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Lorraine Iacovitti

TitleProfessor
InstitutionThomas Jefferson University
DepartmentDepartment of Neurosciences
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-955-9427
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    Collapse Overview 
    Collapse overview
    INTRAMURAL COMMITTEES AND ACTIVITIES (1997-present)
    1995-1998 University Grievance Committee
    1997-1998 University Steering Committee for the Faculty (elected)
    1998-2000 Chairman, Research Committee, Department of Neurology
    1998-2000 University Research Council
    2000-2001 Co-chairman, University Research Committee
    2001-2005 Chairman, University Research Committee

    EXTRAMURAL COMMITTEES AND ACTIVITIES (1997-present)
    NSF Grant Reviewer - 1983-present
    NIH Study Section Subcommittee NLS 1 - 1991, 1992, 1993, 1997
    NIH NRSA Study Section- 1997
    NIH Special Review Panel- Parkinson's Disease Center Grants- 1998
    Philadelphia Chapter of the Society for Neuroscience 1996-1998
    Drexel University Honors Program in Science, Consultant 1997-1999
    Board of Trustees, Educational Committee, Germantown Academy 1997-1999
    Advisor, The Lee Foundation 1998

    OTHER PROFESSIONAL ACTIVITIES (1997-present)
    1983-present NSF Grant Reviewer
    1991, 1992, 1993, 1997 NIH Study Section Subcommittee NLS 1
    1998,1999, 2000 NIH Special Review Panel- Parkinson's Disease Center of Excellence Grants

    EDITORIAL ACTIVITIES
    Journal of Neuroscience, Neuroscience, Journal of Neurochemistry, Developmental Biology, Neuroscience Letters, Journal of Neurobiology, Anatomy and Embryology, Journal of Neurocytology, Neuroendocrinology, Biotechniques



