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Dennis Leeper

TitleProfessor
InstitutionThomas Jefferson University
DepartmentRadiation Oncology
Address111 S. 11th Street
Philadelphia PA 19107
Phone215-955-8092
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    T32CA009137     (LEEPER, DENNIS B)Jul 1, 1978 - May 31, 2004
    NIH/NCI
    CANCER TRAINING IN THE SCIENCE OF DNA DAMAGE RESPONSE
    Role: Principal Investigator

    R01CA039487     (LEEPER, DENNIS B)Sep 1, 1985 - Aug 31, 1988
    NIH/NCI
    THERMOTOLERANCE, PROTEIN SYNTHESIS, AND STEPDOWN HEATING
    Role: Principal Investigator

    R01CA042210     (LEEPER, DENNIS B)May 1, 1987 - Mar 31, 1991
    NIH/NCI
    HYPERTHERMIA RESPONSE OF BONE MARROW STEM CELLS
    Role: Principal Investigator

    R01CA044431     (LEEPER, DENNIS B)May 1, 1987 - Mar 31, 1991
    NIH/NCI
    PH, HYPERGLYCEMIA AND HYPERTHERMIA IN HUMAN TUMORS
    Role: Principal Investigator

    R13CA049370     (LEEPER, DENNIS B)Sep 7, 1988 - Sep 6, 1989
    NIH/NCI
    5TH INTERNATIONAL SYMPOSIUM--HYPERTHERMIC ONCOLOGY
    Role: Principal Investigator

