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Laurence Eisenlohr

TitleProfessor
InstitutionThomas Jefferson University
DepartmentMicrobiology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-4540
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    Collapse Research 
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    T32CA009683     (EISENLOHR, LAURENCE CRANE)Feb 5, 1993 - Jul 31, 2009
    NIH/NCI
    TRAINING PROGRAM IN CANCER IMMUNOLOGY
    Role: Principal Investigator

    R01AI036331     (EISENLOHR, LAURENCE CRANE)Apr 1, 1995 - Apr 30, 2010
    NIH/NIAID
    Class II Processing Delineated by Flu Glycoproteins
    Role: Principal Investigator

    R01AI039501     (EISENLOHR, LAURENCE CRANE)Jun 1, 1997 - Dec 31, 2012
    NIH/NIAID
    Accessing the MHC Class I Processing Pathway
    Role: Principal Investigator

    R01AI046511     (EISENLOHR, LAURENCE CRANE)Apr 1, 2000 - Mar 31, 2005
    NIH/NIAID
    IMPACT OF EPITOPE DENSITY ON TCD8, ACTIVATION AND MEMORY
    Role: Principal Investigator

    R21AI063065     (EISENLOHR, LAURENCE CRANE)Apr 1, 2006 - Mar 31, 2009
    NIH/NIAID
    The Role of the RET Receptor in Autoimmune Disease
    Role: Principal Investigator

    R01AI069192     (EISENLOHR, LAURENCE CRANE)Jan 8, 2007 - Dec 31, 2011
    NIH/NIAID
    The Basis for MHC Class II-restricted proteasome-dependent epitopes
    Role: Principal Investigator

    R21AI077053     (EISENLOHR, LAURENCE CRANE)Sep 1, 2007 - Aug 31, 2009
    NIH/NIAID
    Dissecting 3 processing pathways that generate class II-restricted flu epitopes
    Role: Principal Investigator

    R21AI079526     (EISENLOHR, LAURENCE CRANE)Jun 20, 2008 - May 31, 2011
    NIH/NIAID
    Non-proteasomal protease(s) that define C-termini of MHC class I epitopes
    Role: Principal Investigator

    R21CA135602     (EISENLOHR, LAURENCE CRANE)Jul 1, 2008 - Dec 31, 2011
    NIH/NCI
    Dynamics of tolerance induction to tumor associated antigens
    Role: Principal Investigator

    R01AI100561     (EISENLOHR, LAURENCE CRANE)Feb 1, 2012 - Jan 31, 2016
    NIH/NIAID
    Antigen stability as a parameter in rational T(CD8+)-targeting vaccine design
    Role: Principal Investigator

    R21AI101929     (EISENLOHR, LAURENCE CRANE)Jul 3, 2012 - Jun 30, 2014
    NIH/NIAID
    The RET/PTC3 Oncogene: Antigenic and Inflammatory Properties
    Role: Principal Investigator

    R56AI101134     (EISENLOHR, LAURENCE CRANE)Aug 1, 2013 - Jul 31, 2014
    NIH/NIAID
    Alternative Pathways for CD4+ T Cell Epitope Generation from Influenza Antigens
    Role: Principal Investigator

    R01AI113286     (EISENLOHR, LAURENCE CRANE)Jun 15, 2014 - May 31, 2019
    NIH/NIAID
    Alternative MHCII Processing of Influenza Virus Proteins
    Role: Principal Investigator

    R21AI110848     (EISENLOHR, LAURENCE CRANE)Dec 1, 2014 - Nov 30, 2016
    NIH/NIAID
    Class II Processing and Presentation During Secondary Responses to Influenza
    Role: Principal Investigator

