Mani Kavuru

TitleProfessor
InstitutionThomas Jefferson University
DepartmentPulmonary Diseases
Address800 Walnut Street
Philadelphia PA 19107
Phone215-955-1672
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Scherzer R, Dennis MP, Swan BA, Kavuru MS, Oxman DA. A Comparison of Usage and Outcomes Between Nurse Practitioner and Resident-Staffed Medical ICUs. Crit Care Med. 2017 Feb; 45(2):e132-e137. PMID: 27632677.
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    2. Ward L, Powell RE, Scharf ML, Chapman A, Kavuru M. Patient-Centered Specialty Practice: Defining the Role of Specialists in Value-Based Health Care. Chest. 2017 Apr; 151(4):930-935. PMID: 28089817.
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    3. Wang Z, DiDonato JA, Buffa J, Comhair SA, Aronica MA, Dweik RA, Lee NA, Lee JJ, Thomassen MJ, Kavuru M, Erzurum SC, Hazen SL. Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem. 2016 Oct 14; 291(42):22118-22135. PMID: 27587397.
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    4. Gharib SA, Malur A, Huizar I, Barna BP, Kavuru MS, Schnapp LM, Thomassen MJ. Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells. Respir Res. 2016; 17(1):93. PMID: 27460362.
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    5. Konikkara J, Tavella R, Willes L, Kavuru M, Sharma S. Early recognition of obstructive sleep apnea in patients hospitalized with COPD exacerbation is associated with reduced readmission. Hosp Pract (1995). 2016 Feb; 44(1):41-7. PMID: 26691510.
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    6. Romero F, Shah D, Duong M, Penn RB, Fessler MB, Madenspacher J, Stafstrom W, Kavuru M, Lu B, Kallen CB, Walsh K, Summer R. A Pneumocyte-Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis. Am J Respir Cell Mol Biol. 2015 Jul; 53(1):74-86. PMID: 25409201.
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    7. Thomassen MJ, Kavuru MS. Lung disease: Treatment by cell transplant. Nature. 2014 Oct 23; 514(7523):438-40. PMID: 25274303.
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    8. Hasan N, Kumar R, Kavuru MS. Lung cancer screening beyond low-dose computed tomography: the role of novel biomarkers. Lung. 2014 Oct; 192(5):639-48. PMID: 25108403.
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    9. Gaurav K, Vaid U, Sexauer W, Kavuru MS. Readmissions after hospital discharge with acute exacerbation of COPD: are we missing something? Hosp Pract (1995). 2014 Apr; 42(2):58-69. PMID: 24769785.
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    10. Barna BP, Huizar I, Malur A, McPeek M, Marshall I, Jacob M, Dobbs L, Kavuru MS, Thomassen MJ. Carbon nanotube-induced pulmonary granulomatous disease: twist1 and alveolar macrophage m1 activation. Int J Mol Sci. 2013; 14(12):23858-71. PMID: 24322444.
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    11. Dalrymple H, Barna BP, Malur A, Malur AG, Kavuru MS, Thomassen MJ. Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes. BMC Immunol. 2013; 14:41. PMID: 24044676.
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    12. Hasan N, Bagga S, Monteagudo J, Hirose H, Cavarocchi NC, Hehn BT, Kavuru MS. Extracorporeal Membrane Oxygenation to Support Whole-lung Lavage in Pulmonary Alveolar Proteinosis: Salvage of the Drowned Lungs. J Bronchology Interv Pulmonol. 2013 Jan; 20(1):41-4. PMID: 23328142.
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    13. Barna BP, Culver DA, Kanchwala A, Singh RJ, Huizar I, Abraham S, Malur A, Marshall I, Kavuru MS, Thomassen MJ. Alveolar macrophage cathelicidin deficiency in severe sarcoidosis. J Innate Immun. 2012; 4(5-6):569-78. PMID: 22759465.
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    14. Malur A, Kavuru MS, Marshall I, Barna BP, Huizar I, Karnekar R, Thomassen MJ. Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis. Respir Res. 2012; 13:46. PMID: 22697800.
