Nicole Simone

TitleProfessor
InstitutionThomas Jefferson University
DepartmentRadiation Oncology
Address111 S. 11th Street
Philadelphia PA 19107
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    Dr. Simone is an expert in using dietary alteration to increase the effectiveness of cytotoxic therapy, such as radiation and chemotherapy, in breast and prostate cancer in both the laboratory and clinic. Her research interest is to change the landscape of cancer care by empowering patients to use dietary interventions to improve outcomes. The overarching goal of the Simone laboratory, is to increase the radiation sensitivity of tumors with a poor response to standard therapies. To accomplish this, the lab uses diet to alter cell metabolism via signaling pathways to increase cancer cells’ vulnerability to cytotoxic therapy. Through the laboratory studies, new strategies for treating radiation resistant tumors, which has led to the development of innovative clinical trials.

    Dr. Simone is the Co-Leader of the Breast Cancer Research Program for the Sidney Kimmel Cancer Center and the Margaret Q. Landenberger Endowed Associate Professor in the Department of Radiation Oncology at Thomas Jefferson University. She has considerable experience in translational research, medical treatment, education and training. I joined the Jefferson faculty after a position as an Assistant Clinical Investigator at the National Cancer Institute.

    Dr. Simone’s laboratory has contributed significantly to studying regulation of microRNAs and the downstream effects of microRNAs on cell metabolism via dietary alterations. Her laboratory demonstrated for the first time that caloric restriction (CR) modifies microRNA expression (Ørom et al., Cell Cycle, 2012). The Simone laboratory then explored the physiologic impact of CR and demonstrated that CR can augment radiation therapy (Saleh et al., Cell Cycle, 2013), which she then translated directly into a clinical trial using diet during radiation for early stage breast cancer patients (NCT01819233). The lab found the same improved physiologic response of the primary tumor in vivo when CR was combined with chemotherapy, which was translated directly to a clinical trial (NCT02827370). Dr. Simone’s laboratory also investigated the role of microRNAs in the ability of CR to decrease metastatic disease burden via control of the ECM (Jin et al., Breast Cancer Res Treat, 2014; Simone et al., Cell Cycle, 2016) which is being considered as a NRG Oncology clinical trial concept. These findings led to her third IIT in which diet modulation prior to definitive oncologic surgery for patients with endometrial, prostate, and breast cancer will be evaluated to favorably alter expression of microRNAs as drivers of cancer progression (NCT02983279).

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Manukian G, Kivolowitz C, DeAngelis T, Shastri AA, Savage JE, Camphausen K, Rodeck U, Zarif JC, Simone NL. Caloric Restriction Impairs Regulatory T cells Within the Tumor Microenvironment After Radiation and Primes Effector T cells. Int J Radiat Oncol Biol Phys. 2021 Feb 26. PMID: 33647370.
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    2. Dan T, Shastri AA, Palagani A, Buraschi S, Neill T, Savage JE, Kapoor A, DeAngelis T, Addya S, Camphausen K, Iozzo RV, Simone NL. miR-21 Plays a Dual Role in Tumor Formation and Cytotoxic Response in Breast Tumors. Cancers (Basel). 2021 Feb 20; 13(4). PMID: 33672628.
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    3. Taylor JM, Song A, Nowak K, Dan T, Simone B, Harrison A, Doyle L, Lockamy V, Anne P, Simone N. Dosimetric Comparisons of Simulation Techniques for Left-Sided Breast Cancer in the COVID-19 Era: Techniques to Reduce Viral Transmission and Respect the Therapeutic Ratio. Cureus. 2021 Feb 15; 13(2):e13354. PMID: 33747655.
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    4. Zaorsky NG, Allenby T, Lin J, Rosenberg J, Simone NL, Schmitz KH. TEMPORARY REMOVAL: Exercise therapy and radiation therapy (EXERT) for cancer: a systematic review. Int J Radiat Oncol Biol Phys. 2020 Nov 19. PMID: 33220396.
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    5. Allenby TH, Crenshaw ML, Mathis K, Champ CE, Simone NL, Schmitz KH, Tchelebi LT, Zaorsky NG. A systematic review of home-based dietary interventions during radiation therapy for cancer. Tech Innov Patient Support Radiat Oncol. 2020 Dec; 16:10-16. PMID: 32995577.
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    6. Wright CM, Shastri AA, Bongiorno E, Palagani A, Rodeck U, Simone NL. Is Host Metabolism the Missing Link to Improving Cancer Outcomes? Cancers (Basel). 2020 Aug 19; 12(9). PMID: 32825010.
