Omar Tliba

TitleAssoc Prof CHP
InstitutionThomas Jefferson University
DepartmentTJU School of Pharmacy
Address901 Walnut Street
Philadelphia PA 19107
Phone215-503-9000
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    Transcriptional regulation of cytokine functions in airway cells. ASM cells respond to many cytokines, growth factors and lipid mediators to produce a wide array of immuno-modulatory molecules which may in turn orchestrate and perpetuate the disease process in asthma. Our goals are to identify intracellular signaling pathways by which cytokines modulate or induce these cellular responses. A focus of this project is to investigate the transcriptional and post-transcriptional mechanisms regulating cytokine functions in ASM cells.



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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ramos-Ramírez P, Tliba O. Glucocorticoid Receptor ß (GRß): Beyond Its Dominant-Negative Function. Int J Mol Sci. 2021 Mar 31; 22(7). PMID: 33807481.
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    2. Alzahrani A, Hussain A, Alhadian F, Hakeem J, Douaoui S, Tliba O, Bradding P, Amrani Y. Potential Role of Mast Cells in Regulating Corticosteroid Insensitivity in Severe Asthma. Adv Exp Med Biol. 2021; 1303:1-12. PMID: 33788184.
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    3. Amrani Y, Panettieri RA, Ramos-Ramírez P, Schaafsma D, Kaczmarek K, Tliba O. Important lessons learned from studies on the pharmacology of glucocorticoids in human airway smooth muscle cells: Too much of a good thing may be a problem. Pharmacol Ther. 2020 May 27; 107589. PMID: 32473159.
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    4. Nuñez FJ, Johnstone TB, Corpuz ML, Kazarian AG, Mohajer NN, Tliba O, Panettieri RA, Koziol-White C, Roosan MR, Ostrom RS. Glucocorticoids rapidly activate cAMP production via Gas to initiate non-genomic signaling that contributes to one-third of their canonical genomic effects. FASEB J. 2019 Dec 27. PMID: 31908022.
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    5. Koziol-White CJ, Johnstone TB, Corpuz ML, Cao G, Orfanos S, Parikh V, Deeney BT, Tliba O, Ostrom RS, Dainty I, Panettieri RA. Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 20. PMID: 31747297.
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    6. Zhang J, Koussih L, Shan L, Halayko AJ, Tliba O, Gounni AS. Glucocorticoids regulate pentraxin-3 expression in human airway smooth muscle cells. PLoS One. 2019; 14(8):e0220772. PMID: 31437159.
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    7. Bui H, Amrani Y, Deeney B, Panettieri RA, Tliba O. Airway smooth muscle cells are insensitive to the anti-proliferative effects of corticosteroids: The novel role of insulin growth factor binding Protein-1 in asthma. Immunobiology. 2019 Jul; 224(4):490-496. PMID: 31133345.
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    8. Panettieri RA, Schaafsma D, Amrani Y, Koziol-White C, Ostrom R, Tliba O. Non-genomic Effects of Glucocorticoids: An Updated View. Trends Pharmacol Sci. 2019 01; 40(1):38-49. PMID: 30497693.
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    9. Tliba O, Panettieri RA. Paucigranulocytic asthma: The uncoupling of airway obstruction from inflammation. J Allergy Clin Immunol. 2018 Jun 18. PMID: 29928921.
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    10. Gavrila A, Chachi L, Tliba O, Brightling C, Amrani Y. Effect of the Plant Derivative Compound A on the Production of Corticosteroid-Resistant Chemokines in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2015 Nov; 53(5):728-37. PMID: 25897650.
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    11. O'Connell D, Bouazza B, Kokalari B, Amrani Y, Khatib A, Ganther JD, Tliba O. IFN-?-induced JAK/STAT, but not NF-?B, signaling pathway is insensitive to glucocorticoid in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L348-59. PMID: 26092996.
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    12. Bouazza B, Debba-Pavard M, Amrani Y, Isaacs L, O'Connell D, Ahamed S, Formella D, Tliba O. Basal p38 Mitogen-Activated Protein Kinase Regulates Unliganded Glucocorticoid Receptor Function in Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):301-15. PMID: 24024586.
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    13. Chachi L, Shikotra A, Duffy SM, Tliba O, Brightling C, Bradding P, Amrani Y. Functional KCa3.1 Channels Regulate Steroid Insensitivity in Bronchial Smooth Muscle Cells. J Immunol. 2013 Sep 1; 191(5):2624-36. PMID: 23904164.
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    14. Bouazza B, Krytska K, Debba-Pavard M, Amrani Y, Honkanen RE, Tran J, Tliba O. Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):464-73. PMID: 22592921.
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    15. Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O. Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells. Am J Respir Cell Mol Biol. 2010 Jan; 42(1):9-15. PMID: 19805480.
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    16. Goncharova EA, Goncharov DA, Damera G, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP. Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis. Mol Pharmacol. 2009 Oct; 76(4):766-77. PMID: 19596836.
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    17. Bailey MT, Kierstein S, Sharma S, Spaits M, Kinsey SG, Tliba O, Amrani Y, Sheridan JF, Panettieri RA, Haczku A. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production. J Immunol. 2009 Jun 15; 182(12):7888-96. PMID: 19494313.
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    18. Clarke D, Damera G, Sukkar MB, Tliba O. Transcriptional regulation of cytokine function in airway smooth muscle cells. Pulm Pharmacol Ther. 2009 Oct; 22(5):436-45. PMID: 19393330.
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    19. Tliba O, Panettieri RA. Noncontractile functions of airway smooth muscle cells in asthma. Annu Rev Physiol. 2009; 71:509-35. PMID: 18851708.
