Hideko Kaji

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address1020 Locust St.
Philadelphia PA 19107
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    Laboratory Staff
    Postdoctoral fellows:
    1) Dr. Nobuhiro Iwakura, Ph.D. He received his Ph.D in microbiology at Niigata School of Medicine, Japan under the guidance of Professor Tatsuo Yamamoto in 2005. He joined our laboratory right after his Ph.D and has been with us since. He works on prokaryotic ribosome recycling system. He has made important contributions and they are listed in the list of academic report of CV of Hideko Kaji.
    2) Dr. Shinya Kurata, Ph.D He received his Ph.D in biochemistry and molecular biology at School of Engineering , Tokyo University, Japan under the guidance of Professor Tsutomu Suzuki in 2007. He joined our laboratory right after his Ph.D and has been with us since. He discovered that ribosome recycling in yeast is catalyzed by elongation factor 3 and ATP. This seminal discovery was reported in Proc. Nat. Acad. Sci (June 2010). He is continuing studies on the eukaryotic ribosome recycling.

    Medical Students:
    1) Andrew Baron; He is a second year Jefferson Medical College student and works as a work study student. His work is related to both eukaryotic and prokaryotic ribosome recycling.
    2) Tomoya Inukai: He is a fourth year Medical Student of Niigata School of Medicine (the Japanese Medical School takes students from high school and educate them for total of six years). He is a part time student who works on eukaryotic ribosome recycling system together with Dr. Shinya Kurata.
    3) Sohei Abe: He is a fourth year Medical Student of Niigata School of Medicine. He is a part time student who works on prokaryotic ribosome recycling system in prokaryotes. He collaborates with Dr. Nobuhiro Iwakura.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen Y, Kaji A, Kaji H, Cooperman BS. The kinetic mechanism of bacterial ribosome recycling. Nucleic Acids Res. 2017 Sep 29; 45(17):10168-10177. PMID: 28973468.
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    2. Iwakura N, Yokoyama T, Quaglia F, Mitsuoka K, Mio K, Shigematsu H, Shirouzu M, Kaji A, Kaji H. Chemical and structural characterization of a model Post-Termination Complex (PoTC) for the ribosome recycling reaction: Evidence for the release of the mRNA by RRF and EF-G. PLoS One. 2017; 12(5):e0177972. PMID: 28542628.
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    3. Kaji H, Kaji A. Recollection of How We Came Across the Protein Modification with Amino Acids by Aminoacyl tRNA-Protein Transferase. Methods Mol Biol. 2015; 1337:13-8. PMID: 26285875.
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    4. Kaji H, Kaji A. Correlated Measurement of Endogenous ATE1 Activity on Native Acceptor Proteins in Tissues and Cultured Cells to Detect Cellular Aging. Methods Mol Biol. 2015; 1337:39-48. PMID: 26285879.
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    5. Kurata S, Shen B, Liu JO, Takeuchi N, Kaji A, Kaji H. Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors. Nucleic Acids Res. 2013 Jan 7; 41(1):264-76. PMID: 23087377.
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    6. Kaji H, Kaji A. Global cellular regulation including cardiac function by post-translational protein arginylation. J Mol Cell Cardiol. 2012 Sep; 53(3):314-6. PMID: 22749823.
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    7. Yokoyama T, Shaikh TR, Iwakura N, Kaji H, Kaji A, Agrawal RK. Structural insights into initial and intermediate steps of the ribosome-recycling process. EMBO J. 2012 Apr 4; 31(7):1836-46. PMID: 22388519.
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    8. Vivanco-Domínguez S, Bueno-Martínez J, León-Avila G, Iwakura N, Kaji A, Kaji H, Guarneros G. Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons. J Mol Biol. 2012 Apr 13; 417(5):425-39. PMID: 22326347.
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    9. Kaji H, Kaji A. Protein modification by arginylation. Chem Biol. 2011 Jan 28; 18(1):6-7. PMID: 21276933.
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    10. Kurata S, Nielsen KH, Mitchell SF, Lorsch JR, Kaji A, Kaji H. Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10854-9. PMID: 20534490.
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    11. Hirokawa G, Iwakura N, Kaji A, Kaji H. The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G). Nucleic Acids Res. 2008 Dec; 36(21):6676-87. PMID: 18948280.
