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Glenn Radice

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1020 Locust St.
Philadelphia PA 19107
Phone215-503-5157
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    R01HL057554     (RADICE, GLENN LAWRENCE)Aug 1, 1997 - Jul 31, 2003
    NIH/NHLBI
    CELL ADHESION AND REGULATION OF CARDIAC MYOCYTE FUNCTION
    Role: Principal Investigator

    R21CA087261     (RADICE, GLENN LAWRENCE)Aug 8, 2000 - Jul 31, 2003
    NIH/NCI
    CAP CELL DERIVED TUMORS--MODEL OF INVASIVE BREAST CANCER
    Role: Principal Investigator

    R01DK062748     (RADICE, GLENN LAWRENCE)Sep 30, 2002 - Jun 30, 2007
    NIH/NIDDK
    CADHERIN-MEDIATED ADHESION AND PANCREATIC DEVELOPMENT
    Role: Principal Investigator

    R01HL081569     (RADICE, GLENN LAWRENCE)Feb 15, 2007 - Oct 31, 2012
    NIH/NHLBI
    Cadherin/Catenin Function in Arrhythmogenesis
    Role: Principal Investigator

    R21CA133609     (RADICE, GLENN LAWRENCE)Jan 1, 2009 - Dec 31, 2010
    NIH/NCI
    The Role of N-cadherin in Tumor Progresion
    Role: Principal Investigator

    R21HL111788     (RADICE, GLENN LAWRENCE)Jul 15, 2012 - Jun 30, 2014
    NIH/NHLBI
    Role of the cytoskeleton in cardiac regeneration
    Role: Principal Investigator

    R21CA176097     (RADICE, GLENN LAWRENCE)Dec 1, 2013 - Nov 30, 2015
    NIH/NCI
    N-cadherin and Metastatic Dissemination
    Role: Principal Investigator

    R56HL125988     (RADICE, GLENN LAWRENCE)Sep 1, 2015 - Aug 31, 2016
    NIH/NHLBI
    Alpha-Catenins in Mechanochemical Signaling
    Role: Principal Investigator