    R01AI110542     (EISENLOHR, LAURENCE CRANE)Jul 15, 2015 - Dec 31, 2019
    NIH/NIAID
    MHCII Cross-presentation as a Driver of CD4+ T Cell Responses to Poxviruses
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Veerappan Ganesan AP, Eisenlohr LC. The elucidation of non-classical MHC class II antigen processing through the study of viral antigens. Curr Opin Virol. 2017 Feb; 22:71-76. PMID: 28081485.
      View in: PubMed
    2. Norbury CC, Eisenlohr LC. Editorial overview: Antigen processing. Curr Opin Immunol. 2016 Jun; 40:v-vi. PMID: 27178764.
      View in: PubMed
    3. Forsyth KS, Eisenlohr LC. Giving CD4+ T cells the slip: viral interference with MHC class II-restricted antigen processing and presentation. Curr Opin Immunol. 2016 Jun; 40:123-9. PMID: 27115617.
      View in: PubMed
    4. Miller MA, Ganesan AP, Luckashenak N, Mendonca M, Eisenlohr LC. Endogenous antigen processing drives the primary CD4(+) T cell response to influenza. Nat Med. 2015 Oct; 21(10):1216-22. PMID: 26413780.
      View in: PubMed
    5. Eisenlohr LC, Denzin LK. Cretaceous collegiality. Mol Immunol. 2015 Dec; 68(2 Pt A):67. PMID: 26359187.
      View in: PubMed
    6. Siciliano NA, Hersperger AR, Lacuanan AM, Xu RH, Sidney J, Sette A, Sigal LJ, Eisenlohr LC. Impact of Distinct Poxvirus Infections on the Specificities and Functionalities of CD4+ T Cell Responses. J Virol. 2014 Sep 1; 88(17):10078-91. PMID: 24965457.
      View in: PubMed
    7. Hersperger AR, Siciliano NA, DeHaven BC, Snook AE, Eisenlohr LC. Epithelial Immunization Induces Polyfunctional CD8+ T Cells and Optimal Mousepox Protection. J Virol. 2014 Aug 15; 88(16):9472-5. PMID: 24899206.
      View in: PubMed
    8. Walline CC, Deffit SN, Wang N, Guindon LM, Crotzer VL, Liu J, Hollister K, Eisenlohr LC, Brutkiewicz RR, Kaplan MH, Blum JS. Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy. Immunology. 2014 Apr; 141(4):531-9. PMID: 24205828.
      View in: PubMed
    9. Goodenough E, Robinson TM, Zook MB, Flanigan KM, Atkins JF, Howard MT, Eisenlohr LC. Cryptic MHC class I-binding peptides are revealed by aminoglycoside-induced stop codon read-through into the 3' UTR. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5670-5. PMID: 24706797.
      View in: PubMed
    10. Davies ML, Sei JJ, Siciliano NA, Xu RH, Roscoe F, Sigal LJ, Eisenlohr LC, Norbury CC. MyD88-Dependent Immunity to a Natural Model of Vaccinia Virus Infection Does Not Involve Toll-Like Receptor 2. J Virol. 2014 Mar; 88(6):3557-67. PMID: 24403581.
      View in: PubMed
    11. Miller MA, Ganesan AP, Eisenlohr LC. Toward a Network Model of MHC Class II-Restricted Antigen Processing. Front Immunol. 2013; 4:464. PMID: 24379819.
      View in: PubMed
    12. Siciliano NA, Huang L, Eisenlohr LC. Recombinant poxviruses: versatile tools for immunological assays. Methods Mol Biol. 2013; 960:219-45. PMID: 23329491.
      View in: PubMed
    13. Eisenlohr LC. Alternative generation of MHC class II-restricted epitopes: Not so exceptional? Mol Immunol. 2013 Sep; 55(2):169-71. PMID: 23200635.
      View in: PubMed
    14. Fang M, Siciliano NA, Hersperger AR, Roscoe F, Hu A, Ma X, Shamsedeen AR, Eisenlohr LC, Sigal LJ. Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9983-8. PMID: 22665800.
      View in: PubMed
    15. Hersperger AR, Siciliano NA, Eisenlohr LC. Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity. J Virol. 2012 Jul; 86(13):7298-309. PMID: 22532670.
      View in: PubMed
    16. Wixted JH, Rothstein JL, Eisenlohr LC. Identification of functionally distinct TRAF proinflammatory and phosphatidylinositol 3-kinase/mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (PI3K/MEK) transforming activities emanating from RET/PTC fusion oncoprotein. J Biol Chem. 2012 Feb 3; 287(6):3691-703. PMID: 22158616.
