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Andrzej Fertala

TitleProfessor
InstitutionThomas Jefferson University
DepartmentOrthopedic Surgery
Address1015 Walnut St.
Philadelphia PA 19107
Phone215-955-1500
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rivlin M, Miller A, Tulipan J, Beredjiklian PK, Wang ML, Fertala J, Steplewski A, Kostas J, Fertala A. Patterns of production of collagen-rich deposits in peripheral nerves in response to injury: A pilot study in a rabbit model. Brain Behav. 2017 Jul; 7(7):e00659. PMID: 28729925.
      View in: PubMed
    2. Zhang J, Eisenhauer P, Kaya O, Vaccaro AR, Diallo C, Fertala A, Freeman TA. P15 peptide stimulates chondrogenic commitment and endochondral ossification. Int Orthop. 2017 Jul; 41(7):1413-1422. PMID: 28389839.
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    3. Arita M, Fertala J, Hou C, Kostas J, Steplewski A, Fertala A. Prospects and limitations of improving skeletal growth in a mouse model of spondyloepiphyseal dysplasia caused by R992C (p.R1192C) substitution in collagen II. PLoS One. 2017; 12(2):e0172068. PMID: 28182776.
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    4. Gawron K, Lazarz-Bartyzel K, Fertala A, Plakwicz P, Potempa J, Chomyszyn-Gajewska M. Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence. Am J Case Rep. 2016; 17:655-9. PMID: 27609299.
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    5. Steplewski A, Fertala J, Beredjiklian PK, Abboud JA, Wang MLY, Namdari S, Barlow J, Rivlin M, Arnold WV, Kostas J, Hou C, Fertala A. Blocking collagen fibril formation in injured knees reduces flexion contracture in a rabbit model. J Orthop Res. 2017 May; 35(5):1038-1046. PMID: 27419365.
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    6. Steplewski A, Fertala J, Beredjiklian PK, Abboud JA, Wang ML, Namdari S, Barlow J, Rivlin M, Arnold WV, Kostas J, Hou C, Fertala A. Auxiliary proteins that facilitate formation of collagen-rich deposits in the posterior knee capsule in a rabbit-based joint contracture model. J Orthop Res. 2016 Mar; 34(3):489-501. PMID: 26241613.
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    7. Steplewski A, Fertala J, Beredjiklian P, Wang ML, Fertala A. Matrix-specific anchors: a new concept for targeted delivery and retention of therapeutic cells. Tissue Eng Part A. 2015 Apr; 21(7-8):1207-16. PMID: 25435302.
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    8. Arita M, Fertala J, Hou C, Steplewski A, Fertala A. Mechanisms of Aberrant Organization of Growth Plates in Conditional Transgenic Mouse Model of Spondyloepiphyseal Dysplasia Associated with the R992C Substitution in Collagen II. Am J Pathol. 2015 Jan; 185(1):214-29. PMID: 25451152.
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    9. Barski JJ, Denker BM, Guan J, Lauth M, Spreafico F, Fertala A, Meyer M. Developmental Upregulation of an Alternative Form of pcp2 with Reduced GDI Activity. Cerebellum. 2014 Apr; 13(2):207-14. PMID: 24092530.
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    10. Fertala J, Kostas J, Hou C, Steplewski A, Beredjiklian P, Abboud J, Arnold WV, Williams G, Fertala A. Testing the anti-fibrotic potential of the single-chain Fv antibody against the a2 C-terminal telopeptide of collagen I. Connect Tissue Res. 2014 Apr; 55(2):115-22. PMID: 24195607.
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    11. Barnes AM, Duncan G, Weis M, Paton W, Cabral WA, Mertz EL, Makareeva E, Gambello MJ, Lacbawan FL, Leikin S, Fertala A, Eyre DR, Bale SJ, Marini JC. Kuskokwim Syndrome, a Recessive Congenital Contracture Disorder, Extends the Phenotype of FKBP10? Mutations. Hum Mutat. 2013 Sep; 34(9):1279-88. PMID: 23712425.
