Hwyda Arafat

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentSurgery
Address1025 Walnut St.
Philadelphia PA 19107
Phone215-593-5565
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    Collapse Overview 
    Collapse overview
    Islet Transplantation
    Osteopontin-Integrin interaction in the pancreas
    Pancreatic renin angiotensin system
    Pancreatic Cancer


    Collapse Research 
    Collapse research activities and funding
    R21CA133753     (ARAFAT, HWYDA A)Apr 1, 2008 - Mar 31, 2011
    NIH
    Nicotine in Pancreatic Cancer: Molecular Mechanisms
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Relles D, Chipitsyna GI, Gong Q, Yeo CJ, Arafat HA. Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation. Adv Prev Med. 2016; 2016:1407840. PMID: 28105374.
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    2. Sarosiek K, Gandhi AV, Saxena S, Kang CY, Chipitsyna GI, Yeo CJ, Arafat HA. Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations. J Thyroid Res. 2016; 2016:2454989. PMID: 27123358.
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    3. Sarosiek K, Pappan KL, Gandhi AV, Saxena S, Kang CY, McMahon H, Chipitsyna GI, Tichansky DS, Arafat HA. Conserved Metabolic Changes in Nondiabetic and Type 2 Diabetic Bariatric Surgery Patients: Global Metabolomic Pilot Study. J Diabetes Res. 2016; 2016:3467403. PMID: 26881244.
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    4. Sarosiek K, Jones E, Chipitsyna G, Al-Zoubi M, Kang C, Saxena S, Gandhi AV, Sendiky J, Yeo CJ, Arafat HA. Osteopontin (OPN) Isoforms, Diabetes, Obesity, and Cancer; What Is One Got to Do with the Other? A New Role for OPN. J Gastrointest Surg. 2015 Apr; 19(4):639-50. PMID: 25583441.
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    5. Gulla A, Evans BJ, Navenot JM, Pundzius J, Barauskas G, Gulbinas A, Dambrauskas Z, Arafat H, Wang ZX. Heme oxygenase-1 gene promoter polymorphism is associated with the development of necrotizing acute pancreatitis. Pancreas. 2014 Nov; 43(8):1271-6. PMID: 25036905.
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    6. Siddiqui AA, Jones E, Andrade D, Shah A, Kowalski TE, Loren DE, Chipitsyna G, Arafat HA. Osteopontin splice variant as a potential marker for metastatic disease in pancreatic adenocarcinoma. J Gastroenterol Hepatol. 2014 Jun; 29(6):1321-7. PMID: 24548099.
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    7. Al-Zoubi M, Chipitsyna G, Saxena S, Sarosiek K, Gandhi A, Kang CY, Relles D, Andrelsendecki J, Hyslop T, Yeo CJ, Arafat HA. Overexpressing TNF-Alpha in Pancreatic Ductal Adenocarcinoma Cells and Fibroblasts Modifies Cell Survival and Reduces Fatty Acid Synthesis via Downregulation of Sterol Regulatory Element Binding Protein-1 and Activation of Acetyl CoA Carboxylase. J Gastrointest Surg. 2014 Feb; 18(2):257-68. PMID: 24091913.
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    8. Kang CY, Wang J, Axell-House D, Soni P, Chu ML, Chipitsyna G, Sarosiek K, Sendecki J, Hyslop T, Al-Zoubi M, Yeo CJ, Arafat HA. Clinical Significance of Serum COL6A3 in Pancreatic Ductal Adenocarcinoma. J Gastrointest Surg. 2014 Jan; 18(1):7-15. PMID: 24002763.
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    9. Gandhi AV, Saxena S, Relles D, Sarosiek K, Kang CY, Chipitsyna G, Andrel Sendecki J, Yeo CJ, Arafat HA. Differential Expression of Cytochrome P450 Omega-hydroxylase Isoforms and Their Association with Clinicopathological Features in Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2013 Dec; 20 Suppl 3:636-43. PMID: 23846787.
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    10. Saxena S, Gandhi A, Lim PW, Relles D, Sarosiek K, Kang C, Chipitsyna G, Sendecki J, Yeo CJ, Arafat HA. RAN GTPase and Osteopontin in Pancreatic Cancer. Pancreat Disord Ther. 2013 Apr 1; 3(1):113. PMID: 24749004.
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    11. Relles D, Sendecki J, Chipitsyna G, Hyslop T, Yeo CJ, Arafat HA. Circadian gene expression and clinicopathologic correlates in pancreatic cancer. J Gastrointest Surg. 2013 Mar; 17(3):443-50. PMID: 23254314.
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    12. Al-Zoubi M, Salem AF, Martinez-Outschoorn UE, Whitaker-Menezes D, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Arafat H, Bevilacqua G, Sotgia F, Lisanti MP. Creating a tumor-resistant microenvironment: Cell-mediated delivery of TNFa completely prevents breast cancer tumor formation in vivo. Cell Cycle. 2013 Feb 1; 12(3):480-90. PMID: 23292149.
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    13. Salem AF, Bonuccelli G, Bevilacqua G, Arafat H, Pestell RG, Sotgia F, Lisanti MP. Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle. 2011 Nov 1; 10(21):3692-700. PMID: 22041584.
