Natalia Riobo

TitleAsst Professor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
Phone215-503-8549
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    The Hedgehog family of ligands regulates a plethora of biological processes involved in embryonic development, tissue homeostasis and regeneration, and cancer progression. The canonical Hedgehog pathway is based on a series of de-repression events mediated by the proteins Patched, Smoothened, and Su(Fu) that allow a tightly controlled activation of the downstream transcription factors Gli1, Gli2, and Gli3. We and others have recently shown that Hedgehog, signaling through Smoothened, also activates Gi proteins/GRK2/arrestin, PI3K/Akt, and ERK signaling pathways which may have physiological significance on their own. In addition, Patched directly regulates cell cycle progression in a Hedgehog-dependent manner. These newly discovered events are grouped into the so-called non-canonical Hedgehog pathway.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR. Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget. 2015 Oct 20; 6(32):34038. PMID: 26513314.
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    2. Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR. Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget. 2015 Jun 10; 6(16):14318-28. PMID: 26015409.
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    3. Brennan-Crispi DM, Hossain C, Sahu J, Brady M, Riobo NA, Mahoney MG. Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis. Oncotarget. 2015 Apr 20; 6(11):8593-605. PMID: 25871385.
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    4. Gupta A, Nitoiu D, Brennan-Crispi D, Addya S, Riobo NA, Kelsell DP, Mahoney MG. Cell cycle- and cancer-associated gene networks activated by dsg2: evidence of cystatin a deregulation and a potential role in cell-cell adhesion. PLoS One. 2015; 10(3):e0120091. PMID: 25785582.
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    5. Manning DR, Shen F, Riobo NA. Evaluating the Activity of Smoothened Toward G Proteins Using [(35)S]Guanosine 5'-(3-O-thio)triphosphate ([ (35)S]GTP?S). Methods Mol Biol. 2015; 1322:35-44. PMID: 26179037.
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    6. Brennan-Crispi DM, Mahoney MG, Riobo NA. Methods for Detection of Ptc1-Driven LacZ Expression in Adult Mouse Skin. Methods Mol Biol. 2015; 1322:167-85. PMID: 26179048.
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    7. Ho L, Riobo NA. Posttranslational Modifications and Secretion of the Hedgehog (Hh) Proteins. Preface. Methods Mol Biol. 2015; 1322:v-xi. PMID: 26380847.
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    8. Chen XL, Chinchilla P, Fombonne J, Ho L, Guix C, Keen JH, Mehlen P, Riobo NA. Patched-1 proapoptotic activity is downregulated by modification of k1413 by the e3 ubiquitin-protein ligase itchy homolog. Mol Cell Biol. 2014 Oct 15; 34(20):3855-66. PMID: 25092867.
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    9. Teperino R, Aberger F, Esterbauer H, Riobo N, Pospisilik JA. Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol. 2014 Sep; 33:81-92. PMID: 24862854.
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    10. Carbe CJ, Cheng L, Addya S, Gold JI, Gao E, Koch WJ, Riobo NA. Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol. 2014 Jul 1; 307(1):H66-72. PMID: 24816261.
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    11. Shen F, Cheng L, Douglas AE, Riobo NA, Manning DR. Smoothened is a fully competent activator of the heterotrimeric g protein gi. Mol Pharmacol. 2013 Mar; 83(3):691-7. PMID: 23292797.
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    12. Robbins DJ, Fei DL, Riobo NA. The hedgehog signal transduction network. Sci Signal. 2012; 5(246):re6. PMID: 23074268.
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    13. Riobo NA. Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr Opin Pharmacol. 2012 Dec; 12(6):736-41. PMID: 22832232.
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    14. Brennan D, Chen X, Cheng L, Mahoney M, Riobo NA. Noncanonical Hedgehog signaling. Vitam Horm. 2012; 88:55-72. PMID: 22391299.
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    15. Polizio AH, Chinchilla P, Chen X, Manning DR, Riobo NA. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Sci Signal. 2011; 4(200):pt7. PMID: 22114142.
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    16. Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernández-Zapico ME, Manning DR. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem. 2011 Sep 2; 286(35):30714-22. PMID: 21757753.
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    17. Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR, Riobo NA. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem. 2011 Jun 3; 286(22):19589-96. PMID: 21474452.
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    18. Chinchilla P, Xiao L, Kazanietz MG, Riobo NA. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle. 2010 Feb 1; 9(3):570-79. PMID: 20081366.
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    19. Han F, Da T, Riobo NA, Becker LB. Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest. Crit Care Med. 2008 Nov; 36(11 Suppl):S447-53. PMID: 20449909.
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    20. Martinez-Chinchilla P, Riobo NA. Purification and bioassay of hedgehog ligands for the study of cell death and survival. Methods Enzymol. 2008; 446:189-204. PMID: 18603123.
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    21. Riobo NA, Manning DR. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J. 2007 May 1; 403(3):369-79. PMID: 17419683.
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    22. Gavrielides MV, Gonzalez-Guerrico AM, Riobo NA, Kazanietz MG. Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res. 2006 Dec 15; 66(24):11792-801. PMID: 17178875.
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    23. Riobo NA, Saucy B, Dilizio C, Manning DR. Activation of heterotrimeric G proteins by Smoothened. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12607-12. PMID: 16885213.
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    24. Riobo NA, Lu K, Emerson CP. Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle. 2006 Aug; 5(15):1612-5. PMID: 16880744.
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    25. Riobo NA, Haines GM, Emerson CP. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res. 2006 Jan 15; 66(2):839-45. PMID: 16424016.
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    26. Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends Pharmacol Sci. 2005 Mar; 26(3):146-54. PMID: 15749160.
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    27. Riobo NA, Melani M, Sanjuan N, Fiszman ML, Gravielle MC, Carreras MC, Cadenas E, Poderoso JJ. The modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J Biol Chem. 2002 Nov 8; 277(45):42447-55. PMID: 12202479.
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