Colin Thorpe

TitleProfessor
InstitutionUniversity of Delaware
DepartmentChemistry & Biochemistry
Address160 Academy St.
Newark DE 19716
Phone302-831-2689
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    Other Positions
    TitleWillis Harrington Professor
    InstitutionUniversity of Delaware
    DepartmentChemistry & Biochemistry


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Poole LB, Thorpe C. Redox proteins. Protein Sci. 2019 Jan; 28(1):5-7. PMID: 30461094.
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    2. Yu T, Laird JR, Prescher JA, Thorpe C. Gaussia princeps luciferase: A bioluminescent substrate for oxidative protein folding. Protein Sci. 2018 Apr 26. PMID: 29696739.
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    3. Hudson DA, Caplan JL, Thorpe C. Designing Flavoprotein-GFP Fusion Probes for Analyte-Specific Ratiometric Fluorescence Imaging. Biochemistry. 2018 Feb 20; 57(7):1178-1189. PMID: 29341594.
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    4. Fass D, Thorpe C. Chemistry and Enzymology of Disulfide Cross-Linking in Proteins. Chem Rev. 2017 Jul 12. PMID: 28699750.
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    5. Foster CK, Thorpe C. Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide Isomerase. Free Radic Biol Med. 2017 Jul; 108:741-749. PMID: 28465261.
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    6. Zhang H, Trout WS, Liu S, Andrade GA, Hudson DA, Scinto SL, Dicker KT, Li Y, Lazouski N, Rosenthal J, Thorpe C, Jia X, Fox JM. Rapid Bioorthogonal Chemistry Turn-on through Enzymatic or Long Wavelength Photocatalytic Activation of Tetrazine Ligation. J Am Chem Soc. 2016 May 11; 138(18):5978-83. PMID: 27078610.
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    7. Hudson DA, Thorpe C. Mia40 is a facile oxidant of unfolded reduced proteins but shows minimal isomerase activity. Arch Biochem Biophys. 2015 Aug 1; 579:1-7. PMID: 26014136.
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    8. Sapra A, Ramadan D, Thorpe C. Multivalency in the Inhibition of Oxidative Protein Folding by Arsenic(III) Species. Biochemistry. 2015 Jan 20; 54(2):612-21. PMID: 25506675.
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    9. Hudson DA, Gannon SA, Thorpe C. Oxidative protein folding: from thiol-disulfide exchange reactions to the redox poise of the endoplasmic reticulum. Free Radic Biol Med. 2015 Mar; 80:171-82. PMID: 25091901.
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    10. Schaefer-Ramadan S, Thorpe C, Rozovsky S. Site-specific insertion of selenium into the redox-active disulfide of the flavoprotein augmenter of liver regeneration. Arch Biochem Biophys. 2014 Apr 15; 548:60-5. PMID: 24582598.
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    11. Israel BA, Jiang L, Gannon SA, Thorpe C. Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase. Free Radic Biol Med. 2014 Apr; 69:129-35. PMID: 24468475.
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    12. Israel BA, Kodali VK, Thorpe C. Going through the Barrier: COUPLED DISULFIDE EXCHANGE REACTIONS PROMOTE EFFICIENT CATALYSIS IN QUIESCIN SULFHYDRYL OXIDASE. J Biol Chem. 2014 Feb 21; 289(8):5274-84. PMID: 24379406.
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    13. Schaefer-Ramadan S, Gannon SA, Thorpe C. Human augmenter of liver regeneration: probing the catalytic mechanism of a flavin-dependent sulfhydryl oxidase. Biochemistry. 2013 Nov 19; 52(46):8323-32. PMID: 24147449.
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    14. Winther JR, Thorpe C. Quantification of thiols and disulfides. Biochim Biophys Acta. 2014 Feb; 1840(2):838-46. PMID: 23567800.
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    15. Sapra A, Thorpe C. An arsenical-maleimide for the generation of new targeted biochemical reagents. J Am Chem Soc. 2013 Feb 20; 135(7):2415-8. PMID: 23384038.