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    14. Sullivan J, Gong Q, Hyslop T, Lavu H, Chipitsyna G, Yeo CJ, Arafat HA. Serum monocyte chemoattractant protein-1 in pancreatic cancer. J Oncol. 2011; 2011:518394. PMID: 21977031.
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    15. McGhee A, Sivarajah M, Gong Q, Lim S, Chipitsyna G, Yeo CJ, Arafat HA. Angiotensin II type 2 receptor blockade inhibits fatty acid synthase production through activation of AMP-activated protein kinase in pancreatic cancer cells. Surgery. 2011 Aug; 150(2):284-98. PMID: 21801966.
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    16. Sullivan J, Blair L, Alnajar A, Aziz T, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. Expression and regulation of nicotine receptor and osteopontin isoforms in human pancreatic ductal adenocarcinoma. Histol Histopathol. 2011 Jul; 26(7):893-904. PMID: 21630219.
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    17. Arafat H, Lazar M, Salem K, Chipitsyna G, Gong Q, Pan TC, Zhang RZ, Yeo CJ, Chu ML. Tumor-specific expression and alternative splicing of the COL6A3 gene in pancreatic cancer. Surgery. 2011 Aug; 150(2):306-15. PMID: 21719059.
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    18. Lazar M, Sullivan J, Chipitsyna G, Gong Q, Ng CY, Salem AF, Aziz T, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA. Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells. J Gastrointest Surg. 2010 Oct; 14(10):1566-77. PMID: 20824368.
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    19. Gong Q, Davis M, Chipitsyna G, Yeo CJ, Arafat HA. Blocking angiotensin II Type 1 receptor triggers apoptotic cell death in human pancreatic cancer cells. Pancreas. 2010 Jul; 39(5):581-94. PMID: 20118823.
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    20. Lazar M, Sullivan J, Chipitsyna G, Aziz T, Salem AF, Gong Q, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA. Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin. Surgery. 2010 Aug; 148(2):298-309. PMID: 20579680.
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    21. Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK. Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol Cancer Ther. 2010 May; 9(5):1419-31. PMID: 20423995.
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    22. Chehl N, Gong Q, Chipitsyna G, Aziz T, Yeo CJ, Arafat HA. Angiotensin II regulates the expression of monocyte chemoattractant protein-1 in pancreatic cancer cells. J Gastrointest Surg. 2009 Dec; 13(12):2189-200. PMID: 19816747.
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    23. Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. Surgery. 2009 Aug; 146(2):232-40. PMID: 19628079.
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    24. Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford). 2009 Aug; 11(5):373-81. PMID: 19768141.
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    25. Chipitsyna G, Gong Q, Anandanadesan R, Alnajar A, Batra SK, Wittel UA, Cullen DM, Akhter MP, Denhardt DT, Yeo CJ, Arafat HA. Induction of osteopontin expression by nicotine and cigarette smoke in the pancreas and pancreatic ductal adenocarcinoma cells. Int J Cancer. 2009 Jul 15; 125(2):276-85. PMID: 19358273.
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    26. Gong Q, Chipitsyna G, Gray CF, Anandanadesan R, Arafat HA. Expression and regulation of osteopontin in type 1 diabetes. Islets. 2009 Jul-Aug; 1(1):34-41. PMID: 21084847.
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    27. Anandanadesan R, Gong Q, Chipitsyna G, Witkiewicz A, Yeo CJ, Arafat HA. Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling. J Gastrointest Surg. 2008 Jan; 12(1):57-66. PMID: 18026817.
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    28. Arafat HA, Gong Q, Chipitsyna G, Rizvi A, Saa CT, Yeo CJ. Antihypertensives as novel antineoplastics: angiotensin-I-converting enzyme inhibitors and angiotensin II type 1 receptor blockers in pancreatic ductal adenocarcinoma. J Am Coll Surg. 2007 May; 204(5):996-1005; discussion 1005-6. PMID: 17481528.
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    29. Chipitsyna G, Gong Q, Gray CF, Haroon Y, Kamer E, Arafat HA. Induction of monocyte chemoattractant protein-1 expression by angiotensin II in the pancreatic islets and beta-cells. Endocrinology. 2007 May; 148(5):2198-208. PMID: 17303665.
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    30. Arafat HA, Katakam AK, Chipitsyna G, Gong Q, Vancha AR, Gabbeta J, Dafoe DC. Osteopontin protects the islets and beta-cells from interleukin-1 beta-mediated cytotoxicity through negative feedback regulation of nitric oxide. Endocrinology. 2007 Feb; 148(2):575-84. PMID: 17110428.
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    31. Timmapuri SJ, Otterburn DM, Arafat H, Schwartz MZ. Hepatocyte growth factor increases glucagon immunoreactivity in jejunal cells during intestinal adaptation. J Pediatr Surg. 2006 Jan; 41(1):150-4; discussion 150-4. PMID: 16410125.
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    32. Mazurek T, Zhang L, Zalewski A, Mannion JD, Diehl JT, Arafat H, Sarov-Blat L, O'Brien S, Keiper EA, Johnson AG, Martin J, Goldstein BJ, Shi Y. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation. 2003 Nov 18; 108(20):2460-6. PMID: 14581396.
      Citations:    
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