"Hybridomas" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
| Descriptor ID |
D006825
|
| MeSH Number(s) |
A11.251.353.485 A11.251.600.485
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hybridomas".
Below are MeSH descriptors whose meaning is more specific than "Hybridomas".
This graph shows the total number of publications written about "Hybridomas" by people in this website by year, and whether "Hybridomas" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 4 | 4 |
| 2004 | 0 | 4 | 4 |
| 2005 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 2 | 3 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hybridomas" by people in Profiles.
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Lemons AR, Siegel PD, Mhike M, Law BF, Hettick JM, Bledsoe TA, Nayak AP, Beezhold DH, Green BJ. A murine monoclonal antibody with broad specificity for occupationally relevant diisocyanates. J Occup Environ Hyg. 2014; 11(2):101-10.
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Nayak AP, Green BJ, Friend S, Beezhold DH. Development of monoclonal antibodies to recombinant terrelysin and characterization of expression in Aspergillus terreus. J Med Microbiol. 2012 Apr; 61(Pt 4):489-99.
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Gangavarapu KJ, Olbertz JL, Bhushan A, Lai JC, Daniels CK. Apoptotic resistance exhibited by dexamethasone-resistant murine 7TD1 cells is controlled independently of interleukin-6 triggered signaling. Apoptosis. 2008 Nov; 13(11):1394-400.
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Adekar SP, Jones RM, Elias MD, Al-Saleem FH, Root MJ, Simpson LL, Dessain SK. Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins. J Immunol Methods. 2008 Apr 20; 333(1-2):156-66.
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Adekar SP, Jones RM, Elias MD, Al-Saleem FH, Root MJ, Simpson LL, Dessain SK. A human monoclonal antibody that binds serotype A botulinum neurotoxin. Hybridoma (Larchmt). 2008 Feb; 27(1):11-7.
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Li J, Sai T, Berger M, Chao Q, Davidson D, Deshmukh G, Drozdowski B, Ebel W, Harley S, Henry M, Jacob S, Kline B, Lazo E, Rotella F, Routhier E, Rudolph K, Sage J, Simon P, Yao J, Zhou Y, Kavuru M, Bonfield T, Thomassen MJ, Sass PM, Nicolaides NC, Grasso L. Human antibodies for immunotherapy development generated via a human B cell hybridoma technology. Proc Natl Acad Sci U S A. 2006 Mar 7; 103(10):3557-62.
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Anikeeva N, Somersalo K, Sims TN, Thomas VK, Dustin ML, Sykulev Y. Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 2005 May 3; 102(18):6437-42.
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Liu X, Manser T. Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro. J Immunol. 2005 Apr 15; 174(8):4505-15.
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Lepin EJ, Jin YP, Barwe SP, Rozengurt E, Reed EF. HLA class I signal transduction is dependent on Rho GTPase and ROK. Biochem Biophys Res Commun. 2004 Oct 08; 323(1):213-7.
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Mareeva T, Lebedeva T, Anikeeva N, Manser T, Sykulev Y. Antibody specific for the peptide.major histocompatibility complex. Is it T cell receptor-like? J Biol Chem. 2004 Oct 22; 279(43):44243-9.