    R01HL138493     (RADICE, GLENN LAWRENCE)Apr 1, 2018 - Mar 31, 2022
    NIH/NHLBI
    Mechanotransduction in Heart Development and Regeneration
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vite A, Zhang C, Yi R, Emms S, Radice GL. a-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development. 2018 03 08; 145(5). PMID: 29467248.
      View in: PubMed
    2. Goel AJ, Rieder MK, Arnold HH, Radice GL, Krauss RS. Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells. Cell Rep. 2017 Nov 21; 21(8):2236-2250. PMID: 29166613.
      View in: PubMed
    3. Logan CM, Rajakaruna S, Bowen C, Radice GL, Robinson ML, Menko AS. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017 May 26. PMID: 28552735.
      View in: PubMed
    4. Mui KL, Bae YH, Gao L, Liu SL, Xu T, Radice GL, Chen CS, Assoian RK. N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells. Cell Rep. 2015 Mar 4. PMID: 25753414.
      View in: PubMed
    5. Vite A, Li J, Radice GL. New functions for alpha-catenins in health and disease: from cancer to heart regeneration. Cell Tissue Res. 2015 Jun; 360(3):773-83. PMID: 25673211.
      View in: PubMed
    6. Li J, Gao E, Vite A, Yi R, Gomez L, Goossens S, van Roy F, Radice GL. Alpha-catenins control cardiomyocyte proliferation by regulating yap activity. Circ Res. 2015 Jan 2; 116(1):70-9. PMID: 25305307.
      View in: PubMed
    7. Vite A, Radice GL. N-cadherin/catenin complex as a master regulator of intercalated disc function. Cell Commun Adhes. 2014 Jun; 21(3):169-79. PMID: 24766605.
      View in: PubMed
    8. Lanza-Jacoby S, Yan G, Radice G, Lephong C, Baliff J, Hess R. Calorie restriction delays the progression of lesions to pancreatic cancer in the LSL-KrasG12D; Pdx-1/Cre mouse model of pancreatic cancer. Exp Biol Med (Maywood). 2013 Jul 1; 238(7):787-97. PMID: 23828595.
      View in: PubMed
    9. Radice GL. N-cadherin-mediated adhesion and signaling from development to disease: lessons from mice. Prog Mol Biol Transl Sci. 2013; 116:263-89. PMID: 23481199.
      View in: PubMed
    10. Swope D, Li J, Radice GL. Beyond cell adhesion: The role of armadillo proteins in the heart. Cell Signal. 2013 Jan; 25(1):93-100. PMID: 23022961.
      View in: PubMed
    11. Swope D, Li J, Muller EJ, Radice GL. Analysis of a Jup hypomorphic allele reveals a critical threshold for postnatal viability. Genesis. 2012 Oct; 50(10):717-27. PMID: 22522917.
      View in: PubMed
    12. Li J, Goossens S, van Hengel J, Gao E, Cheng L, Tyberghein K, Shang X, De Rycke R, van Roy F, Radice GL. Loss of aT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci. 2012 Feb 15; 125(Pt 4):1058-67. PMID: 22421363.
      View in: PubMed
    13. Broders-Bondon F, Paul-Gilloteaux P, Carlier C, Radice GL, Dufour S. N-cadherin and ß1-integrins cooperate during the development of the enteric nervous system. Dev Biol. 2012 Apr 15; 364(2):178-91. PMID: 22342243.
      View in: PubMed
    14. Swope D, Cheng L, Gao E, Li J, Radice GL. Loss of cadherin-binding proteins ß-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis. Mol Cell Biol. 2012 Mar; 32(6):1056-67. PMID: 22252313.
      View in: PubMed
    15. Su Y, Li J, Witkiewicz AK, Brennan D, Neill T, Talarico J, Radice GL. N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer. Oncogene. 2012 Oct 11; 31(41):4484-9. PMID: 22158044.
      View in: PubMed
    16. Piven OO, Kostetskii IE, Macewicz LL, Kolomiets YM, Radice GL, Lukash LL. Requirement for N-cadherin-catenin complex in heart development. Exp Biol Med (Maywood). 2011 Jul 1; 236(7):816-22. PMID: 21680756.
      View in: PubMed
    17. Cheng L, Yung A, Covarrubias M, Radice GL. Cortactin is required for N-cadherin regulation of Kv1.5 channel function. J Biol Chem. 2011 Jun 10; 286(23):20478-89. PMID: 21507952.
      View in: PubMed
    18. Li J, Swope D, Raess N, Cheng L, Muller EJ, Radice GL. Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol. 2011 Mar; 31(6):1134-44. PMID: 21245375.
