Methotrexate

"Methotrexate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Descriptor ID	D008727
MeSH Number(s)	D03.633.100.733.631.192.500
Concept/Terms	Methotrexate Methotrexate Amethopterin Methotrexate, (D)-Isomer Methotrexate, (D)-Isomer Methotrexate, (DL)-Isomer Methotrexate, (DL)-Isomer Mexate Mexate Methotrexate Sodium Methotrexate Sodium Sodium, Methotrexate Methotrexate, Sodium Salt Methotrexate, Disodium Salt Methotrexate Hydrate Methotrexate Hydrate Hydrate, Methotrexate Methotrexate, Dicesium Salt Methotrexate, Dicesium Salt Dicesium Salt Methotrexate

Below are MeSH descriptors whose meaning is more general than "Methotrexate".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, Fused-Ring [D03.633]
Heterocyclic Compounds, 2-Ring [D03.633.100]
Pteridines [D03.633.100.733]
Pterins [D03.633.100.733.631]
Aminopterin [D03.633.100.733.631.192]
Methotrexate [D03.633.100.733.631.192.500]

Below are MeSH descriptors whose meaning is related to "Methotrexate".

Below are MeSH descriptors whose meaning is more specific than "Methotrexate".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Methotrexate" by people in this website by year, and whether "Methotrexate" was a major or minor topic of these publications.

Bar chart showing 70 publications over 23 distinct years, with a maximum of 7 publications in 2010 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2001	0	1	1
2002	2	0	2
2003	2	2	4
2004	1	0	1
2005	0	3	3
2006	0	3	3
2007	2	2	4
2008	2	1	3
2009	2	4	6
2010	1	6	7
2011	2	3	5
2012	1	0	1
2013	1	1	2
2014	5	2	7
2015	1	5	6
2016	2	1	3
2017	0	1	1
2019	0	4	4
2020	0	2	2
2021	1	1	2
2023	0	1	1
2024	1	0	1

Below are the most recent publications written about "Methotrexate" by people in Profiles.

Loesch AJ, Jin A, Huang S, Motaparthi K, Lee JB, Hsu S. Methotrexate-Induced Epidermal Necrosis. Skinmed. 2024; 22(5):387-389.

View in: PubMed
Bola?os-Meade J, Hamadani M, Wu J, Al Malki MM, Martens MJ, Runaas L, Elmariah H, Rezvani AR, Gooptu M, Larkin KT, Shaffer BC, El Jurdi N, Loren AW, Solh M, Hall AC, Alousi AM, Jamy OH, Perales MA, Yao JM, Applegate K, Bhatt AS, Kean LS, Efebera YA, Reshef R, Clark W, DiFronzo NL, Leifer E, Horowitz MM, Jones RJ, Holtan SG. Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis. N Engl J Med. 2023 Jun 22; 388(25):2338-2348.

View in: PubMed
Vinekar K, Achilles SL, Chen BA. Management of heterotopic pregnancy with uterine aspiration and systemic two-dose methotrexate. Contraception. 2021 10; 104(4):444-446.

View in: PubMed
Tam Tam H, Putterman D, Sinha R, Woods Ludwig J, Gulersen M. Computed tomography-guided injection for management of caesarean scar pregnancy. Clin Radiol. 2021 Sep; 76(9):696-700.

View in: PubMed
Han YS, Mehta AM, Lee TC, Nagiel A, Pulido JS. Diagnostic and Therapeutic Challenges. Retina. 2020 Aug; 40(8):1641-1643.

View in: PubMed
Sparano JA, Gray RJ, Makower DF, Albain KS, Saphner TJ, Badve SS, Wagner LI, Kaklamani VG, Keane MM, Gomez HL, Reddy PS, Goggins TF, Mayer IA, Toppmeyer DL, Brufsky AM, Goetz MP, Berenberg JL, Mahalcioiu C, Desbiens C, Hayes DF, Dees EC, Geyer CE, Olson JA, Wood WC, Lively T, Paik S, Ellis MJ, Abrams J, Sledge GW. Clinical Outcomes in Early Breast Cancer With a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy Plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial. JAMA Oncol. 2020 03 01; 6(3):367-374.

View in: PubMed
deShazo R, Soltani-Arabshahi R, Krishnasamy S, Langley RG, Kalia S, St?hle M, Langholff W, Goyal K, Fakharzadeh S, Galindo C, Srivastava B, Krueger G. Non-Melanoma Skin Cancer Risk Among Patients in the Psoriasis Longitudinal Assessment and Registry (PSOLAR) J Drugs Dermatol. 2019 Oct 01; 18(10):1059-1060.

View in: PubMed
Starr MR, Garrity JA, Tooley AA, Salom?o DR. Clinical and histopathological findings of patients with orbital granulomatosis with polyangiitis cases refractory to rituximab. Can J Ophthalmol. 2019 12; 54(6):682-687.

View in: PubMed
Larsen V, Barlow WE, Yang JJ, Zhu Q, Liu S, Kwan ML, Ergas IJ, Roh JM, Hutchins LF, Kadlubar SA, Albain KS, Rae JM, Yeh IT, Ravdin PM, Martino S, Lyss AP, Osborne CK, Hortobagyi GN, Kushi LH, Hayes DF, Ambrosone CB, Yao S. Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study. Clin Breast Cancer. 2019 08; 19(4):225-235.e2.

View in: PubMed
Karadag AS, Parish LC. Sarcoidosis: A great imitator. Clin Dermatol. 2019 May - Jun; 37(3):240-254.

View in: PubMed

People

Explore

Similar Concepts

Top Journals

The Thomas Jefferson University web site, its contents and programs, is provided for informational and educational purposes only and is not intended as medical advice nor is it intended to create any physician-patient relationship. Please remember that this information should not substitute for a visit or a consultation with a health care provider. The views or opinions expressed in the resources provided do not necessarily reflect those of Thomas Jefferson University, Thomas Jefferson University Hospital, or the Jefferson Health System or staff.
Please read our Privacy Statement