based Method to Detect RNA-DNA Association. Methods Mol Biol. 2019; 2008:121-129. PMID: 31124093.
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    4. Akishina AA, Vorontsova JE, Cherezov RO, Mertsalov IB, Zatsepina OG, Slezinger MS, Panin VM, Petruk S, Enikolopov GN, Mazo A, Simonova OB, Kuzin BA. Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers. Oncotarget. 2017 Nov 28; 8(61):102934-102947. PMID: 29262535.
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    5. Li T, Hodgson JW, Petruk S, Mazo A, Brock HW. Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. Epigenetics Chromatin. 2017 09 19; 10(1):43. PMID: 28927461.
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    6. Petruk S, Cai J, Sussman R, Sun G, Kovermann SK, Mariani SA, Calabretta B, McMahon SB, Brock HW, Iacovitti L, Mazo A. Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation. Mol Cell. 2017 Apr 20; 66(2):247-257.e5. PMID: 28410996.
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    7. Petruk S, Mariani SA, De Dominici M, Porazzi P, Minieri V, Cai J, Iacovitti L, Flomenberg N, Calabretta B, Mazo A. Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification. Cell Rep. 2017 Apr 11; 19(2):295-306. PMID: 28402853.
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    8. L Black K, Petruk S, Fenstermaker TK, Hodgson JW, Caplan JL, Brock HW, Mazo A. Chromatin proteins and RNA are associated with DNA during all phases of mitosis. Cell Discov. 2016; 2:16038. PMID: 27807477.
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    9. Petruk S, Fenstermaker TK, Black KL, Brock HW, Mazo A. Detection of RNA-DNA association by a proximity ligation-based method. Sci Rep. 2016; 6:27313. PMID: 27256324.
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    10. Petruk S, Black KL, Kovermann SK, Brock HW, Mazo A. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication. Nat Commun. 2013 Nov 26; 4:2841. PMID: 24276476.
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    11. Carbonell A, Mazo A, Serras F, Corominas M. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr. Mol Biol Cell. 2013 Feb; 24(3):361-72. PMID: 23197473.
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    12. Petruk S, Sedkov Y, Johnston DM, Hodgson JW, Black KL, Kovermann SK, Beck S, Canaani E, Brock HW, Mazo A. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell. 2012 Aug 31; 150(5):922-33. PMID: 22921915.
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    13. Johnston DM, Sedkov Y, Petruk S, Riley KM, Fujioka M, Jaynes JB, Mazo A. Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development. Mol Cell. 2011 Oct 7; 44(1):51-61. PMID: 21981918.
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    14. Brock HW, Hodgson JW, Petruk S, Mazo A. Regulatory noncoding RNAs at Hox loci. Biochem Cell Biol. 2009 Feb; 87(1):27-34. PMID: 19234521.
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    15. Petruk S, Smith ST, Sedkov Y, Mazo A. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity. Development. 2008 Aug; 135(14):2383-90. PMID: 18550707.
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    16. Mazo A, Hodgson JW, Petruk S, Sedkov Y, Brock HW. Transcriptional interference: an unexpected layer of complexity in gene regulation. J Cell Sci. 2007 Aug 15; 120(Pt 16):2755-61. PMID: 17690303.
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    17. Petruk S, Sedkov Y, Brock HW, Mazo A. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos. RNA Biol. 2007 Jan-Mar; 4(1):1-6. PMID: 17568198.
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    18. Petruk S, Sedkov Y, Riley KM, Hodgson J, Schweisguth F, Hirose S, Jaynes JB, Brock HW, Mazo A. Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference. Cell. 2006 Dec 15; 127(6):1209-21. PMID: 17174895.
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    19. Krajewski WA, Nakamura T, Mazo A, Canaani E. A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes. Mol Cell Biol. 2005 Mar; 25(5):1891-9. PMID: 15713643.
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    20. Smith ST, Petruk S, Sedkov Y, Cho E, Tillib S, Canaani E, Mazo A. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex. Nat Cell Biol. 2004 Feb; 6(2):162-7. PMID: 14730313.
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    21. Petruk S, Sedkov Y, Smith ST, Krajewski W, Nakamura T, Canaani E, Croce CM, Mazo A. Purification and biochemical properties of the Drosophila TAC1 complex. Methods Enzymol. 2004; 377:255-66. PMID: 14979030.
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    22. Sedkov Y, Cho E, Petruk S, Cherbas L, Smith ST, Jones RS, Cherbas P, Canaani E, Jaynes JB, Mazo A. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature. 2003 Nov 6; 426(6962):78-83. PMID: 14603321.
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    23. Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell. 2002 Nov; 10(5):1119-28. PMID: 12453419.
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