"Iduronate Sulfatase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that specifically cleaves the ester sulfate of iduronic acid. Its deficiency has been demonstrated in Hunter's syndrome, which is characterized by an excess of dermatan sulfate and heparan sulfate. EC 3.1.6.13.
| Descriptor ID |
D007066
|
| MeSH Number(s) |
D08.811.277.352.827.500
|
| Concept/Terms |
Iduronate Sulfatase- Iduronate Sulfatase
- Sulfatase, Iduronate
- Iduronate Sulfate Sulfatase
- Sulfatase, Iduronate Sulfate
- Sulfate Sulfatase, Iduronate
- Sulfoiduronate Sulfatase
- Sulfatase, Sulfoiduronate
- Hunter Corrective Factor
- Corrective Factor, Hunter
- Factor, Hunter Corrective
- Iduronatesulfate Sulfohydrolase
- Sulfohydrolase, Iduronatesulfate
|
Below are MeSH descriptors whose meaning is more general than "Iduronate Sulfatase".
Below are MeSH descriptors whose meaning is more specific than "Iduronate Sulfatase".
This graph shows the total number of publications written about "Iduronate Sulfatase" by people in this website by year, and whether "Iduronate Sulfatase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Iduronate Sulfatase" by people in Profiles.
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Tomatsu S, Vogler C, Monta?o AM, Gutierrez M, Oikawa H, Dung VC, Orii T, Noguchi A, Sly WS. Murine model (Galns(tm(C76S)slu)) of MPS IVA with missense mutation at the active site cysteine conserved among sulfatase proteins. Mol Genet Metab. 2007 Jul; 91(3):251-8.
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Tomatsu S, Orii KO, Bi Y, Gutierrez MA, Nishioka T, Yamaguchi S, Kondo N, Orii T, Noguchi A, Sly WS. General implications for CpG hot spot mutations: methylation patterns of the human iduronate-2-sulfatase gene locus. Hum Mutat. 2004 Jun; 23(6):590-8.