Bernard Lopez

TitleAssoc Dean
InstitutionThomas Jefferson University
DepartmentSKMC - Senior Administration
Address1020 Sansom St.
Philadelphia PA 19107
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    Society Memberships:

    American College of Emergency Physicians
    American Academy of Emergency Medicine
    Society for Academic Emergency Medicine
    Council of Residency Directors in Emergency Medicine
    American Medical Association

    Committee Memberships:

    American College of Emergency Physicians, Research Forum Committee

    Society for Academic Emergency Medicine, Faculty Development Committee



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu D, Gu G, Gan L, Yan W, Zhang Z, Yao P, Zhu D, Lau WB, Xie D, Wu S, Meng Z, Tsukuda J, Christopher T, Lopez B, Zhao J, Gao E, Koch W, Ma XL, Wang Y. Identification of a CTRP9 C-Terminal polypeptide capable of enhancing bone-derived mesenchymal stem cell cardioprotection through promoting angiogenic exosome production. Redox Biol. 2021 May; 41:101929. PMID: 33714738.
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    2. Xie Y, Meng Z, Gao J, Liu C, Wang J, Guo R, Zhao J, Lopez B, Christopher T, Lee D, Ma X, Wang Y. C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19. Proteomes. 2021 Mar 01; 9(1). PMID: 33804408.
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    3. Liu J, Meng Z, Gan L, Guo R, Gao J, Liu C, Zhu D, Liu D, Zhang L, Zhang Z, Xie D, Jiao X, Lau WB, Lopez BL, Christopher TA, Ma X, Cao J, Wang Y. C1q/TNF-related protein 5 contributes to diabetic vascular endothelium dysfunction through promoting Nox-1 signaling. Redox Biol. 2020 Feb 24; 101476. PMID: 32122792.
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    4. Gan L, Xie D, Liu J, Lau WB, Christopher TA, Lopez B, Zhang L, Gao E, Koch W, Ma XL, Wang Y. Small Extracellular Microvesicles Mediated Pathological Communications between Dysfunctional Adipocytes and Cardiomyocytes as a Novel Mechanisms Exacerbating Ischemia/Reperfusion Injury in Diabetic Mice. Circulation. 2020 Jan 10. PMID: 31918577.
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    5. Xie D, Zhao J, Guo R, Jiao L, Zhang Y, Lau WB, Lopez B, Christopher T, Gao E, Cao J, Ma X, Wang Y. Sevoflurane Pre-conditioning Ameliorates Diabetic Myocardial Ischemia/Reperfusion Injury Via Differential Regulation of p38 and ERK. Sci Rep. 2020 Jan 08; 10(1):23. PMID: 31913350.
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    6. Pierce AE, Moreno-Walton L, Boatright D, Moll JL, Hicks MN, Druck J, Lopez BL, Oral E, Heron SL. Advancing Diversity and Inclusion: An Organized Approach Through a Medical Specialty Academy. AEM Educ Train. 2020 Feb; 4(Suppl 1):S40-S46. PMID: 32072106.
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    7. Salhi BA, Tsai JW, Druck J, Ward-Gaines J, White MH, Lopez BL. Toward Structural Competency in Emergency Medical Education. AEM Educ Train. 2020 Feb; 4(Suppl 1):S88-S97. PMID: 32072112.
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    8. Du Y, Wang X, Li LY, Hao W, Zhang H, Li Y, Qin Y, Nie S, Christopher T, Lopez B, Wang Y, Lau WB, Wei YX, Ma XL. miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders. Circ Res. 2019 Nov 07. PMID: 31694459.
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    9. Fernandez C, Lopez BL, Kushner M, Leiby BE, Den RB. Overemphasis of Step 1 Scores May Impact Application Pool Diversity in Radiation Oncology. Pract Radiat Oncol. 2019 Jul 29. PMID: 31369886.