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    15. Sharma S, Malur A, Marshall I, Huizar I, Barna BP, Pories W, Dohm L, Kavuru MS, Thomassen MJ. Alveolar macrophage activation in obese patients with obstructive sleep apnea. Surgery. 2012 Jan; 151(1):107-12. PMID: 21982524.
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    16. Loza MJ, Brodmerkel C, Du Bois RM, Judson MA, Costabel U, Drent M, Kavuru M, Flavin S, Lo KH, Barnathan ES, Baughman RP. Inflammatory profile and response to anti-tumor necrosis factor therapy in patients with chronic pulmonary sarcoidosis. Clin Vaccine Immunol. 2011 Jun; 18(6):931-9. PMID: 21508170.
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    17. Huizar I, Malur A, Midgette YA, Kukoly C, Chen P, Ke PC, Podila R, Rao AM, Wingard CJ, Dobbs L, Barna BP, Kavuru MS, Thomassen MJ. Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes. Am J Respir Cell Mol Biol. 2011 Oct; 45(4):858-66. PMID: 21398620.
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    18. Malur A, Baker AD, McCoy AJ, Wells G, Barna BP, Kavuru MS, Malur AG, Thomassen MJ. Restoration of PPAR? reverses lipid accumulation in alveolar macrophages of GM-CSF knockout mice. Am J Physiol Lung Cell Mol Physiol. 2011 Jan; 300(1):L73-80. PMID: 21036914.
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    19. Djukanovic R, Wilson SJ, Moore WC, Koenig SM, Laviolette M, Bleecker ER, Davis WB, Doherty DE, Olivenstein R, Israel E, Kavuru MS, Kleerup E, Reilly DS, Yancey SW, Edwards LD, Stauffer JL, Dorinsky PM, Jarjour NN. Montelukast added to fluticasone propionate does not alter inflammation or outcomes. Respir Med. 2010 Oct; 104(10):1425-35. PMID: 20709517.
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    20. Sharma S, Kavuru M. Sleep and metabolism: an overview. Int J Endocrinol. 2010; 2010. PMID: 20811596.
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    21. Baker AD, Malur A, Barna BP, Kavuru MS, Malur AG, Thomassen MJ. PPARgamma regulates the expression of cholesterol metabolism genes in alveolar macrophages. Biochem Biophys Res Commun. 2010 Mar 19; 393(4):682-7. PMID: 20170635.
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    22. Baker AD, Malur A, Barna BP, Ghosh S, Kavuru MS, Malur AG, Thomassen MJ. Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism. J Lipid Res. 2010 Jun; 51(6):1325-31. PMID: 20064973.
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    23. Huizar I, Kavuru MS. Alveolar proteinosis syndrome: pathogenesis, diagnosis, and management. Curr Opin Pulm Med. 2009 Sep; 15(5):491-8. PMID: 19561506.
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    24. Malur A, Mccoy AJ, Arce S, Barna BP, Kavuru MS, Malur AG, Thomassen MJ. Deletion of PPAR gamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response. J Immunol. 2009 May 1; 182(9):5816-22. PMID: 19380830.
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    25. Baughman RP, Shipley R, Desai S, Drent M, Judson MA, Costabel U, du Bois RM, Kavuru M, Schlenker-Herceg R, Flavin S, Lo KH, Barnathan ES. Changes in chest roentgenogram of sarcoidosis patients during a clinical trial of infliximab therapy: comparison of different methods of evaluation. Chest. 2009 Aug; 136(2):526-35. PMID: 19395578.
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    26. Barna BP, Malur A, Dalrymple H, Karnekar R, Culver DA, Abraham S, Singh RJ, Brescia D, Kavuru MS, Thomassen MJ. A novel 1,25-dihydroxyvitamin D-activin A pathway in human alveolar macrophages is dysfunctional in patients with pulmonary alveolar proteinosis (PAP). Autoimmunity. 2009 Jan; 42(1):56-62. PMID: 18803071.