      View in: PubMed
    19. Bozdagi O, Wang XB, Nikitczuk JS, Anderson TR, Bloss EB, Radice GL, Zhou Q, Benson DL, Huntley GW. Persistence of coordinated long-term potentiation and dendritic spine enlargement at mature hippocampal CA1 synapses requires N-cadherin. J Neurosci. 2010 Jul 28; 30(30):9984-9. PMID: 20668183.
      View in: PubMed
    20. Di Benedetto A, Watkins M, Grimston S, Salazar V, Donsante C, Mbalaviele G, Radice GL, Civitelli R. N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms. J Cell Sci. 2010 Aug 1; 123(Pt 15):2640-8. PMID: 20605916.
      View in: PubMed
    21. Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H. N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover. Genesis. 2010 Jun; 48(6):374-81. PMID: 20533404.
      View in: PubMed
    22. Li J, Radice GL. A new perspective on intercalated disc organization: implications for heart disease. Dermatol Res Pract. 2010; 2010:207835. PMID: 20585598.
      View in: PubMed
    23. Hamad EA, Li X, Song J, Zhang XQ, Myers V, Funakoshi H, Zhang J, Wang J, Li J, Swope D, Madonick A, Farber J, Radice GL, Cheung JY, Chan TO, Feldman AM. Effects of cardiac-restricted overexpression of the A(2A) adenosine receptor on adriamycin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1738-47. PMID: 20363887.
      View in: PubMed
    24. Smith AN, Radice G, Lang RA. Which FGF ligands are involved in lens induction? Dev Biol. 2010 Jan 15; 337(2):195-8. PMID: 19913010.
      View in: PubMed
    25. Stepniak E, Radice GL, Vasioukhin V. Adhesive and signaling functions of cadherins and catenins in vertebrate development. Cold Spring Harb Perspect Biol. 2009 Nov; 1(5):a002949. PMID: 20066120.
      View in: PubMed
    26. Smith AN, Miller LA, Radice G, Ashery-Padan R, Lang RA. Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Development. 2009 Sep; 136(17):2977-85. PMID: 19666824.
      View in: PubMed
    27. Kiel MJ, Acar M, Radice GL, Morrison SJ. Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. Cell Stem Cell. 2009 Feb 6; 4(2):170-9. PMID: 19119091.
      View in: PubMed
    28. Pontoriero GF, Smith AN, Miller LA, Radice GL, West-Mays JA, Lang RA. Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Dev Biol. 2009 Feb 15; 326(2):403-17. PMID: 18996109.
      View in: PubMed
    29. Salvador LM, Silva CP, Kostetskii I, Radice GL, Strauss JF. The promoter of the oocyte-specific gene, Gdf9, is active in population of cultured mouse embryonic stem cells with an oocyte-like phenotype. Methods. 2008 Jun; 45(2):172-81. PMID: 18593614.
      View in: PubMed
    30. Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. Cell Stem Cell. 2008 Apr 10; 2(4):367-79. PMID: 18397756.
      View in: PubMed
    31. Li J, Levin MD, Xiong Y, Petrenko N, Patel VV, Radice GL. N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility. J Mol Cell Cardiol. 2008 Mar; 44(3):597-606. PMID: 18201716.
      View in: PubMed
    32. Kiel MJ, Radice GL, Morrison SJ. Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell. 2007 Aug 16; 1(2):204-17. PMID: 18371351.
      View in: PubMed
    33. Kadowaki M, Nakamura S, Machon O, Krauss S, Radice GL, Takeichi M. N-cadherin mediates cortical organization in the mouse brain. Dev Biol. 2007 Apr 1; 304(1):22-33. PMID: 17222817.
      View in: PubMed
    34. Lai CF, Cheng SL, Mbalaviele G, Donsante C, Watkins M, Radice GL, Civitelli R. Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice. J Bone Miner Res. 2006 Dec; 21(12):1897-906. PMID: 17002573.
      View in: PubMed
    35. Luo Y, High FA, Epstein JA, Radice GL. N-cadherin is required for neural crest remodeling of the cardiac outflow tract. Dev Biol. 2006 Nov 15; 299(2):517-28. PMID: 17014840.
      View in: PubMed
    36. Li J, Patel VV, Radice GL. Dysregulation of cell adhesion proteins and cardiac arrhythmogenesis. Clin Med Res. 2006 Mar; 4(1):42-52. PMID: 16595792.