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    10. Guo R, Gan L, Lau WB, Yan Z, Xie D, Gao E, Christopher TA, Lopez BL, Ma X, Wang Y. Withaferin A Prevents Myocardial Ischemia/Reperfusion Injury by Upregulating AMP-Activated Protein Kinase-Dependent B-Cell Lymphoma2 Signaling. Circ J. 2019 Jul 25; 83(8):1726-1736. PMID: 31217391.
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    11. Zeidan AJ, Khatri UG, Aysola J, Shofer FS, Mamtani M, Scott KR, Conlon LW, Lopez BL. Implicit Bias Education and Emergency Medicine Training: Step One? Awareness. AEM Educ Train. 2019 Jan; 3(1):81-85. PMID: 30680351.
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    12. Yan Z, Guo R, Gan L, Lau WB, Cao X, Zhao J, Ma X, Christopher TA, Lopez BL, Wang Y. Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress. Life Sci. 2018 Oct 15; 211:91-101. PMID: 30213729.
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    13. Hurwitz A, Massone R, Lopez BL. Acquired Bleeding Disorders. Hematol Oncol Clin North Am. 2017 12; 31(6):1123-1145. PMID: 29078927.
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    14. Lovett PB, Sule HP, Lopez BL. Sickle Cell Disease in the Emergency Department. Hematol Oncol Clin North Am. 2017 12; 31(6):1061-1079. PMID: 29078924.
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    15. Samuels EA, Boatright D, Sanchez LD, Heron SL, Liferidge AT, Wilson T, Pierce A, Landry A, Moreno-Walton L, Druck J, Moll J, Lopez BL. Clinical Vignettes Inadequate to Assess Impact of Implicit Bias: Concerning Limitations of a Systematic Review. Acad Emerg Med. 2017 Dec; 24(12):1531-1532. PMID: 28981996.
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    16. Madsen TE, Linden JA, Rounds K, Hsieh YH, Lopez BL, Boatright D, Garg N, Heron SL, Jameson A, Kass D, Lall MD, Melendez AM, Scheulen JJ, Sethuraman KN, Westafer LM, Safdar B. Current Status of Gender and Racial/ Ethnic Disparities Among Academic Emergency Medicine Physicians. Acad Emerg Med. 2017 Aug 05. PMID: 28779488.
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    17. Liu GZ, Liang B, Lau WB, Wang Y, Zhao J, Li R, Wang X, Yuan Y, Lopez BL, Christopher TA, Xiao C, Ma XL, Wang Y. High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1/AdipoR1 signalsome formation. Free Radic Biol Med. 2015 Dec; 89:473-85. PMID: 26453924.
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    18. Yuan Y, Lau WB, Su H, Sun Y, Yi W, Du Y, Christopher T, Lopez B, Wang Y, Ma XL. C1q-TNF-related protein-9, a novel cardioprotetcive cardiokine, requires proteolytic cleavage to generate a biologically active globular domain isoform. Am J Physiol Endocrinol Metab. 2015 May 15; 308(10):E891-8. PMID: 25783894.
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    19. Hasegawa K, Tsugawa Y, Lopez BL, Smithline HA, Sullivan AF, Camargo CA. Body Mass Index and Risk of Hospitalization among Adults Presenting with Asthma Exacerbation to the Emergency Department. Ann Am Thorac Soc. 2014 Nov; 11(9):1439-44. PMID: 25314160.
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    20. Lovett PB, Sule HP, Lopez BL. Sickle cell disease in the emergency department. Emerg Med Clin North Am. 2014 Aug; 32(3):629-47. PMID: 25060254.
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    21. Lovett PB, Massone RJ, Holmes MN, Hall RV, Lopez BL. Rapid response team activations within 24 hours of admission from the emergency department: an innovative approach for performance improvement. Acad Emerg Med. 2014 Jun; 21(6):667-72. PMID: 25039551.
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    22. Hurwitz A, Massone R, Lopez BL. Acquired bleeding disorders. Emerg Med Clin North Am. 2014 Aug; 32(3):691-713. PMID: 25060257.