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    27. Thomassen MJ, Barna BP, Malur AG, Bonfield TL, Farver CF, Malur A, Dalrymple H, Kavuru MS, Febbraio M. ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis. J Lipid Res. 2007 Dec; 48(12):2762-8. PMID: 17848583.
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    28. Culver DA, Newman LS, Kavuru MS. Gene-environment interactions in sarcoidosis: challenge and opportunity. Clin Dermatol. 2007 May-Jun; 25(3):267-75. PMID: 17560304.
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    29. Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J. Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health. Am J Physiol Lung Cell Mol Physiol. 2007 May; 292(5):L1052-63. PMID: 17189324.
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    30. Judson MA, Hirst K, Iyengar SK, Rybicki BA, El-Ghormli L, Baughman RP, Donohue JF, Elston RC, Kavuru MS, Moller DR, Newman LS, Rabin DL, Rossman MD, Teirstein AS, Iannuzzi MC. Comparison of sarcoidosis phenotypes among affected African-American siblings. Chest. 2006 Sep; 130(3):855-62. PMID: 16963686.
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    31. Baughman RP, Drent M, Kavuru M, Judson MA, Costabel U, du Bois R, Albera C, Brutsche M, Davis G, Donohue JF, Müller-Quernheim J, Schlenker-Herceg R, Flavin S, Lo KH, Oemar B, Barnathan ES. Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am J Respir Crit Care Med. 2006 Oct 1; 174(7):795-802. PMID: 16840744.
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    32. Venkateshiah SB, Yan TD, Bonfield TL, Thomassen MJ, Meziane M, Czich C, Kavuru MS. An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis. Chest. 2006 Jul; 130(1):227-37. PMID: 16840407.
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    33. Jarjour NN, Wilson SJ, Koenig SM, Laviolette M, Moore WC, Davis WB, Doherty DE, Hamid Q, Israel E, Kavuru MS, Ramsdell JW, Tashkin DP, Reilly DS, Yancey SW, Edwards LD, Stauffer JL, Dorinsky PM, Djukanovic R. Control of airway inflammation maintained at a lower steroid dose with 100/50 microg of fluticasone propionate/salmeterol. J Allergy Clin Immunol. 2006 Jul; 118(1):44-52. PMID: 16815137.
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    34. Barna BP, Culver DA, Abraham S, Malur A, Bonfield TL, John N, Farver CF, Drazba JA, Raychaudhuri B, Kavuru MS, Thomassen MJ. Depressed peroxisome proliferator-activated receptor gamma (PPargamma) is indicative of severe pulmonary sarcoidosis: possible involvement of interferon gamma (IFN-gamma). Sarcoidosis Vasc Diffuse Lung Dis. 2006 Jun; 23(2):93-100. PMID: 17937104.
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    35. Li J, Sai T, Berger M, Chao Q, Davidson D, Deshmukh G, Drozdowski B, Ebel W, Harley S, Henry M, Jacob S, Kline B, Lazo E, Rotella F, Routhier E, Rudolph K, Sage J, Simon P, Yao J, Zhou Y, Kavuru M, Bonfield T, Thomassen MJ, Sass PM, Nicolaides NC, Grasso L. Human antibodies for immunotherapy development generated via a human B cell hybridoma technology. Proc Natl Acad Sci U S A. 2006 Mar 7; 103(10):3557-62. PMID: 16505368.
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    36. Rambasek T, Kavuru MS. Omalizumab dosing via the recommended card versus use of the published formula. J Allergy Clin Immunol. 2006 Mar; 117(3):708-9. PMID: 16522477.
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    37. Bonfield TL, Barna BP, John N, Malur A, Culver DA, Kavuru MS, Thomassen MJ. Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF. J Autoimmun. 2006 Feb; 26(1):37-41. PMID: 16337108.
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    38. Bonfield TL, Swaisgood CM, Barna BP, Farver CF, Kavuru MS, Thomassen MJ. Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor. J Leukoc Biol. 2006 Jan; 79(1):133-9. PMID: 16275889.
