Last Name

Jin Ouchi

InstitutionThomas Jefferson University
DepartmentCenter for Translational Medic
Address1025 Walnut St.
Philadelphia PA 19107

 awards and honors
2015 - APS New Investigator Award of Cell and Molecular Physiology Section (CaMPS)
2015 - W. W. Smith Medical Research Grant
2014 - Finalist, APS New Investigator Award of Cell and Molecular Physiology Section (CaMPS)
2014 - 2015AHA Beginning Grant-in Aid
2013 - APS Research Career Enhancement Award
2013 - ISHR World Congress Early Career Investigator Travel Awards
2012 - Finalist, AHA BCVS Outstanding Early Career Investigator Award
2011 - PSJ Irisawa Memorial Promotion Award
2010 - ISHR Richard J. Bing Award 1st prize
2009 - PSJ Promotion Award
2009 - 2011AHA Postdoctoral Fellowship grant
2008 - 2011Grant-in-Aid, Japan
2008 - 2009Kanae Foundation Foreign study Award
2007 - 2008Jikei University Research Grant Award
2007 - Jikei University Graduate Student Best Paper Award
2007 - 2008Kato Memorial Bioscience Foundation Medical Science Research Award
2006 - 2008Japan Heart Foundation, Young Investigator's Research Grant Award
2006 - 2007Japan Foundation of Cardiovascular Research , Fellowship Award
2006 - Travel Grant Award
2006 - IACS, Young Investigator Award
2006 - Kato Memorial Bioscience Foundation, Young Investigator's Travel Grant Award
2005 - ISHR Japanese section, Best Oral Presentation Award
2005 - 2006Jikei University, Graduate Student's Research Grant Award
2005 - Naito Foundation, Young Investigator's Travel Grant Award
2005 - Jikei Alumni Association, Young Investigator's Travel Grant Award