    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Horowitz A, Yang J, Cai J, Iacovitti L. The versatility of RhoA activities in neural differentiation. Small GTPases. 2017 Jan 26; 1-7. PMID: 28125332.
      View in: PubMed
    2. Lin R, Cai J, Kostuk EW, Rosenwasser R, Iacovitti L. Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats. J Neuroinflammation. 2016 Oct 13; 13(1):269. PMID: 27733178.
      View in: PubMed
    3. Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell Rep. 2016 Oct 11; 17(3):645-652. PMID: 27732842.
      View in: PubMed
    4. Lang MJ, Lin R, Sharan AD, Rosenwasser RH, Iacovitti L. 155 Enhanced Stem Cell Delivery by Functional Blood-Brain Barrier Modulation Improves Neurological Recovery in a Rodent Stroke Model. Neurosurgery. 2016 Aug; 63 Suppl 1:162-3. PMID: 27399434.
      View in: PubMed
    5. Monti DA, Zabrecky G, Kremens D, Liang TW, Wintering NA, Cai J, Wei X, Bazzan AJ, Zhong L, Bowen B, Intenzo CM, Iacovitti L, Newberg AB. N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data. PLoS One. 2016; 11(6):e0157602. PMID: 27309537.
      View in: PubMed
    6. Gu H, Lazarenko RM, Koktysh D, Iacovitti L, Zhang Q. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem Cells Transl Med. 2015 Aug; 4(8):887-93. PMID: 26025981.
      View in: PubMed
    7. Lin R, Cai J, Nathan C, Wei X, Schleidt S, Rosenwasser R, Iacovitti L. Neurogenesis is enhanced by stroke in multiple new stem cell niches along the ventricular system at sites of high BBB permeability. Neurobiol Dis. 2015 Feb; 74:229-39. PMID: 25484283.
      View in: PubMed
    8. Iacovitti L, Wei X, Cai J, Kostuk EW, Lin R, Gorodinsky A, Roman P, Kusek G, Das SS, Dufour A, Martinez TN, Dave KD. The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease. PLoS One. 2014; 9(12):e113151. PMID: 25462571.
      View in: PubMed
    9. Sun Y, Williams A, Waisbourd M, Iacovitti L, Katz LJ. Stem cell therapy for glaucoma: science or snake oil? Surv Ophthalmol. 2015 Mar-Apr; 60(2):93-105. PMID: 25132498.
      View in: PubMed
    10. Sheela Rani CS, Soto-Pina A, Iacovitti L, Strong R. Evolutionary conservation of an atypical glucocorticoid-responsive element in the human tyrosine hydroxylase gene. J Neurochem. 2013 Jul; 126(1):19-28. PMID: 23647419.
      View in: PubMed
    11. Goldmacher GV, Nasser R, Lee DY, Yigit S, Rosenwasser R, Iacovitti L. Tracking Transplanted Bone Marrow Stem Cells and Their Effects in the Rat MCAO Stroke Model. PLoS One. 2013; 8(3):e60049. PMID: 23555879.
      View in: PubMed
    12. Cai J, Schleidt S, Pelta-Heller J, Hutchings D, Cannarsa G, Iacovitti L. BMP and TGF-ß pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev Biol. 2013 Apr 1; 376(1):62-73. PMID: 23352789.
      View in: PubMed
    13. Phani S, Jablonski M, Pelta-Heller J, Cai J, Iacovitti L. Gremlin is a novel VTA derived neuroprotective factor for dopamine neurons. Brain Res. 2013 Mar 15; 1500:88-98. PMID: 23348379.
      View in: PubMed
    14. Cai J, Yang M, Poremsky E, Kidd S, Schneider JS, Iacovitti L. Dopaminergic neurons derived from human induced pluripotent stem cells survive and integrate into 6-OHDA-lesioned rats. Stem Cells Dev. 2010 Jul; 19(7):1017-23. PMID: 19824823.
      View in: PubMed
    15. Phani S, Gonye G, Iacovitti L. VTA neurons show a potentially protective transcriptional response to MPTP. Brain Res. 2010 Jul 9; 1343:1-13. PMID: 20462502.
      View in: PubMed
    16. Yang M, Wei X, Li J, Heine LA, Rosenwasser R, Iacovitti L. Changes in host blood factors and brain glia accompanying the functional recovery after systemic administration of bone marrow stem cells in ischemic stroke rats. Cell Transplant. 2010; 19(9):1073-84. PMID: 20412636.
      View in: PubMed
    17. Bennett LB, Cai J, Enikolopov G, Iacovitti L. Heterotopically transplanted CVO neural stem cells generate neurons and migrate with SVZ cells in the adult mouse brain. Neurosci Lett. 2010 May 7; 475(1):1-6. PMID: 20298755.
      View in: PubMed
    18. Jasmin JF, Yang M, Iacovitti L, Lisanti MP. Genetic ablation of caveolin-1 increases neural stem cell proliferation in the subventricular zone (SVZ) of the adult mouse brain. Cell Cycle. 2009 Dec; 8(23):3978-83. PMID: 19923909.
      View in: PubMed
