Philip Wedegaertner

TitleProfessor
InstitutionThomas Jefferson University
DepartmentBiochem & Molecular Biology
Address233 S. 10th Street
Philadelphia PA 19107
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lapadula D, Farias E, Randolph CE, Purwin T, McGrath D, Charpentier T, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner P, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gaq and Ga11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res. 2018 Dec 19. PMID: 30567972.
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    2. Xiao P, Huang X, Huang L, Yang J, Li A, Shen K, Wedegaertner PB, Jiang X. G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. Exp Cell Res. 2017 11 15; 360(2):273-280. PMID: 28912086.
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    3. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 Jul; 13(7):799-806. PMID: 28553949.
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    4. Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. Mol Cancer Res. 2017 May; 15(5):501-506. PMID: 28223438.
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    5. Klayman LM, Wedegaertner PB. Inducible Inhibition of Gß? Reveals Localization-dependent Functions at the Plasma Membrane and Golgi. J Biol Chem. 2017 Feb 03; 292(5):1773-1784. PMID: 27994056.
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    6. Helms MC, Grabocka E, Martz MK, Fischer CC, Suzuki N, Wedegaertner PB. Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1. Cell Signal. 2016 Jan; 28(1):43-52. PMID: 26483157.
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    7. Hewavitharana T, Wedegaertner PB. PAQR3 regulates Golgi vesicle fission and transport via the Gß?-PKD signaling pathway. Cell Signal. 2015 Dec; 27(12):2444-51. PMID: 26327583.
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    8. Xu H, Jiang X, Shen K, Fischer CC, Wedegaertner PB. The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function. Mol Biol Cell. 2014 Jul 1; 25(13):2105-15. PMID: 24807909.
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    9. Martz MK, Grabocka E, Beeharry N, Yen TJ, Wedegaertner PB. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Mol Biol Cell. 2013 Sep; 24(18):2785-94. PMID: 23885121.
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    10. Wedegaertner PB. G protein trafficking. Subcell Biochem. 2012; 63:193-223. PMID: 23161140.
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    11. Hewavitharana T, Wedegaertner PB. Non-canonical signaling and localizations of heterotrimeric G proteins. Cell Signal. 2012 Jan; 24(1):25-34. PMID: 21907280.
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    12. Irannejad R, Wedegaertner PB. Regulation of constitutive cargo transport from the trans-Golgi network to plasma membrane by Golgi-localized G protein betagamma subunits. J Biol Chem. 2010 Oct 15; 285(42):32393-404. PMID: 20720014.
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    13. Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB. An N-terminal polybasic motif of Gaq is required for signaling and influences membrane nanodomain distribution. Mol Pharmacol. 2010 Oct; 78(4):767-77. PMID: 20664004.
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    14. Banerjee J, Fischer CC, Wedegaertner PB. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF. Biochemistry. 2009 Aug 25; 48(33):8032-43. PMID: 19618964.
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    15. Bhattacharyya R, Banerjee J, Khalili K, Wedegaertner PB. Differences in Galpha12- and Galpha13-mediated plasma membrane recruitment of p115-RhoGEF. Cell Signal. 2009 Jun; 21(6):996-1006. PMID: 19249348.
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    16. Crouthamel M, Thiyagarajan MM, Evanko DS, Wedegaertner PB. N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q). Cell Signal. 2008 Oct; 20(10):1900-10. PMID: 18647648.
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    17. Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci. 2008 Mar 15; 121(Pt 6):895-905. PMID: 18303050.
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    18. Grabocka E, Wedegaertner PB. Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor. Mol Pharmacol. 2007 Oct; 72(4):993-1002. PMID: 17609419.
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    19. Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB. Assembly and trafficking of heterotrimeric G proteins. Biochemistry. 2007 Jul 3; 46(26):7665-77. PMID: 17559193.
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    20. Jiang X, Benovic JL, Wedegaertner PB. Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A. Mol Biol Cell. 2007 Aug; 18(8):2960-9. PMID: 17538017.
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    21. Escribá PV, Wedegaertner PB, Goñi FM, Vögler O. Lipid-protein interactions in GPCR-associated signaling. Biochim Biophys Acta. 2007 Apr; 1768(4):836-52. PMID: 17067547.
