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David Abraham

TitleAssoc Dean
InstitutionThomas Jefferson University
DepartmentSKMC - Senior Administration
Address233 S. 10th Street
Philadelphia PA 19107
Phone610-642-1222
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bennuru S, Lustigman S, Abraham D, Nutman TB. Metabolite profiling of infection-associated metabolic markers of onchocerciasis. Mol Biochem Parasitol. 2017 Jul; 215:58-69. PMID: 28188804.
      View in: PubMed
    2. Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis. 2016 Jul; 10(7):e0004797. PMID: 27387453.
      View in: PubMed
    3. Arumugam S, Wei J, Liu Z, Abraham D, Bell A, Bottazzi ME, Hotez PJ, Zhan B, Lustigman S, Klei TR. Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004586. PMID: 27045170.
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    4. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa-TOVA-Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641.
      View in: PubMed
    5. Arumugam S, Wei J, Ward D, Abraham D, Lustigman S, Zhan B, Klei TR. Vaccination with a genetically modified Brugia malayi cysteine protease inhibitor-2 reduces adult parasite numbers and affects the fertility of female worms following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Int J Parasitol. 2014 Sep; 44(10):675-9. PMID: 24929131.
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    6. Hess JA, Zhan B, Bonne-Année S, Deckman JM, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int J Parasitol. 2014 Aug; 44(9):637-46. PMID: 24907553.
      View in: PubMed
    7. Bonne-Année S, Kerepesi LA, Hess JA, Wesolowski J, Paumet F, Lok JB, Nolan TJ, Abraham D. Extracellular traps are associated with human and mouse neutrophil and macrophage mediated killing of larval Strongyloides stercoralis. Microbes Infect. 2014 Jun; 16(6):502-11. PMID: 24642003.
      View in: PubMed
    8. Arumugam S, Zhan B, Abraham D, Ward D, Lustigman S, Klei TR. Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae. Parasit Vectors. 2014; 7(1):43. PMID: 24450869.
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    9. Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ, Abraham D, Denton CP. Endothelial injury in a transforming growth factor ß-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum. 2013 Nov; 65(11):2928-39. PMID: 23839959.
      View in: PubMed
    10. Maurer B, Distler A, Dees C, Khan K, Denton CP, Abraham D, Gay RE, Michel BA, Gay S, Hw Distler J, Distler O. Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. Ann Rheum Dis. 2013 Dec; 72(12):2039-46. PMID: 24013728.
      View in: PubMed
    11. Bonne-Année S, Kerepesi LA, Hess JA, O'Connell AE, Lok JB, Nolan TJ, Abraham D. Human and Mouse Macrophages Collaborate with Neutrophils To Kill Larval Strongyloides stercoralis. Infect Immun. 2013 Sep; 81(9):3346-55. PMID: 23798541.
      View in: PubMed
    12. Krolewiecki AJ, Lammie P, Jacobson J, Gabrielli AF, Levecke B, Socias E, Arias LM, Sosa N, Abraham D, Cimino R, Echazú A, Crudo F, Vercruysse J, Albonico M. A Public Health Response against Strongyloides stercoralis: Time to Look at Soil-Transmitted Helminthiasis in Full. PLoS Negl Trop Dis. 2013 May; 7(5):e2165. PMID: 23675541.
      View in: PubMed
    13. Sonnylal S, Xu S, Jones H, Tam A, Sreeram VR, Ponticos M, Norman J, Agrawal P, Abraham D, de Crombrugghe B. Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci. 2013 May 15; 126(Pt 10):2164-75. PMID: 23525012.
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    14. Bonne-Année S, Hess JA, Abraham D. Innate and adaptive immunity to the nematode Strongyloides stercoralis in a mouse model. Immunol Res. 2011 Dec; 51(2-3):205-14. PMID: 22101674.
      View in: PubMed
    15. Colombo MJ, Abraham D, Shibuya A, Alugupalli KR. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fca/µ receptor and in the absence of host cell contact. Immunol Res. 2011 Dec; 51(2-3):249-56. PMID: 22139824.