      View in: PubMed
    37. Zhang Z, Kostetskii I, Tang W, Haig-Ladewig L, Sapiro R, Wei Z, Patel AM, Bennett J, Gerton GL, Moss SB, Radice GL, Strauss JF. Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Biol Reprod. 2006 Apr; 74(4):751-9. PMID: 16382026.
      View in: PubMed
    38. Li J, Patel VV, Kostetskii I, Xiong Y, Chu AF, Jacobson JT, Yu C, Morley GE, Molkentin JD, Radice GL. Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ Res. 2005 Sep 2; 97(5):474-81. PMID: 16100040.
      View in: PubMed
    39. Luo Y, Radice GL. N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J Cell Biol. 2005 Apr 11; 169(1):29-34. PMID: 15809310.
      View in: PubMed
    40. Edsbagge J, Johansson JK, Esni F, Luo Y, Radice GL, Semb H. Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. Development. 2005 Mar; 132(5):1085-92. PMID: 15689381.
      View in: PubMed
    41. Luo Y, Kostetskii I, Radice GL. N-cadherin is not essential for limb mesenchymal chondrogenesis. Dev Dyn. 2005 Feb; 232(2):336-44. PMID: 15614770.
      View in: PubMed
    42. Kostetskii I, Li J, Xiong Y, Zhou R, Ferrari VA, Patel VV, Molkentin JD, Radice GL. Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res. 2005 Feb 18; 96(3):346-54. PMID: 15662031.
      View in: PubMed
    43. Zhang Z, Kostetskii I, Moss SB, Jones BH, Ho C, Wang H, Kishida T, Gerton GL, Radice GL, Strauss JF. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12946-51. PMID: 15328412.
      View in: PubMed
    44. Kishida T, Kostetskii I, Zhang Z, Martinez F, Liu P, Walkley SU, Dwyer NK, Blanchette-Mackie EJ, Radice GL, Strauss JF. Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem. 2004 Apr 30; 279(18):19276-85. PMID: 14963026.
      View in: PubMed
    45. Luo Y, Lee A, Shen H, Radice GL. Altering tissue tropism of Listeria monocytogenes by ectopically expressing human E-cadherin in transgenic mice. Microb Pathog. 2003 Aug; 35(2):57-62. PMID: 12901844.
      View in: PubMed
    46. Radice GL, Sauer CL, Kostetskii I, Peralta Soler A, Knudsen KA. Inappropriate P-cadherin expression in the mouse mammary epithelium is compatible with normal mammary gland function. Differentiation. 2003 Aug; 71(6):361-73. PMID: 12919105.
      View in: PubMed
    47. Luo Y, Radice GL. Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus. J Cell Sci. 2003 Apr 15; 116(Pt 8):1471-9. PMID: 12640032.
      View in: PubMed
    48. Sapiro R, Kostetskii I, Olds-Clarke P, Gerton GL, Radice GL, Strauss III JF. Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6. Mol Cell Biol. 2002 Sep; 22(17):6298-305. PMID: 12167721.
      View in: PubMed
    49. Ferreira-Cornwell MC, Luo Y, Narula N, Lenox JM, Lieberman M, Radice GL. Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart. J Cell Sci. 2002 Apr 15; 115(Pt 8):1623-34. PMID: 11950881.
      View in: PubMed
    50. Dahl U, Sjödin A, Larue L, Radice GL, Cajander S, Takeichi M, Kemler R, Semb H. Genetic dissection of cadherin function during nephrogenesis. Mol Cell Biol. 2002 Mar; 22(5):1474-87. PMID: 11839813.
      View in: PubMed
    51. Esni F, Johansson BR, Radice GL, Semb H. Dorsal pancreas agenesis in N-cadherin- deficient mice. Dev Biol. 2001 Oct 1; 238(1):202-12. PMID: 11784004.
      View in: PubMed
    52. Xu X, Li WE, Huang GY, Meyer R, Chen T, Luo Y, Thomas MP, Radice GL, Lo CW. Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. J Cell Biol. 2001 Jul 9; 154(1):217-30. PMID: 11449002.
      View in: PubMed
    53. Kostetskii I, Moore R, Kemler R, Radice GL. Differential adhesion leads to segregation and exclusion of N-cadherin-deficient cells in chimeric embryos. Dev Biol. 2001 Jun 1; 234(1):72-9. PMID: 11356020.
      View in: PubMed
    54. Luo Y, Ferreira-Cornwell M, Baldwin H, Kostetskii I, Lenox J, Lieberman M, Radice G. Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin. Development. 2001 Feb; 128(4):459-69. PMID: 11171330.