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    7. Meneveau MO, Petroni GR, Varhegyi NE, Hulse JC, Schroen AT, Brenin DR, Janowski EM, Berger AC, Lazar MA, Simone NL, Showalter TN, Showalter SL. Toxicity and cosmetic outcomes after treatment with a novel form of breast IORT. Brachytherapy. 2020 Jun 19. PMID: 32571746.
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    8. Lombardo J, Simone N. Care of Transgender Persons. N Engl J Med. 2020 04 09; 382(15):1481. PMID: 32268037.
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    9. Song A, Manukian G, Taylor A, Anne PR, Simone NL. Concerns for activated breathing control (ABC) with breast cancer in the era of COVID-19: Maximizing infection control while minimizing heart dose. Adv Radiat Oncol. 2020 Apr 01. PMID: 32292838.
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    10. Shastri AA, Saleh A, Savage JE, DeAngelis T, Camphausen K, Simone NL. Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis. Nutr Metab (Lond). 2020; 17:23. PMID: 32211051.
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    11. Puccetti MV, Adams CM, Dan TD, Palagani A, Simone BA, DeAngelis T, Eischen CM, Simone NL. miR-21 is required for hematopoietic cell viability following radiation exposure. Int J Radiat Oncol Biol Phys. 2019 Apr 27. PMID: 31039423.
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    12. Scott DA, Casadonte R, Cardinali B, Spruill L, Mehta AS, Carli F, Simone N, Kriegsmann M, Del Mastro L, Kriegsmann J, Drake RR. Increases in Tumor N-Glycan Polylactosamines Associated with Advanced HER2-Positive and Triple-Negative Breast Cancer Tissues. Proteomics Clin Appl. 2019 01; 13(1):e1800014. PMID: 30592377.
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    13. Simone BA, Ko K, Simone NL. Re: Elevated BMI might more significantly affect the outcome negatively in luminal type breast cancer patients with brain metastases. Breast Cancer Res Treat. 2018 Nov; 172(2):511. PMID: 30259336.
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    14. McCall NS, Simone BA, Mehta M, Zhan T, Ko K, Nowak-Choi K, Rese A, Venkataraman C, Andrews DW, Anne' PR, Dicker AP, Shi W, Simone NL. Onco-metabolism: defining the prognostic significance of obesity and diabetes in women with brain metastases from breast cancer. Breast Cancer Res Treat. 2018 Nov; 172(1):221-230. PMID: 30022328.
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    15. Simone BA, Palagani A, Strickland K, Ko K, Jin L, Lim MK, Dan TD, Sarich M, Monti DA, Cristofanilli M, Simone NL. Caloric restriction counteracts chemotherapy-induced inflammation and increases response to therapy in a triple negative breast cancer model. Cell Cycle. 2018 Jun 18. PMID: 29912618.
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    16. Arthur DW, Winter KA, Kuerer HM, Haffty BG, Cuttino LW, Todor DA, Simone NL, Hayes SB, Woodward WA, McCormick B, Cohen RJ, Sahijdak WM, Canaday DJ, Brown DR, Currey AD, Fisher CM, Jagsi R, White J. NRG Oncology-Radiation Therapy Oncology Group Study 1014: 1-Year Toxicity Report From a Phase 2 Study of Repeat Breast-Preserving Surgery and 3-Dimensional Conformal Partial-Breast Reirradiation for In-Breast Recurrence. Int J Radiat Oncol Biol Phys. 2017 Aug 01; 98(5):1028-1035. PMID: 28721885.
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    17. Toss A, Palazzo J, Berger A, Guiles F, Sendecki JA, Simone N, Anne R, Avery T, Jaslow R, Lazar M, Tsangaris T, Cristofanilli M. Clinical-pathological features and treatment modalities associated with recurrence in DCIS and micro-invasive carcinoma: Who to treat more and who to treat less. Breast. 2016 Oct; 29:223-30. PMID: 27506636.
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    18. Wright C, Simone NL. Obesity and tumor growth: inflammation, immunity, and the role of a ketogenic diet. Curr Opin Clin Nutr Metab Care. 2016 Jul; 19(4):294-9. PMID: 27168354.
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    19. Simone BA, Dan T, Palagani A, Jin L, Han SY, Wright C, Savage JE, Gitman R, Lim MK, Palazzo J, Mehta MP, Simone NL. Caloric restriction coupled with radiation decreases metastatic burden in triple negative breast cancer. Cell Cycle. 2016 Sep; 15(17):2265-74. PMID: 27027731.