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    12. Arnold WV, Fertala A. Skeletal diseases caused by mutations that affect collagen structure and function. Int J Biochem Cell Biol. 2013 Aug; 45(8):1556-67. PMID: 23707199.
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    13. Fertala J, Steplewski A, Kostas J, Beredjiklian P, Williams G, Arnold W, Abboud J, Bhardwaj A, Hou C, Fertala A. Engineering and Characterization of the Chimeric Antibody That Targets the C-terminal Telopeptide of the a2 Chain of Human Collagen I: A Next Step in the Quest to Reduce Localized Fibrosis. Connect Tissue Res. 2013; 54(3):187-96. PMID: 23586407.
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    14. Denning D, Alilat S, Habelitz S, Fertala A, Rodriguez BJ. Visualizing molecular polar order in tissues via electromechanical coupling. J Struct Biol. 2012 Dec; 180(3):409-19. PMID: 22985991.
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    15. Steplewski A, Fertala A. Inhibition of collagen fibril formation. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S29. PMID: 23259659.
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    16. Steplewski A, Kasinskas A, Fertala A. Remodeling of the dermal-epidermal junction in bilayered skin constructs after silencing the expression of the p.R2622Q and p.G2623C collagen VII mutants. Connect Tissue Res. 2012; 53(5):379-89. PMID: 22352907.
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    17. Lee B, Clarke D, Al Ahmad A, Kahle M, Parham C, Auckland L, Shaw C, Fidanboylu M, Orr AW, Ogunshola O, Fertala A, Thomas SA, Bix GJ. Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents. J Clin Invest. 2011 Aug; 121(8):3005-23. PMID: 21747167.
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    18. Jensen DA, Steplewski A, Gawron K, Fertala A. Persistence of intracellular and extracellular changes after incompletely suppressing expression of the R789C (p.R989C) and R992C (p.R1192C) collagen II mutants. Hum Mutat. 2011 Jul; 32(7):794-805. PMID: 21472893.
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    19. Al Ahmad A, Lee B, Stack J, Parham C, Campbell J, Clarke D, Fertala A, Bix GJ. Endostatin binds nerve growth factor and thereby inhibits neurite outgrowth and neuronal migration in-vitro. Brain Res. 2010 Nov 11; 1360:28-39. PMID: 20846515.
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    20. Gawron K, Jensen DA, Steplewski A, Fertala A. Reducing the effects of intracellular accumulation of thermolabile collagen II mutants by increasing their thermostability in cell culture conditions. Biochem Biophys Res Commun. 2010 May 28; 396(2):213-8. PMID: 20394730.
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    21. Zhang RZ, Zou Y, Pan TC, Markova D, Fertala A, Hu Y, Squarzoni S, Reed UC, Marie SK, Bönnemann CG, Chu ML. Recessive COL6A2 C-globular missense mutations in Ullrich congenital muscular dystrophy: role of the C2a splice variant. J Biol Chem. 2010 Mar 26; 285(13):10005-15. PMID: 20106987.
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    22. Mahoney MG, Sadowski S, Brennan D, Pikander P, Saukko P, Wahl J, Aho H, Heikinheimo K, Bruckner-Tuderman L, Fertala A, Peltonen J, Uitto J, Peltonen S. Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities. J Invest Dermatol. 2010 Apr; 130(4):968-78. PMID: 19924139.
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    23. Chung HJ, Steplewski A, Uitto J, Fertala A. Fluorescent protein markers to tag collagenous proteins: the paradigm of procollagen VII. Biochem Biophys Res Commun. 2009 Dec 18; 390(3):662-6. PMID: 19822129.