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    39. Kobayashi M, Thomassen MJ, Rambasek T, Bonfield TL, Raychaudhuri B, Malur A, Winkler AR, Barna BP, Goldman SJ, Kavuru MS. An inverse relationship between peroxisome proliferator-activated receptor gamma and allergic airway inflammation in an allergen challenge model. Ann Allergy Asthma Immunol. 2005 Nov; 95(5):468-73. PMID: 16312170.
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    40. Ioachimescu OC, Venkateshiah SB, Kavuru MS, McCarthy K, Stoller JK. Estimating FVC from FEV2 and FEV3: assessment of a surrogate spirometric parameter. Chest. 2005 Sep; 128(3):1274-81. PMID: 16162718.
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    41. Bonfield TL, John N, Barna BP, Kavuru MS, Thomassen MJ, Yen-Lieberman B. Multiplexed particle-based anti-granulocyte macrophage colony stimulating factor assay used as pulmonary diagnostic test. Clin Diagn Lab Immunol. 2005 Jul; 12(7):821-4. PMID: 16002629.
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    42. Wu J, Kobayashi M, Sousa EA, Liu W, Cai J, Goldman SJ, Dorner AJ, Projan SJ, Kavuru MS, Qiu Y, Thomassen MJ. Differential proteomic analysis of bronchoalveolar lavage fluid in asthmatics following segmental antigen challenge. Mol Cell Proteomics. 2005 Sep; 4(9):1251-64. PMID: 15951573.
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    43. Rybicki BA, Hirst K, Iyengar SK, Barnard JG, Judson MA, Rose CS, Donohue JF, Kavuru MS, Rabin DL, Rossman MD, Baughman RP, Elston RC, Maliarik MJ, Moller DR, Newman LS, Teirstein AS, Iannuzzi MC. A sarcoidosis genetic linkage consortium: the sarcoidosis genetic analysis (SAGA) study. Sarcoidosis Vasc Diffuse Lung Dis. 2005 Jun; 22(2):115-22. PMID: 16053026.
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    44. Bonfield TL, John N, Malur A, Barna BP, Culver DA, Kavuru MS, Thomassen MJ. Elevated monocyte chemotactic proteins 1, 2, and 3 in pulmonary alveolar proteinosis are associated with chemokine receptor suppression. Clin Immunol. 2005 Jan; 114(1):79-85. PMID: 15596412.
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    45. Meaney S, Bonfield TL, Hansson M, Babiker A, Kavuru MS, Thomassen MJ. Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis. J Lipid Res. 2004 Dec; 45(12):2354-60. PMID: 15466366.
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    46. Seshadri N, Gildea TR, McCarthy K, Pothier C, Kavuru MS, Lauer MS. Association of an abnormal exercise heart rate recovery with pulmonary function abnormalities. Chest. 2004 Apr; 125(4):1286-91. PMID: 15078736.
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    47. Rambasek TE, Lang DM, Kavuru MS. Omalizumab: where does it fit into current asthma management? Cleve Clin J Med. 2004 Mar; 71(3):251-61. PMID: 15055248.
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    48. Culver DA, Thomassen MJ, Kavuru MS. Pulmonary sarcoidosis: new genetic clues and ongoing treatment controversies. Cleve Clin J Med. 2004 Feb; 71(2):88, 90, 92 passim. PMID: 14982192.
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    49. Venkateshiah SB, Thomassen MJ, Kavuru MS. Pulmonary alveolar proteinosis. Clinical manifestations and optimal treatment strategies. Treat Respir Med. 2004; 3(4):217-27. PMID: 15350160.
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    50. Culver DA, Barna BP, Raychaudhuri B, Bonfield TL, Abraham S, Malur A, Farver CF, Kavuru MS, Thomassen MJ. Peroxisome proliferator-activated receptor gamma activity is deficient in alveolar macrophages in pulmonary sarcoidosis. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):1-5. PMID: 14512375.