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    23. Lau WB, Zhang Y, Zhao J, Liu B, Wang X, Yuan Y, Christopher TA, Lopez B, Gao E, Koch WJ, Ma XL, Wang Y. Lymphotoxin-a is a novel adiponectin expression suppressor following myocardial ischemia/reperfusion. Am J Physiol Endocrinol Metab. 2013 Mar; 304(6):E661-7. PMID: 23360826.
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    24. Shin NC, Ramoska EA, Garg M, Rowh A, Nyce D, Deroos F, Carter M, Hall RV, Lopez BL. Google internet searches on residency applicants do not facilitate the ranking process. J Emerg Med. 2013 May; 44(5):995-8. PMID: 23351574.
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    25. Estreicher M, Portale J, Lopez B. Aortic dissection presenting as gait disturbance: a case report. Am J Emerg Med. 2013 Jan; 31(1):269.e1-2. PMID: 22742952.
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    26. Zheng Q, Yuan Y, Yi W, Lau WB, Wang Y, Wang X, Sun Y, Lopez BL, Christopher TA, Peterson JM, Wong GW, Yu S, Yi D, Ma XL. C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2616-23. PMID: 21836066.
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    27. Rodriguez F, Lopez B, Perez C, Fenoy FJ, Hernandez I, Stec DE, Li Volti G, Salom MG. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a heme oxygenase inhibitor in streptozotocin diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2011 Nov; 301(5):R1540-8. PMID: 21849637.
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    28. Wang XL, Lau WB, Yuan YX, Wang YJ, Yi W, Christopher TA, Lopez BL, Liu HR, Ma XL. Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity. Am J Physiol Endocrinol Metab. 2010 Aug; 299(2):E207-14. PMID: 20460580.
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    29. Yuan Y, Jiao X, Lau WB, Wang Y, Christopher TA, Lopez BL, Ramachandrarao SP, Tao L, Ma XL. Thioredoxin glycation: A novel posttranslational modification that inhibits its antioxidant and organ protective actions. Free Radic Biol Med. 2010 Aug 1; 49(3):332-8. PMID: 20416371.
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    30. Li R, Xu M, Wang X, Wang Y, Lau WB, Yuan Y, Yi W, Wei X, Lopez BL, Christopher TA, Wang XM, Ma XL. Reduced vascular responsiveness to adiponectin in hyperlipidemic rats--mechanisms and significance. J Mol Cell Cardiol. 2010 Sep; 49(3):508-15. PMID: 20303976.
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    31. Chen G, Lai W, Liu F, Mao Q, Tu F, Wen J, Xiao H, Zhang JC, Zhu T, Chen B, Hu ZY, Li RM, Liang Z, Nie H, Yan H, Yang BX, Du Q, Huang WX, Jiang YW, Kwan AS, Song L, Wu CM, Xiang T, Xu HW, Lau WB, Song HB, Wen CB, Yao ZH, Zhang L, Zeng J, Dai YE, Lopez BL, Zheng JQ, Zhou J, Christopher TA, Ma XL, Yu H, Xu LL, Guo Q, Song ZP, Volinn E, Kryger K, Cao Y, Ge H, Liu H, Luo CZ, Tao W, Zuo YX, Liu J. The dragon strikes: lessons from the Wenchuan earthquake. Anesth Analg. 2010 Mar 1; 110(3):908-15. PMID: 20185667.
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    32. Nie H, Tang SY, Lau WB, Zhang JC, Jiang YW, Lopez BL, Ma XL, Cao Y, Christopher TA. Triage during the week of the Sichuan earthquake: a review of utilized patient triage, care, and disposition procedures. Injury. 2011 May; 42(5):515-20. PMID: 20153857.
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    33. Wang Y, Tao L, Yuan Y, Lau WB, Li R, Lopez BL, Christopher TA, Tian R, Ma XL. Cardioprotective effect of adiponectin is partially mediated by its AMPK-independent antinitrative action. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E384-91. PMID: 19470831.
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    34. Wang Y, Gao E, Tao L, Lau WB, Yuan Y, Goldstein BJ, Lopez BL, Christopher TA, Tian R, Koch W, Ma XL. AMP-activated protein kinase deficiency enhances myocardial ischemia/reperfusion injury but has minimal effect on the antioxidant/antinitrative protection of adiponectin. Circulation. 2009 Feb 17; 119(6):835-44. PMID: 19188503.