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    24. Chung HJ, Jensen DA, Gawron K, Steplewski A, Fertala A. R992C (p.R1192C) Substitution in collagen II alters the structure of mutant molecules and induces the unfolded protein response. J Mol Biol. 2009 Jul 10; 390(2):306-18. PMID: 19433093.
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    25. Chung HJ, Steplewski A, Chung KY, Uitto J, Fertala A. Collagen fibril formation. A new target to limit fibrosis. J Biol Chem. 2008 Sep 19; 283(38):25879-86. PMID: 18650436.
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    26. Hintze V, Steplewski A, Ito H, Jensen DA, Rodeck U, Fertala A. Cells expressing partially unfolded R789C/p.R989C type II procollagen mutant associated with spondyloepiphyseal dysplasia undergo apoptosis. Hum Mutat. 2008 Jun; 29(6):841-51. PMID: 18383211.
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    27. Sweeney SM, Orgel JP, Fertala A, McAuliffe JD, Turner KR, Di Lullo GA, Chen S, Antipova O, Perumal S, Ala-Kokko L, Forlino A, Cabral WA, Barnes AM, Marini JC, San Antonio JD. Candidate cell and matrix interaction domains on the collagen fibril, the predominant protein of vertebrates. J Biol Chem. 2008 Jul 25; 283(30):21187-97. PMID: 18487200.
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    28. Rodeck U, Fertala A, Uitto J. Anchorless keratinocyte survival: an emerging pathogenic mechanism for squamous cell carcinoma in recessive dystrophic epidermolysis bullosa. Exp Dermatol. 2007 Jun; 16(6):465-7. PMID: 17518985.
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    29. Cabral WA, Makareeva E, Letocha AD, Scribanu N, Fertala A, Steplewski A, Keene DR, Persikov AV, Leikin S, Marini JC. Y-position cysteine substitution in type I collagen (alpha1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers-Danlos syndrome phenotype. Hum Mutat. 2007 Apr; 28(4):396-405. PMID: 17206620.
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    30. Steplewski A, Hintze V, Fertala A. Molecular basis of organization of collagen fibrils. J Struct Biol. 2007 Feb; 157(2):297-307. PMID: 17126032.
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    31. Fujimoto N, Terlizzi J, Aho S, Brittingham R, Fertala A, Oyama N, McGrath JA, Uitto J. Extracellular matrix protein 1 inhibits the activity of matrix metalloproteinase 9 through high-affinity protein/protein interactions. Exp Dermatol. 2006 Apr; 15(4):300-7. PMID: 16512877.
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    32. Brittingham R, Uitto J, Fertala A. High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV. Biochem Biophys Res Commun. 2006 May 12; 343(3):692-9. PMID: 16563355.
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    33. Ito H, Steplewski A, Alabyeva T, Fertala A. Testing the utility of rationally engineered recombinant collagen-like proteins for applications in tissue engineering. J Biomed Mater Res A. 2006 Mar 1; 76(3):551-60. PMID: 16278869.
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    34. Wang H, Fertala A, Ratner BD, Sage EH, Jiang S. Identifying the SPARC binding sites on collagen I and procollagen I by atomic force microscopy. Anal Chem. 2005 Nov 1; 77(21):6765-71. PMID: 16255572.
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    35. Steplewski A, Brittingham R, Jimenez SA, Fertala A. Single amino acid substitutions in the C-terminus of collagen II alter its affinity for collagen IX. Biochem Biophys Res Commun. 2005 Sep 30; 335(3):749-55. PMID: 16087158.
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    36. Ito H, Rucker E, Steplewski A, McAdams E, Brittingham RJ, Alabyeva T, Fertala A. Guilty by association: some collagen II mutants alter the formation of ECM as a result of atypical interaction with fibronectin. J Mol Biol. 2005 Sep 16; 352(2):382-95. PMID: 16083907.
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    37. Fujimoto N, Terlizzi J, Brittingham R, Fertala A, McGrath JA, Uitto J. Extracellular matrix protein 1 interacts with the domain III of fibulin-1C and 1D variants through its central tandem repeat 2. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1327-33. PMID: 15990087.