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    51. Raychaudhuri B, Abraham S, Bonfield TL, Malur A, Deb A, DiDonato JA, Kavuru MS, Thomassen MJ. Surfactant blocks lipopolysaccharide signaling by inhibiting both mitogen-activated protein and IkappaB kinases in human alveolar macrophages. Am J Respir Cell Mol Biol. 2004 Feb; 30(2):228-32. PMID: 12920056.
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    52. Thomassen MJ, Raychaudhuri B, Bonfield TL, Malur A, Abraham S, Barna BP, Kavuru MS. Elevated IL-10 inhibits GM-CSF synthesis in pulmonary alveolar proteinosis. Autoimmunity. 2003 Aug; 36(5):285-90. PMID: 14567558.
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    53. Bonfield TL, Raychaudhuri B, Malur A, Abraham S, Trapnell BC, Kavuru MS, Thomassen MJ. PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol. 2003 Nov; 285(5):L1132-6. PMID: 12896880.
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    54. Bonfield TL, Farver CF, Barna BP, Malur A, Abraham S, Raychaudhuri B, Kavuru MS, Thomassen MJ. Peroxisome proliferator-activated receptor-gamma is deficient in alveolar macrophages from patients with alveolar proteinosis. Am J Respir Cell Mol Biol. 2003 Dec; 29(6):677-82. PMID: 12805087.
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    55. Kavuru MS, Bonfield TL, Thomassen MJ. Plasmapheresis, GM-CSF, and alveolar proteinosis. Am J Respir Crit Care Med. 2003 Apr 1; 167(7):1036; author reply 1036-7. PMID: 12663343.
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    56. Khatri SB, Hammel J, Kavuru MS, Erzurum SC, Dweik RA. Temporal association of nitric oxide levels and airflow in asthma after whole lung allergen challenge. J Appl Physiol. 2003 Jul; 95(1):436-40; discussion 435. PMID: 12576414.
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    57. Bonfield TL, Kavuru MS, Thomassen MJ. Anti-GM-CSF titer predicts response to GM-CSF therapy in pulmonary alveolar proteinosis. Clin Immunol. 2002 Dec; 105(3):342-50. PMID: 12498816.
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    58. Bonfield TL, Russell D, Burgess S, Malur A, Kavuru MS, Thomassen MJ. Autoantibodies against granulocyte macrophage colony-stimulating factor are diagnostic for pulmonary alveolar proteinosis. Am J Respir Cell Mol Biol. 2002 Oct; 27(4):481-6. PMID: 12356582.
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    59. Kavuru MS, Popovich M. Therapeutic whole lung lavage: a stop-gap therapy for alveolar proteinosis. Chest. 2002 Oct; 122(4):1123-4. PMID: 12377831.
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    60. Raychaudhuri B, Bonfield TL, Malur A, Hague K, Kavuru MS, Arroliga AC, Thomassen MJ. Circulating monocytes from patients with primary pulmonary hypertension are hyporesponsive. Clin Immunol. 2002 Aug; 104(2):191-8. PMID: 12165280.
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    61. Wishah K, Malur A, Raychaudhuri B, Melton AL, Kavuru MS, Thomassen MJ. Nitric oxide blocks inflammatory cytokine secretion triggered by CD23 in monocytes from allergic, asthmatic patients and healthy controls. Ann Allergy Asthma Immunol. 2002 Jul; 89(1):78-82. PMID: 12141726.
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    62. Raychaudhuri B, Malur A, Bonfield TL, Abraham S, Schilz RJ, Farver CF, Kavuru MS, Arroliga AC, Thomassen MJ. The prostacyclin analogue treprostinil blocks NFkappaB nuclear translocation in human alveolar macrophages. J Biol Chem. 2002 Sep 6; 277(36):33344-8. PMID: 12082102.
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    63. Mazzone PJ, Jane Thomassen M, Kavuru MS. Pulmonary Alveolar Proteinosis: recent advances. Semin Respir Crit Care Med. 2002 Apr; 23(2):115-26. PMID: 16088604.
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