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    22. Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA, Chan TO, Penn RB. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry. 2005 Nov 8; 44(44):14595-605. PMID: 16262259.
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    23. Grabocka E, Wedegaertner PB. Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF. Oncogene. 2005 Mar 24; 24(13):2155-65. PMID: 15735747.
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    24. Evanko DS, Thiyagarajan MM, Takida S, Wedegaertner PB. Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling. Cell Signal. 2005 Oct; 17(10):1218-28. PMID: 16038796.
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    25. Cui J, Holgado-Madruga M, Su W, Tsuiki H, Wedegaertner P, Wong AJ. Identification of a specific domain responsible for JNK2alpha2 autophosphorylation. J Biol Chem. 2005 Mar 18; 280(11):9913-20. PMID: 15637069.
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    26. Takida S, Fischer CC, Wedegaertner PB. Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Mol Pharmacol. 2005 Jan; 67(1):132-9. PMID: 15496508.
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    27. Day PW, Tesmer JJ, Sterne-Marr R, Freeman LC, Benovic JL, Wedegaertner PB. Characterization of the GRK2 binding site of Galphaq. J Biol Chem. 2004 Dec 17; 279(51):53643-52. PMID: 15471870.
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    28. Takida S, Wedegaertner PB. Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins. FEBS Lett. 2004 Jun 4; 567(2-3):209-13. PMID: 15178324.
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    29. Thiyagarajan MM, Stracquatanio RP, Pronin AN, Evanko DS, Benovic JL, Wedegaertner PB. A predicted amphipathic helix mediates plasma membrane localization of GRK5. J Biol Chem. 2004 Apr 23; 279(17):17989-95. PMID: 14976207.
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    30. Banerjee J, Wedegaertner PB. Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton. Mol Biol Cell. 2004 Apr; 15(4):1760-75. PMID: 14742719.
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    31. Day PW, Wedegaertner PB, Benovic JL. Analysis of G-protein-coupled receptor kinase RGS homology domains. Methods Enzymol. 2004; 390:295-310. PMID: 15488185.
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    32. Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB. Differential interaction of GRK2 with members of the G alpha q family. Biochemistry. 2003 Aug 5; 42(30):9176-84. PMID: 12885252.
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    33. Bhattacharyya R, Wedegaertner PB. Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. Biochem J. 2003 May 1; 371(Pt 3):709-20. PMID: 12534370.
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    34. Bhattacharyya R, Wedegaertner PB. Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment. FEBS Lett. 2003 Apr 10; 540(1-3):211-6. PMID: 12681510.
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    35. Takida S, Wedegaertner PB. Heterotrimer formation, together with isoprenylation, is required for plasma membrane targeting of Gbetagamma. J Biol Chem. 2003 May 9; 278(19):17284-90. PMID: 12609996.
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    36. Sterne-Marr R, Tesmer JJ, Day PW, Stracquatanio RP, Cilente JA, O'Connor KE, Pronin AN, Benovic JL, Wedegaertner PB. G protein-coupled receptor Kinase 2/G alpha q/11 interaction. A novel surface on a regulator of G protein signaling homology domain for binding G alpha subunits. J Biol Chem. 2003 Feb 21; 278(8):6050-8. PMID: 12427730.
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    37. Thiyagarajan MM, Bigras E, Van Tol HH, Hébert TE, Evanko DS, Wedegaertner PB. Activation-induced subcellular redistribution of G alpha(s) is dependent upon its unique N-terminus. Biochemistry. 2002 Jul 30; 41(30):9470-84. PMID: 12135370.
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    38. Wedegaertner PB. Characterization of subcellular localization and stability of a splice variant of G alpha i2. BMC Cell Biol. 2002 May 31; 3:12. PMID: 12057015.
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    39. Filhol O, Cochet C, Wedegaertner P, Gill GN, Chambaz EM. Coexpression of both alpha and beta subunits is required for assembly of regulated casein kinase II. Biochemistry. 1991 Nov 19; 30(46):11133-40. PMID: 1932033.
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