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    20. Shi W, Palmer JD, Werner-Wasik M, Andrews DW, Evans JJ, Glass J, Kim L, Bar-Ad V, Judy K, Farrell C, Simone N, Liu H, Dicker AP, Lawrence YR. Phase I trial of panobinostat and fractionated stereotactic re-irradiation therapy for recurrent high grade gliomas. J Neurooncol. 2016 May; 127(3):535-9. PMID: 26821711.
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    21. Kim H, Malatesta TM, Simone NL, Den RB, McAna J, Dicker AP, Bar Ad V. A single activity with a practice quality improvement project for faculty and a quality improvement project for residents. Pract Radiat Oncol. 2016 Mar-Apr; 6(2):114-8. PMID: 26723550.
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    22. Dan TD, Simone NL. Not so fast: dietary restriction improves chemotherapy-related toxicity. Cell Cycle. 2015 Aug 18; 14(16):2554-5. PMID: 26102577.
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    23. Eldredge-Hindy HB, Duffy D, Yamoah K, Simone NL, Skowronski J, Dicker AP, Anne PR. Modeled risk of ischemic heart disease following left breast irradiation with deep inspiration breath hold. Pract Radiat Oncol. 2015 May-Jun; 5(3):162-8. PMID: 25957186.
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    24. Eldredge-Hindy H, Lockamy V, Crawford A, Nettleton V, Werner-Wasik M, Siglin J, Simone NL, Sidhu K, Anne PR. Active Breathing Coordinator reduces radiation dose to the heart and preserves local control in patients with left breast cancer: Report of a prospective trial. Pract Radiat Oncol. 2015 Jan-Feb; 5(1):4-10. PMID: 25567159.
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    25. Dan TD, Wright CM, Simone NL. What benefits could caloric restriction bring to cancer patients? Future Oncol. 2014 Dec; 10(16):2543-6. PMID: 25531042.
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    26. Eldredge-Hindy HB, Rosenberg AL, Simone NL. Intraoperative radiotherapy for breast cancer: the lasting effects of a fleeting treatment. Int J Breast Cancer. 2014; 2014:214325. PMID: 25180098.
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    27. Simone BA, Ly D, Savage JE, Hewitt SM, Dan TD, Ylaya K, Shankavaram U, Lim M, Jin L, Camphausen K, Mitchell JB, Simone NL. microRNA Alterations Driving Acute and Late Stages of Radiation-Induced Fibrosis in a Murine Skin Model. Int J Radiat Oncol Biol Phys. 2014 Sep 1; 90(1):44-52. PMID: 24986745.
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    28. Wright CM, Dan T, Dicker AP, Simone NL. microRNAs: The Short Link between Cancer and RT-Induced DNA Damage Response. Front Oncol. 2014; 4:133. PMID: 24926436.
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    29. Jin L, Lim M, Zhao S, Sano Y, Simone BA, Savage JE, Wickstrom E, Camphausen K, Pestell RG, Simone NL. The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster. Breast Cancer Res Treat. 2014 Jul; 146(1):41-50. PMID: 24863696.
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    30. Palmer JD, Soule BP, Simone BA, Zaorsky NG, Jin L, Simone NL. MicroRNA expression altered by diet: can food be medicinal? Ageing Res Rev. 2014 Sep; 17:16-24. PMID: 24833329.
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    31. Simone BA, Champ CE, Rosenberg AL, Berger AC, Monti DA, Dicker AP, Simone NL. Selectively starving cancer cells through dietary manipulation: methods and clinical implications. Future Oncol. 2013 Jul; 9(7):959-76. PMID: 23837760.
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    32. Saleh AD, Simone BA, Palazzo J, Savage JE, Sano Y, Dan T, Jin L, Champ CE, Zhao S, Lim M, Sotgia F, Camphausen K, Pestell RG, Mitchell JB, Lisanti MP, Simone NL. Caloric restriction augments radiation efficacy in breast cancer. Cell Cycle. 2013 Jun 15; 12(12):1955-63. PMID: 23708519.
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    33. Champ CE, Mishra MV, Showalter TN, Ohri N, Dicker AP, Simone NL. Dietary recommendations during and after cancer treatment: consistently inconsistent? Nutr Cancer. 2013 Apr; 65(3):430-9. PMID: 23530643.
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    34. Champ CE, Baserga R, Mishra MV, Jin L, Sotgia F, Lisanti MP, Pestell RG, Dicker AP, Simone NL. Nutrient restriction and radiation therapy for cancer treatment: when less is more. Oncologist. 2013; 18(1):97-103. PMID: 23299773.
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    35. Champ CE, Simone NL. In reply. Oncologist. 2013; 18(9):1057. PMID: 24062423.
