"Insulysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.
| Descriptor ID |
D007339
|
| MeSH Number(s) |
D08.811.277.656.300.480.300 D08.811.277.656.675.374.300
|
| Concept/Terms |
Insulysin- Insulysin
- Insulin-Degrading Enzyme
- Enzyme, Insulin-Degrading
- Insulin Degrading Enzyme
- Insulin Protease
- Protease, Insulin
- Insulin Proteinase
- Proteinase, Insulin
- Insulinase
|
Below are MeSH descriptors whose meaning is more general than "Insulysin".
Below are MeSH descriptors whose meaning is more specific than "Insulysin".
This graph shows the total number of publications written about "Insulysin" by people in this website by year, and whether "Insulysin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
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Below are the most recent publications written about "Insulysin" by people in Profiles.
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Kulstad JJ, McMillan PJ, Leverenz JB, Cook DG, Green PS, Peskind ER, Wilkinson CW, Farris W, Mehta PD, Craft S. Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque. J Neuropathol Exp Neurol. 2005 Feb; 64(2):139-46.
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Cook DG, Leverenz JB, McMillan PJ, Kulstad JJ, Ericksen S, Roth RA, Schellenberg GD, Jin LW, Kovacina KS, Craft S. Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele. Am J Pathol. 2003 Jan; 162(1):313-9.