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    16. Abraham D, Hess JA, Mejia R, Nolan TJ, Lok JB, Lustigman S, Nutman TB. Immunization with the recombinant antigen Ss-IR induces protective immunity to infection with Strongyloides stercoralis in mice. Vaccine. 2011 Oct 19; 29(45):8134-40. PMID: 21856350.
      View in: PubMed
    17. Ramanathan R, Varma S, Ribeiro JM, Myers TG, Nolan TJ, Abraham D, Lok JB, Nutman TB. Microarray-based analysis of differential gene expression between infective and noninfective larvae of Strongyloides stercoralis. PLoS Negl Trop Dis. 2011; 5(5):e1039. PMID: 21572524.
      View in: PubMed
    18. O'Connell AE, Hess JA, Santiago GA, Nolan TJ, Lok JB, Lee JJ, Abraham D. Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice. Infect Immun. 2011 Jul; 79(7):2770-8. PMID: 21482685.
      View in: PubMed
    19. O'Connell AE, Redding KM, Hess JA, Lok JB, Nolan TJ, Abraham D. Soluble extract from the nematode Strongyloides stercoralis induces CXCR2 dependent/IL-17 independent neutrophil recruitment. Microbes Infect. 2011 Jun; 13(6):536-44. PMID: 21315175.
      View in: PubMed
    20. McCann MR, Monemdjou R, Ghassemi-Kakroodi P, Fahmi H, Perez G, Liu S, Shi-Wen X, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A, Kapoor M. mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. Arthritis Res Ther. 2011; 13(1):R6. PMID: 21266028.
      View in: PubMed
    21. Liu S, Shi-wen X, Abraham DJ, Leask A. CCN2 is required for bleomycin-induced skin fibrosis in mice. Arthritis Rheum. 2011 Jan; 63(1):239-46. PMID: 20936632.
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    22. Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci. 2010 Nov 1; 123(Pt 21):3674-82. PMID: 20940256.
      View in: PubMed
    23. Krolewiecki AJ, Ramanathan R, Fink V, McAuliffe I, Cajal SP, Won K, Juarez M, Di Paolo A, Tapia L, Acosta N, Lee R, Lammie P, Abraham D, Nutman TB. Improved diagnosis of Strongyloides stercoralis using recombinant antigen-based serologies in a community-wide study in northern Argentina. Clin Vaccine Immunol. 2010 Oct; 17(10):1624-30. PMID: 20739501.
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    24. Hoyles RK, Derrett-Smith EC, Khan K, Shiwen X, Howat SL, Wells AU, Abraham DJ, Denton CP. An essential role for resident fibroblasts in experimental lung fibrosis is defined by lineage-specific deletion of high-affinity type II transforming growth factor ß receptor. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):249-61. PMID: 20709822.
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    25. Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de Crombrugghe B. Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis. Arthritis Rheum. 2010 May; 62(5):1523-32. PMID: 20213804.
      View in: PubMed
    26. Derrett-Smith EC, Dooley A, Khan K, Shi-wen X, Abraham D, Denton CP. Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma. Arthritis Res Ther. 2010; 12(2):R69. PMID: 20398328.
      View in: PubMed
    27. Liu S, Kapoor M, Denton CP, Abraham DJ, Leask A. Loss of beta1 integrin in mouse fibroblasts results in resistance to skin scleroderma in a mouse model. Arthritis Rheum. 2009 Sep; 60(9):2817-21. PMID: 19714619.
      View in: PubMed
    28. Kapoor M, McCann M, Liu S, Huh K, Denton CP, Abraham DJ, Leask A. Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum. 2009 Sep; 60(9):2822-9. PMID: 19714649.
      View in: PubMed
    29. Stein LH, Redding KM, Lee JJ, Nolan TJ, Schad GA, Lok JB, Abraham D. Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis. J Innate Immun. 2009; 1(6):618-30. PMID: 20375616.
      View in: PubMed
    30. Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE. Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. Arthritis Rheum. 2009 Jul; 60(7):2142-55. PMID: 19565505.
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    31. Alugupalli KR, Abraham D. B cell multitasking is required to control nematode infection. Immunity. 2009 Mar 20; 30(3):317-9. PMID: 19303384.
