"Hemoglobin, Sickle" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
| Descriptor ID |
D006451
|
| MeSH Number(s) |
D12.776.124.400.463.588 D12.776.422.316.762.426.588
|
| Concept/Terms |
Deoxyhemoglobin S- Deoxyhemoglobin S
- Deoxygenated Sickle Hemoglobin
- Hemoglobin, Deoxygenated Sickle
- Sickle Hemoglobin, Deoxygenated
|
Below are MeSH descriptors whose meaning is more general than "Hemoglobin, Sickle".
Below are MeSH descriptors whose meaning is more specific than "Hemoglobin, Sickle".
This graph shows the total number of publications written about "Hemoglobin, Sickle" by people in this website by year, and whether "Hemoglobin, Sickle" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 3 | 0 | 3 |
| 1997 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2006 | 2 | 1 | 3 |
| 2008 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hemoglobin, Sickle" by people in Profiles.
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Early ML, Luo A, Solow M, Matusiak K, Eke AC, Shehata N, August P, Kuo KHM, Lanzkron S, Malinowski AK, Pecker LH. Natural history of blood pressure in sickle cell disease pregnancy. Br J Haematol. 2024 02; 204(2):658-667.
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Jones JM, Swett AD, Crowe EP, Lawrence C, Bloch EM, Lanzkron SM. Implementation of national blood conservation recommendations at an adult sickle cell center. Transfusion. 2022 09; 62(9):1763-1771.
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Pecker LH, Lanzkron S. Sickle Cell Disease. Ann Intern Med. 2021 01; 174(1):ITC1-ITC16.
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Pecker LH, Hussain S, Christianson MS, Lanzkron S. Hydroxycarbamide exposure and ovarian reserve in women with sickle cell disease in the Multicenter Study of Hydroxycarbamide. Br J Haematol. 2020 12; 191(5):880-887.
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Razdan S, Strouse JJ, Reddy A, Resar DF, Hasan RK, Resar JR, Naik RP, Urrutia VC, Lanzkron S, Resar LM. Patent foramen ovale in adults with sickle cell disease and stroke. Am J Hematol. 2016 09; 91(9):E358-60.
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Lanzkron S, Haywood C. The five key things you need to know to manage adult patients with sickle cell disease. Hematology Am Soc Hematol Educ Program. 2015; 2015:420-5.
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Adachi K, Ding M, Asakura T, Surrey S. Relationship between beta4 hydrogen bond and beta6 hydrophobic interactions during aggregate, fiber or crystal formation in oversaturated solutions of hemoglobin A and S. Arch Biochem Biophys. 2009 Jan 15; 481(2):137-44.
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Adachi K, Ding M, Surrey S. Role of the beta4Thr-beta73Asp hydrogen bond in HbS polymer and domain formation from multinucleate-containing clusters. Biochemistry. 2008 May 13; 47(19):5441-9.
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Adachi K, Ding M, Surrey S, Rotter M, Aprelev A, Zakharov M, Weng W, Ferrone FA. The Hb A variant (beta73 Asp-->Leu) disrupts Hb S polymerization by a novel mechanism. J Mol Biol. 2006 Sep 22; 362(3):528-38.
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Akbar MG, Tamura Y, Ding M, Ding H, Rosenblatt MM, Reddy KS, Surrey S, Adachi K. Inhibition of hemoglobin S polymerization in vitro by a novel 15-mer EF-helix beta73 histidine-containing peptide. Biochemistry. 2006 Jul 11; 45(27):8358-67.