Killer Cells, Natural

"Killer Cells, Natural" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.

Descriptor ID	D007694
MeSH Number(s)	A11.118.637.555.567.537 A15.145.229.637.555.567.537 A15.382.490.555.567.537
Concept/Terms	Killer Cells, Natural Killer Cells, Natural NK Cells Cell, NK Cells, NK NK Cell Natural Killer Cells Cell, Natural Killer Cells, Natural Killer Killer Cell, Natural Natural Killer Cell

Below are MeSH descriptors whose meaning is more general than "Killer Cells, Natural".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Killer Cells, Natural [A11.118.637.555.567.537]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Killer Cells, Natural [A15.145.229.637.555.567.537]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Killer Cells, Natural [A15.382.490.555.567.537]

Below are MeSH descriptors whose meaning is related to "Killer Cells, Natural".

Below are MeSH descriptors whose meaning is more specific than "Killer Cells, Natural".

Killer Cells, Natural
Killer Cells, Lymphokine-Activated

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Killer Cells, Natural" by people in this website by year, and whether "Killer Cells, Natural" was a major or minor topic of these publications.

Bar chart showing 131 publications over 26 distinct years, with a maximum of 15 publications in 2008 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	2	3
1998	1	1	2
1999	1	0	1
2001	0	1	1
2002	2	0	2
2003	3	1	4
2004	4	1	5
2005	4	1	5
2006	3	2	5
2007	6	1	7
2008	9	6	15
2009	7	4	11
2010	11	4	15
2011	2	2	4
2012	2	2	4
2013	5	1	6
2014	4	0	4
2015	5	2	7
2016	3	1	4
2017	1	2	3
2018	5	0	5
2019	5	0	5
2020	0	3	3
2021	0	4	4
2022	1	2	3
2023	0	3	3

Below are the most recent publications written about "Killer Cells, Natural" by people in Profiles.

Sykulev Y. Factors contributing to the potency of CD8+ T cells. Trends Immunol. 2023 09; 44(9):693-700.

View in: PubMed
Campbell KS. Murine Cytomegalovirus Encodes a Specific Cell Surface Marker That Can Trigger Attack by NK Cells. J Immunol. 2023 03 01; 210(5):519-520.

View in: PubMed
Richardson K, Keam SP, Zhu JJ, Meyran D, D'Souza C, Macdonald S, Campbell K, Robbins M, Bezman NA, Todd K, Quach H, Ritchie DS, Harrison SJ, Prince HM, Trapani JA, Jenkins MR, Beavis PA, Darcy PK, Neeson PJ. The efficacy of combination treatment with elotuzumab and lenalidomide is dependent on crosstalk between natural killer cells, monocytes and myeloma cells. Haematologica. 2023 01 01; 108(1):83-97.

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Shapiro RM, Birch GC, Hu G, Vergara Cadavid J, Nikiforow S, Baginska J, Ali AK, Tarannum M, Sheffer M, Abdulhamid YZ, Rambaldi B, Arihara Y, Reynolds C, Halpern MS, Rodig SJ, Cullen N, Wolff JO, Pfaff KL, Lane AA, Lindsley RC, Cutler CS, Antin JH, Ho VT, Koreth J, Gooptu M, Kim HT, Malmberg KJ, Wu CJ, Chen J, Soiffer RJ, Ritz J, Romee R. Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse. J Clin Invest. 2022 Jun 01; 132(11).

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Iraqi M, Edri A, Greenshpan Y, Goldstein O, Ofir N, Bolel P, Abu Ahmad M, Zektser M, Campbell KS, Rouvio O, Gazit R, Porgador A. Blocking the PCNA/NKp44 Checkpoint to Stimulate NK Cell Responses to Multiple Myeloma. Int J Mol Sci. 2022 Apr 25; 23(9).

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Maskalenko NA, Zhigarev D, Campbell KS. Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders. Nat Rev Drug Discov. 2022 08; 21(8):559-577.

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Weiss SL, Henrickson SE, Lindell RB, Sartori LF, Zhang D, Bush J, Farooqi S, Starr J, Deutschman CS, McGowan FX, Becker L, Tuluc F, Wherry EJ, Picard M, Wallace DC. Influence of Immune Cell Subtypes on Mitochondrial Measurements in Peripheral Blood Mononuclear Cells From Children with Sepsis. Shock. 2022 05 01; 57(5):630-638.

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Trikha P, Moseman JE, Thakkar A, Campbell AR, Elmas E, Foltz JA, Chakravarti N, Fitch JR, Mardis ER, Lee DA. Defining the AHR-regulated transcriptome in NK cells reveals gene expression programs relevant to development and function. Blood Adv. 2021 11 23; 5(22):4605-4618.

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Melo-Silva CR, Alves-Peixoto P, Heath N, Tang L, Montoya B, Knudson CJ, Stotesbury C, Ferez M, Wong E, Sigal LJ. Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells. PLoS Pathog. 2021 05; 17(5):e1009593.

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Campbell KS. Mystery Checkpoint Revealed: KIR3DL3 Finally Found a Ligand in HHLA2. Cancer Immunol Res. 2021 02; 9(2):128.

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