    19. Daniel JA, Galbraith S, Iacovitti L, Abdipranoto A, Vissel B. Functional heterogeneity at dopamine release sites. J Neurosci. 2009 Nov 18; 29(46):14670-80. PMID: 19923300.
      View in: PubMed
    20. Donaldson AE, Cai J, Yang M, Iacovitti L. Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo. Stem Cells Dev. 2009 Sep; 18(7):1003-12. PMID: 19049321.
      View in: PubMed
    21. Bennett L, Yang M, Enikolopov G, Iacovitti L. Circumventricular organs: a novel site of neural stem cells in the adult brain. Mol Cell Neurosci. 2009 Jul; 41(3):337-47. PMID: 19409493.
      View in: PubMed
    22. Cai J, Donaldson A, Yang M, German MS, Enikolopov G, Iacovitti L. The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease model. Stem Cells. 2009 Jan; 27(1):220-9. PMID: 18832589.
      View in: PubMed
    23. Han BS, Iacovitti L, Katano T, Hattori N, Seol W, Kim KS. Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra. Neurosci Lett. 2008 Sep 19; 442(3):190-4. PMID: 18634852.
      View in: PubMed
    24. Romano G, Macaluso M, Lucchetti C, Iacovitti L. Transcription and epigenetic profile of the promoter, first exon and first intron of the human tyrosine hydroxylase gene. J Cell Physiol. 2007 May; 211(2):431-8. PMID: 17195153.
      View in: PubMed
    25. Iacovitti L, Donaldson AE, Marshall CE, Suon S, Yang M. A protocol for the differentiation of human embryonic stem cells into dopaminergic neurons using only chemically defined human additives: Studies in vitro and in vivo. Brain Res. 2007 Jan 5; 1127(1):19-25. PMID: 17123482.
      View in: PubMed
    26. Suon S, Yang M, Iacovitti L. Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease. Brain Res. 2006 Aug 23; 1106(1):46-51. PMID: 16828720.
      View in: PubMed
    27. Jin H, Romano G, Marshall C, Donaldson AE, Suon S, Iacovitti L. Tyrosine hydroxylase gene regulation in human neuronal progenitor cells does not depend on Nurr1 as in the murine and rat systems. J Cell Physiol. 2006 Apr; 207(1):49-57. PMID: 16252282.
      View in: PubMed
    28. Donaldson AE, Marshall CE, Yang M, Suon S, Iacovitti L. Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture. Mol Cell Neurosci. 2005 Dec; 30(4):601-10. PMID: 16456927.
      View in: PubMed
    29. Donaldson AE, Marshall CE, Yang M, Suon S, Iacovitti L. Purified mouse dopamine neurons thrive and function after transplantation into brain but require novel glial factors for survival in culture. Mol Cell Neurosci. 2005 Sep; 30(1):108-17. PMID: 16024255.
      View in: PubMed
    30. Romano G, Suon S, Jin H, Donaldson AE, Iacovitti L. Characterization of five evolutionary conserved regions of the human tyrosine hydroxylase (TH) promoter: implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system. J Cell Physiol. 2005 Aug; 204(2):666-77. PMID: 15744773.
      View in: PubMed
    31. Suon S, Jin H, Donaldson AE, Caterson EJ, Tuan RS, Deschennes G, Marshall C, Iacovitti L. Transient differentiation of adult human bone marrow cells into neuron-like cells in culture: development of morphological and biochemical traits is mediated by different molecular mechanisms. Stem Cells Dev. 2004 Dec; 13(6):625-35. PMID: 15684830.
      View in: PubMed
    32. Yang M, Donaldson AE, Marshall CE, Shen J, Iacovitti L. Studies on the differentiation of dopaminergic traits in human neural progenitor cells in vitro and in vivo. Cell Transplant. 2004; 13(5):535-47. PMID: 15565866.
      View in: PubMed
    33. Yang M, Donaldson AE, Jiang Y, Iacovitti L. Factors influencing the differentiation of dopaminergic traits in transplanted neural stem cells. Cell Mol Neurobiol. 2003 Oct; 23(4-5):851-64. PMID: 14514036.
      View in: PubMed
    34. Kessler MA, Yang M, Gollomp KL, Jin H, Iacovitti L. The human tyrosine hydroxylase gene promoter. Brain Res Mol Brain Res. 2003 Apr 10; 112(1-2):8-23. PMID: 12670698.
      View in: PubMed
    35. Yang M, Stull ND, Berk MA, Snyder EY, Iacovitti L. Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat. Exp Neurol. 2002 Sep; 177(1):50-60. PMID: 12429210.
      View in: PubMed
    36. Stull ND, Polan DP, Iacovitti L. Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro. Brain Res. 2002 Mar 29; 931(2):181-5. PMID: 11897104.
      View in: PubMed
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