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    38. Leitinger B, Steplewski A, Fertala A. The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. J Mol Biol. 2004 Dec 3; 344(4):993-1003. PMID: 15544808.
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    39. Steplewski A, Ito H, Rucker E, Brittingham RJ, Alabyeva T, Gandhi M, Ko FK, Birk DE, Jimenez SA, Fertala A. Position of single amino acid substitutions in the collagen triple helix determines their effect on structure of collagen fibrils. J Struct Biol. 2004 Dec; 148(3):326-37. PMID: 15522781.
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    40. Kisiel DG, Calvete JJ, Katzhendler J, Fertala A, Lazarovici P, Marcinkiewicz C. Structural determinants of the selectivity of KTS-disintegrins for the alpha1beta1 integrin. FEBS Lett. 2004 Nov 19; 577(3):478-82. PMID: 15556632.
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    41. Sun YL, Luo ZP, Fertala A, An KN. Stretching type II collagen with optical tweezers. J Biomech. 2004 Nov; 37(11):1665-9. PMID: 15388308.
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    42. Brittingham R, Colombo M, Ito H, Steplewski A, Birk DE, Uitto J, Fertala A. Single amino acid substitutions in procollagen VII affect early stages of assembly of anchoring fibrils. J Biol Chem. 2005 Jan 7; 280(1):191-8. PMID: 15509587.
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    43. Brennan D, Hu Y, Kljuic A, Choi Y, Joubeh S, Bashkin M, Wahl J, Fertala A, Pulkkinen L, Uitto J, Christiano AM, Panteleyev A, Mahoney MG. Differential structural properties and expression patterns suggest functional significance for multiple mouse desmoglein 1 isoforms. Differentiation. 2004 Oct; 72(8):434-49. PMID: 15606502.
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    44. Steplewski A, Majsterek I, McAdams E, Rucker E, Brittingham RJ, Ito H, Hirai K, Adachi E, Jimenez SA, Fertala A. Thermostability gradient in the collagen triple helix reveals its multi-domain structure. J Mol Biol. 2004 May 14; 338(5):989-98. PMID: 15111062.
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    45. Colombo M, Brittingham RJ, Klement JF, Majsterek I, Birk DE, Uitto J, Fertala A. Procollagen VII self-assembly depends on site-specific interactions and is promoted by cleavage of the NC2 domain with procollagen C-proteinase. Biochemistry. 2003 Oct 7; 42(39):11434-42. PMID: 14516194.
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    46. Majsterek I, McAdams E, Adachi E, Dhume ST, Fertala A. Prospects and limitations of the rational engineering of fibrillar collagens. Protein Sci. 2003 Sep; 12(9):2063-72. PMID: 12931004.
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    47. McGinley JC, Heller JE, Fertala A, Gaughan JP, Kozin SH. Biochemical composition and histologic structure of the forearm interosseous membrane. J Hand Surg Am. 2003 May; 28(3):503-10. PMID: 12772112.
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    48. Sun YL, Luo ZP, Fertala A, An KN. Direct quantification of the flexibility of type I collagen monomer. Biochem Biophys Res Commun. 2002 Jul 12; 295(2):382-6. PMID: 12150960.
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    49. Sieron AL, Louneva N, Fertala A. Site-specific interaction of bone morphogenetic protein 2 with procollagen II. Cytokine. 2002 May 21; 18(4):214-21. PMID: 12126644.
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    50. Cabral WA, Fertala A, Green LK, Korkko J, Forlino A, Marini JC. Procollagen with skipping of alpha 1(I) exon 41 has lower binding affinity for alpha 1(I) C-telopeptide, impaired in vitro fibrillogenesis, and altered fibril morphology. J Biol Chem. 2002 Feb 8; 277(6):4215-22. PMID: 11706004.
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