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    20. Damera G, Tliba O, Panettieri RA. Airway smooth muscle as an immunomodulatory cell. Pulm Pharmacol Ther. 2009 Oct; 22(5):353-9. PMID: 19121407.
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    21. Tliba O, Panettieri RA. Regulation of inflammation by airway smooth muscle. Curr Allergy Asthma Rep. 2008 May; 8(3):262-8. PMID: 18589846.
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    22. Jain D, Keslacy S, Tliba O, Cao Y, Kierstein S, Amin K, Panettieri RA, Haczku A, Amrani Y. Essential role of IFNbeta and CD38 in TNFalpha-induced airway smooth muscle hyper-responsiveness. Immunobiology. 2008; 213(6):499-509. PMID: 18514752.
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    23. Tliba O, Amrani Y. Airway smooth muscle cell as an inflammatory cell: lessons learned from interferon signaling pathways. Proc Am Thorac Soc. 2008 Jan 1; 5(1):106-12. PMID: 18094092.
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    24. Tliba O, Amrani Y, Panettieri RA. Is airway smooth muscle the "missing link" modulating airway inflammation in asthma? Chest. 2008 Jan; 133(1):236-42. PMID: 18187748.
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    25. Goncharova EA, Goncharov DA, Chisolm A, Spaits MS, Lim PN, Cesarone G, Khavin I, Tliba O, Amrani Y, Panettieri RA, Krymskaya VP. Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Mol Pharmacol. 2008 Mar; 73(3):778-88. PMID: 18094073.
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    26. Tliba O, Damera G, Banerjee A, Gu S, Baidouri H, Keslacy S, Amrani Y. Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):463-72. PMID: 17947510.
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    27. Keslacy S, Tliba O, Baidouri H, Amrani Y. Inhibition of tumor necrosis factor-alpha-inducible inflammatory genes by interferon-gamma is associated with altered nuclear factor-kappaB transactivation and enhanced histone deacetylase activity. Mol Pharmacol. 2007 Feb; 71(2):609-18. PMID: 17108260.
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    28. Tliba O, Cidlowski JA, Amrani Y. CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol Pharmacol. 2006 Feb; 69(2):588-96. PMID: 16291871.
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    29. Huang CD, Ammit AJ, Tliba O, Kuo HP, Penn RB, Panettieri RA, Amrani Y. G-protein-coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha-stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells. J Biomed Sci. 2005 Oct; 12(5):763-76. PMID: 16228299.
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    30. Kim JH, Jain D, Tliba O, Yang B, Jester WF, Panettieri RA, Amrani Y, Puré E. TGF-beta potentiates airway smooth muscle responsiveness to bradykinin. Am J Physiol Lung Cell Mol Physiol. 2005 Oct; 289(4):L511-20. PMID: 15923209.
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    31. Syed F, Panettieri RA, Tliba O, Huang C, Li K, Bracht M, Amegadzie B, Griswold D, Li L, Amrani Y. The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells. Respir Res. 2005; 6:9. PMID: 15661077.
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    32. Sibille P, Tliba O, Boulard C. Early and transient cytotoxic response of peritoneal cells from Fasciola hepatica-infected rats. Vet Res. 2004 Sep-Oct; 35(5):573-84. PMID: 15369660.
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    33. Tliba O, Panettieri RA, Tliba S, Walseth TF, Amrani Y. Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway. Mol Pharmacol. 2004 Aug; 66(2):322-9. PMID: 15266023.
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    34. Howarth PH, Knox AJ, Amrani Y, Tliba O, Panettieri RA, Johnson M. Synthetic responses in airway smooth muscle. J Allergy Clin Immunol. 2004 Aug; 114(2 Suppl):S32-50. PMID: 15309017.
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    35. Amrani Y, Tliba O, Deshpande DA, Walseth TF, Kannan MS, Panettieri RA. Bronchial hyperresponsiveness: insights into new signaling molecules. Curr Opin Pharmacol. 2004 Jun; 4(3):230-4. PMID: 15140413.
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    36. Kazi AS, Lotfi S, Goncharova EA, Tliba O, Amrani Y, Krymskaya VP, Lazaar AL. Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L539-45. PMID: 14633511.
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    37. Tliba O, Deshpande D, Chen H, Van Besien C, Kannan M, Panettieri RA, Amrani Y. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. Br J Pharmacol. 2003 Dec; 140(7):1159-62. PMID: 14597600.
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    38. Tliba O, Tliba S, Da Huang C, Hoffman RK, DeLong P, Panettieri RA, Amrani Y. Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta. J Biol Chem. 2003 Dec 12; 278(50):50615-23. PMID: 14519761.
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    39. Chen H, Tliba O, Van Besien CR, Panettieri RA, Amrani Y. TNF-[alpha] modulates murine tracheal rings responsiveness to G-protein-coupled receptor agonists and KCl. J Appl Physiol. 2003 Aug; 95(2):864-72; discussion 863. PMID: 12730147.
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    40. Huang CD, Tliba O, Panettieri RA, Amrani Y. Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Am J Respir Cell Mol Biol. 2003 Mar; 28(3):330-8. PMID: 12594059.
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    41. Amrani Y, Tliba O, Choubey D, Huang CD, Krymskaya VP, Eszterhas A, Lazaar AL, Panettieri RA. IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am J Physiol Lung Cell Mol Physiol. 2003 Jun; 284(6):L1063-71. PMID: 12588705.
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    42. Tliba O, Moire N, Le Vern Y, Boulard C, Chauvin A, Sibille P. Early hepatic immune response in rats infected with Fasciola hepatica. Vet Res. 2002 May-Jun; 33(3):261-70. PMID: 12056477.
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    43. Tliba O, Chauvin A, Le Vern Y, Boulard C, Sbille P. Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats. Vet Res. 2002 May-Jun; 33(3):327-32. PMID: 12056483.
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