      View in: PubMed
    55. Xu X, Li WE, Huang GY, Meyer R, Chen T, Luo Y, Thomas MP, Radice GL, Lo CW. N-cadherin and Cx43alpha1 gap junctions modulates mouse neural crest cell motility via distinct pathways. Cell Commun Adhes. 2001; 8(4-6):321-4. PMID: 12064611.
      View in: PubMed
    56. Lenox JM, Koch PJ, Mahoney MG, Lieberman M, Stanley JR, Radice GL. Postnatal lethality of P-cadherin/desmoglein 3 double knockout mice: demonstration of a cooperative effect of these cell adhesion molecules in tissue homeostasis of stratified squamous epithelia. J Invest Dermatol. 2000 May; 114(5):948-52. PMID: 10771476.
      View in: PubMed
    57. Horikawa K, Radice G, Takeichi M, Chisaka O. Adhesive subdivisions intrinsic to the epithelial somites. Dev Biol. 1999 Nov 15; 215(2):182-9. PMID: 10545229.
      View in: PubMed
    58. Moore R, Radice GL, Dominis M, Kemler R. The generation and in vivo differentiation of murine embryonal stem cells genetically null for either N-cadherin or N- and P-cadherin. Int J Dev Biol. 1999 Nov; 43(8):831-4. PMID: 10707907.
      View in: PubMed
    59. Radice GL. Mouse chromosome 18. Mamm Genome. 1999 Oct; 10(10):959. PMID: 10501960.
      View in: PubMed
    60. Makrigiannakis A, Coukos G, Christofidou-Solomidou M, Gour BJ, Radice GL, Blaschuk O, Coutifaris C. N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis? Am J Pathol. 1999 May; 154(5):1391-406. PMID: 10329592.
      View in: PubMed
    61. Linask KK, Ludwig C, Han MD, Liu X, Radice GL, Knudsen KA. N-cadherin/catenin-mediated morphoregulation of somite formation. Dev Biol. 1998 Oct 1; 202(1):85-102. PMID: 9758705.
      View in: PubMed
    62. Radice GL, Ferreira-Cornwell MC, Robinson SD, Rayburn H, Chodosh LA, Takeichi M, Hynes RO. Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol. 1997 Nov 17; 139(4):1025-32. PMID: 9362520.
      View in: PubMed
    63. Charlton CA, Mohler WA, Radice GL, Hynes RO, Blau HM. Fusion competence of myoblasts rendered genetically null for N-cadherin in culture. J Cell Biol. 1997 Jul 28; 138(2):331-6. PMID: 9230075.
      View in: PubMed
    64. Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO. Developmental defects in mouse embryos lacking N-cadherin. Dev Biol. 1997 Jan 1; 181(1):64-78. PMID: 9015265.
      View in: PubMed
    65. Griffith AJ, Radice GL, Burgess DL, Kohrman DC, Hansen GM, Justice MJ, Johnson KR, Davisson MT, Meisler MH. Location of the 9257 and ataxia mutations on mouse chromosome 18. Mamm Genome. 1996 Jun; 7(6):417-9. PMID: 8662222.
      View in: PubMed
    66. Lee JJ, Radice G, Perkins CP, Costantini F. Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. Development. 1992 May; 115(1):277-88. PMID: 1638986.
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    67. Radice G, Lee JJ, Costantini F. H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Development. 1991 Mar; 111(3):801-11. PMID: 1879343.
      View in: PubMed
    68. Costantini F, Radice G, Lee JL, Chada KK, Perry W, Son HJ. Insertional mutations in transgenic mice. Prog Nucleic Acid Res Mol Biol. 1989; 36:159-69. PMID: 2544006.
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    69. Radice G, Costantini F. Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice. Nucleic Acids Res. 1986 Dec 22; 14(24):9765-80. PMID: 3808955.
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    70. Chada K, Magram J, Raphael K, Radice G, Lacy E, Costantini F. Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature. 1985 Mar 28-Apr 3; 314(6009):377-80. PMID: 3982505.
      View in: PubMed
    71. Costantini F, Radice G, Magram J, Stamatoyannopoulos G, Papayannopoulou T, Chada K. Developmental regulation of human globin genes in transgenic mice. Cold Spring Harb Symp Quant Biol. 1985; 50:361-70. PMID: 3868484.
      View in: PubMed
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