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    12. Pai RD, Zhang W, Schuwirth BS, Hirokawa G, Kaji H, Kaji A, Cate JH. Structural Insights into ribosome recycling factor interactions with the 70S ribosome. J Mol Biol. 2008 Mar 7; 376(5):1334-47. PMID: 18234219.
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    13. Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate JH. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug; 14(8):727-32. PMID: 17660832.
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    14. Barat C, Datta PP, Raj VS, Sharma MR, Kaji H, Kaji A, Agrawal RK. Progression of the ribosome recycling factor through the ribosome dissociates the two ribosomal subunits. Mol Cell. 2007 Jul 20; 27(2):250-61. PMID: 17643374.
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    15. Demeshkina N, Hirokawa G, Kaji A, Kaji H. Novel activity of eukaryotic translocase, eEF2: dissociation of the 80S ribosome into subunits with ATP but not with GTP. Nucleic Acids Res. 2007; 35(14):4597-607. PMID: 17586816.
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    16. Kiel MC, Kaji H, Kaji A. Ribosome recycling: An essential process of protein synthesis. Biochem Mol Biol Educ. 2007 Jan; 35(1):40-4. PMID: 21591054.
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    17. Hirokawa G, Kaji H, Kaji A. Inhibition of antiassociation activity of translation initiation factor 3 by paromomycin. Antimicrob Agents Chemother. 2007 Jan; 51(1):175-80. PMID: 17088492.
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    18. Hirokawa G, Demeshkina N, Iwakura N, Kaji H, Kaji A. The ribosome-recycling step: consensus or controversy? Trends Biochem Sci. 2006 Mar; 31(3):143-9. PMID: 16487710.
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    19. Hirokawa G, Nijman RM, Raj VS, Kaji H, Igarashi K, Kaji A. The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits. RNA. 2005 Aug; 11(8):1317-28. PMID: 16043510.
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    20. Raj VS, Kaji H, Kaji A. Interaction of RRF and EF-G from E. coli and T. thermophilus with ribosomes from both origins--insight into the mechanism of the ribosome recycling step. RNA. 2005 Mar; 11(3):275-84. PMID: 15661844.
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    21. Hirokawa G, Inokuchi H, Kaji H, Igarashi K, Kaji A. In vivo effect of inactivation of ribosome recycling factor - fate of ribosomes after unscheduled translation downstream of open reading frame. Mol Microbiol. 2004 Nov; 54(4):1011-21. PMID: 15522083.
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    22. Kaji A, Kaji H. The history of deciphering the genetic code: setting the record straight. Trends Biochem Sci. 2004 Jun; 29(6):293. PMID: 15276182.
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    23. Kiel MC, Raj VS, Kaji H, Kaji A. Release of ribosome-bound ribosome recycling factor by elongation factor G. J Biol Chem. 2003 Nov 28; 278(48):48041-50. PMID: 12960150.
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    24. Teyssier E, Hirokawa G, Tretiakova A, Jameson B, Kaji A, Kaji H. Temperature-sensitive mutation in yeast mitochondrial ribosome recycling factor (RRF). Nucleic Acids Res. 2003 Jul 15; 31(14):4218-26. PMID: 12853640.
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    25. Hirokawa G, Kiel MC, Muto A, Kawai G, Igarashi K, Kaji H, Kaji A. Binding of ribosome recycling factor to ribosomes, comparison with tRNA. J Biol Chem. 2002 Sep 27; 277(39):35847-52. PMID: 12138121.
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    26. Hirokawa G, Kiel MC, Muto A, Selmer M, Raj VS, Liljas A, Igarashi K, Kaji H, Kaji A. Post-termination complex disassembly by ribosome recycling factor, a functional tRNA mimic. EMBO J. 2002 May 1; 21(9):2272-81. PMID: 11980724.
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    27. Zhou N, Luo Z, Luo J, Fan X, Cayabyab M, Hiraoka M, Liu D, Han X, Pesavento J, Dong CZ, Wang Y, An J, Kaji H, Sodroski JG, Huang Z. Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines. J Biol Chem. 2002 May 17; 277(20):17476-85. PMID: 11880384.
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