    P01CA056690     (LEEPER, DENNIS B.)Apr 23, 1993 - Mar 31, 2009
    NIH/NCI
    Modification of hyperthermia response
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nath K, Nelson DS, Roman J, Putt ME, Lee SC, Leeper DB, Glickson JD. Effect of Lonidamine on Systemic Therapy of DB-1 Human Melanoma Xenografts with Temozolomide. Anticancer Res. 2017 Jul; 37(7):3413-3421. PMID: 28668829.
      View in: PubMed
    2. Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD. Mechanism of antineoplastic activity of lonidamine. Biochim Biophys Acta. 2016 Aug 4; 1866(2):151-162. PMID: 27497601.
      View in: PubMed
    3. Du S, Lockamy V, Zhou L, Xue C, LeBlanc J, Glenn S, Shukla G, Yu Y, Dicker AP, Leeper DB, Lu Y, Lu B. Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer. Int J Radiat Oncol Biol Phys. 2016 Nov 1; 96(3):529-37. PMID: 27681749.
      View in: PubMed
    4. Shestov AA, Lee SC, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA, Glickson JD. (13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. Front Oncol. 2016; 6:135. PMID: 27379200.
      View in: PubMed
    5. Nath K, Nelson DS, Putt ME, Leeper DB, Garman B, Nathanson KL, Glickson JD. Comparison of the Lonidamine Potentiated Effect of Nitrogen Mustard Alkylating Agents on the Systemic Treatment of DB-1 Human Melanoma Xenografts in Mice. PLoS One. 2016; 11(6):e0157125. PMID: 27285585.
      View in: PubMed
    6. Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1; 473(7):929-36. PMID: 26831515.
      View in: PubMed
    7. Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD. Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. J Biol Chem. 2016 Mar 4; 291(10):5157-71. PMID: 26703469.
      View in: PubMed
    8. Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1; 291(1):42-57. PMID: 26521302.
      View in: PubMed
    9. Nath K, Nelson DS, Heitjan DF, Zhou R, Leeper DB, Glickson JD. Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan. NMR Biomed. 2015 Mar; 28(3):395-403. PMID: 25702942.
      View in: PubMed
    10. Nath K, Nelson DS, Heitjan DF, Leeper DB, Zhou R, Glickson JD. Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin. NMR Biomed. 2015 Mar; 28(3):281-90. PMID: 25504852.
      View in: PubMed
    11. Coss RA, Storck CW, Wells TC, Kulp KA, Wahl M, Leeper DB. Thermal sensitisation by lonidamine of human melanoma cells grown at low extracellular pH. Int J Hyperthermia. 2014 Feb; 30(1):75-8. PMID: 24295212.
      View in: PubMed
    12. Nath K, Nelson DS, Ho AM, Lee SC, Darpolor MM, Pickup S, Zhou R, Heitjan DF, Leeper DB, Glickson JD. (31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR Biomed. 2013 Jan; 26(1):98-105. PMID: 22745015.
      View in: PubMed
    13. Mendoza EE, Pocceschi MG, Kong X, Leeper DB, Caro J, Limesand KH, Burd R. Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pH. Transl Oncol. 2012 Jun; 5(3):208-16. PMID: 22741040.
      View in: PubMed
    14. Li LZ, Zhou R, Leeper DB, Glickson JD. ³¹P-MRS studies of melanoma xenografts with different metastatic potential. Adv Exp Med Biol. 2011; 701:69-73. PMID: 21445771.
      View in: PubMed
    15. Li LZ, Zhou R, Xu HN, Moon L, Zhong T, Kim EJ, Qiao H, Reddy R, Leeper D, Chance B, Glickson JD. Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6608-13. PMID: 19366661.
      View in: PubMed
    16. Sugahara T, van der Zee J, Kampinga HH, Vujaskovic Z, Kondo M, Ohnishi T, Li G, Park HJ, Leeper DB, Ostapenko V, Repasky EA, Watanabe M, Song CW. Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report. Int J Hyperthermia. 2008 Mar; 24(2):123-40. PMID: 18283589.
      View in: PubMed
    17. Li LZ, Zhou R, Zhong T, Moon L, Kim EJ, Qiao H, Pickup S, Hendrix MJ, Leeper D, Chance B, Glickson JD. Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Adv Exp Med Biol. 2007; 599:67-78. PMID: 17727249.
      View in: PubMed
    18. Biaglow J, Dewhirst M, Leeper D, Burd R, Tuttle S. Factors controlling oxygen utilization. Adv Exp Med Biol. 2005; 566:317-23. PMID: 16594168.
      View in: PubMed
    19. Canter RJ, Zhou R, Kesmodel SB, Zhang Y, Heitjan DF, Glickson JD, Leeper DB, Fraker DL. Metaiodobenzylguanidine and hyperglycemia augment tumor response to isolated limb perfusion in a rodent model of human melanoma. Ann Surg Oncol. 2004 Mar; 11(3):265-73. PMID: 14993021.
      View in: PubMed
    20. Burd R, Lavorgna SN, Daskalakis C, Wachsberger PR, Wahl ML, Biaglow JE, Stevens CW, Leeper DB. Tumor oxygenation and acidification are increased in melanoma xenografts after exposure to hyperglycemia and meta-iodo-benzylguanidine. Radiat Res. 2003 Mar; 159(3):328-35. PMID: 12600235.
      View in: PubMed
    21. Lee I, Glickson JD, Dewhirst MW, Leeper DB, Burd R, Poptani H, Nadal L, McKenna WG, Biaglow JE. Effect of mild hyperglycemia +/- meta-iodo-benzylguanidine on the radiation response of R3230 Ac tumors. Adv Exp Med Biol. 2003; 530:177-86. PMID: 14562715.
      View in: PubMed
    22. Wahl ML, Owen JA, Burd R, Herlands RA, Nogami SS, Rodeck U, Berd D, Leeper DB, Owen CS. Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther. 2002 Jun; 1(8):617-28. PMID: 12479222.
      View in: PubMed
    23. Guan J, Stavridi E, Leeper DB, Iliakis G. Effects of hyperthermia on p53 protein expression and activity. J Cell Physiol. 2002 Mar; 190(3):365-74. PMID: 11857452.
      View in: PubMed
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