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    36. Siglin J, Champ CE, Vakhnenko Y, Anne PR, Simone NL. Radiation therapy for locally recurrent breast cancer. Int J Breast Cancer. 2012; 2012:571946. PMID: 23091733.
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    37. Champ CE, Volek JS, Siglin J, Jin L, Simone NL. Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data? Int J Breast Cancer. 2012; 2012:506868. PMID: 23050155.
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    38. Ørom UA, Lim MK, Savage JE, Jin L, Saleh AD, Lisanti MP, Simone NL. MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction. Cell Cycle. 2012 Apr 1; 11(7):1291-5. PMID: 22421148.
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    39. Simone NL, Dan T, Shih J, Smith SL, Sciuto L, Lita E, Lippman ME, Glatstein E, Swain SM, Danforth DN, Camphausen K. Twenty-five year results of the national cancer institute randomized breast conservation trial. Breast Cancer Res Treat. 2012 Feb; 132(1):197-203. PMID: 22113254.
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    40. Saleh AD, Savage JE, Cao L, Soule BP, Ly D, DeGraff W, Harris CC, Mitchell JB, Simone NL. Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53. PLoS One. 2011; 6(10):e24429. PMID: 22022355.
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    41. Simone CB, Lonser RR, Ondos J, Oldfield EH, Camphausen K, Simone NL. Infratentorial craniospinal irradiation for von Hippel-Lindau: a retrospective study supporting a new treatment for patients with CNS hemangioblastomas. Neuro Oncol. 2011 Sep; 13(9):1030-6. PMID: 21798886.
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    42. Argiris A, Duffy AG, Kummar S, Simone NL, Arai Y, Kim SW, Rudy SF, Kannabiran VR, Yang X, Jang M, Chen Z, Suksta N, Cooley-Zgela T, Ramanand SG, Ahsan A, Nyati MK, Wright JJ, Van Waes C. Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer. Clin Cancer Res. 2011 Sep 1; 17(17):5755-64. PMID: 21750205.
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    43. Simone CB, Ly D, Dan TD, Ondos J, Ning H, Belard A, O'Connell J, Miller RW, Simone NL. Comparison of intensity-modulated radiotherapy, adaptive radiotherapy, proton radiotherapy, and adaptive proton radiotherapy for treatment of locally advanced head and neck cancer. Radiother Oncol. 2011 Dec; 101(3):376-82. PMID: 21663988.
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    44. Soule BP, Simone NL, DeGraff WG, Choudhuri R, Cook JA, Mitchell JB. Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. Radiat Oncol. 2010; 5:8. PMID: 20128919.
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    45. Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB. Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One. 2009; 4(7):e6377. PMID: 19633716.
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    46. Simone NL, Singh AK, Cowan JE, Soule BP, Carroll PR, Litwin MS. Pretreatment predictors of death from other causes in men with prostate cancer. J Urol. 2008 Dec; 180(6):2447-51; discussion 2451-2. PMID: 18930498.
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    47. Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. Therapeutic and clinical applications of nitroxide compounds. Antioxid Redox Signal. 2007 Oct; 9(10):1731-43. PMID: 17665971.
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    48. Simone NL, Ménard C, Soule BP, Albert PS, Guion P, Smith S, Godette D, Crouse NS, Sciuto LC, Cooley-Zgela T, Camphausen K, Coleman CN, Singh AK. Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. Int J Radiat Oncol Biol Phys. 2008 Jan 1; 70(1):90-5. PMID: 17855015.
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    49. Soule BP, Brown JM, Kushnir-Sukhov NM, Simone NL, Mitchell JB, Metcalfe DD. Effects of gamma radiation on FcepsilonRI and TLR-mediated mast cell activation. J Immunol. 2007 Sep 1; 179(5):3276-86. PMID: 17709544.
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    50. Simone NL, Soule BP, Gerber L, Augustine E, Smith S, Altemus RM, Mitchell JB, Camphausen KA. Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study. Radiat Oncol. 2007; 2:19. PMID: 17540023.
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    51. Soule BP, Hyodo F, Matsumoto K, Simone NL, Cook JA, Krishna MC, Mitchell JB. The chemistry and biology of nitroxide compounds. Free Radic Biol Med. 2007 Jun 1; 42(11):1632-50. PMID: 17462532.
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    52. Singh AK, Ménard C, Guion P, Simone NL, Smith S, Crouse NS, Godette DJ, Cooley-Zgela T, Sciuto LC, Coleman J, Pinto P, Albert PS, Camphausen K, Coleman CN. Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study. Int J Radiat Oncol Biol Phys. 2006 Jul 15; 65(4):1008-13. PMID: 16730138.
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