"Kainic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
| Descriptor ID |
D007608
|
| MeSH Number(s) |
D03.383.773.400
|
| Concept/Terms |
Kainic Acid- Kainic Acid
- Acid, Kainic
- Digenic Acid
- Acid, Digenic
|
Below are MeSH descriptors whose meaning is more general than "Kainic Acid".
Below are MeSH descriptors whose meaning is more specific than "Kainic Acid".
This graph shows the total number of publications written about "Kainic Acid" by people in this website by year, and whether "Kainic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Kainic Acid" by people in Profiles.
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Friedman LK, Sharma A, Corcia M, Webster T, Qazi L, Simsovits D, Khalil Y, Hu S, Kantrowitz M, Hong H. Selective inhibition of metabotropic glutamate type 1 alpha receptor (mGluR1a) reduces cell proliferation and migration following status epilepticus in early development. Int J Dev Neurosci. 2016 Nov; 54:6-21.
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Liu L, Hamre KM, Goldowitz D. Kainic acid-induced neuronal degeneration in hippocampal pyramidal neurons is driven by both intrinsic and extrinsic factors: analysis of FVB/N?C57BL/6 chimeras. J Neurosci. 2012 Aug 29; 32(35):12093-101.
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Louboutin JP, Chekmasova A, Marusich E, Agrawal L, Strayer DS. Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage. FASEB J. 2011 Feb; 25(2):737-53.
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Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47.
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Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Robinson MB, Rothstein JD. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron. 2009 Mar 26; 61(6):880-94.
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Schock SC, Xu J, Duquette PM, Qin Z, Lewandowski AJ, Rai PS, Thompson CS, Seifert EL, Harper ME, Chen HH. Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4. J Neurosci. 2008 Nov 19; 28(47):12433-44.
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Monnerie H, Le Roux PD. Glutamate receptor agonist kainate enhances primary dendrite number and length from immature mouse cortical neurons in vitro. J Neurosci Res. 2006 May 01; 83(6):944-56.
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Yang Y, Kinney GA, Spain WJ, Breitner JC, Cook DG. Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J Neurochem. 2004 Mar; 88(6):1361-72.
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Monnerie H, Shashidhara S, Le Roux PD. Decreased dendrite growth from cultured mouse cortical neurons surviving excitotoxic activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate/kainate receptors. Neurosci Lett. 2003 Jul 24; 345(3):182-6.
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Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH, Hediger MA. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. J Biol Chem. 2001 Jan 5; 276(1):576-82.