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. Isoform-specific dynamic translocation of PKC by a1-adrenoceptor stimulation in live cells. Biochem Biophys Res Commun. 2015 Aug 12.
    View in: PubMed
  2. O-Uchi J, Rice JJ, Ruwald MH, Parks XX, Ronzier E, Moss AJ, Zareba W, Lopes CM. Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1. J Mol Cell Cardiol. 2014 Dec 2; 79C:203-211.
    View in: PubMed
  3. Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 Jul 11; 575:7-12.
    View in: PubMed
  4. O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, Rizzuto R, Sheu SS. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter Antioxid Redox Signal. 2014 May 7.
    View in: PubMed
  5. O-Uchi J, Ryu SY, Jhun BS, Hurst S, Sheu SS. Mitochondrial Ion Channels/Transporters as Sensors and Regulators of Cellular Redox Signaling. Antioxid Redox Signal. 2014 Feb 3.
    View in: PubMed
  6. Morimoto S, Hongo K, Kusakari Y, Komukai K, Kawai M, O-Uchi J, Nakayama H, Asahi M, Otsu K, Yoshimura M, Kurihara S. Genetic modulation of the SERCA activity does not affect the Ca(2+) leak from the cardiac sarcoplasmic reticulum. Cell Calcium. 2014 Jan; 55(1):17-23.
    View in: PubMed
  7. O-Uchi J, Jhun BS, Hurst S, Bisetto S, Gross P, Chen M, Kettlewell S, Park J, Oyamada H, Smith GL, Murayama T, Sheu SS. Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1736-51.
    View in: PubMed
  8. O-Uchi J, Komukai K, Kusakari Y, Morimoto S, Kawai M, Jhun BS, Hurst S, Hongo K, Sheu SS, Kurihara S. Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor. Biochem Biophys Res Commun. 2013 Apr 5; 433(2):188-93.
    View in: PubMed
  9. Hoefen R, Reumann M, Goldenberg I, Moss AJ, O-Uchi J, Gu Y, McNitt S, Zareba W, Jons C, Kanters JK, Platonov PG, Shimizu W, Wilde AA, Rice JJ, Lopes CM. In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models. J Am Coll Cardiol. 2012 Nov 20; 60(21):2182-91.
    View in: PubMed
  10. O-Uchi J, Pan S, Sheu SS. Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease. J Gen Physiol. 2012 Jun; 139(6):435-43.
    View in: PubMed
  11. Barsheshet A, Goldenberg I, O-Uchi J, Moss AJ, Jons C, Shimizu W, Wilde AA, McNitt S, Peterson DR, Zareba W, Robinson JL, Ackerman MJ, Cypress M, Gray DA, Hofman N, Kanters JK, Kaufman ES, Platonov PG, Qi M, Towbin JA, Vincent GM, Lopes CM. Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to ß-blocker therapy in type 1 long-QT syndrome. Circulation. 2012 Apr 24; 125(16):1988-96.
    View in: PubMed
  12. Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circ Res. 2012 Jan 6; 110(1):59-70.
    View in: PubMed
  13. Goldenberg I, Thottathil P, Lopes CM, Moss AJ, McNitt S, O-Uchi J, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Towbin JA, Vincent M, Barsheshet A. Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome. Heart Rhythm. 2012 Jan; 9(1):49-56.
    View in: PubMed
  14. Jons C, O-Uchi J, Moss AJ, Reumann M, Rice JJ, Goldenberg I, Zareba W, Wilde AA, Shimizu W, Kanters JK, McNitt S, Hofman N, Robinson JL, Lopes CM. Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients. Sci Transl Med. 2011 Mar 30; 3(76):76ra28.
    View in: PubMed
  15. Horr S, Goldenberg I, Moss AJ, O-Uchi J, Barsheshet A, Connelly H, Gray DA, Zareba W, Lopes CM. Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation. J Cardiovasc Electrophysiol. 2011 Feb; 22(2):193-200.
    View in: PubMed
  16. Williams DM, Lopes CM, Rosenhouse-Dantsker A, Connelly HL, Matavel A, O-Uchi J, McBeath E, Gray DA. Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome. J Am Soc Nephrol. 2010 Dec; 21(12):2117-29.
    View in: PubMed
  17. O-Uchi J, Lopes CM. Combined blockade of ß- and a1-adrenoceptors in left ventricular remodeling induced by hypertension: beneficial or not? Hypertens Res. 2010 Oct; 33(10):984-5.
    View in: PubMed
  18. Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S. Role of Ca(2+)/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca(2+) current during endothelin-1 stimulation. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1902-7.
    View in: PubMed
  19. Morimoto S, O-Uchi J, Kawai M, Hoshina T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S. Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart. Biochem Biophys Res Commun. 2009 Dec 4; 390(1):87-92.
    View in: PubMed
  20. Hama T, Yuza Y, Saito Y, O-uchi J, Kondo S, Okabe M, Yamada H, Kato T, Moriyama H, Kurihara S, Urashima M. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist. 2009 Sep; 14(9):900-8.
    View in: PubMed
  21. Matsuba D, Terui T, O-Uchi J, Tanaka H, Ojima T, Ohtsuki I, Ishiwata S, Kurihara S, Fukuda N. Protein kinase A-dependent modulation of Ca2+ sensitivity in cardiac and fast skeletal muscles after reconstitution with cardiac troponin. J Gen Physiol. 2009 Jun; 133(6):571-81.
    View in: PubMed
  22. O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 2008 Jun 6; 102(11):1378-88.
    View in: PubMed
  23. Fukuda N, O-Uchi J, Kurihara S. Neuronal NO synthase-derived NO: a novel relaxing factor in myocardium? Circ Res. 2008 Feb 1; 102(2):148-50.
    View in: PubMed
  24. Hirano S, Kusakari Y, O-Uchi J, Morimoto S, Kawai M, Hongo K, Kurihara S. Intracellular mechanism of the negative inotropic effect induced by alpha1-adrenoceptor stimulation in mouse myocardium. J Physiol Sci. 2006 Aug; 56(4):297-304.
    View in: PubMed
  25. O-Uchi J, Komukai K, Kusakari Y, Obata T, Hongo K, Sasaki H, Kurihara S. alpha1-adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9400-5.
    View in: PubMed
  26. Ishikawa T, O-Uchi J, Mochizuki S, Kurihara S. Evaluation of the cross-bridge-dependent change in the Ca2+ affinity of troponin C in aequorin-injected ferret ventricular muscles. Cell Calcium. 2005 Feb; 37(2):153-62.
    View in: PubMed
  27. O-uchi J, Komukai K, Tohyama J, Inada K, Iwano K, Yamane T, Shibata T, Mochizuki S. Coronary artery spasm discovered in thorough examination of perioperative VT in a 26-year-old Japanese male. Jpn Heart J. 2003 Nov; 44(6):1021-6.
    View in: PubMed
  28. Fukuda N, O-Uchi J, Sasaki D, Kajiwara H, Ishiwata S, Kurihara S. Acidosis or inorganic phosphate enhances the length dependence of tension in rat skinned cardiac muscle. J Physiol. 2001 Oct 1; 536(Pt 1):153-60.
    View in: PubMed
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