"Mecamylamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Descriptor ID |
D008464
|
| MeSH Number(s) |
D02.455.849.575.781.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Mecamylamine".
Below are MeSH descriptors whose meaning is more specific than "Mecamylamine".
This graph shows the total number of publications written about "Mecamylamine" by people in this website by year, and whether "Mecamylamine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mecamylamine" by people in Profiles.
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Hahn B, Harvey AN, Concheiro-Guisan M, Huestis MA, Ross TJ, Stein EA. Nicotinic receptor modulation of the default mode network. Psychopharmacology (Berl). 2021 Feb; 238(2):589-597.
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Singh NS, Paul RK, Ramamoorthy A, Torjman MC, Moaddel R, Bernier M, Wainer IW. Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells. Cell Signal. 2013 Dec; 25(12):2634-45.
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Scheidweiler KB, Shakleya DM, Huestis MA. Simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine, norcotinine and mecamylamine in human urine by liquid chromatography-tandem mass spectrometry. Clin Chim Acta. 2012 Jun 14; 413(11-12):978-84.
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Wang DX, Sheu SS, Sharma VK, Rubin L, Journet M, Kende AS, Abood LG. [3H]benzylpempidine, a new radioligand for probing a putative channel site on nicotinic cholinergic receptors. Life Sci. 1997; 60(15):1271-7.