Olga Igoucheva

TitleAssoc Professor
InstitutionThomas Jefferson University
DepartmentDermatology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Huitema L, Phillips T, Alexeev V, Tomic-Canic M, Pastar I, Igoucheva O. Intracellular escape strategies of Staphylococcus aureus in persistent cutaneous infections. Exp Dermatol. 2020 Nov 11. PMID: 33179358.
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    2. Alexeev V, Olavarria J, Bonaldo P, Merlini L, Igoucheva O. Congenital muscular dystrophy-associated inflammatory chemokines provide axes for effective recruitment of therapeutic adult stem cell into muscles. Stem Cell Res Ther. 2020 Nov 02; 11(1):463. PMID: 33138863.
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    3. Phillips T, Huitema L, Cepeda R, Cobos DL, Perez RIM, Garza MS, Ringpfeil F, Dasgeb B, Uitto J, Salas-Alanis JC, Alexeev V, Igoucheva O. Aberrant recruitment of leukocytes defines poor wound healing in patients with recessive dystrophic epidermolysis bullosa. J Dermatol Sci. 2020 Dec; 100(3):209-216. PMID: 33143962.
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    4. Alexeev V, Salas-Alanis JC, Palisson F, Mukhtarzada L, Fortuna G, Uitto J, South A, Igoucheva O. Pro-Inflammatory Chemokines and Cytokines Dominate the Blister Fluid Molecular Signature in Patients with Epidermolysis Bullosa and Affect Leukocyte and Stem Cell Migration. J Invest Dermatol. 2017 Nov; 137(11):2298-2308. PMID: 28736230.
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    5. Meester I, Igoucheva O, Alexeev V, South A, Moreno-Treviño MG, Salas-Alanis JC. High concordance between clinical diagnosis of epidermolysis bullosa and immunofluorescence with a small, well-matched antibody panel. Australas J Dermatol. 2017 Jul 13. PMID: 28707324.
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    6. Kemp DM, Pidich A, Larijani M, Jonas R, Lash E, Sato T, Terai M, De Pizzol M, Allegretti M, Igoucheva O, Alexeev V. Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment. Oncotarget. 2017 Feb 28; 8(9):14428-14442. PMID: 28129639.
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    7. Rezk AF, Kemp DM, El-Domyati M, El-Din WH, Lee JB, Uitto J, Igoucheva O, Alexeev V. Misbalanced CXCL12 and CCL5 Chemotactic Signals in Vitiligo Onset and Progression. J Invest Dermatol. 2017 May; 137(5):1126-1134. PMID: 28132854.
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    8. Alexeev V, Donahue A, Uitto J, Igoucheva O. Chemotaxis-driven disease-site targeting of therapeutic adult stem cells in dystrophic epidermolysis bullosa. Stem Cell Res Ther. 2016; 7(1):124. PMID: 27568180.
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    9. Zhou D, Gao Y, Aied A, Cutlar L, Igoucheva O, Newland B, Alexeeve V, Greiser U, Uitto J, Wang W. Highly branched poly(ß-amino ester)s for skin gene therapy. J Control Release. 2016 Dec 28; 244(Pt B):336-346. PMID: 27288877.
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    10. Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML. Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. J Biol Chem. 2015 Aug 28; 290(35):21443-59. PMID: 26178373.
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    11. Alexeev V, Arita M, Donahue A, Bonaldo P, Chu ML, Igoucheva O. Human adipose-derived stem cell transplantation as a potential therapy for collagen VI-related congenital muscular dystrophy. Stem Cell Res Ther. 2014; 5(1):21. PMID: 24522088.
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    12. Igoucheva O, Jonas R, Alexeev V. Chemokine-enhanced DNA vaccination in cancer immunotherapy. Oncoimmunology. 2013 Oct 01; 2(10):e26092. PMID: 24251079.
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    13. Alexeev V, Donahue A, Uitto J, Igoucheva O. Analysis of chemotactic molecules in bone marrow-derived mesenchymal stem cells and the skin: Ccl27-Ccr10 axis as a basis for targeting to cutaneous tissues. Cytotherapy. 2013 Feb; 15(2):171-184.e1. PMID: 23321329.
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    14. Alexeev V, Uitto J, Igoucheva O. Gene expression signatures of mouse bone marrow-derived mesenchymal stem cells in the cutaneous environment and therapeutic implications for blistering skin disorder. Cytotherapy. 2011 Jan; 13(1):30-45. PMID: 20854215.
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    15. Smith JA, Ndoye AM, Geary K, Lisanti MP, Igoucheva O, Daniel R. A role for the Werner syndrome protein in epigenetic inactivation of the pluripotency factor Oct4. Aging Cell. 2010 Aug; 9(4):580-91. PMID: 20477760.
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    16. Alexeev V, Igoucheva O. Retroviral delivery of ECM genes. Methods Mol Biol. 2009; 522:3-14. PMID: 19247621.
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    17. Igoucheva O, Alexeev V, Anni H, Rubin E. Oligonucleotide-mediated gene targeting in human hepatocytes: implications of mismatch repair. Oligonucleotides. 2008 Jun; 18(2):111-22. PMID: 18637729.
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    18. Igoucheva O, Kelly A, Uitto J, Alexeev V. Protein therapeutics for junctional epidermolysis bullosa: incorporation of recombinant beta3 chain into laminin 332 in beta3-/- keratinocytes in vitro. J Invest Dermatol. 2008 Jun; 128(6):1476-86. PMID: 18079746.
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    19. Novak L, Igoucheva O, Cho S, Alexeev V. Characterization of the CCL21-mediated melanoma-specific immune responses and in situ melanoma eradication. Mol Cancer Ther. 2007 Jun; 6(6):1755-64. PMID: 17575105.
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    20. Cesarone G, Garofalo C, Abrams MT, Igoucheva O, Alexeev V, Yoon K, Surmacz E, Wickstrom E. RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells. J Cell Biochem. 2006 May 15; 98(2):440-50. PMID: 16440325.
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    21. Igoucheva O, Alexeev V, Scharer O, Yoon K. Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification. Oligonucleotides. 2006; 16(1):94-104. PMID: 16584298.
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    22. Igoucheva O, Yoon K. Gene targeting by oligonucleotides in keratinocytes. Methods Mol Biol. 2005; 289:287-302. PMID: 15502193.
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    23. Igoucheva O, Alexeev V, Yoon K. Oligonucleotide-directed mutagenesis and targeted gene correction: a mechanistic point of view. Curr Mol Med. 2004 Aug; 4(5):445-63. PMID: 15267219.
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    24. Igoucheva O, Alexeev V, Yoon K. Mechanism of gene repair open for discussion. Oligonucleotides. 2004; 14(4):311-21. PMID: 15665598.
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    25. Igoucheva O, Alexeev V, Pryce M, Yoon K. Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration. Nucleic Acids Res. 2003 May 15; 31(10):2659-70. PMID: 12736316.
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    26. Yoon K, Igoucheva O, Alexeev V. Expectations and reality in gene repair. Nat Biotechnol. 2002 Dec; 20(12):1197-8. PMID: 12454668.
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    27. Igoucheva O, Alexeev V, Yoon K. Nuclear extracts promote gene correction and strand pairing of oligonucleotides to the homologous plasmid. Antisense Nucleic Acid Drug Dev. 2002 Aug; 12(4):235-46. PMID: 12238812.
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    28. Igoucheva OA, Yoon K. Gene correction frequency by chimeric RNA-DNA oligonucleotide using nuclear extracts. Methods Mol Med. 2002; 69:95-107. PMID: 11987801.
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