      View in: PubMed
    17. Eisenlohr LC, Luckashenak N, Apcher S, Miller MA, Sinnathamby G. Beyond the classical: influenza virus and the elucidation of alternative MHC class II-restricted antigen processing pathways. Immunol Res. 2011 Dec; 51(2-3):237-48. PMID: 22101673.
      View in: PubMed
    18. Comber JD, Robinson TM, Siciliano NA, Snook AE, Eisenlohr LC. Functional macroautophagy induction by influenza A virus without a contribution to major histocompatibility complex class II-restricted presentation. J Virol. 2011 Jul; 85(13):6453-63. PMID: 21525345.
      View in: PubMed
    19. Huang L, Kuhls MC, Eisenlohr LC. Hydrophobicity as a driver of MHC class I antigen processing. EMBO J. 2011 Apr 20; 30(8):1634-44. PMID: 21378750.
      View in: PubMed
    20. Huang L, Marvin JM, Tatsis N, Eisenlohr LC. Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation. J Immunol. 2011 Feb 15; 186(4):1904-8. PMID: 21239720.
      View in: PubMed
    21. Testa JS, Apcher GS, Comber JD, Eisenlohr LC. Exosome-driven antigen transfer for MHC class II presentation facilitated by the receptor binding activity of influenza hemagglutinin. J Immunol. 2010 Dec 1; 185(11):6608-16. PMID: 21048109.
      View in: PubMed
    22. Fernandes-Alnemri T, Yu JW, Juliana C, Solorzano L, Kang S, Wu J, Datta P, McCormick M, Huang L, McDermott E, Eisenlohr L, Landel CP, Alnemri ES. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat Immunol. 2010 May; 11(5):385-93. PMID: 20351693.
      View in: PubMed
    23. Snook AE, Li P, Stafford BJ, Faul EJ, Huang L, Birbe RC, Bombonati A, Schulz S, Schnell MJ, Eisenlohr LC, Waldman SA. Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease. Cancer Res. 2009 Apr 15; 69(8):3537-44. PMID: 19351847.
      View in: PubMed
    24. Snook AE, Huang L, Schulz S, Eisenlohr LC, Waldman SA. Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens. Clin Transl Sci. 2008 Dec; 1(3):263-4. PMID: 19956776.
      View in: PubMed
    25. Snook AE, Stafford BJ, Li P, Tan G, Huang L, Birbe R, Schulz S, Schnell MJ, Thakur M, Rothstein JL, Eisenlohr LC, Waldman SA. Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. J Natl Cancer Inst. 2008 Jul 2; 100(13):950-61. PMID: 18577748.
      View in: PubMed
    26. Plesa G, Snook AE, Waldman SA, Eisenlohr LC. Derivation and fluidity of acutely induced dysfunctional CD8+ T cells. J Immunol. 2008 Apr 15; 180(8):5300-8. PMID: 18390711.
      View in: PubMed
    27. Snook AE, Stafford BJ, Eisenlohr LC, Rothstein JL, Waldman SA. Mucosally restricted antigens as novel immunological targets for antitumor therapy. Biomark Med. 2007 Jun; 1(1):187-202. PMID: 20477468.
      View in: PubMed
    28. Eisenlohr LC, Huang L, Golovina TN. Rethinking peptide supply to MHC class I molecules. Nat Rev Immunol. 2007 May; 7(5):403-10. PMID: 17457346.
      View in: PubMed
    29. Tang J, Murtadha M, Schnell M, Eisenlohr LC, Hooper J, Flomenberg P. Human T-cell responses to vaccinia virus envelope proteins. J Virol. 2006 Oct; 80(20):10010-20. PMID: 17005679.
      View in: PubMed
    30. Plesa G, McKenna PM, Schnell MJ, Eisenlohr LC. Immunogenicity of cytopathic and noncytopathic viral vectors. J Virol. 2006 Jul; 80(13):6259-66. PMID: 16775313.
      View in: PubMed
    31. Zook MB, Howard MT, Sinnathamby G, Atkins JF, Eisenlohr LC. Epitopes derived by incidental translational frameshifting give rise to a protective CTL response. J Immunol. 2006 Jun 1; 176(11):6928-34. PMID: 16709853.
      View in: PubMed