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    32. Kapoor M, Liu S, Shi-wen X, Huh K, McCann M, Denton CP, Woodgett JR, Abraham DJ, Leask A. GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. J Clin Invest. 2008 Oct; 118(10):3279-90. PMID: 18802478.
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    33. Liu S, Kapoor M, Shi-wen X, Kennedy L, Denton CP, Glogauer M, Abraham DJ, Leask A. Role of Rac1 in a bleomycin-induced scleroderma model using fibroblast-specific Rac1-knockout mice. Arthritis Rheum. 2008 Jul; 58(7):2189-95. PMID: 18576327.
      View in: PubMed
    34. Hoyles RK, Khan K, Shiwen X, Howat SL, Lindahl GE, Leoni P, du Bois RM, Wells AU, Black CM, Abraham DJ, Denton CP. Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model. Arthritis Rheum. 2008 Apr; 58(4):1175-88. PMID: 18383385.
      View in: PubMed
    35. Padigel UM, Hess JA, Lee JJ, Lok JB, Nolan TJ, Schad GA, Abraham D. Eosinophils act as antigen-presenting cells to induce immunity to Strongyloides stercoralis in mice. J Infect Dis. 2007 Dec 15; 196(12):1844-51. PMID: 18190266.
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    36. Sinagra A, Luna C, Abraham D, Iannella Mdel C, Riarte A, Krolewiecki AJ. The activity of azithromycin against Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazonensis in the golden hamster model. Rev Soc Bras Med Trop. 2007 Nov-Dec; 40(6):627-30. PMID: 18200413.
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    37. Krolewiecki AJ, Romero HD, Cajal SP, Abraham D, Mimori T, Matsumoto T, Juarez M, Taranto NJ. A randomized clinical trial comparing oral azithromycin and meglumine antimoniate for the treatment of American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis. Am J Trop Med Hyg. 2007 Oct; 77(4):640-6. PMID: 17978064.
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    38. Padigel UM, Stein L, Redding K, Lee JJ, Nolan TJ, Schad GA, Birnbaumer L, Abraham D. Signaling through Galphai2 protein is required for recruitment of neutrophils for antibody-mediated elimination of larval Strongyloides stercoralis in mice. J Leukoc Biol. 2007 Apr; 81(4):1120-6. PMID: 17242370.
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    39. Kennedy L, Liu S, Shi-Wen X, Chen Y, Eastwood M, Sabetkar M, Carter DE, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res. 2007 Mar 10; 313(5):952-64. PMID: 17239853.
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    40. Kerepesi LA, Hess JA, Leon O, Nolan TJ, Schad GA, Abraham D. Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice. Microbes Infect. 2007 Jan; 9(1):28-34. PMID: 17196865.
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    41. Galioto AM, Hess JA, Nolan TJ, Schad GA, Lee JJ, Abraham D. Role of eosinophils and neutrophils in innate and adaptive protective immunity to larval strongyloides stercoralis in mice. Infect Immun. 2006 Oct; 74(10):5730-8. PMID: 16988250.
      View in: PubMed
    42. Padigel UM, Lee JJ, Nolan TJ, Schad GA, Abraham D. Eosinophils can function as antigen-presenting cells to induce primary and secondary immune responses to Strongyloides stercoralis. Infect Immun. 2006 Jun; 74(6):3232-8. PMID: 16714550.
      View in: PubMed
    43. Kerepesi LA, Hess JA, Nolan TJ, Schad GA, Abraham D. Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice. J Immunol. 2006 Apr 1; 176(7):4315-22. PMID: 16547268.
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    44. Shi-wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem. 2006 Apr 21; 281(16):10715-26. PMID: 16484225.
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    45. Kerepesi LA, Leon O, Lustigman S, Abraham D. Protective immunity to the larval stages of onchocerca volvulus is dependent on Toll-like receptor 4. Infect Immun. 2005 Dec; 73(12):8291-7. PMID: 16299326.
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    46. Kerepesi LA, Keiser PB, Nolan TJ, Schad GA, Abraham D, Nutman TB. DNA immunization with Na+-K+ ATPase (Sseat-6) induces protective immunity to larval Strongyloides stercoralis in mice. Infect Immun. 2005 Apr; 73(4):2298-305. PMID: 15784574.
