James Keen

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tsygankova OM, Keen JH. A unique role for clathrin light chain a in cell spreading and migration. J Cell Sci. 2019 Apr 11. PMID: 30975920.
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    2. Singh A, Fedele C, Lu H, Nevalainen MT, Keen JH, Languino LR. Exosome-mediated Transfer of avß3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype. Mol Cancer Res. 2016 Nov; 14(11):1136-1146. PMID: 27439335.
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    3. Steblyanko M, Anikeeva N, Campbell KS, Keen JH, Sykulev Y. Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner. J Biol Chem. 2015 May 8; 290(19):11833-42. PMID: 25778396.
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    4. Chen XL, Chinchilla P, Fombonne J, Ho L, Guix C, Keen JH, Mehlen P, Riobo NA. Patched-1 proapoptotic activity is downregulated by modification of k1413 by the e3 ubiquitin-protein ligase itchy homolog. Mol Cell Biol. 2014 Oct 15; 34(20):3855-66. PMID: 25092867.
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    5. Majeed SR, Vasudevan L, Chen CY, Luo Y, Torres JA, Evans TM, Sharkey A, Foraker AB, Wong NM, Esk C, Freeman TA, Moffett A, Keen JH, Brodsky FM. Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. Nat Commun. 2014; 5:3891. PMID: 24852344.
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    6. Luo Y, Zhan Y, Keen JH. Arf6 regulation of gyrating-clathrin. Traffic. 2013 Jan; 14(1):97-106. PMID: 22998223.
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    7. Parachoniak CA, Luo Y, Abella JV, Keen JH, Park M. GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev Cell. 2011 Jun 14; 20(6):751-63. PMID: 21664574.
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    8. Varma D, Dawn A, Ghosh-Roy A, Weil SJ, Ori-McKenney KM, Zhao Y, Keen J, Vallee RB, Williams JC. Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3493-8. PMID: 20133681.
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    9. Zhao Y, Keen JH. Gyrating clathrin: highly dynamic clathrin structures involved in rapid receptor recycling. Traffic. 2008 Dec; 9(12):2253-64. PMID: 18817526.
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    10. Goodman OB, Barwe SP, Ritter B, McPherson PS, Vasko AJ, Keen JH, Nanus DM, Bander NH, Rajasekaran AK. Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol. 2007 Nov; 31(5):1199-203. PMID: 17912448.
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    11. Zhao Y, Gaidarov I, Keen JH. Phosphoinositide 3-kinase C2alpha links clathrin to microtubule-dependent movement. J Biol Chem. 2007 Jan 12; 282(2):1249-56. PMID: 17110375.
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    12. Warner AK, Keen JH, Wang YL. Dynamics of membrane clathrin-coated structures during cytokinesis. Traffic. 2006 Feb; 7(2):205-15. PMID: 16420528.
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    13. Gaidarov I, Zhao Y, Keen JH. Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. J Biol Chem. 2005 Dec 9; 280(49):40766-72. PMID: 16215232.
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    14. Gaidarov I, Keen JH. Membrane targeting of endocytic adaptors: cargo and lipid do it together. Dev Cell. 2005 Jun; 8(6):801-2. PMID: 15935770.
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    15. Lebedeva T, Anikeeva N, Kalams SA, Walker BD, Gaidarov I, Keen JH, Sykulev Y. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: implications for antigen presentation to cytotoxic T lymphocytes. Immunology. 2004 Dec; 113(4):460-71. PMID: 15554924.
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    16. Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell. 2003 Nov; 5(5):709-22. PMID: 14602072.
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    17. Santini F, Keen JH. A glimpse of coated vesicle creation? Well almost! Nat Cell Biol. 2002 Oct; 4(10):E230-2. PMID: 12360302.
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    18. Santini F, Gaidarov I, Keen JH. G protein-coupled receptor/arrestin3 modulation of the endocytic machinery. J Cell Biol. 2002 Feb 18; 156(4):665-76. PMID: 11839771.
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