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    16. Schaefer SA, Dong M, Rubenstein RP, Wilkie WA, Bahnson BJ, Thorpe C, Rozovsky S. (77)Se enrichment of proteins expands the biological NMR toolbox. J Mol Biol. 2013 Jan 23; 425(2):222-31. PMID: 23159557.
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    17. Alon A, Grossman I, Gat Y, Kodali VK, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D. The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature. 2012 Aug 16; 488(7411):414-8. PMID: 22801504.
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    18. Codding JA, Israel BA, Thorpe C. Protein substrate discrimination in the quiescin sulfhydryl oxidase (QSOX) family. Biochemistry. 2012 May 22; 51(20):4226-35. PMID: 22582951.
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    19. Daithankar VN, Wang W, Trujillo JR, Thorpe C. Flavin-linked Erv-family sulfhydryl oxidases release superoxide anion during catalytic turnover. Biochemistry. 2012 Jan 10; 51(1):265-72. PMID: 22148553.
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    20. Kodali VK, Gannon SA, Paramasivam S, Raje S, Polenova T, Thorpe C. A novel disulfide-rich protein motif from avian eggshell membranes. PLoS One. 2011; 6(3):e18187. PMID: 21479176.
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    21. Kodali VK, Thorpe C. Oxidative protein folding and the Quiescin-sulfhydryl oxidase family of flavoproteins. Antioxid Redox Signal. 2010 Oct; 13(8):1217-30. PMID: 20136510.
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    22. Daithankar VN, Schaefer SA, Dong M, Bahnson BJ, Thorpe C. Structure of the human sulfhydryl oxidase augmenter of liver regeneration and characterization of a human mutation causing an autosomal recessive myopathy . Biochemistry. 2010 Aug 10; 49(31):6737-45. PMID: 20593814.
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    23. Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2; 285(27):20993-1003. PMID: 20442408.
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    24. Kodali VK, Thorpe C. Quiescin sulfhydryl oxidase from Trypanosoma brucei: catalytic activity and mechanism of a QSOX family member with a single thioredoxin domain. Biochemistry. 2010 Mar 9; 49(9):2075-85. PMID: 20121244.
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    25. Alon A, Heckler EJ, Thorpe C, Fass D. QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains. FEBS Lett. 2010 Apr 16; 584(8):1521-5. PMID: 20211621.
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    26. Daithankar VN, Farrell SR, Thorpe C. Augmenter of liver regeneration: substrate specificity of a flavin-dependent oxidoreductase from the mitochondrial intermembrane space. Biochemistry. 2009 Jun 9; 48(22):4828-37. PMID: 19397338.
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    27. Ramadan D, Rancy PC, Nagarkar RP, Schneider JP, Thorpe C. Arsenic(III) species inhibit oxidative protein folding in vitro. Biochemistry. 2009 Jan 20; 48(2):424-32. PMID: 19102631.
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    28. Rancy PC, Thorpe C. Oxidative protein folding in vitro: a study of the cooperation between quiescin-sulfhydryl oxidase and protein disulfide isomerase. Biochemistry. 2008 Nov 18; 47(46):12047-56. PMID: 18937500.
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    29. Heckler EJ, Alon A, Fass D, Thorpe C. Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis. Biochemistry. 2008 Apr 29; 47(17):4955-63. PMID: 18393449.
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    30. Bach RD, Dmitrenko O, Thorpe C. Mechanism of thiolate-disulfide interchange reactions in biochemistry. J Org Chem. 2008 Jan 4; 73(1):12-21. PMID: 18052192.
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    31. Jaje J, Wolcott HN, Fadugba O, Cripps D, Yang AJ, Mather IH, Thorpe C. A flavin-dependent sulfhydryl oxidase in bovine milk. Biochemistry. 2007 Nov 13; 46(45):13031-40. PMID: 17944490.
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    32. Heckler EJ, Rancy PC, Kodali VK, Thorpe C. Generating disulfides with the Quiescin-sulfhydryl oxidases. Biochim Biophys Acta. 2008 Apr; 1783(4):567-77. PMID: 17980160.