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    47. Denton CP, Abraham DJ. Transgenic analysis of scleroderma: understanding key pathogenic events in vivo. Autoimmun Rev. 2004 Jun; 3(4):285-93. PMID: 15246024.
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    48. Kerepesi LA, Nolan TJ, Schad GA, Lustigman S, Herbert DR, Keiser PB, Nutman TB, Krolewiecki AJ, Abraham D. Human immunoglobulin G mediates protective immunity and identifies protective antigens against larval Strongyloides stercoralis in mice. J Infect Dis. 2004 Apr 1; 189(7):1282-90. PMID: 15031798.
      View in: PubMed
    49. Abraham D, Leon O, Schnyder-Candrian S, Wang CC, Galioto AM, Kerepesi LA, Lee JJ, Lustigman S. Immunoglobulin E and eosinophil-dependent protective immunity to larval Onchocerca volvulus in mice immunized with irradiated larvae. Infect Immun. 2004 Feb; 72(2):810-7. PMID: 14742524.
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    50. Ligas JA, Kerepesi LA, Galioto AM, Lustigman S, Nolan TJ, Schad GA, Abraham D. Specificity and mechanism of immunoglobulin M (IgM)- and IgG-dependent protective immunity to larval Strongyloides stercoralis in mice. Infect Immun. 2003 Dec; 71(12):6835-43. PMID: 14638770.
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    51. Lustigman S, MacDonald AJ, Abraham D. CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions. Int J Parasitol. 2003 Sep 30; 33(11):1161-71. PMID: 13678632.
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    52. Ong VH, Evans LA, Shiwen X, Fisher IB, Rajkumar V, Abraham DJ, Black CM, Denton CP. Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse. Arthritis Rheum. 2003 Jul; 48(7):1979-91. PMID: 12847692.
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    53. Denton CP, Zheng B, Evans LA, Shi-wen X, Ong VH, Fisher I, Lazaridis K, Abraham DJ, Black CM, de Crombrugghe B. Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice. J Biol Chem. 2003 Jul 4; 278(27):25109-19. PMID: 12707256.
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    54. Krolewiecki A, Leon S, Scott P, Abraham D. Activity of azithromycin against Leishmania major in vitro and in vivo. Am J Trop Med Hyg. 2002 Sep; 67(3):273-7. PMID: 12408666.
      View in: PubMed
    55. Abraham D, Lucius R, Trees AJ. Immunity to Onchocerca spp. in animal hosts. Trends Parasitol. 2002 Apr; 18(4):164-71. PMID: 11998704.
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    56. Lustigman S, James ER, Tawe W, Abraham D. Towards a recombinant antigen vaccine against Onchocerca volvulus. Trends Parasitol. 2002 Mar; 18(3):135-41. PMID: 11854092.
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    57. Nolan TJ, Bhopale VM, Rotman HL, Abraham D, Schad GA. Strongyloides stercoralis: high worm population density leads to autoinfection in the jird (Meriones unguiculatus). Exp Parasitol. 2002 Mar; 100(3):173-8. PMID: 12173402.
      View in: PubMed
    58. Herbert DR, Nolan TJ, Schad GA, Abraham D. The role of B cells in immunity against larval Strongyloides stercoralis in mice. Parasite Immunol. 2002 Feb; 24(2):95-101. PMID: 11874564.
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    59. Herbert DR, Nolan TJ, Schad GA, Lustigman S, Abraham D. Immunoaffinity-isolated antigens induce protective immunity against larval Strongyloides stercoralis in mice. Exp Parasitol. 2002 Feb; 100(2):112-20. PMID: 12054701.
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    60. McCarthy JS, Wieseman M, Tropea J, Kaslow D, Abraham D, Lustigman S, Tuan R, Guderian RH, Nutman TB. Onchocerca volvulus glycolytic enzyme fructose-1,6-bisphosphate aldolase as a target for a protective immune response in humans. Infect Immun. 2002 Feb; 70(2):851-8. PMID: 11796620.
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