    32. Eisenlohr LC, Rothstein JL. Oncogenic inflammation and autoimmune disease. Autoimmun Rev. 2006 Dec; 6(2):107-14. PMID: 17138254.
      View in: PubMed
    33. Tang J, Olive M, Pulmanausahakul R, Schnell M, Flomenberg N, Eisenlohr L, Flomenberg P. Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins. Virology. 2006 Jul 5; 350(2):312-22. PMID: 16499941.
      View in: PubMed
    34. Wherry EJ, Golovina TN, Morrison SE, Sinnathamby G, McElhaugh MJ, Shockey DC, Eisenlohr LC. Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope. J Immunol. 2006 Feb 15; 176(4):2249-61. PMID: 16455981.
      View in: PubMed
    35. McGettigan JP, Koser ML, McKenna PM, Smith ME, Marvin JM, Eisenlohr LC, Dietzschold B, Schnell MJ. Enhanced humoral HIV-1-specific immune responses generated from recombinant rhabdoviral-based vaccine vectors co-expressing HIV-1 proteins and IL-2. Virology. 2006 Jan 20; 344(2):363-77. PMID: 16226782.
      View in: PubMed
    36. Lefebvre JM, Haks MC, Carleton MO, Rhodes M, Sinnathamby G, Simon MC, Eisenlohr LC, Garrett-Sinha LA, Wiest DL. Enforced expression of Spi-B reverses T lineage commitment and blocks beta-selection. J Immunol. 2005 May 15; 174(10):6184-94. PMID: 15879115.
      View in: PubMed
    37. Golovina TN, Morrison SE, Eisenlohr LC. The impact of misfolding versus targeted degradation on the efficiency of the MHC class I-restricted antigen processing. J Immunol. 2005 Mar 1; 174(5):2763-9. PMID: 15728485.
      View in: PubMed
    38. Tewari MK, Sinnathamby G, Rajagopal D, Eisenlohr LC. A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent. Nat Immunol. 2005 Mar; 6(3):287-94. PMID: 15711549.
      View in: PubMed
    39. Eisenlohr LC, Rothstein JL. Antigen processing and presentation. Cancer Treat Res. 2005; 123:3-36. PMID: 16211864.
      View in: PubMed
    40. Sinnathamby G, Maric M, Cresswell P, Eisenlohr LC. Differential requirements for endosomal reduction in the presentation of two H2-E(d)-restricted epitopes from influenza hemagglutinin. J Immunol. 2004 Jun 1; 172(11):6607-14. PMID: 15153475.
      View in: PubMed
    41. Tatsis N, Sinnathamby G, Eisenlohr LC. Vaccinia virus as a tool for immunologic studies. Methods Mol Biol. 2004; 269:267-88. PMID: 15114021.
      View in: PubMed
    42. Sinnathamby G, Eisenlohr LC. Presentation by recycling MHC class II molecules of an influenza hemagglutinin-derived epitope that is revealed in the early endosome by acidification. J Immunol. 2003 Apr 1; 170(7):3504-13. PMID: 12646611.
      View in: PubMed
    43. Spierings E, Brickner AG, Caldwell JA, Zegveld S, Tatsis N, Blokland E, Pool J, Pierce RA, Mollah S, Shabanowitz J, Eisenlohr LC, van Veelen P, Ossendorp F, Hunt DF, Goulmy E, Engelhard VH. The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. Blood. 2003 Jul 15; 102(2):621-9. PMID: 12663445.
      View in: PubMed
    44. Powell DJ, Eisenlohr LC, Rothstein JL. A thyroid tumor-specific antigen formed by the fusion of two self proteins. J Immunol. 2003 Jan 15; 170(2):861-9. PMID: 12517951.
      View in: PubMed
    45. Olive M, Eisenlohr L, Flomenberg N, Hsu S, Flomenberg P. The adenovirus capsid protein hexon contains a highly conserved human CD4+ T-cell epitope. Hum Gene Ther. 2002 Jul 1; 13(10):1167-78. PMID: 12133270.
      View in: PubMed
    46. Wherry EJ, McElhaugh MJ, Eisenlohr LC. Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope. J Immunol. 2002 May 1; 168(9):4455-61. PMID: 11970989.
      View in: PubMed
    47. Golovina TN, Wherry EJ, Bullock TN, Eisenlohr LC. Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum. J Immunol. 2002 Mar 15; 168(6):2667-75. PMID: 11884431.
      View in: PubMed
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