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One or more keywords matched the following items that are connected to Shapiro, Irving
Item TypeName
Concept Intervertebral Disc
Concept Intervertebral Disc Displacement
Concept Intervertebral Disc Degeneration
Academic Article Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling.
Academic Article Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc.
Academic Article Transcriptional profiling of the nucleus pulposus: say yes to notochord.
Academic Article Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord.
Academic Article Hypoxia activates the notch signaling pathway in cells of the intervertebral disc: implications in degenerative disc disease.
Academic Article Hypoxic regulation of ß-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins.
Academic Article Transforming growth factor ß controls CCN3 expression in nucleus pulposus cells of the intervertebral disc.
Academic Article TNF-a and IL-1ß promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
Academic Article Notochordal cells in the adult intervertebral disc: new perspective on an old question.
Academic Article HIF-1a and HIF-2a degradation is differentially regulated in nucleus pulposus cells of the intervertebral disc.
Academic Article An organ culture system to model early degenerative changes of the intervertebral disc.
Academic Article Is the spinal motion segment a diarthrodial polyaxial joint: what a nice nucleus like you doing in a joint like this?
Academic Article Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1a degradation.
Academic Article Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1a activity in hypoxia.
Academic Article Molecular regulation of CCN2 in the intervertebral disc: Lessons learned from other connective tissues.
Academic Article Inflammatory Cytokines Induce NOTCH Signaling in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION.
Academic Article Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2.
Academic Article Intervertebral disc tissue engineering I: characterization of the nucleus pulposus.
Academic Article Intervertebral disc tissue engineering II: cultures of nucleus pulposus cells.
Academic Article An organ culture system for the study of the nucleus pulposus: description of the system and evaluation of the cells.
Academic Article Stem cell regeneration of the nucleus pulposus.
Academic Article Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy.
Academic Article Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal.
Academic Article Cellular therapy for disc degeneration.
Academic Article Hypoxia activates MAPK activity in rat nucleus pulposus cells: regulation of integrin expression and cell survival.
Academic Article Cell-based therapy for disc repair.
Academic Article Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment.
Academic Article Toward an optimum system for intervertebral disc organ culture: TGF-beta 3 enhances nucleus pulposus and anulus fibrosus survival and function through modulation of TGF-beta-R expression and ERK signaling.
Academic Article TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc.
Academic Article Galectin-3 expression in the intervertebral disc: a useful marker of the notochord phenotype?
Academic Article In situ oxygen utilization in the rat intervertebral disc.
Academic Article Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro: implications for cell-based transplantation therapy.
Academic Article MEK/ERK signaling controls osmoregulation of nucleus pulposus cells of the intervertebral disc by transactivation of TonEBP/OREBP.
Academic Article Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk.
Academic Article HIF-1 alpha is a regulator of galectin-3 expression in the intervertebral disc.
Academic Article Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling.
Academic Article Evidence for skeletal progenitor cells in the degenerate human intervertebral disc.
Academic Article SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc.
Academic Article Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc.
Academic Article Osmolarity and intracellular calcium regulate aquaporin2 expression through TonEBP in nucleus pulposus cells of the intervertebral disc.
Academic Article Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc.
Academic Article PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc.
Academic Article Reversine enhances generation of progenitor-like cells by dedifferentiation of annulus fibrosus cells.
Academic Article BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs.
Academic Article Role of cytokines in intervertebral disc degeneration: pain and disc content.
Academic Article An organ culture system to model early degenerative changes of the intervertebral disc II: profiling global gene expression changes.
Academic Article CCN2 Suppresses Catabolic Effects of Interleukin-1ß through a5ß1 and aVß3 Integrins in Nucleus Pulposus Cells: IMPLICATIONS IN INTERVERTEBRAL DISC DEGENERATION.
Academic Article Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: evolving role of TonEBP.
Academic Article Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: Novel HIF-1-mediated regulation of aquaporins in NP cells.
Academic Article TGFß regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration.
Academic Article Syndecan-4 in intervertebral disc and cartilage: Saint or synner?
Academic Article Class I and IIa HDACs Mediate HIF-1a Stability Through PHD2-Dependent Mechanism, While HDAC6, a Class IIb Member, Promotes HIF-1a Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc.
Academic Article Circadian factors BMAL1 and RORa control HIF-1a transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health.
Grant New Horizons in Intervertebral Disc Research
Grant Regeneration of Nucleus Pulposus by Tissue Engineering
Grant New Horizons in Intervertebral Disc Research
Academic Article TNF-a promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells.
Academic Article A novel mouse model of intervertebral disc degeneration shows altered cell fate and matrix homeostasis.
Academic Article Transgenic mice overexpressing human TNF-a experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration.
Academic Article p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence.
Academic Article A new understanding of the role of IL-1 in age-related intervertebral disc degeneration in a murine model.
Academic Article NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis.
Academic Article Lactate Efflux from Intervertebral Disc Cells is Required for Maintenance of Spine Health.
Academic Article Differential Effect of Long-Term Systemic Exposure of TNFa on Health of the Annulus Fibrosus and Nucleus Pulposus of the Intervertebral Disc.
Academic Article TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression.
Academic Article Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.
Academic Article Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging.
Academic Article Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes.
Academic Article The role of HIF proteins in maintaining the metabolic health of the intervertebral disc.
Academic Article Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.
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