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    33. Dmitrenko O, Thorpe C, Bach RD. Mechanism of SN2 disulfide bond cleavage by phosphorus nucleophiles. Implications for biochemical disulfide reducing agents. J Org Chem. 2007 Oct 26; 72(22):8298-307. PMID: 17914842.
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    34. Thorpe C, Coppock DL. Generating disulfides in multicellular organisms: emerging roles for a new flavoprotein family. J Biol Chem. 2007 May 11; 282(19):13929-33. PMID: 17353193.
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    35. Ramadan D, Cline DJ, Bai S, Thorpe C, Schneider JP. Effects of As(III) binding on beta-hairpin structure. J Am Chem Soc. 2007 Mar 14; 129(10):2981-8. PMID: 17311379.
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    36. Wang W, Winther JR, Thorpe C. Erv2p: characterization of the redox behavior of a yeast sulfhydryl oxidase. Biochemistry. 2007 Mar 20; 46(11):3246-54. PMID: 17298084.
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    37. Coppock DL, Thorpe C. Multidomain flavin-dependent sulfhydryl oxidases. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):300-11. PMID: 16677076.
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    38. Kay CW, Elsässer C, Bittl R, Farrell SR, Thorpe C. Determination of the distance between the two neutral flavin radicals in augmenter of liver regeneration by pulsed ELDOR. J Am Chem Soc. 2006 Jan 11; 128(1):76-7. PMID: 16390129.
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    39. Gross E, Sevier CS, Heldman N, Vitu E, Bentzur M, Kaiser CA, Thorpe C, Fass D. Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):299-304. PMID: 16407158.
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    40. Farrell SR, Thorpe C. Augmenter of liver regeneration: a flavin-dependent sulfhydryl oxidase with cytochrome c reductase activity. Biochemistry. 2005 Feb 8; 44(5):1532-41. PMID: 15683237.
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    41. Cline DJ, Redding SE, Brohawn SG, Psathas JN, Schneider JP, Thorpe C. New water-soluble phosphines as reductants of peptide and protein disulfide bonds: reactivity and membrane permeability. Biochemistry. 2004 Dec 7; 43(48):15195-203. PMID: 15568811.
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    42. Cline DJ, Thorpe C, Schneider JP. General method for facile intramolecular disulfide formation in synthetic peptides. Anal Biochem. 2004 Dec 1; 335(1):168-70. PMID: 15519585.
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    43. Cline DJ, Thorpe C, Schneider JP. Structure-based design of a fluorimetric redox active peptide probe. Anal Biochem. 2004 Feb 1; 325(1):144-50. PMID: 14715295.
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    44. Brohawn SG, Miksa IR, Thorpe C. Avian sulfhydryl oxidase is not a metalloenzyme: adventitious binding of divalent metal ions to the enzyme. Biochemistry. 2003 Sep 23; 42(37):11074-82. PMID: 12974644.
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    45. Raje S, Thorpe C. Inter-domain redox communication in flavoenzymes of the quiescin/sulfhydryl oxidase family: role of a thioredoxin domain in disulfide bond formation. Biochemistry. 2003 Apr 22; 42(15):4560-8. PMID: 12693953.
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    46. Cline DJ, Thorpe C, Schneider JP. Effects of As(III) binding on alpha-helical structure. J Am Chem Soc. 2003 Mar 12; 125(10):2923-9. PMID: 12617659.
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    47. Thorpe C, Hoober KL, Raje S, Glynn NM, Burnside J, Turi GK, Coppock DL. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Arch Biochem Biophys. 2002 Sep 1; 405(1):1-12. PMID: 12176051.
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    48. Raje S, Glynn NM, Thorpe C. A continuous fluorescence assay for sulfhydryl oxidase. Anal Biochem. 2002 Aug 15; 307(2):266-72. PMID: 12202243.
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    49. Hoober KL, Thorpe C. Flavin-dependent sulfhydryl oxidases in protein disulfide bond formation. Methods Enzymol. 2002; 348:30-4. PMID: 11885284.
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