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    35. Liu HR, Tao L, Gao E, Qu Y, Lau WB, Lopez BL, Christopher TA, Koch W, Yue TL, Ma XL. Rosiglitazone inhibits hypercholesterolaemia-induced myeloperoxidase upregulation--a novel mechanism for the cardioprotective effects of PPAR agonists. Cardiovasc Res. 2009 Feb 1; 81(2):344-52. PMID: 19010810.
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    36. Zhang H, Li J, Li R, Zhang Q, Ma H, Ji Q, Guo W, Wang H, Lopez BL, Christopher TA, Ma X, Gao F. Reduced cardiotropic response to insulin in spontaneously hypertensive rats: role of peroxisome proliferator-activated receptor-gamma-initiated signaling. J Hypertens. 2008 Mar; 26(3):560-9. PMID: 18300869.
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    37. Li R, Wang WQ, Zhang H, Yang X, Fan Q, Christopher TA, Lopez BL, Tao L, Goldstein BJ, Gao F, Ma XL. Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1703-8. PMID: 17895290.
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    38. Salom MG, Cerón SN, Rodriguez F, Lopez B, Hernández I, Martínez JG, Losa AM, Fenoy FJ. Heme oxygenase-1 induction improves ischemic renal failure: role of nitric oxide and peroxynitrite. Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6):H3542-9. PMID: 17890422.
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    39. Gupta MX, Silberstein SD, Young WB, Hopkins M, Lopez BL, Samsa GP. Less is not more: underutilization of headache medications in a university hospital emergency department. Headache. 2007 Sep; 47(8):1125-33. PMID: 17883517.
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    40. Li S, Jiao X, Tao L, Liu H, Cao Y, Lopez BL, Christopher TA, Ma XL. Tumor necrosis factor-alpha in mechanic trauma plasma mediates cardiomyocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1847-52. PMID: 17616742.
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    41. Wang XL, Liu HR, Tao L, Liang F, Yan L, Zhao RR, Lopez BL, Christopher TA, Ma XL. Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion. Apoptosis. 2007 Jul; 12(7):1209-17. PMID: 17333318.
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    42. Zhang H, Tao L, Jiao X, Gao E, Lopez BL, Christopher TA, Koch W, Ma XL. Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart. Free Radic Biol Med. 2007 Jul 1; 43(1):39-47. PMID: 17561092.
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    43. Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation. 2007 Mar 20; 115(11):1408-16. PMID: 17339545.
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    44. Yu M, Lopez B, Dos Santos EA, Falck JR, Roman RJ. Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2400-5. PMID: 17303679.
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    45. Lopez BL, Flenders P, Davis-Moon L, Corbin T, Ballas SK. Clinically significant differences in the visual analog pain scale in acute vasoocclusive sickle cell crisis. Hemoglobin. 2007; 31(4):427-32. PMID: 17994376.
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    46. Tao L, Jiao X, Gao E, Lau WB, Yuan Y, Lopez B, Christopher T, RamachandraRao SP, Williams W, Southan G, Sharma K, Koch W, Ma XL. Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis. Circulation. 2006 Sep 26; 114(13):1395-402. PMID: 16966583.
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    47. Wang HC, Zhang HF, Guo WY, Su H, Zhang KR, Li QX, Yan W, Ma XL, Lopez BL, Christopher TA, Gao F. Hypoxic postconditioning enhances the survival and inhibits apoptosis of cardiomyocytes following reoxygenation: role of peroxynitrite formation. Apoptosis. 2006 Aug; 11(8):1453-60. PMID: 16761110.
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    48. Jacobs ER, Zhu D, Gruenloh S, Lopez B, Medhora M. VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. Am J Physiol Lung Cell Mol Physiol. 2006 Sep; 291(3):L369-77. PMID: 16679379.
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    49. Dhanasekaran A, Al-Saghir R, Lopez B, Zhu D, Gutterman DD, Jacobs ER, Medhora M. Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature. Am J Physiol Heart Circ Physiol. 2006 Aug; 291(2):H517-31. PMID: 16617127.
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    50. Lopez BL, Cogen JF, Kerkula L, Corbin T, Flenders P. Pulse oximetry in the adult ED patient with sickle cell. Am J Emerg Med. 2005 Jul; 23(4):429-32. PMID: 16032605.
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    51. Tao L, Liu HR, Gao F, Qu Y, Christopher TA, Lopez BL, Ma XL. Mechanical traumatic injury without circulatory shock causes cardiomyocyte apoptosis: role of reactive nitrogen and reactive oxygen species. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2811-8. PMID: 15695560.
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    52. Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL. Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion. Circulation. 2005 Jan 4; 111(1):90-6. PMID: 15611365.
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    53. Tao L, Gao E, Bryan NS, Qu Y, Liu HR, Hu A, Christopher TA, Lopez BL, Yodoi J, Koch WJ, Feelisch M, Ma XL. Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A. 2004 Aug 3; 101(31):11471-6. PMID: 15277664.
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    54. Liang F, Gao E, Tao L, Liu H, Qu Y, Christopher TA, Lopez BL, Ma XL. Critical timing of L-arginine treatment in post-ischemic myocardial apoptosis-role of NOS isoforms. Cardiovasc Res. 2004 Jun 1; 62(3):568-77. PMID: 15158149.
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    55. Liu HR, Gao F, Tao L, Yan WL, Gao E, Christopher TA, Lopez BL, Hu A, Ma XL. Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart. Br J Pharmacol. 2004 Jun; 142(4):627-34. PMID: 15172961.
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    56. Liu HR, Tao L, Gao E, Lopez BL, Christopher TA, Willette RN, Ohlstein EH, Yue TL, Ma XL. Anti-apoptotic effects of rosiglitazone in hypercholesterolemic rabbits subjected to myocardial ischemia and reperfusion. Cardiovasc Res. 2004 Apr 1; 62(1):135-44. PMID: 15023560.
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    57. Tao L, Liu HR, Gao E, Teng ZP, Lopez BL, Christopher TA, Ma XL, Batinic-Haberle I, Willette RN, Ohlstein EH, Yue TL. Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. Circulation. 2003 Dec 2; 108(22):2805-11. PMID: 14610009.
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    58. Lopez BL, Davis-Moon L, Sterious W, Bulette M, Liang-Ma X, Christopher TA. The Power Infuser: a new device for rapid fluid infusion. Am J Emerg Med. 2003 Mar; 21(2):129-32. PMID: 12671814.
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    59. Lopez BL, Kreshak AA, Morris CR, Davis-Moon L, Ballas SK, Ma XL. L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. Br J Haematol. 2003 Feb; 120(3):532-4. PMID: 12580975.
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    60. Christopher TA, Lopez BL, Stillwagon JC, Gao F, Gao E, Ma XL, Ohlstein EH, Yue TL. Idoxifene causes endothelium-dependent, nitric oxide-mediated vasorelaxation in male rats. Eur J Pharmacol. 2002 Jun 20; 446(1-3):139-43. PMID: 12098595.
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    61. Gao F, Yao CL, Gao E, Mo QZ, Yan WL, McLaughlin R, Lopez BL, Christopher TA, Ma XL. Enhancement of glutathione cardioprotection by ascorbic acid in myocardial reperfusion injury. J Pharmacol Exp Ther. 2002 May; 301(2):543-50. PMID: 11961055.
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    62. Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, Ma XL. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002 Mar 26; 105(12):1497-502. PMID: 11914261.
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    63. Gao F, Yue TL, Shi DW, Christopher TA, Lopez BL, Ohlstein EH, Barone FC, Ma XL. p38 MAPK inhibition reduces myocardial reperfusion injury via inhibition of endothelial adhesion molecule expression and blockade of PMN accumulation. Cardiovasc Res. 2002 Feb 1; 53(2):414-22. PMID: 11827692.
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